
Vacation rentals in Santiago
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Top-rated vacation rentals in Santiago
Guests agree: these stays are highly rated for location, cleanliness, and more.

Salamanca Loft
Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Casa a minutos de Santiago, U Latina, HospChichoF.
Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Peaceful home w/ spacious living & office area
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Studio Hotel Gran David
This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

2A Apartment
Accessible apartment in downtown Santiago, located 300 meters from the Transportation Terminal and within walking distance of supermarkets and businesses. With a good layout, fresh and bright, and with all the basic amenities. The apartments provide a harmonious balance in the middle of the characteristic comings and goings of the center, perfect for stays of families, friends, professionals, couples.

Furnished apartment Aguadulce
Mini house ideal for 1 or 2 people. It has a king size bed, private bathroom, closet, TV, wifi and ceiling fan. Integrated kitchen with breakfast bar, refrigerator, microwave, coffee maker and kitchen utensils. Located in a quiet and safe residential area, just 10 minutes from downtown Aguadulce. Perfect for those who need a comfortable and accessible place to rest during their time in the city.

d'rosas apartments 5PA
Enjoy the simplicity of this quiet and central accommodation. Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Accommodation in Santiago Centro
Enjoy easy access to everything from this perfectly located accommodation in downtown Santiago, 2 minutes from the cathedral church, park, and the central avenue. Fresh and comfortable on the ground floor of a property with a large terrace with access to the courtyard surrounded by nature.

Farmhouse
Relax with the whole family in this accommodation where tranquility is breathed. It is a farmhouse 100 meters from a Grade A milking parlor. Surrounded by nature with beautiful sunsets and centuries-old trees. It is fully equipped.

2 bedroom house in Santiago
centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

3BD, 2BTHS, furnished house
House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

Meters from Mall, Supermarkets, Hospital, etc.
Cozy, spacious, wifi, meters from Pricemart, pharmacies, restaurants, 40 minutes from Playa Torio, for families and groups of friends
Popular amenities for Santiago vacation rentals
Other great vacation rentals in Santiago

Hostal Brisas Calobreñas, A home to stay in Panama

Private room in Santiago

Entire private villa

Casa Pueblo - Ocú

Main room-San Miguel Clean House, Santiago.

Full room with private bathroom, residential

My little house

Cozy room, the moon
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in Santiago?
Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.
Do house rentals in Santiago have air conditioning?
Absolutely! We offer over 20 house rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly vacation rentals in Santiago?
Santiago has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.
What are the most popular amenities for House Rentals in Santiago?
Enhance your stay in our House Rentals with the most popular amenities: over 20 homes with free parking, over 20 homes with wifi, over 20 homes with a kitchen, over 20 homes with air conditioning, and more. Indulge in the ultimate retreat, tailored to your preferences.
Do house rentals in Santiago have wifi?
Absolutely! We offer over 20 house rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.
Are there pet-friendly vacation rentals in Santiago?
Four-legged friends are welcome in Santiago. Choose from more than 20 vacation rentals for guests traveling with pets.
How much does it cost to stay in house rentals in Santiago?
Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Do house rentals in Santiago have a kitchen?
Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.
Quick stats about vacation rentals in Santiago

Total vacation rentals
Explore 60 vacation rentals in Santiago

Nightly prices starting at
Santiago vacation rentals start at G$2,093 GYD per night before taxes and fees

Verified guest reviews
Over 600 verified reviews to help you choose

Family-friendly vacation rentals
20 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 30 rentals that welcome pets

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wi-Fi availability
40 of Santiago vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santiago rentals

4.7 Average rating
Santiago stays receive an average rating of 4.7 out of 5 from guests
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