House vacation rentals in Pickens County

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Top-rated house rentals in Pickens County

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Top guest favorite

A wooden dock extends into the clear green waters of the lake, surrounded by lush trees and a sandy shoreline. The retreat is nestled in the background, partially obscured by foliage, offering a tranquil natural setting.

Home in Seneca

5 out of 5 average rating, 106 reviews

Modern Lake Vibes – Kayaks, Dock & Fireplace

The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Top guest favorite

An inviting outdoor space features a large in-ground saltwater pool surrounded by lush greenery. Comfortable lounge chairs and umbrellas provide shade, while a gazebo stands in the background. The neatly manicured lawn enhances the tranquil setting, creating an ideal area for relaxation.

Home in Greenville

4.99 out of 5 average rating, 160 reviews

Palmetto Escape - Serene- Pool- 6.6 mi DTWN GVL

Beautiful, updated 2 story home on secluded fenced in resort-like half acre. In-ground saltwater pool. Gazebo with mosquito netting, ceiling fans and lighting. Keyless entry. Bedrooms are upstairs, all include Smart TVs and workspaces. High-speed Internet. Bathrooms w/a variety of amenities. Laundry Room. Fully stocked kitchen and propane grill. Perfect for family escapes, working professionals, outdoor adventurers, sports fans, child friendly. 2 car garage. Quite, residential neighborhood.

Guest favorite

A lush green lawn extends across the image, framed by trees and a backdrop of rolling hills. A bright blue sky dotted with fluffy white clouds adds to the serene atmosphere. The spacious landscape offers a tranquil view of the surrounding nature.

Home in Liberty

4.93 out of 5 average rating, 107 reviews

3 Bed Home Overlooking Fishing Pond on 10 Acres

This Home is a retreat in of itself! All New Accommodations offer Large eat in Kitchen, Primary Suite with Primary Bath. Stocked Fishing Pond! Peaceful and relaxing property to enjoy privately. If you are a foodie or shopper Greenville is only 15 miles away. Greenville has landed on countless "best of" lists so it's a must see! If Clemson is what you love we are twenty minutes from campus! Business class wifi too and cable TV Enjoy Great hiking at one of the close state parks too

Guest favorite

A newly constructed duplex is depicted, featuring a light grey exterior with black shutters. The entrance is framed by two elegant chairs on the porch. A spacious driveway leads to a well-maintained area, surrounded by neat landscaping and a clear blue sky.

Home in Pickens

4.95 out of 5 average rating, 131 reviews

Cottage in Pickens

Enjoy easy access to all the Upstate has to offer! This newly constructed 2 bedroom, 1 bath duplex apartment is located along the Doodle Trail bike route. Enjoy hiking trails and waterfalls at Table Rock and Caesars Head State Parks, catch a Clemson football game, or check out Falls Park and downtown Greenville, all from one convenient location! The home is across the street from a well-maintained local park and playground and within walking distance to a coffee shop and restaurants.

Guest favorite

A single-story home is presented with a light-colored facade and a covered front porch. The driveway leads to a garage, and neatly trimmed bushes frame the entrance. Tall trees and greenery provide a natural backdrop, enhancing the property's privacy and peaceful setting.

Home in Pendleton

4.9 out of 5 average rating, 186 reviews

Comfort & Convenience Close to Campus

The perfect blend of modern charm and full comfort & convenience just minutes from Clemson, The Pendleton Square and HWY access. You will be sure to have everything you need for your visit. Comfortably sized bedrooms with queen size beds. Spacious living area with cable TV & Netflix. Bright and open kitchen and dining fully equipped for all your cooking needs. Whether you're traveling alone for a little peace & quiet, with friends, or with family... we hope you enjoy your time here!

Top guest favorite

A modern one-story ranch house is depicted in a tranquil setting, featuring a spacious driveway and manicured landscaping. Natural light illuminates the exterior, enhanced by a welcoming entryway with decorative planters and a covered porch, surrounded by lush greenery and large trees.

Home in Travelers Rest

5 out of 5 average rating, 120 reviews

Modern Wooded Retreat

Modern, 1.6 acre retreat. Relax in fun + style & seclusion! Dog friendly, fully fenced back yard! Located 5 min. To downtown TR and 20 min to downtown Greenville! Roast marshmallows by the firepit, play giant jenga and connect 4, and take in the Carolina sunset. Minutes to the swamp rabbit trail and centrally located to lakes, hiking and exciting nightlife. Let us host you, while you explore everything Greenville and Travelers Rest have to offer, with all the comforts of home.

Superhost

A spacious porch offers panoramic mountain views through large glass panels, framed by soft white curtains. The wooden floor extends outdoors, inviting relaxation amidst the surrounding greenery and distant mountain ranges.

Home in Pickens

4.96 out of 5 average rating, 186 reviews

“Mountain View Paradise” Waterfall Oasis

The peaceful sounds of a Rushing Waterfall welcome you to “Mountain Paradise”. Surrounded by 500 acres of forest and waterfalls, you have the ultimate level of privacy. Exquisitely furnished oasis with 3 bedrooms and 3 Full Baths. Enjoy 2 Master Suites with their own en suite Master Baths. Enjoy a game of golf at The Rock Golf Resort. Lake Keowee and Lake Jocassee are just minutes away. Visit Greenville, SC or head up to Brevard, NC both just 45 minutes away.

Top guest favorite

An aerial view showcases a serene landscape featuring a four-acre pond surrounded by lush greenery and autumn foliage. A winding driveway leads to a guest house nestled within the wooded area. Rolling hills provide a backdrop, enhancing the natural beauty of the property.

Home in Pickens

4.97 out of 5 average rating, 152 reviews

Our Slice of Heaven w/Views of Table Rock-Pickens

Our slice of heaven is located in the foothills of the Blue Ridge Mountains only 8 mins from Table Rock State Park. Our guest house is sitting on 55 wooded acres with our 4-acre pond and amazing awe-inspiring panoramic views of Pinnacle and Table Rock Mountain. Wrap yourself in the serenity of nature, with nothing more to wake you in the morning than the pleasant sounds of songbirds beckoning you to delight in the new day.

Guest favorite

A welcoming cabin is nestled among tall trees, softly illuminated by string lights against the evening sky. A pathway leads toward the water, inviting relaxation with the gentle ambiance of nature surrounding the space.

Home in Easley

4.92 out of 5 average rating, 193 reviews

Spectacular Lakefront Retreat on the Saluda

Stunning views, quiet, still waters, wildlife in its natural habitat. This and more is what you'll find at Lakepoint on the Saluda. Better yet, this property is located on the water with 460' of lakefront and is just minutes from downtown Greenville, Furman, and Paris Mountain. Within 35 minutes you can be in Clemson. Includes kayaks, a canoe, hot tub (SEASONAL), work out room, and some of the best fishing in the upstate!

Guest favorite

A living area is presented with a brown leather sofa and a white coffee table atop a textured rug. Light is provided by a ceiling fan and window, accompanied by framed artwork on the walls. A wall-mounted television is visible opposite the seating arrangement.

Home in Easley

4.88 out of 5 average rating, 153 reviews

Livin' Easley-walk to downtown-close to everything

Welcome to Livin' Easley! Your family will be close to everything when you stay at this newly renovated bungalow style house. Downtown Easley shops, restaurants, bars and The Silos are within walking distance, and Greenville and Clemson are just a short drive away. If you'd rather stay in, enjoy everything the house has to offer including bumper pool, a card table, board games, horseshoe pits, and Netflix.

Top guest favorite

The exterior of a spacious single-story home features a red metal roof and light-colored siding. A welcoming blue front door is positioned under a small porch, surrounded by green shrubs. A gravel driveway leads up to the house, framed by trees and a clear blue sky.

Home in Central

4.98 out of 5 average rating, 103 reviews

The House on Oak Grove

Enjoy your time spent in this spacious and peaceful pet friendly space. Nicely appointed with everything you need for a short or long term stay. Ten easy miles to Clemson and 3 miles to SWU. Besides the open living space the house has a screened porch and accomodates 4 with 2 bedroom & 2 adjoining baths. The home includes washer & dryer, coffee bar, granite countertops, and microwave.

Top guest favorite

The living room features two dark gray sofas arranged around a round coffee table, which holds a decorative bowl. A colorful area rug adds warmth to the hardwood floor. Soft lighting is provided by two lamps beside the sofas, and a large mirror hangs on the wall.

Home in Easley

4.96 out of 5 average rating, 363 reviews

Blue Ridge Retreat | Min to Greenville/ Clemson

Escape to the Blue Ridge Retreat in the foothills of the Blue Ridge Mountains. Our pet-friendly entire home features a large fenced yard and is conveniently located near Clemson University, Greenville, and downtown Easley. Enjoy comfortable accommodations and all the amenities you need to feel at home. Book your stay now and experience the beauty of the upstate!