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Vacation home rentals in Santa Maria di Leuca

Find and book unique vacation home rentals on Airbnb

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Popular amenities for Santa Maria di Leuca vacation home rentals

Family-friendly vacation home rentals

Guest favorite

Vacation home in Castromediano

4.89 out of 5 average rating, 105 reviews

A Lecce da Sergio

Jun 19 – 26

G$9,651 GYD per night
Guest favorite

Vacation home in Ruffano

5.0 out of 5 average rating, 19 reviews

Romantic Suite with Garden in Salento

Oct 25 – Nov 1

G$17,300 GYD per night
Guest favorite

Vacation home in Lecce

4.96 out of 5 average rating, 25 reviews

Valentini Historic Home

Jan 14 – 21

G$28,571 GYD per night
Guest favorite

Vacation home in Otranto

4.87 out of 5 average rating, 61 reviews

"The Barge"

Feb 1 – 8

G$12,601 GYD per night
Guest favorite

Vacation home in San Foca

4.84 out of 5 average rating, 68 reviews

La Patula Apartment - San Foca - Salento

Sep 8 – 15

G$16,731 GYD per night
Superhost

Vacation home in Salve

4.86 out of 5 average rating, 14 reviews

Dimora Pesco, your window on Salento

Sep 29 – Oct 6

G$26,916 GYD per night
Superhost

Vacation home in Otranto

4.83 out of 5 average rating, 59 reviews

Two-room apartment with a large terrace 100 meters from the sea

Dec 26 – Jan 2

G$20,811 GYD per night
Guest favorite

Vacation home in Ruffano

4.75 out of 5 average rating, 81 reviews

Charming White House Salento - A Casa Da Martino

May 17 – 24

G$16,138 GYD per night

Vacation home rentals with a patio

Destinations to explore