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Boutique hotel vacation rentals in Missouri

Find and book unique boutique hotel rentals on Airbnb

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Popular amenities for Missouri boutique hotel rentals

Family-friendly boutique hotels rentals

Guest favorite
Hotel room in St. Louis
4.9 out of 5 average rating, 896 reviews

King Redwood Bedroom at BnB in CWE!

RachelRating, 5 stars2 weeks ago
We had a fantastic time staying here during our time in St. Louis! Our room was spacious and comfortable. We really appreciated the great kitchen area and the breakfast foods and coffee/tea that were provided - thank you! It was also super nice to be able to leave our bags after checkout and pick them up in the evening before our night time flights.
Guest favorite
Hotel room in St. Louis
4.87 out of 5 average rating, 720 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

TannerRating, 5 stars2 weeks ago
Great stay, second time in this location, will be interested in coming back
Guest favorite
Hotel room in Hermann
4.95 out of 5 average rating, 44 reviews

Hermann Crown's New Pet Friendly Shepherd's Suite

CassieRating, 5 stars1 month ago
The place was just a described. We liked the location was walkable and that we had access to the hotel amenities, but felt like we had a private space.
Guest favorite
Hotel room in Hermann
4.82 out of 5 average rating, 45 reviews

Hermann Crown's Victorian Suite, Tons of Amenities

ShannaRating, 5 stars5 months ago
Very quaint boutique. Room was perfect. Everyone was very friendly and helpful with any questions we had. We loved the shuttle service to and from the wineries. The downstairs bar and live music was the perfect way to end the evening. We will definitely be back.
Hotel room in La Plata
4.73 out of 5 average rating, 11 reviews

Depot Inn & Suites - Luxury Themed Suites

MichaelRating, 5 stars3 months ago
This was a great place for a relaxing little Valentine’s Day getaway for my wife and I. Our lives are very busy and stressful and it was nice to be here and relax in the jetted tub while watching TV and then play board games and sleep.
Guest favorite
Hotel room in St. Louis
4.87 out of 5 average rating, 634 reviews

Evergreen Room Queen Bed at BnB in CWE

JocelynRating, 5 stars2 weeks ago
We really enjoyed this Airbnb! They had such clear instructions both in the bathroom and kitchen - I wish more Airbnb’s were that thorough.
Hotel room in Lexington
4.8 out of 5 average rating, 45 reviews

Wentworth Mansion Suite 1

NiekoleRating, 5 stars1 month ago
Absolutely loved our stay! The house had beautiful furniture that matched the time period it was built!!
Guest favorite
Hotel room in Hermann
4.8 out of 5 average rating, 30 reviews

Hermann Crown's Presidents Suite, 3 Beds & 2 Baths

ChristinaRating, 5 stars4 months ago
My girlfriends and I stayed here to celebrate a birthday, and it was perfect! Plenty of space for 8 of us! There is a restaurant/bar with live music right underneath the hotel, and you can walk across the street to the Piano Bar, and have a blast! Bring some tip money to hear your favorite requests 💃🏽🎶 There are also cute stores and shops within walking distance.

Boutique hotels rentals with a patio

Superhost
Hotel room in Osceola
5 out of 5 average rating, 10 reviews

Historic Commercial Hotel(1868)Karolyn Grimes Room

KevinRating, 5 stars10 months ago
This is a neat little spot. Definitely felt like an old west hotel in terms of decor. Simple room and to the point. Comfy bed. I know this town since I'm from the area, but there's good printed info in the room for the local spots to check out. On the town square, so great if you're visiting for a car show! Easy parking (I was in a Uhaul).
Hotel room in Ste. Genevieve

QUAINT AND CUTE ROOM OFF THE BEATEN PATH...

MichaelRating, 5 stars14 months ago
We needed to bring our kitty with us because she needs medication, so that was our main priority in selecting a place to stay in Ste. Genevieve. To set expectations: The motel is older, so if you're expecting a modern B&B experience with all the latest updates, this isn't the place for you. We were simply looking for a good location and the ability to keep our kitty healthy, and this place was perfect for us. The owners (and management) are nice and made sure we were comfortable. They allowed us the privacy we needed, and went the extra mile to recommend restaurants in the area that were Celiac-friendly. You could technically walk to Old Town, but it's best to drive your car. The motel is, however, walking distance to the best Mexican food we've ever tasted. The bed was very comfortable, the shower was pleasantly hot, and the owners and management were very nice people. We slept well, and our kitty was even a little disappointed when we had to go home. We would stay there again!
Guest favorite
Hotel room in Versailles
4.9 out of 5 average rating, 40 reviews

Cozy hotel secluded in the woods 4 Full size beds

KelseyRating, 5 stars6 months ago
Great stay for one night weekend get away! Very clean and just very proactive and responsive to us! Able to check in early and fit our needs exactly!
Superhost
Hotel room in Kansas City
New place to stay

Leroy Satchel Paige at Southmoreland on the Plaza

SebastianRating, 5 stars2 weeks ago
This mansion was amazing!! I absolutely loved the history. It was clean and there was plenty of stuff to do. They do an amazing job here and I can’t wait to get back! Also, Kristen communicated awesome and was a great host!! 10/10
Top guest favorite
Hotel room in St. Louis
5 out of 5 average rating, 12 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

AkshayRating, 5 stars3 months ago
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.
Hotel room in St. Louis
4.74 out of 5 average rating, 65 reviews

The West End by Cortex, Forest Park, BJC & Zoo

TrianaRating, 5 stars1 week ago
Really nice area, with plenty of things to do. Room was clean and nice.
Guest favorite
Hotel room in Versailles
4.77 out of 5 average rating, 22 reviews

Secluded Rustic theme Hotel - Queen room

RonRating, 5 stars6 months ago
Fantastic stay! Even though it was quick for me, everything was perfect from Matt's communication to location to cleanliness. I needed a special accomodation for some unusual hours and Matt didn't flinch! And, the setting was peaceful, just like I needed! The setting is a remote, rural wooded area! Totally will be staying here again! Thank you, Matt!
Superhost
Hotel room in Saint Charles
5 out of 5 average rating, 3 reviews

#6 The Green Tyke Le Velo Inn

SierraRating, 5 stars3 days ago
The best Airbnb i’ve ever stayed at. The aesthetics are amazing. I took pictures for inspiration -from the glasses to drink out of to the wall decorations - to the couch. I felt right at home & I have such a peaceful experience when I stayed here. I can’t wait to come back.

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