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Vacation rentals in Panama Canal

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Panama Canal

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Home in Gamboa
4.86 out of 5 average rating, 109 reviews

BirdHouse@ Gamboa Panamá Canal

Explore the wonders of the Panama rainforest and return to our magical tropical home! This unique house and pool is a wonderful place to escape the hustle of Panama City, celebrate nature, and enjoy family and friends. Gamboa is a safe, quiet town embedded in the Soberania National Park; it is the entry point to Pipeline Road, some of the best birding in the world. Or take leave of the forest and watch manatee, while fishing for peacock bass in Gatun Lake or paddling kayaks up the Chagres River.

Guest favorite
An open-concept loft is showcased with a high, sloped ceiling and large windows that invite natural light. Comfortable seating is arranged around a glass table, while a dining area and a cozy sleeping space can be seen in the background. Nature views are visible through the windows.
Home in Santa Rita Arriba
4.94 out of 5 average rating, 18 reviews

The Bird's Nest in the Clouds

Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain and birds. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. PLEASE READ ENTIRE DESCRIPTION BEFORE BOOKING.

Top guest favorite
Place to stay in Panamá
5 out of 5 average rating, 14 reviews

Casa Condal - Your Luxury Retreat in Cerro Azul

Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

Superhost
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Apartment in Panamá
4.86 out of 5 average rating, 404 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Top guest favorite
Apartment in Panama City
4.98 out of 5 average rating, 121 reviews

The View of Casco: Designer Loft with best Balcony

Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! ​Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. ​You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Guest favorite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in Panamá
4.93 out of 5 average rating, 121 reviews

Loft 3b Casco Antiguo Best! Son 150 m2 (492 feet)

Sumérgete en el encanto histórico y la elegancia moderna de nuestro loft de 3 recámaras y 150 m2, en el corazón del Casco Antiguo. Con pisos de madera que irradian calidez y una cocina moderna de diseño abierto ideal para compartir, este espacio garantiza unas vacaciones memorables. Situado en la Avenida A, te encontrarás a solo unos pasos de exquisitos restaurantes, museos, iglesias coloniales y los codiciados rooftops del Casco, convirtiendo cada día en una aventura.

Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 29 reviews

Walk to Everything | Luxury Stay in Casco Viej

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Top guest favorite
Apartment in Panamá
4.95 out of 5 average rating, 43 reviews

Casco Antiguo Apartment with Balcony & Stone Wall

Elegante apartamento en el corazón de Casco Antiguo. Disfruta de un espacio colonial con paredes de piedra expuesta, iluminación cálida y un encantador balcón con vista a calles vibrantes. Ubicado en Avenida B, a pasos de restaurantes, cafeterías, rooftop bars y lugares históricos. Capacidad para hasta 5 huéspedes. Perfecto para vivir la cultura y energía de Casco Viejo. Debido al ambiente animado del área, puede escucharse ruido nocturno los fines de semana.

Top guest favorite
Apartment in Panamá
5 out of 5 average rating, 35 reviews

Private parking & rooftop | Studio Casco Center

This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Guest favorite
The image captures a stunning view from a balcony, overlooking a historic cathedral with intricate architectural detailing. The white buildings frame the scene, and cloudy skies add a soft contrast to the vibrant structure of the cathedral, highlighting its grandeur.
Loft in Panamá
4.89 out of 5 average rating, 298 reviews

Amazing Loft with the Best view of Casco viejo for

Beautiful loft located in the center of Casco Antiguo, the most touristic area of Panama. This spacious loft comfortably accommodates up to 6 guests, making it perfect for families or groups of friends. Come, enjoy and relax in this impressive loft, featuring an incredible view of the Panama Cathedral. You can easily visit museums, bars, restaurants, and historic churches located just a few meters away.

Guest favorite
A central pool area is surrounded by tropical plants and trees, adding greenery to the space. Comfortable lounge chairs are positioned by the water, inviting relaxation. The building showcases a modern design with glass balconies that overlook the pool, enhancing the open atmosphere.
Condo in Panamá
4.92 out of 5 average rating, 114 reviews

CASA SAENA "B"- Apto de Diseño, Casco Viejo Panamá

Hermoso Apto "B" en Panamá Casco Antiguo, renovado con materiales de primera calidad, diseño exclusivo y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina con lavavajillas y lavadora, El edificio cuenta con una piscina en patio central compartida Aptos., ascensor, portero 24-7, Gran variedad de ocio en la zona, no se permiten niños que no sepan nadar.

Top guest favorite
A spacious rooftop terrace is featured, framed by a pergola. Outdoor furniture, including a dining set, is positioned to enjoy panoramic views of the ocean and surrounding hills, creating a serene space for relaxation.
Condo in Panama
4.99 out of 5 average rating, 109 reviews

Patty’s Bay View Home @ the Causeway with bikes

Beautiful and well-appointed spacious 1-bedroom condo featuring a large bathroom & fully stocked kitchen. Gorgeous Ocean views onto Casco Viejo, downtown Skyline & lush hills of Ancon as a background. Enjoy the Canal views, with ships, from the common roof top terraces. Its close location by the Causeway, Casco Viejo & down town makes it the perfect "pied à terre".

Popular amenities for Panama Canal vacation rentals

  1. Airbnb
  2. Panama
  3. Panama Canal