Guesthouse vacation rentals in James Island
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Top-rated guesthouse rentals in James Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.93 out of 5 average rating, 316 reviewsCozy Island Cottage
Feb 4 – 11
Guesthouse in Charleston
4.99 out of 5 average rating, 263 reviewsSpacious Daniel Island Apartment
Feb 14 – 21
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 214 reviewsBungalow Under The Oaks
Sep 21 – 28
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Sep 4 – 11
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Apr 16 – 23
Guesthouse in Charleston
4.84 out of 5 average rating, 110 reviewsRomantic Beach Style Cottage close to everything!
Dec 13 – 20
Guesthouse in Johns Island
4.98 out of 5 average rating, 238 reviewsPrivate waterfront apt in the oaks
Mar 30 – Apr 6
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Jun 20 – 27
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 122 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Apr 6 – 13
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Mar 10 – 17
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Aug 2 – 9
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Feb 21 – 28
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Jul 9 – 16
Guesthouse in Charleston
5.0 out of 5 average rating, 74 reviewsLuxury Loft (2 miles from Folly Beach)
Dec 8 – 15
Guesthouse in Charleston
4.95 out of 5 average rating, 40 reviewsGuest suite in Charleston
Oct 9 – 16
Guesthouse in Charleston
4.82 out of 5 average rating, 93 reviewsGuest Suite by the Beach
Oct 2 – 9
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.99 out of 5 average rating, 206 reviewsRedesigned suite! 12min to city, pet-friendly
Aug 14 – 21
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 406 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Mar 30 – Apr 6
Guesthouse in Charleston
4.9 out of 5 average rating, 548 reviewsCute, Cozy, Charleston Cottage
Sep 25 – Oct 2
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Mar 4 – 11
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
Apr 23 – 30
Guesthouse in Charleston
4.99 out of 5 average rating, 141 reviewsLarge Guesthouse with Private Dock & Marsh Views
Jan 26 – Feb 2
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Nov 2 – 9
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 248 reviewsUpscale Couple's Escape | Beach & Downtown CHS
Jul 5 – 12
Destinations to explore
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- House rentals South Carolina
- Rentals with a patio James Island
- Rentals with an EV charger James Island
- Family-friendly rentals James Island
- Private suite rentals James Island
- Rentals with a washer and dryer James Island
- Rentals with a kayak James Island
- Rentals with outdoor seating James Island
- Bed and breakfasts James Island
- Kid-friendly rentals James Island
- Rentals with a fireplace James Island
- Apartment rentals James Island
- House rentals James Island
- Villa rentals James Island
- Monthly Rentals James Island
- Rentals with lake access James Island
- Rentals with a fire pit James Island
- Fitness-friendly rentals James Island
- Pet-friendly rentals James Island
- Townhouse rentals James Island
- Rentals with a hot tub James Island
- Waterfront rentals James Island
- Rentals with beach access James Island
- Condo rentals James Island
- Rentals with breakfast James Island
- Rentals with pools James Island
- Beachfront rentals James Island
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