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Guesthouse vacation rentals in Nassau County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Nassau County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A cozy living space showcases a dark leather sofa and two patterned armchairs, providing a comfortable seating area. A decorative ottoman sits in front of the sofa, with a small table positioned nearby. Natural light filters through the windows, illuminating the warm wood flooring.
Guesthouse in Jacksonville North

Location! Pelican Point riverfront with oceanview

LOCATION,Private! Island Life Mouth of St.John's River.Deep water, great fishing. Atlantic Ocean! In Preserves surrounded by beaches, nature, creeks, inlets, rivers. On A1A Buccaneer Trail scenic hwy. Pelicans, dolphins, manatees, huge ships, yachts, shrimpboats, etc. seen daily Located between Jax & Amelia Island/Fernandina.20 mins airport/Zoo. Slow down in our peaceful, private, rustic, not fancy but clean home. Dock fishing. Limited to 2 adult guest. No Pets/children/guest of guest!!

4.9 out of 5 average rating, 133 reviews
Top guest favorite
Guesthouse in Springfield

La Casita Chiquita Near Events & Entertainment!

Welcome to "La Casita Chiquita" our unique little guest cottage - in the heart of Jacksonville! It's a 250 SF tiny cottage, with a loft bed and comfortable amenities - nestled in a garden setting, underneath majestic trees. You can be away from it all - and just blocks to sports, entertainment & convention venues, craft breweries, sports bars, great eateries, and museums. Are you here for business? Downtown is 5 minutes, UF & other medical facilities less than 10 minutes, Mayo- 25 minutes.

4.92 out of 5 average rating, 102 reviews
Guest favorite
A newly renovated living space is highlighted by light wooden flooring and a bright, airy atmosphere. A modern kitchen area features stainless steel appliances and a dining table with two chairs. A cozy seating area includes a patterned chair and a decorative storage chest.
Guesthouse in St. Marys

Next - ta - Sea

This is a detached two bedroom chalet. The inside has been newly renovated and we are constantly touching up! The St Marys’ ferry to Cumberland Island is a few blocks away! The host will help make the most of your trip by providing beach chairs, coolers, umbrellas, wagons and tips for a great day at the beach. Jacksonville, Amelia Island, Fernandina, Jekyll and St Simmons Island are all within 30 min. Go enjoy the day there, then relax with marsh views next to the sea ~ it’s pure Next-ta-Sea

4.92 out of 5 average rating, 204 reviews
Guest favorite
A well-appointed kitchen features a retro teal refrigerator and modern appliances set against dark blue cabinetry. White countertops provide ample prep space. A dining area with wooden bar stools invites casual meals, while a vibrant artwork on the wall adds a touch of character to the room.
Guesthouse in Avondale

Stylish Bungalow Near Dining,Parks & Entertainment

Welcome to our highly-rated charming bungalow in Jacksonville's historic Avondale neighborhood. Perfect for couples or small families, enjoy a cozy queen bed, high-speed Wi-Fi, and a 50-inch HDTV with Roku. The fully-equipped kitchen boasts retro appliances and a delightful dining area. Step outside to our pet-friendly garden with a spacious deck for relaxation. With award-winning restaurants and beautiful parks just a stroll away, this is your ideal retreat for both adventure and relaxation.

4.93 out of 5 average rating, 224 reviews
Top guest favorite
A bright kitchen features open shelving and stylish cabinetry with a farmhouse sink. A dining table is set for two, showcasing elegant dishware. Soft light is provided by a gold pendant light overhead, highlighting the clean lines and modern design.
Guesthouse in Avondale

Luxury Avondale Guest House, Walk to Shops

Featured in the Jacksonville Home Magazine! The Luxury Avondale Guest House is in the exquisite historic neighborhood of Avondale. Ten minutes from downtown sports & entertainment complexes, and several major health care facilities, St. Vincent's Hospital, Baptist Medical Center and the world renowned MD Anderson Cancer Center. Three short blocks to “The Shoppes of Avondale,” with an outstanding array of restaurants and venues to enjoy a streetside café-style meal, cocktail and desserts.

4.99 out of 5 average rating, 277 reviews
Top guest favorite
Guesthouse in Jacksonville

Jax Backyard Bungalow

Rent this dog friendly guest house in our quiet well-groomed backyard. Studio comes with queen-size bed, couch, closet, mini fridge, Keurig, microwave, table & chairs. Enjoy DirecTV & dedicated WiFi router. Savor a peaceful cup of coffee or evening cocktail on the attached wood deck. Well behaved dogs are encouraged to run free in the fully fenced in yard. Our black lab would love the company! Get to TIAA Bank Field in less than 5 mins or the beach in about 25 mins. Must be 25 to book

4.95 out of 5 average rating, 625 reviews
Top guest favorite
A red multi-story house is depicted, surrounded by lush greenery and trees. The front porch is adorned with plants, and several parked cars are visible along the driveway. A white picket fence frames the scene, creating a welcoming neighborhood atmosphere.
Guesthouse in Riverside

The Funk House-A Retreat

The perfect place to call home, long term stays are welcome and all stay include unlimited YMCA access during your stay. Feel free to send an inquiry if you have any questions prior to requesting to book. The Retreat is separate from the main house (The Funk House) it is located in the back, on the top floor garage apartment. It has been completely renovated and furnished into a comfortable place to "Retreat". Please inquire before requesting to book. Looking forward to your stay!l

4.96 out of 5 average rating, 217 reviews
Guest favorite
The living space features a modern design with a comfortable sofa and an armchair, complemented by a glass coffee table. A mounted flat-screen TV is positioned against a wooden accent wall. A spiral staircase leads to the upper level, and a small dining area is visible.
Guesthouse in Southwest Jacksonville

The Captain's Quarters o|--)

This two story loft garage is detached and is set in the back of the property 45 feet from the main house. The first floor has the kitchen and living space, then walk up the spiral staircase to the bedroom with cathedral ceiling with track lights and ensuite bathroom. I love dogs and allow them with permission first. No pets without prior approval (pet fee is min $50 per stay or $10 per day which ever is greater) My location is a short walk to Starbucks and other restaurants.

4.95 out of 5 average rating, 684 reviews
Guest favorite
The exterior view showcases a two-story blue carriage house surrounded by lush greenery. A saltwater pool lies in the foreground, accompanied by paved seating areas featuring comfortable chairs. The fenced yard offers privacy, with mature trees providing ample shade.
Guesthouse in Springfield

Spacious 2/1 in historic neighborhood- NO parties

Welcome to Happy's Hideaway, a family-friendly carriage house that checks all the boxes! Our bright 2-bedroom carriage house apartment is close to downtown and 12 miles from JIA. Nestled on a quiet street among mature oaks with a saltwater pool, it is just 15 miles to Atlantic Beach (a 22-28 minute drive.) We are just off Main Street, where you can enjoy local beer, ice cream, coffee, pizza & axe-throwing! This unit is on the 2nd floor and accessible only by stairs.

4.96 out of 5 average rating, 154 reviews
Top guest favorite
A peaceful riverfront scene is depicted, featuring the sun rising above calm waters. Silhouetted trees frame the view, while colorful clouds reflect on the water. Adjoining the shore, a dock extends into the water, complemented by wooden chairs placed on the grassy lawn.
Guesthouse in Jacksonville North

Florida Riverfront Sunrise | Fish, Boat, Unwind

Welcome to Sunrise Suite — a private 2,000 sq ft retreat with breathtaking sunrise views and no shared indoor spaces. Located above the garage, this spacious guest suite features one bedroom, one bathroom, and three comfortable beds within an airy open layout. Large windows fill the space with natural light, creating the perfect place to relax and recharge. Nestled in nature yet minutes from Jacksonville International Airport and major highways for easy access.

5.0 out of 5 average rating, 110 reviews
Guest favorite
A well-appointed studio apartment features an open layout with a combined kitchen and living area. Warm wood tones mingle with soft white walls, while leather seating surrounds a coffee table. A spacious bed with crisp linens is positioned near large windows, allowing natural light to fill the space.
Guesthouse in Avondale

Avondale Studio

Located in Avondale, Jacksonvilles historic district, this Garage Studio offers everything one needs for a getaway or a business trip. Walking distance to the Shoppes of Avondale. There are multiple restaurants/bars/outdoor cafe dining all within walking distance in either direction. The 2nd story garage apartment offers a balcony with views into Boone Park. Fully renovated in 2021 offering a full kitchen and bathroom. You have a private parking space as well.

4.93 out of 5 average rating, 302 reviews
Top guest favorite
The open studio apartment features a modern kitchen with stainless steel appliances and an island. A cozy recliner sofa and plush bed are positioned in the well-lit space, accented by a rustic ceiling with exposed beams and a ladder leading to a loft area.
Guesthouse in St. Marys

Beautiful detached apt. in Downtown St. Marys, GA

Retreat to southern coastal Georgia in this beautiful and clean vacation rental close to downtown St. Marys. Located a few blocks from the ferry to visit Cumberland Island National Seashore. Enjoy easy access to downtown restaurants, shops and the St. Mary's waterfront area. This detached studio apartment shares a driveway with the owners' residential home, but you'll have privacy with a separate entrance and an enclosed yard with chairs and a firepit.

4.98 out of 5 average rating, 294 reviews

Popular amenities for Nassau County guesthouse rentals

KitchenWifiPoolFree parking on premisesAir conditioning

Family-friendly guest house rentals

Guest favorite
The entrance of the guesthouse features a cheerful yellow door with a decorative awning above it. A welcome mat with the word 'hello' is placed at the doorstep, and a window box is adorned with greenery, enhancing the inviting facade.
Guesthouse in Avondale

Sunshine Guesthouse

4.98 out of 5 average rating, 125 reviews
Guest favorite
Guesthouse in Southeast Jacksonville

Private Bungalow with Pool/55” tv

4.91 out of 5 average rating, 415 reviews
Guest favorite
A cozy sleeping loft is featured with a spacious bed, draped in an earthy orange and green bedding. Soft light emanates from a bedside lamp, complementing the warm hues of the room. Blackout curtains frame a window, enhancing privacy and comfort.
Guesthouse in Murray Hill

MidCentury Guesthouse-NO Cleaning Fee+Restaurants

4.96 out of 5 average rating, 188 reviews
Guest favorite
A spacious guest area features a queen bed with light bedding. A mirrored wall enhances the room's brightness. A small dining table with two chairs is present, along with a cozy sofa. Two bedside lamps complement the neutral color scheme, creating a calm environment.
Guesthouse in Avondale

Pine Grove Studio A

4.87 out of 5 average rating, 206 reviews
Top guest favorite
A bright studio suite features a queen-sized bed with a checked blanket and crisp white linens. A retro refrigerator stands nearby, while a sitting area includes a comfortable chair and a small side table. Art decorates the blue-paneled walls, and soft light filters in from a window.
Guesthouse in Avondale

Cast 'n Anchor in Walkable Avondale

4.95 out of 5 average rating, 169 reviews
Guest favorite
A bright living space is featured with a gray sofa and a light wood coffee table. An office area includes a desk and an ergonomic chair. Two decorative paddles hang on the wall above a lamp, and natural light filters through sheer curtains on the windows.
Guesthouse in Jacksonville Beach

Cozy Cottage only 4 Blocks from the Ocean!

4.9 out of 5 average rating, 110 reviews
Top guest favorite
The guesthouse exterior features a welcoming front porch with two chairs and a small side table, surrounded by colorful plants. Sheer curtains adorn the entrance, and bicycles are parked nearby, creating an inviting space for relaxation and leisure.
Guesthouse in Southwest Jacksonville

{Owl's Nest} Avondale Guesthouse *No Cleaning Fee!

4.92 out of 5 average rating, 173 reviews
Top guest favorite
The exterior of the guest house features a welcoming front door with a decorative panel. A pathway leads to a small patio area with a picnic table surrounded by landscaped flower beds. Two green windows on either side of the door invite natural light into the space.
Guesthouse in Jacksonville

Cute backyard one bedroom guesthouse

4.98 out of 5 average rating, 127 reviews

Guest house rentals with a patio

Top guest favorite
A spacious studio suite features a large bed with a decorative yellow throw and patterned bedding. A cozy blue accent chair and ottoman are positioned nearby, alongside a small table. The kitchen area is visible in the background, with modern appliances and cabinetry.
Guesthouse in Riverside

Modern Riverside Private Studio

4.96 out of 5 average rating, 208 reviews
Top guest favorite
Guesthouse in Murray Hill

The Treehouse - Murray Hill

4.95 out of 5 average rating, 174 reviews
Top guest favorite
A spacious studio guest house is showcased with modern decor. The full-sized bed is dressed in dark bedding, and a light area rug adds texture to the tiled floor. A kitchenette area is visible in the background, providing essential appliances and a warm atmosphere.
Guesthouse in Jacksonville

La Casita on Jupiter

4.96 out of 5 average rating, 131 reviews
Superhost
A modern outdoor area features a round table with four green chairs, surrounded by gravel and greenery. A raised planter box displays various plants, while a small building with large glass doors complements the peaceful setting, enclosed by a wooden fence.
Guesthouse in Murray Hill

The Moody Loft (Murray Hill)

4.88 out of 5 average rating, 370 reviews
Guest favorite
Guesthouse in Jacksonville

Clean & Modern Studio in East Jacksonville.

4.88 out of 5 average rating, 41 reviews
Guest favorite
A modern living area features a light beige couch and two armchairs, accompanied by a tufted ottoman. A standing lamp and a framed coastal artwork enhance the soft lighting. The kitchen is visible in the background, showcasing stainless steel appliances against gray cabinets.
Guesthouse in Jacksonville Beach

Beach Bliss Hideaway: 1bd Gem!

4.96 out of 5 average rating, 84 reviews
Superhost
Guesthouse in Jacksonville

Cozy Private Guesthouse •Downtown•king bed•

5.0 out of 5 average rating, 4 reviews
Top guest favorite
A light beige couch is adorned with a variety of decorative pillows, including patterns and text. Large windows provide a view of lush greenery outside, complemented by soft, neutral curtains. A small side table is positioned beside the couch, enhancing the inviting space.
Guesthouse in Fernandina Beach

Island Guesthouse in the Oaks

5.0 out of 5 average rating, 47 reviews

Guest house rentals with a washer and dryer

Guest favorite
A modern kitchen space features a round dining table with woven chairs, set with dishes and glassware. A soothing green wall and natural light from the window enhance the atmosphere. Open shelves display kitchenware, while a stainless steel refrigerator adds a contemporary touch.
Guesthouse in Murray Hill

Hip + Modern Florida Hideaway

4.98 out of 5 average rating, 173 reviews
Guest favorite
A spacious studio features a large bed adorned with a patterned quilt. Light green walls are complemented by nautical decor. A small dining area and access to an outdoor space are visible through glass doors, while a cozy seating area is also present.
Guesthouse in Avondale

Jax Coastal Cottage

4.94 out of 5 average rating, 166 reviews
Top guest favorite
A cozy seating area is presented with a light-colored couch and matching ottoman, featuring a soft throw. A wooden dresser adds warmth, complemented by an art piece depicting a coastal scene and a small flag. Natural light enters through the adjacent glass door.
Guesthouse in Fernandina Beach

Cord Grass Court

4.92 out of 5 average rating, 159 reviews
Top guest favorite
A cozy living area is presented with a gray sofa adorned with red pillows, paired with a checkered accent chair. Natural light enters through multiple windows, and a ceiling fan is visible above. A small wooden table sits in front of the sofa, accompanied by a flat-screen TV on the wall.
Guesthouse in Avondale

Charming Pet-Friendly Guesthouse in Avondale

4.98 out of 5 average rating, 128 reviews
Superhost
A modern kitchen features ample counter space with quartz countertops and a marble backsplash. Stainless steel appliances include a refrigerator, oven, and dishwasher. A large sink is positioned beside light wooden cabinetry, with decorative pendant lights illuminating the area.
Guesthouse in Springfield

Charming Carriage House with Private Balcony

4.87 out of 5 average rating, 337 reviews
Top guest favorite
A cozy living area features a blue sectional sofa with decorative pillows, complemented by woven wall hangings. A soft throw blanket is casually draped over the sofa. Natural light filters through sheer curtains, while a small plant adds a touch of greenery to the space.
Guesthouse in Avondale

Henry’s Pad

4.97 out of 5 average rating, 413 reviews
Guest favorite
A light-filled living area features a comfortable black sofa adorned with textured cushions. A round dining table with wooden chairs sits nearby. Natural elements are introduced through a potted plant and a woven light fixture, while a piece of artwork adds a touch of color to the wall.
Guesthouse in Springfield

Cozy Cottage in Springfield, Downtown Jax

4.98 out of 5 average rating, 186 reviews
Top guest favorite
Guesthouse in Jacksonville

Dolce Haven | Brand-New Luxury Retreat in Jax

5.0 out of 5 average rating, 29 reviews

Destinations to explore