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Vacation rentals in Santiago

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Top-rated vacation rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
Home in Santiago
4.82 out of 5 average rating, 22 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Casa amplia, cómoda y totalmente equipada en una ubicación estratégica de Santiago.Perfecta para todo tipo de huéspedes: familias, viajeros de trabajo, estudiantes, personas que vienen a citas médicas o quienes buscan un espacio tranquilo y accesible. La casa está ubicada muy cerca del Hospital Dr. Chicho Fábrega, Clínica Norte, U.Latina, Oxford School, Comercios Supermercados, farmacia, ,restaurantes, y minutos de Santiago centro. Un lugar seguro para estadías cortas y de larga estancia.

A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.72 out of 5 average rating, 47 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Guest favorite
Home in Canto del Llano
4.9 out of 5 average rating, 21 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 4 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Apartment in Santiago
4.6 out of 5 average rating, 15 reviews

d'rosas apartamentos 5PA

Disfruta de la sencillez de este alojamiento tranquilo y céntrico.Descubre la comodidad en nuestro acogedor alojamiento en el corazón de Santiago, Veraguas. A solo 5 minutos a pie del centro de la ciudad, disfrutarás de un espacio bien equipado que incluye todas las comodidades necesarias para una estancia relajante. Ideal para explorar la cultura local y descansar después de un día de aventuras. ¡Te esperamos!

A spacious living area is presented with a light-toned sofa adjacent to large windows, providing natural light. A metal shelving unit adorned with plants stands in the center, complemented by a simple round mirror on the wall. A wooden table and chair add functionality to the space.
Condo in Santiago
4.68 out of 5 average rating, 19 reviews

Departamento 2A

Departamento accesible en el centro de Santiago, ubicado a 300m de la terminal de Transporte y a poca distancia de supermercados y negocios. Con buena distribución del espacio, frescos e iluminados y con todos los servicios básicos. Los apartamentos brindan un balance armonioso en medio del va y ven característico del centro, perfecto para estadías de familias, amigos, profesionales, parejas.

Guest favorite
Apartment in Santiago
4.9 out of 5 average rating, 10 reviews

Alojamiento en Santiago Centro

Disfruta del fácil acceso a todo desde este alojamiento perfectamente ubicado, en el centro de Santiago a 2 minutos de la iglesia catedral, parque, y la Ave central. Fresco y cómodo en planta baja de una propiedad una terraza amplia con acceso al patio rodeado de naturaleza.

Guest favorite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A modern tiny house constructed from a shipping container stands with a spacious rooftop overhang. Large glass doors provide access to the interior, while small planters frame the entrance. Surrounding greenery adds a natural element to the setting.
Shipping container in El Espino de Santa Rosa
4.33 out of 5 average rating, 33 reviews

Confort house 8

Tiny house, contenedor de 20" , completamente adaptado para descanzar y passe un momento agradable. Con una puscina, del conplejo donde nos encontramos, muy grande y rodeada de naturaleza.

A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 112 reviews

Casa de 3BD, 2BTHS, amoblada

Casa de 3 recámaras, 2 baños, céntrica, amoblada, garita de seguridad, cocina, lavadora Automática, A/A, Wi-fi, TV cable, construcción nueva en bonito residencial.

Guest favorite
Home in Santiago
5 out of 5 average rating, 5 reviews

A metros de Mall, Supermercados, Hospital, etc.

Acogedor, espaciosa, wifi, a metros dé Pricemart, farmacias, restaurantes, a 40 minutos de Playa Torio, para familias y grupos de amigos

A softly lit bedroom features a spacious bed covered with a textured grey bedspread. Two pieces of wall art adorn the walls above the bed, with a bedside table holding a small plant. A full-length mirror supports the decor, complemented by light-grey curtains.
Apartment in Santiago
4.23 out of 5 average rating, 13 reviews

Apartamento Señorial Urraca

Disfruta de la sencillez de este alojamiento tranquilo y céntrico, ideal para ti, con todo lo necesario para una estadía placentera.

Popular amenities for Santiago vacation rentals

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Santiago?

    Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santiago have air conditioning?

    Absolutely! We offer over 20 house rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly vacation rentals in Santiago?

    Santiago has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • What are the most popular amenities for House Rentals in Santiago?

    Enhance your stay in our House Rentals with the most popular amenities: over 20 homes with free parking, over 20 homes with wifi, over 20 homes with a kitchen, over 20 homes with air conditioning, and more. Indulge in the ultimate retreat, tailored to your preferences.

  • Do house rentals in Santiago have wifi?

    Absolutely! We offer over 20 house rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Are there pet-friendly vacation rentals in Santiago?

    Four-legged friends are welcome in Santiago. Choose from more than 20 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Santiago?

    Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Santiago have a kitchen?

    Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.

Quick stats about vacation rentals in Santiago

  • Total vacation rentals

    Explore 60 vacation rentals in Santiago

  • Nightly prices starting at

    Santiago vacation rentals start at G$2,089 GYD per night before taxes and fees

  • Verified guest reviews

    Over 600 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santiago vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santiago rentals

  • 4.7 Average rating

    Santiago stays receive an average rating of 4.7 out of 5 from guests

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