Guesthouse vacation rentals in Central Illinois

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Central Illinois

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Urbana

4.97 out of 5 average rating, 388 reviews

Private Studio Loft for People, Pets, and Yoga

This private and sanitized 700 sqft second story loft with an outside entrance, sits atop our garage in the historic west Urbana neighborhood. This sun lit space is finished with two queen sized futon beds, a full bathroom, a kitchenette with fridge and stovetop, saniwipes, a dining/work space, yoga props, and an inflatable queen bed. MAX 4 adults. Pets are welcome as booked pets.* See below for details and services, such as yoga classes and pet sitting! We'll take good care of you in Urbana.

G$13,115 GYD per night

Guest favorite

Guesthouse in Berwick

4.99 out of 5 average rating, 189 reviews

Private Guest Lake House On 37 Acres In Country

Private guest lake house, located next to main house, on private lake in the country. 2 bedroom, 1 full bath, full kitchen, washer and dryer and large attached screen porch. Private 37 acres of woods and prairie. Fishing and walking trails. Great window views of lake, woods, prairies and river valley. Please note, this guest house is located 1 mile down a county maintained gravel road. 25 minutes from Galesburg, IL, 20 minutes from Monmouth, IL and 35 minutes from Macomb, IL.

Aug 19 – 26

G$35,332 GYD per night

Guest favorite

Guesthouse in Terre Haute

4.96 out of 5 average rating, 134 reviews

College Cottage

Centrally located to 3 colleges and 2 hospitals in a peaceful neighborhood, this cozy, open concept studio guesthouse is perfect for a short- or long-term stay. This newly renovated garage apartment to guesthouse requires no steps and features a spacious fenced in area for your pet. Creativity abounds in this uniquely decorated space. It features a king-sized bed as well as queen sized sofa sleeper. The kitchen is well stocked and has a coffee/tea bar for your enjoyment. Pets are welcome.

Apr 16 – 23

G$17,434 GYD per night

Guest favorite

Guesthouse in Lebanon

4.96 out of 5 average rating, 179 reviews

Pool, Hot Tub and Dog Paradise

As of 5/6/24 the pool is open. Located close to Scott Air Force Base and STL. Home is on 5 acres and has plenty of privacy. Beds are memory foam mattresses. Heated pool (May-September). Pet friendly (dog/cat) & have 1 XL kennel and 1 small pet carrier we can set up. Our home has a large circle drive that goes behind the barn. There is more than enough room for Handicap parking, the gate and sidewalk to the main patio are 48 inches wide. We have a handicap shower seat as well.

Nov 17 – 24

G$25,715 GYD per night

Guest favorite

Guesthouse in Mascoutah

4.97 out of 5 average rating, 189 reviews

The Carriage House

Cute and cozy, this tiny carriage house is packed with charm. Originally used as a place to store a horse-drawn carriage, this delightful building has been completely refurbished with everything you need for a clean and comfortable stay, including endless hot water, vinyl plank flooring, front porch, laundry, and eat-in kitchen. The bedroom has a queen bed, comfy recliner, and Roku-enabled TV. Please notify me if you are bringing any pets. I want to know dog breed and age.

Sep 29 – Oct 6

G$15,649 GYD per night

Guest favorite

Guesthouse in Urbana

4.95 out of 5 average rating, 179 reviews

West Urbana state street guest suite

Next to the heart of University of Illinois campus, surrounded by beautiful mature trees, this spacious and serene guest suite will enhance your experience in town. The guest suite has it own entrance. It is connected to the sunroom of our main house. This space do not come with TV, washer and dryer. And the space do not have kitchenette. However, we provide microwave, mini fridge, and coffee maker. This space is not limited mobility accessible. And no smoking.

Jun 13 – 20

G$15,406 GYD per night

Guest favorite

Guesthouse in Effingham

4.92 out of 5 average rating, 213 reviews

Country cottage tiny home.

This 240sq ft cottage offers big living in a tiny space. The cottage is on our 2 acre property that is used for a hobby farm and primary residence. The cottage features luxury vinyl flooring, granite counter tops and an updated farm house feel. The queen size bed is sure to provide the right amount of comfort. When you wake up, walk on over and grab a cup of coffee from the keurig. Enjoy a walk around to see the goats and chickens before heading off for the day.

Aug 12 – 19

G$11,878 GYD per night

Guest favorite

Guesthouse in Rockville

4.96 out of 5 average rating, 184 reviews

Hideaway Hollow

This is a fully furnished picturesque Amish-built cabin in beautiful and secluded Parke County, Indiana. The cabin comes complete with all amenities including full bath with shower, queen bed, A/C, dish TV, wifi internet and full kitchen. There is a large deck attached with a beautiful view of the swinging bridge and the woods. Cook out on the deck's gas grill and enjoy cool evenings by the fire pit (wood provided). Enjoy a nap in the shade in the hammock.

Jul 9 – 16

G$19,768 GYD per night

Guest favorite

Guesthouse in Iowa City

4.98 out of 5 average rating, 190 reviews

River Street Suite

Enjoy the beautiful Iowa River and Pennisula Park Views, in this private and peaceful guest suite apartment with private outdoor entrance and driveway. Walk to the Carver-Hawkeye Arena, Kinnick Stadium, UI Medical Campus & Veterans Hospital. Located in a highly sought-after walkable location off the Iowa River Corridor Trail. Less than a mile away from Hancher Auditorium & UI Campus. A 5 min drive to downtown Iowa City, Iowa River Landing Coralville and I-80.

Dec 5 – 12

G$28,207 GYD per night

Guest favorite

Guesthouse in Marthasville

4.96 out of 5 average rating, 224 reviews

Hazel's House by the Katy Trail

In the heart of Missouri Wine Country. Within walking distance of the Katy Trail and Lake Creek Winery. Many wineries within a 25-30 minute drive. Enjoy a weekend getaway in a 2 bed 1 bath home. Hazel's House is clean, comfortable and private overnight accommodations. We are not a bed and breakfast, no food included, but there is coffee. Please make sure the location is suitable. We are located out in the country and the internet can be spotty.

Oct 28 – Nov 4

G$23,571 GYD per night

Superhost

Guesthouse in Springfield

4.73 out of 5 average rating, 217 reviews

Charming Cottage Close to Downtown.

Stay minutes from downtown Springfield without expensive downtown hotel pricing and parking. 1 bedroom, 1 bathroom cozy guest house with a futon for extra sleeping accommodations. There are Roku's in both the living room and bedroom for seamless streaming of Netflix and Hulu. Your own private driveway that leads to the front door. All the amenities you need for your trip.

Jun 16 – 23

G$13,234 GYD per night

Guest favorite

Guesthouse in St. Louis

4.95 out of 5 average rating, 779 reviews

The Garage Mahal

Man Cave turned Airbnb! We are providing the highest level of disinfection & cleaning 1.7 miles To Saint Louis University and Cardinal Glennon 4.7 miles to Barnes campus and Saint Louis Childrens 13 miles to Mercy hospital and Missouri Baptist 13 miles to Mercy South, 14 miles to St Clare 3.2 miles to Touchette Regional 15 miles to Belleville Memorial Hospital

Nov 10 – 17

G$15,915 GYD per night