Vacation rentals with lake access in Pickens County

Find and book unique lake access rentals on Airbnb

Top-rated lake access rentals in Pickens County

Guests agree: these lake access rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Cottage in Sunset

4.95 out of 5 average rating, 110 reviews

River Cottage Nature Privacy

Great place for families, friends, or solo. Get away from the tech and grind life that drags you down. Get close to nature here at the river house. This property backs up to thousands of acres of Department of Natural Resources land. The sound of the river is soothing to your soul. Get away today. Twin Falls is just a short, easy hike away. Lake Keowee and Lake Jocassee are a 5 to ten minute drive. Great home base to cycle in the blue ridge mountains. The trout fishing is fantastic too!!

Jul 23 – 30

G$44,689 GYD per night

Guest favorite

Condo in Salem

4.95 out of 5 average rating, 108 reviews

Beautiful Lake Keowee Condo with great Amenities

"Boasting lake views, a fully equipped kitchen, and resort-style amenities, this 2-bedroom, 2-bath Salem vacation rental condo in Keowee Key will have you experiencing the true meaning of life on the lake. Cool off with a dip in the community's outdoor pool which sits right next to the marina where you can rent a boat for a day out on the water. Tee up a round of golf on the renovated 18-hole course, walk along the trails of Oconee State Park, or catch a football game at Clemson University!"

Nov 4 – 11

G$37,806 GYD per night

Guest favorite

Home in Seneca

4.95 out of 5 average rating, 144 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Aug 27 – Sep 3

G$28,742 GYD per night

Guest favorite

Home in Six Mile

4.86 out of 5 average rating, 198 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Jan 11 – 18

G$37,718 GYD per night

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 169 reviews

Lakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤

Lake lovers and college football fans...you will LOVE this house! Lots of privacy, huge kitchen, dock, fire pit, gas grill, kayaks, and more! Beautiful Lake Hartwell home… where 1000 miles of shore awaits you! Our home is located just minutes away from Clemson, Seneca, Anderson, and more! Just 25 steps to your private dock, and 7 miles/ 10 mins from Death Valley (Memorial Stadium!) 4 bedrooms, and 3 full bathrooms. You must be at least 25 to rent. NO pets allowed, sorry!No fireworks

Feb 21 – 28

G$79,905 GYD per night

Guest favorite

Cabin in Six Mile

4.95 out of 5 average rating, 131 reviews

Lake Keowee, Waterfront Cabin, 2-Story Dock!

Beautiful cabin 15 min from Clemson Stadium. Brand new to the rental market. Boasting cathedral ceilings, this home offers an open floor plan for everyone to gather. Sleeping 10 with 4 bedrooms and 3.5 bathrooms and 2 living rooms, there is space for everyone. Steep incline from lake to house with paved stairs. Tram from deck to dock! Fire pit with wood provided. Large deck and covered porch. Large covered dock for your boat with 650 sq. ft. second floor sundeck. 2 car garage.Hot Tub!

Feb 3 – 10

G$100,244 GYD per night

Guest favorite

Guest suite in Greenville

5.0 out of 5 average rating, 168 reviews

Cozy, Cute & Clean Cottage on Saluda Lake

Stunning lake views from private covered deck with daily western sunsets. Large dock to sit, sun, read or fish. Two kayaks with life vests available to tour the water. Saluda Lake is said to be one of Greenville's best kept secrets. Though a small 331 acre lake, the nearly 2 mile river to the 1920's working dam is great water to boat and fish. 13 mins to main street Greenville; 5 mins to Furman University; 45 mins to Clemson University or Lake Hartwell area. 5 mins to grocery stores.

Sep 4 – 11

G$26,223 GYD per night

Guest favorite

Cabin in Sunset

4.87 out of 5 average rating, 145 reviews

Bear Creek Cabin near Clemson, Brevard, Cashiers

You will fall in love with this hidden gem on 7 private acres nestled in the Jocassee Gorges, the only true Rain Forest east of the Rockies- adjoining 50,000 acres of DNR Wildlife management area. Excellent Mountain get-away for those seeking a relaxing peaceful setting. Wildlife galore (black bear, dear, turkey), hiking, kayaking, Foothills Trail, Palmetto Trail, Sassafras Mountain, Victoria Valley Vineyards, waterfalls, and more! Trout fishing is perfect on the Little Estatooe too!

Dec 18 – 25

G$30,764 GYD per night

Guest favorite

Home in Easley

4.9 out of 5 average rating, 276 reviews

“Lake House Paradise” Waterfront Oasis

“Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views from your bed of the water. Your en suite Master Bathroom has a large luxury marble shower. You will spend many hours of relaxation and peace in the most desirable location in the southeast. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.

Nov 6 – 13

G$30,407 GYD per night

Guest favorite

Shipping container in Easley

4.99 out of 5 average rating, 190 reviews

Luxury lakefront container home + private dock

Start your next adventure at The Hive at Addison Farms! Upon arrival, you will be greeted with an incredible, picturesque view of Saluda Lake. This carefully designed romantic retreat is the ultimate getaway to unwind, reconnect, and relax. The Hive is conveniently located less than 20 mins. from Downtown Greenville, making it the perfect destination for a secluded weekend away, yet close enough to explore the wonderful places and activities in Upstate, SC.

Mar 7 – 14

G$74,969 GYD per night

Guest favorite

Farm stay in Easley

4.99 out of 5 average rating, 189 reviews

Dogwood Cottage- farm charm - Greenville & Clemson

A retreat in and of itself! This perfect, peaceful cottage is complete with full kitchen, bath and private porch. This converted llama barn elevates reclaimed woods and metals into a darling spot on our 24 acre farm. Serene and tranquil yet only minutes from downtown Greenville or Clemson activities. Nature galore with walking, fishing and even farm animals to meet. Our farm sits at the foot of the Blue Ridge with many quaint mountain towns to visit.

Jan 9 – 16

G$21,904 GYD per night

Guest favorite

Guest suite in Greenville

4.9 out of 5 average rating, 221 reviews

modern lux lakefront suite, 6mi dt GVL

PRIVATE DOCK + LAKEFRONT + JET SKI RENTAL + 6 MILES TO DOWNTOWN GREENVILLE! NY Times #1 AMERICAN CITY! Experience luxury in your serene private suite **located in modern scandinavian-style chalet on Saluda Lake** 6mi downtown Greenville, 5mi Traveler’s Rest, 4mi Furman, 4mi Paris Mtn - Private dock / jet ski paddleboard rental - Private entrance flower-friendly patio - 43” Roku TV - Charcoal grill, fire pit - Blackout blinds

Apr 16 – 23

G$20,944 GYD per night