Guesthouse vacation rentals in Missouri

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Missouri

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A spacious guesthouse is set against a clear blue sky, showcasing a facade of stone and large windows. The well-maintained lawn, dotted with greenery, complements the inviting entrance that features a covered porch area.

Guesthouse in Webb City

4.97 out of 5 average rating, 552 reviews

Bright and Modern Private Guesthouse near Route 66

Our guesthouse is ready to host the most discerning traveler. You will appreciate the clean private guesthouse that is located on a quiet neighborhood street in a newer central subdivision that is close to all that SW Missouri has to offer. Please note that we offer a microwave, refrigerator, coffee maker, dishes, and utensils in the kitchen area, there is no stove/ oven. Parties and events are not allowed. Any extra guests need to have prior approval from the host before they arrive on site.

Top guest favorite

A waterfall cascades over a rocky ledge, creating a gentle mist. Sunlight filters through trees in the background, enhancing the natural beauty of the scene. Smooth rock formations line the water's edge, reflecting the tranquility of the surrounding environment.

Guesthouse in Joplin

4.99 out of 5 average rating, 145 reviews

Mike & Angie’s Private-Cozy furnished Guest House

Welcome to Red Roof Creekside Getaway. Escape to this enchanting bungalow in Joplin. This cozy retreat features a fully furnished private Guesthouse with all the essentials for a comfortable stay. Our wish is that everyone who stays with us will have a comfortable, relaxing, stress-free time. We're available for any questions or needs. Our guest house sits on a secluded, private, peaceful two-acre lot, surrounded by trees, a creek and lots of wildlife. Close by Route 66 and local amenities.

Guest favorite

A modern bathroom is seen featuring a spacious shower with dual shower heads and a glass enclosure. Natural light enters through a skylight above, complementing the white tile walls. A floating vanity with a sink and a large mirror is placed above a dark countertop. A washer and dryer are discreetly located in the corner.

Guesthouse in Kansas City

4.98 out of 5 average rating, 115 reviews

Natural Lighting: Our beautiful Guesthouse

Our guesthouse is designed uniquely to accommodate our friends, family & friendly Airbnb guests like you. Our place can fit up to eight guests, has its own washer and dryer, TV with Roku setting, curb-less shower with two shower heads, comfortable beds & lots of daylight due to the six skylights. Come and see for yourself the beauty and comfort that this sweet guesthouse has to offer. (We only accept bookings of guests w/ previous positive reviews on their profile. Feel free to ask though)

Guest favorite

A wall featuring a combination of rough brick and stone textures is displayed. A clear parking sign stating 'GUEST HOUSE PARKING ONLY' is prominently positioned against the wall, ensuring visibility for guests utilizing the designated parking area.

Guesthouse in Cape Girardeau

4.94 out of 5 average rating, 512 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

Superhost

The exterior of the Carriage House is showcased, featuring a charming red brick façade with a grey shingled roof. Surrounding greenery includes flowering plants and shrubs, while a staircase leads to the cozy entry door. A garage door is visible, adding to the building's historic character.

Guesthouse in St. Joseph

4.86 out of 5 average rating, 218 reviews

Vineyard Mansion - Carriage House

The Vineyard Mansion Carriage house is a historic mansion built in 1890. Recently restored, the Carriage House, a 1 bedroom 1 bathroom self sufficient apartment detached from the main house with private access and full home amenities. The mansion is close to the historic city center, art, museums, culture, and parks. You’ll love my place because of the historic neighborhood, the comfy bed, the coziness of the carriage house, and fully functional kitchen.

Superhost

A serene river scene is depicted, featuring smooth stones and towering trees along the bank. The water reflects the lush greenery and clear blue sky, creating a tranquil environment. A rocky cliff rises on one side, adding natural texture to the peaceful landscape.

Guesthouse in Salem

4.8 out of 5 average rating, 374 reviews

Courtesy Curve Traveler's Rest

One large room has 1 queen bed, a futon, and we can add a folding twin bed if needed. Full bathroom with shower and sink. Fullsized fridge with freezer, electric cookstove with oven,big screen TV with netflix, Hulu, etc. New Serta mattress, new hardwood floor, Fast WiFi, Close to town but no neighbors, private entrance. Close to the highway, Off road parking space close to the door. Well mannered pets welcome, ill mannered humans not so much.

Top guest favorite

A set of wooden stairs leads to a gray door framed by a small window. The stairs are flanked by black metal railings, and the exterior features a vibrant blue color. Nearby, a brick pathway provides access to the entrance.

Guesthouse in Kansas City

4.98 out of 5 average rating, 963 reviews

Tiny house living in the heart of Kansas City

Our cute little guesthouse above the garage offers comfort and quiet in this urban walk-able neighborhood. We are walking distance to the free Kansas City Street Car, Crown Center, Union Station, and local restaurants. Enjoy all that Kansas City has to offer within a short uber ride or drive; Crossroads, Crown Center, Children's Mercy, Union Station, Liberty Memorial, Westport, River Market, and Power and Light, we are in the heart of it all!

Guest favorite

A wooden pathway winds down towards a softly lit deck overlooking a tranquil pond. Lush green foliage frames the scene, and warm lighting enhances the inviting space for relaxation. Trees provide shade, with reflections shimmering in the water's surface nearby.

Guesthouse in Lone Jack

4.92 out of 5 average rating, 290 reviews

Adorable cottage on Beautiful property w/ hot tub

Take it easy at this unique and tranquil getaway. Enjoy your own private cottage with all your essentials; You also have access to the property's hot tub and 1 acre pond stocked with catfish, blue gill, and bass! The cottage has a 1 queen size bed and a mattress in the loft . Please note: we do live on this property and the cottage is next to our main house. We have friendly outdoor cats they do freely roam the property.

Top guest favorite

Two wooden Adirondack chairs are placed on a wooden deck in front of a window. A welcome sign hangs beside the window, complemented by a trash can nearby. The setting is surrounded by greenery, contributing to a serene outdoor ambiance.

Guesthouse in Rocheport

4.98 out of 5 average rating, 194 reviews

Just off the beaten path

Take it easy at this unique and tranquil getaway. 5 minutes from I-70. Enjoy nature in the woods in our cozy, quiet guesthouse. Close to the Katy Trail for cyclists, wineries, and I-70 for the weary traveler needing a quiet rest before hitting the city. We offer an easy, accessible place to store your bikes and gear. Coffee/tea to wake up enjoying breathtaking views from your private deck.

Top guest favorite

A newly built guesthouse exterior is shown at dusk, featuring a two-story design with large glass doors that open to a bright interior. A garage is visible on the right, with a golf cart inside. Soft lighting and modern features enhance the welcoming appearance.

Guesthouse in Paris

4.98 out of 5 average rating, 103 reviews

Salt River Alpacas Guesthouse

Kick back and relax in this newly built guesthouse. Located on a peninsula on Mark Twain Lake, this guesthouse is surrounded by 130 acres of rolling pastures, plenty of woodlands, and the lake on three sides of the property. Whether you enjoy hiking, canoeing/kayaking, fishing, hunting, learning about our alpacas, or you just want a quiet place to relax, this property has it all!

Guest favorite

A front door is adorned with a decorative wreath featuring vibrant orange fruit and green foliage. The door boasts multiple glass panels, allowing natural light to enter, and a modern keypad entry system is visible beside it.

Guesthouse in Joplin

4.9 out of 5 average rating, 222 reviews

Charming Studio in Roanoke Terrace

Adorable studio apartment above our 2-car detached garage. We are located in the scenic Roanoke neighborhood, one of the safest neighborhoods in Joplin. Large trees, character, & beautiful historic houses. We are within 5 miles to both hospitals & walking distance to historic downtown Joplin and Ozark Christian College. Private entry & charming decor in a fresh, new space.

Guest favorite

A sunlit kitchen sink area is displayed, featuring a stainless steel sink beneath a decorative wreath adorned with flowers and ribbon. Natural light filters through a nearby window, illuminating the countertop with a light-colored surface and modern cabinetry.

Guesthouse in Hermann

4.97 out of 5 average rating, 240 reviews

The Dogwood Inn Hermann

We are a two bedroom,( 1 King, 1 Queen) one bath guesthouse that rents to one or two couples (if they know each other) at a time. A luxury spa like atmosphere with all the comforts you'd expect. We are located in the historic district of Hermann, MO and are within walking distance of the train station, trolleys, many attractions, food, wineries, and shopping.