Villa vacation rentals in James Island
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Top-rated villa rentals in James Island
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island villa rentals
Private villa rentals
Villa in Kiawah Island
4.97 out of 5 average rating, 88 reviewsLagoon view villa with office, easy walk to beach!
Jun 4 – 11
Villa in Kiawah Island
4.93 out of 5 average rating, 96 reviewsClean & Comfortable! Steps to the beach!
May 12 – 19
Villa in Seabrook Island
4.83 out of 5 average rating, 59 reviewsPrivate island villa with luxury resort amenities!
Oct 15 – 22
Villa in Seabrook Island
4.9 out of 5 average rating, 31 reviewsUpscale Villa, Amenity Included! Dog Friendly
Jun 7 – 14
Villa in Seabrook Island
4.85 out of 5 average rating, 33 reviewsSeabrook Golf View Villa: Pickleball, Pool & Bike
Oct 13 – 20
Villa in Seabrook Island
4.92 out of 5 average rating, 52 reviewsNewly Remodeled Villa, 5 Minute Walk to Beach
Mar 25 – Apr 1
Villa in Folly Beach
4.84 out of 5 average rating, 61 reviews83 Waters Edge - Comfy Cool - Pool
Jan 14 – 21
Villa in Seabrook Island
4.57 out of 5 average rating, 7 reviewsBeach and Golf Paradise | Vaughan Villa
Dec 14 – 21
Luxury villa rentals
Villa in Isle of Palms
4.96 out of 5 average rating, 52 reviewsLuxury Isle of Palms Home Steps to Beach with Pool
Feb 11 – 18
Villa in Seabrook Island
4.91 out of 5 average rating, 11 reviewsLuxury Seabrook Isl Beach Condo
Jun 24 – Jul 1
Villa in Isle of Palms
Ocean 180 | Easily Best Oceanfront View | All New
Feb 14 – 21
Villa in Seabrook Island
Seaside Therapy - An iTrip Vacations Home
Aug 14 – 21
Villa in Kiawah Island
5.0 out of 5 average rating, 15 reviewsOceanfront Windswept Villa
Aug 23 – 30
Villa in Kiawah Island
4.89 out of 5 average rating, 18 reviewsSpacious Penthouse 3BR 3Bath Villa with Ocean View
Sep 7 – 14
Villa in Isle of Palms
5.0 out of 5 average rating, 4 reviewsOceanfront Villa in Wild Dunes! Community Pool!
Oct 6 – 13
Villa in Kiawah Island
4.94 out of 5 average rating, 52 reviewsOpen floor plan 2 Bedroom Turtle Cove Villa
Dec 20 – 27
Villa rentals with a pool
Villa in Folly Beach
4.5 out of 5 average rating, 34 reviews3BR 2nd-Floor | Pool | Dock | Elevator
Jan 22 – 29
Villa in Isle of Palms
4.76 out of 5 average rating, 25 reviewsBeachfront IOP Villa with Outdoor Pool. Remodeled!
Oct 20 – 27
Villa in Isle of Palms
4.76 out of 5 average rating, 46 reviewsUpdated 2BR | Balcony | Pool | Dock
Aug 17 – 24
Villa in Seabrook Island
5.0 out of 5 average rating, 5 reviewsStunning Water Views Renovated Modern Oasis
Jan 28 – Feb 4
Villa in Seabrook Island
4.96 out of 5 average rating, 23 reviewsUpscale, Private,Breathtaking Views
Mar 13 – 20
Villa in Johns Island
4.73 out of 5 average rating, 26 reviewsDog friendly villa on 8th hole of golf course
Dec 27 – Jan 3
Villa in Isle Of Palms
4.78 out of 5 average rating, 37 reviews7C Seagrove - Sweetgrass
Jan 25 – Feb 1
Villa in Johns Island
Tranquil 1BR in High Hammock Villas
Dec 28 – Jan 4
Destinations to explore
- Savannah Vacation rentals
- Hilton Head Island Vacation rentals
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- Rentals with a patio James Island
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