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Vacation rentals in Santiago

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
Home in Santiago
4.95 out of 5 average rating, 20 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Casa amplia, cómoda y totalmente equipada en una ubicación estratégica de Santiago.Perfecta para todo tipo de huéspedes: familias, viajeros de trabajo, estudiantes, personas que vienen a citas médicas o quienes buscan un espacio tranquilo y accesible. La casa está ubicada muy cerca del Hospital Dr. Chicho Fábrega, Clínica Norte, U.Latina, Oxford School, Comercios Supermercados, farmacia, ,restaurantes, y minutos de Santiago centro. Un lugar seguro para estadías cortas y de larga estancia.

A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.71 out of 5 average rating, 45 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Top guest favorite
Home in Canto del Llano
5 out of 5 average rating, 9 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

An outdoor bathroom is enclosed by bamboo walls and natural stone, featuring a wooden basin and a unique circular shower area. Smooth pebbles create a textured border around the space, enhancing its connection to nature.
Cabin in Santa Fe
4.67 out of 5 average rating, 27 reviews

Treehouse

Come relax in this unique logging overlooking the Santa Maria's river. Immerse yourself in nature while having the comfort of quality beds and furniture. Ideal to spend a few nights when you are traveling or a long stay if you feel like reconnecting with what is essential. This beautiful habitat will rock you into the sounds and smells of Panama's mountain's soft nature. Outside kitchen and bathroom. Optional relax massage. Two queen size bed.

A cozy corner is shown with a light-toned futon, paired with a small wooden table and two modern chairs. Natural light enters through two windows, complementing the warm wooden paneling on one wall.
Condo in Panama City
4.63 out of 5 average rating, 32 reviews

Departamento 2E - BEST place in town.

Accessible apartment in the heart of Santiago, located 300m from the Central Bus Station and within walking distance of supermarkets and businesses. With good distribution of space, fresh and illuminated and with all basic services. The apartments provide a harmonious balance in the middle of the rush characteristic of the city, perfect for stays of families, friends, professionals, couples.

The space features a kitchen nook with a wooden table and two patterned stools. Light grey curtains frame a window, while a door leads to an outdoor area. A modern refrigerator and a stovetop are visible in the kitchen area, complemented by a neutral wall color.
Tiny home in El Estero de San José
4.75 out of 5 average rating, 4 reviews

Apartamento amueblado Aguadulce

Mini casa ideal para 1 o 2 personas. Cuenta con cama king, baño privado, clóset, TV, wifi y abanico de techo. Cocina integrada con desayunador, nevera, microondas, cafetera y utensilios de cocina. Ubicada en zona residencial tranquila y segura, a solo 10 minutos del centro de Aguadulce. Perfecta para quienes necesitan un lugar cómodo y accesible para descansar durante su paso por la ciudad.

Superhost
Farm stay in Santa Fe
4.89 out of 5 average rating, 303 reviews

Cabaña del Sol en Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Superhost
Home in Santiago
4.22 out of 5 average rating, 9 reviews

Peaceful, Clean, and Conveniently Located House

This house is located in a quiet location on the edge of the city of Santiago about 10 minutes walking distance from the main shopping area of Central Ave. The house is fully furnished with air conditioning throughout the entire house. There is also a spacious kitchen with all the necessary appliances. You can enjoy the private backyard as you lay in the hammock.

Superhost
A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Apartment in Santiago
4.88 out of 5 average rating, 8 reviews

d'rosas apartamentos 3PB

Descubre la comodidad en nuestro acogedor alojamiento en el corazón de Santiago, Veraguas. A solo 5 minutos a pie del centro de la ciudad, disfrutarás de un espacio bien equipado que incluye todas las comodidades necesarias para una estancia relajante. Ideal para explorar la cultura local y descansar después de un día de aventuras. ¡Te esperamos!

Guest favorite
Apartment in Santiago
4.86 out of 5 average rating, 7 reviews

Alojamiento en Santiago Centro

Disfruta del fácil acceso a todo desde este alojamiento perfectamente ubicado, en el centro de Santiago a 2 minutos de la iglesia catedral, parque, y la Ave central. Fresco y cómodo en planta baja de una propiedad una terraza amplia con acceso al patio rodeado de naturaleza.

A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in Paris
5 out of 5 average rating, 4 reviews

Casa de Finca

Relájate con toda la familia en este alojamiento donde la tranquilidad se respira. Es una casa de finca a 100 mts de una galera de ordeño de leche Grado A. Rodeada de naturaleza con atardeceres hermosos y arboles centenarios. Esta totalmente equipada.

Guest favorite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

Popular amenities for Santiago vacation rentals

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Santiago?

    Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santiago have air conditioning?

    Absolutely! We offer over 20 house rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly vacation rentals in Santiago?

    Santiago has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • What are the most popular amenities for House Rentals in Santiago?

    Enhance your stay in our House Rentals with the most popular amenities: over 20 homes with air conditioning, over 20 homes with wifi, over 20 homes with free parking, over 20 homes with a kitchen, and more. Indulge in the ultimate retreat, tailored to your preferences.

  • Do house rentals in Santiago have wifi?

    Absolutely! We offer over 20 house rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Are there pet-friendly vacation rentals in Santiago?

    Four-legged friends are welcome in Santiago. Choose from more than 20 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Santiago?

    Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Santiago have a kitchen?

    Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.

Quick stats about vacation rentals in Santiago

  • Total vacation rentals

    Explore 60 vacation rentals in Santiago

  • Nightly prices starting at

    Santiago vacation rentals start at G$2,089 GYD per night before taxes and fees

  • Verified guest reviews

    Over 530 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santiago vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santiago rentals

  • 4.7 Average rating

    Santiago stays receive an average rating of 4.7 out of 5 from guests

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