House vacation rentals in Pickens County

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Top-rated house rentals in Pickens County

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Top guest favorite

A fire pit surrounded by eight gray chairs is set in a gravel area, inviting outdoor gatherings. The two-story cottage is visible in the background, nestled among trees, while a deck with seating overlooks the grounds.

Home in Seneca

5 out of 5 average rating, 100 reviews

Clemson Lakehouse - Fire pit, kayaks, games, views

The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Guest favorite

A lush green lawn extends across the image, framed by trees and a backdrop of rolling hills. A bright blue sky dotted with fluffy white clouds adds to the serene atmosphere. The spacious landscape offers a tranquil view of the surrounding nature.

Home in Liberty

4.94 out of 5 average rating, 101 reviews

3 Bed Home Overlooking Fishing Pond on 10 Acres

This Home is a retreat in of itself! All New Accommodations offer Large eat in Kitchen, Primary Suite with Primary Bath. Stocked Fishing Pond! Peaceful and relaxing property to enjoy privately. If you are a foodie or shopper Greenville is only 15 miles away. Greenville has landed on countless "best of" lists so it's a must see! If Clemson is what you love we are twenty minutes from campus! Business class wifi too and cable TV Enjoy Great hiking at one of the close state parks too

Guest favorite

A single-story home is presented with a light-colored facade and a covered front porch. The driveway leads to a garage, and neatly trimmed bushes frame the entrance. Tall trees and greenery provide a natural backdrop, enhancing the property's privacy and peaceful setting.

Home in Pendleton

4.91 out of 5 average rating, 181 reviews

Comfort & Convenience Close to Campus

The perfect blend of modern charm and full comfort & convenience just minutes from Clemson, The Pendleton Square and HWY access. You will be sure to have everything you need for your visit. Comfortably sized bedrooms with queen size beds. Spacious living area with cable TV & Netflix. Bright and open kitchen and dining fully equipped for all your cooking needs. Whether you're traveling alone for a little peace & quiet, with friends, or with family... we hope you enjoy your time here!

Top guest favorite

A charming home is presented in a serene neighborhood setting, featuring a well-maintained lawn and flowering shrubs. The exterior showcases a light-colored façade with a welcoming front porch and a spacious driveway leading to a two-car garage.

Home in Seneca

4.99 out of 5 average rating, 210 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

Guest favorite

A spacious porch offers panoramic mountain views through large glass panels, framed by soft white curtains. The wooden floor extends outdoors, inviting relaxation amidst the surrounding greenery and distant mountain ranges.

Home in Pickens

4.96 out of 5 average rating, 181 reviews

“Mountain View Paradise” Waterfall Oasis

The peaceful sounds of a Rushing Waterfall welcome you to “Mountain Paradise”. Surrounded by 500 acres of forest and waterfalls, you have the ultimate level of privacy. Exquisitely furnished oasis with 3 bedrooms and 3 Full Baths. Enjoy 2 Master Suites with their own en suite Master Baths. Enjoy a game of golf at The Rock Golf Resort. Lake Keowee and Lake Jocassee are just minutes away. Visit Greenville, SC or head up to Brevard, NC both just 45 minutes away.

Top guest favorite

A serene view of the lake is captured at sunset, with soft colors reflected on the water. Docked boats line the marina, visible near the shore. The nearby walking path is bordered by lush greenery and softly illuminated by landscape lighting.

Home in Salem

4.99 out of 5 average rating, 134 reviews

Keowee Key Luxury Condo - Stunning Views!

Freshly renovated condo at the sought after Tall Ship condos in Keowee Key. This is hands down the best unit the complex has to offer with amazing views. Enjoy grilling out on the patio overlooking the marina, walking on the trail, or relax in the pool which is only a short walk away. This is truly a paradise. Guest boat slip is available at the marina for boats or jet skis. Slip is $50 per day. Recommended to book one month in advance.

Top guest favorite

An aerial view showcases a serene landscape featuring a four-acre pond surrounded by lush greenery and autumn foliage. A winding driveway leads to a guest house nestled within the wooded area. Rolling hills provide a backdrop, enhancing the natural beauty of the property.

Home in Pickens

4.97 out of 5 average rating, 149 reviews

Our Slice of Heaven w/Views of Table Rock-Pickens

Our slice of heaven is located in the foothills of the Blue Ridge Mountains only 8 mins from Table Rock State Park. Our guest house is sitting on 55 wooded acres with our 4-acre pond and amazing awe-inspiring panoramic views of Pinnacle and Table Rock Mountain. Wrap yourself in the serenity of nature, with nothing more to wake you in the morning than the pleasant sounds of songbirds beckoning you to delight in the new day.

Guest favorite

A welcoming cabin is nestled among tall trees, softly illuminated by string lights against the evening sky. A pathway leads toward the water, inviting relaxation with the gentle ambiance of nature surrounding the space.

Home in Easley

4.92 out of 5 average rating, 191 reviews

Spectacular Lakefront Retreat on the Saluda

Stunning views, quiet, still waters, wildlife in its natural habitat. This and more is what you'll find at Lakepoint on the Saluda. Better yet, this property is located on the water with 460' of lakefront and is just minutes from downtown Greenville, Furman, and Paris Mountain. Within 35 minutes you can be in Clemson. Includes kayaks, a canoe, hot tub (SEASONAL), work out room, and some of the best fishing in the upstate!

Guest favorite

A cozy living area features a patterned area rug and a colorful loveseat, complemented by a comfortable chair. Light from a nearby lamp casts a warm glow. A small dining area with a wooden table is visible in the background, and a kitchenette is accessible beyond.

Home in Pickens

4.97 out of 5 average rating, 154 reviews

Hidden Retreat

4 private acres just off Hwy 11. HIKE - connector to the Palmetto trail and Table Rock State Park. BIKE - popular biking routes; Hwy 11, Hwy 288 and Hwy 178 + Doodle & Swamp Rabbit Trail. GOLF - 1 course 5 minutes away several others nearby. WATERFALLS - including the highest in the east. MOUNTAIN LAKES - 2 of the best, Jocassee & Keowee. HIDDEN RETREAT - close to many outdoor adventures. Up to 6 guests.

Guest favorite

A living area is presented with a brown leather sofa and a white coffee table atop a textured rug. Light is provided by a ceiling fan and window, accompanied by framed artwork on the walls. A wall-mounted television is visible opposite the seating arrangement.

Home in Easley

4.88 out of 5 average rating, 144 reviews

Livin' Easley-walk to downtown-close to everything

Welcome to Livin' Easley! Your family will be close to everything when you stay at this newly renovated bungalow style house. Downtown Easley shops, restaurants, bars and The Silos are within walking distance, and Greenville and Clemson are just a short drive away. If you'd rather stay in, enjoy everything the house has to offer including bumper pool, a card table, board games, horseshoe pits, and Netflix.

Top guest favorite

A single-story guest house is set within a spacious green lawn, bordered by mature trees. The front porch features a white railing and steps leading to the entrance. The exterior is clad in light-colored siding, complemented by white shutters on the windows.

Home in Central

4.96 out of 5 average rating, 272 reviews

The Little House @ Cozy Hollow

Country living close to town. 2 miles from Cateechee Beach Park, 4 miles from SWU, 10 miles from Clemson, 12 miles from Oconee Nuclear Station, 13 miles from Garrison Arena, and 25 miles from Greenville. Enjoy your getaway at this private guest house with private drive, front & back porches, tv (streaming via Hulu Live, Disney+, Netflix, and more), washer/dryer, and full kichen including Keurig.

Top guest favorite

The living room features two dark gray sofas arranged around a round coffee table, which holds a decorative bowl. A colorful area rug adds warmth to the hardwood floor. Soft lighting is provided by two lamps beside the sofas, and a large mirror hangs on the wall.

Home in Easley

4.96 out of 5 average rating, 357 reviews

Blue Ridge Retreat | Min to Greenville/ Clemson

Escape to the Blue Ridge Retreat in the foothills of the Blue Ridge Mountains. Our pet-friendly entire home features a large fenced yard and is conveniently located near Clemson University, Greenville, and downtown Easley. Enjoy comfortable accommodations and all the amenities you need to feel at home. Book your stay now and experience the beauty of the upstate!