
Vacation rentals in Panama Canal
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Panama Canal
Guests agree: these stays are highly rated for location, cleanliness, and more.

BirdHouse@ Gamboa Panamá Canal
Explore the wonders of the Panama rainforest and return to our magical tropical home! This unique house and pool is a wonderful place to escape the hustle of Panama City, celebrate nature, and enjoy family and friends. Gamboa is a safe, quiet town embedded in the Soberania National Park; it is the entry point to Pipeline Road, some of the best birding in the world. Or take leave of the forest and watch manatee, while fishing for peacock bass in Gatun Lake or paddling kayaks up the Chagres River.

Casa Condal - Your Luxury Retreat in Cerro Azul
Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

Panoramic Casco Viejo Lookout in The Sands
exquisite apartment blends cozy comfort with sophisticated luxury. Every detail radiates elegance, from the plush, high-end furnishings to the warm, inviting ambiance. The open-concept living area is perfect for relaxing or entertaining, with breathtaking views of the UNESCO World Heritage Casco Viejo framing the horizon. The compact kitchen has modern appliances, sleek countertops, and all essentials. With Casco Viejo vistas, this stylish retreat is perfect for exploring culture and history.

CASA SAEMA -PRESTIGIOSO ATICO DUPLEX CON TERRAZAS
Espectacular ático Duplex en Panamá Casco antiguo, de 265 M2 con balcones, terrazas privadas exterior, cuenta con una salón jardín interior, un comedor, 3 hab. (+ sofá cama en studio), recientemente reformado con concepto Loft, diseño exclusivo único y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina , lavavajilla, sala con lavadora. piscina compartida, asc, portero 24-7, no se permiten niños que no sepan nadar, gran variedad de ocio en la zona.

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

En el corazón de Casco, remodelado y con parking
Escápate y descubre casco antiguo en este remodelado , cómodo y céntrico alojamiento en el corazón de Casco Viejo. Nuestra ubicación es lo mejor, te hará regresar. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. La propiedad data del siglo XVII (1756) historia y buen ambiente. Podrás explorar la zona a pie, cocina full equipada, cama king europea, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar -Cocina full equipada

The View of Casco: Designer Loft with best Balcony
Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Loft 3b Casco Antiguo Best! Son 150 m2 (492 feet)
Sumérgete en el encanto histórico y la elegancia moderna de nuestro loft de 3 recámaras y 150 m2, en el corazón del Casco Antiguo. Con pisos de madera que irradian calidez y una cocina moderna de diseño abierto ideal para compartir, este espacio garantiza unas vacaciones memorables. Situado en la Avenida A, te encontrarás a solo unos pasos de exquisitos restaurantes, museos, iglesias coloniales y los codiciados rooftops del Casco, convirtiendo cada día en una aventura.

Patty’s Casco 2BR Loft | Balcony & Personal Touch
“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Walk to Everything | Luxury Stay in Casco Viej
Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Casco Antiguo Apartment with Balcony & Stone Wall
Elegante apartamento en el corazón de Casco Antiguo. Disfruta de un espacio colonial con paredes de piedra expuesta, iluminación cálida y un encantador balcón con vista a calles vibrantes. Ubicado en Avenida B, a pasos de restaurantes, cafeterías, rooftop bars y lugares históricos. Capacidad para hasta 5 huéspedes. Perfecto para vivir la cultura y energía de Casco Viejo. Debido al ambiente animado del área, puede escucharse ruido nocturno los fines de semana.

Private parking & rooftop | Studio Casco Center
This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location
Popular amenities for Panama Canal vacation rentals
Other great vacation rentals in Panama Canal

Casa familiar en Gamboa junto al Canal

Most Beautiful Loft in the Heart of Casco Viejo

Casco Antiguo & Ocean View

The Bird's Nest in the Clouds

Cinta Costera Ocean View Suite

Tropicool Casco Loft w/King Bed & Rooftop

Villas La Fontana Spacious ApartaSuite - Pool 104

Gorgeous Flat in the best location in Casco Viejo
Destinations to explore
- Hostel rentals Panama Canal
- Rentals with a patio Panama Canal
- Rentals with an EV charger Panama Canal
- Rentals with breakfast Panama Canal
- Loft rentals Panama Canal
- Family-friendly rentals Panama Canal
- Guesthouse rentals Panama Canal
- Condo rentals Panama Canal
- Serviced apartment rentals Panama Canal
- Rentals with a sauna Panama Canal
- Waterfront rentals Panama Canal
- Bed and breakfasts Panama Canal
- Hotel rooms Panama Canal
- Rentals with pools Panama Canal
- Rentals with an accessible height bed Panama Canal
- Private suite rentals Panama Canal
- Apartment rentals Panama Canal
- Rentals with a home theater Panama Canal
- Pet-friendly rentals Panama Canal
- Boutique hotels Panama Canal
- Rentals with a washer and dryer Panama Canal
- Rentals with beach access Panama Canal
- Rentals with a fire pit Panama Canal
- Beachfront rentals Panama Canal
- Rentals with a kayak Panama Canal
- Rentals with lake access Panama Canal
- House rentals Panama Canal
- Fitness-friendly rentals Panama Canal
- Rentals with a hot tub Panama Canal
- Smoking-friendly rentals Panama Canal
- Rentals with outdoor seating Panama Canal
- Townhouse rentals Panama Canal





