
Hotel vacation rentals in Mission Bay
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Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay hotel rentals
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Ocean Beach - Bed in a 8-Bed Mixed Dorm

Ocean Beach - Bed in 6-Bed Female Dorm

Ensuite Private Room at Stylish Hostel

Pet-friendly Hotel with Free Breakfast and Pool!

Stay Near Top Attractions | Balcony & Pet-Friendly

Smart perks like free WiFi and parking

Comic-Con 2025! Stay within walking distance!
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

Iconic Resort in San Diego

Soothing neutrals & killer coastline location

Playful escape near games & concerts at Petco Park

Free B’fast & Parking – Minutes to Pacific Beach

Idyllic beachside escape with outdoor pool

2 Queen Beds|Mini Fridge

Modern Room with Surfside Vibes - Steps from Sea
Hotel rentals with a patio

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Comic-Con 2026: Spacious King Suite + Sofa Bed

2 bd/2 bth Resort Style Hotel

Nice Property, stay right in SD!

Worldmark Studio Sleeps 4
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