Guesthouse vacation rentals in Pickens County

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Family · Location · Hiking

The Alley Cat

LOCATION, LOCATION, LOCATION! Be our guest in downtown Clemson! Park your car upon arrival and take leisurely walks (or Uber) to all Clemson has to offer...downtown restaurants/bars, football stadium, and campus sporting events are a short stroll from the Alley Cat. This unique space features a full-size bed, a futon for one additional sleeper, a full bathroom with a stand-up shower, a closet, a Smart TV, and a coffee station. We welcome 3 guests maximum and provide 1 parking spot. Go Tigers!!!

Location · Family · Checkout

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Location · Value · Kitchen

Fairy Forest Cabin with Hot Tub at Table Rock

Adventure and relaxation await you! Set half a mile off the road, surrounded by forest, you’ll feel like you’re far away from the demands of life as you soak in the hot tub. But you are right in the golden corner of SC, NC, GA mountains with the best of hiking, kayaking, cycling and dining nearby! Only 28 miles from Greenville, Clemson and Brevard NC with Table Rock State Park and Lakes Jocassee and Keowee a few minutes away. The perfect couple’s getaway! Use of SC State Park pass included.

Location · Accuracy · Outdoor spaces

Lakeside Haven on Lake Keowee

Relax at this cozy lakefront studio on Lake Keowee with access to kayaks, paddleboards, a dock, fire pit, and pool. Perfect for unwinding or exploring, it's close to state parks with hiking trails and just a short drive to Clemson University-great for football weekends. The studio includes a full kitchen, private bath and in-unit washer/dryer providing all the comforts of home. Whether you're here for adventure or relaxation, this lakeside retreat has everything you need.

Location · Family · Access

Elfwing Carriage House

Bright & comfortable studio apartment located in a quiet family neighborhood in the country, yet minutes to town. We are an easy 15 minute drive to Clemson, less than 5 miles to SWU, 7 miles to Duke Energy. Smart location for the mountains & lakes, visiting colleges, and graduation. Hikes, waterfalls, 12 Mile River & Lake Hartwell are nearby. Friendly dog is fenced or in our home. Come enjoy neighborhood & country living at its finest!

Location · Family · View

Downtown Clemson Guest Suite!

Studio apartment in Downtown Clemson. Walk to downtown shops and restaurants, The Esso, and all of the sports venues. Sleeping area with queen bed, living room with large couch and tv, washer/dryer, kitchenette with refrigerator/freezer, microwave, and coffee maker. Large, private deck with outdoor seating. All linens and extra air mattress included. This apartment is the 2nd floor of a guest house, up a slope to the entry.

Family · Value · Checkout

Quaint guest cottage in Upstate

This special property is near Greenville, Anderson, Clemson and more. Located just 3.6 miles from I-85 on Main Street West Pelzer, you can go any direction making this the perfect home base for exploring the Upstate. This charming cottage combines comfort, city and country. We strive to "think of everything" so your stay is fabulous. And you will love coming "home" to The Canning House after all your daily adventures!

Value · Family · Sleep quality

Holly Hideaway! 10 Highway miles to Clemson U!

Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Family · Value · Hospitality

Gilded Frog Guesthouse. Rainfall Shower, King Bed

Welcome to the Gilded Frog Studio. Conveniently located between Greenville and Easley and only minutes from I85, we are positioned right in the heart of the growing Powdersville area. Whether you're visiting Greenville or looking for a local place to stay to catch a Clemson game, we offer the amenities you need to make your stay effortlessly enjoyable.

Location · Family · Getting around

Nested Studio Woodscape

Escape to our modern rustic and refined small studio apartment, nestled in the country. Tucked away in the trees, it sleeps four, with one bathroom. Experience the perfect blend of serene seclusion and contemporary comfort in this charming retreat. Ideal for nature lovers and close to nearby attractions. Book now for an unforgettable getaway!

Value · Family · Cleanliness

Rest Your Caboose Cottage

"Discover 'Rest Your Caboose Cottage,' nestled between NC mountains and downtown Greenville. Enjoy great food, shopping, hiking, biking on the Swamp Rabbit Trail, golf, Furman University walks, and nearby concerts or picnics. Retreat to this quiet, homey haven for relaxation."

Location · Family · TV