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Vacation rentals in Santiago

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Top-rated vacation rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.72 out of 5 average rating, 47 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Superhost
Home in Santiago
4.82 out of 5 average rating, 22 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Guest favorite
Home in Canto del Llano
4.9 out of 5 average rating, 20 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 4 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A spacious living area is presented with a light-toned sofa adjacent to large windows, providing natural light. A metal shelving unit adorned with plants stands in the center, complemented by a simple round mirror on the wall. A wooden table and chair add functionality to the space.
Condo in Santiago
4.68 out of 5 average rating, 19 reviews

2A Apartment

Accessible apartment in downtown Santiago, located 300 meters from the Transportation Terminal and within walking distance of supermarkets and businesses. With a good layout, fresh and bright, and with all the basic amenities. The apartments provide a harmonious balance in the middle of the characteristic comings and goings of the center, perfect for stays of families, friends, professionals, couples.

The space features a kitchen nook with a wooden table and two patterned stools. Light grey curtains frame a window, while a door leads to an outdoor area. A modern refrigerator and a stovetop are visible in the kitchen area, complemented by a neutral wall color.
Tiny home in El Estero de San José
4.88 out of 5 average rating, 8 reviews

Furnished apartment Aguadulce

Mini house ideal for 1 or 2 people. It has a king size bed, private bathroom, closet, TV, wifi and ceiling fan. Integrated kitchen with breakfast bar, refrigerator, microwave, coffee maker and kitchen utensils. Located in a quiet and safe residential area, just 10 minutes from downtown Aguadulce. Perfect for those who need a comfortable and accessible place to rest during their time in the city.

A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Apartment in Santiago
4.6 out of 5 average rating, 15 reviews

d'rosas apartments 5PA

Enjoy the simplicity of this quiet and central accommodation. Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Guest favorite
Apartment in Santiago
4.9 out of 5 average rating, 10 reviews

Accommodation in Santiago Centro

Enjoy easy access to everything from this perfectly located accommodation in downtown Santiago, 2 minutes from the cathedral church, park, and the central avenue. Fresh and comfortable on the ground floor of a property with a large terrace with access to the courtyard surrounded by nature.

Top guest favorite
A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in Paris
5 out of 5 average rating, 5 reviews

Farmhouse

Relax with the whole family in this accommodation where tranquility is breathed. It is a farmhouse 100 meters from a Grade A milking parlor. Surrounded by nature with beautiful sunsets and centuries-old trees. It is fully equipped.

Guest favorite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 112 reviews

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

Guest favorite
Home in Santiago
5 out of 5 average rating, 5 reviews

Meters from Mall, Supermarkets, Hospital, etc.

Cozy, spacious, wifi, meters from Pricemart, pharmacies, restaurants, 40 minutes from Playa Torio, for families and groups of friends

Popular amenities for Santiago vacation rentals

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Santiago?

    Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santiago have air conditioning?

    Absolutely! We offer over 20 house rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly vacation rentals in Santiago?

    Santiago has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • What are the most popular amenities for House Rentals in Santiago?

    Enhance your stay in our House Rentals with the most popular amenities: over 20 homes with free parking, over 20 homes with wifi, over 20 homes with a kitchen, over 20 homes with air conditioning, and more. Indulge in the ultimate retreat, tailored to your preferences.

  • Do house rentals in Santiago have wifi?

    Absolutely! We offer over 20 house rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Are there pet-friendly vacation rentals in Santiago?

    Four-legged friends are welcome in Santiago. Choose from more than 20 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Santiago?

    Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Santiago have a kitchen?

    Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.

Quick stats about vacation rentals in Santiago

  • Total vacation rentals

    Explore 60 vacation rentals in Santiago

  • Nightly prices starting at

    Santiago vacation rentals start at G$2,093 GYD per night before taxes and fees

  • Verified guest reviews

    Over 600 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santiago vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santiago rentals

  • 4.7 Average rating

    Santiago stays receive an average rating of 4.7 out of 5 from guests

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