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House vacation rentals in La Mesa

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Top-rated house rentals in La Mesa

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Top guest favorite

A spacious outdoor area features a swimming pool, accompanied by colorful lounge chairs and a large umbrella for shade. A unicorn float is visible in the water, with potted flowers adding a touch of vibrancy. The home's façade offers multiple windows and seating options nearby.

Home in La Mesa

4.99 out of 5 average rating, 166 reviews

Mid-Century Style Family House with Spa

Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas, Desert Inn 3/4 acre.Less than 20 minute drive to beaches/Zoo/Sea World/Downtown, 40 minutes to Legoland. With a swimming pool/hot tub, huge lawn surrounded by California Oak/orange/lemonpomegranate trees and herb garden, this home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. No loud parties please, this is a quite community.

A spacious backyard is visible, featuring a large green lawn surrounded by low hedges. Comfortable seating areas are arranged around a fire pit, complemented by a shaded tree. A detached garage and a shed are seen in the background, against a clear blue sky.

Home in La Mesa

4.91 out of 5 average rating, 101 reviews

Fun Family Vibe Large Private Yard Free Parking

Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

The property features a spacious backyard with a heated pool surrounded by lounge chairs. Palm trees line the perimeter, and soft lighting illuminates the outdoor area during sunset. The two-story house overlooks the pool, creating an inviting atmosphere for relaxation and gatherings.

Home in La Mesa

4.95 out of 5 average rating, 194 reviews

XTRA 10% OFF until June: Heated pool, outdoor fire

Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our warm pool year-round, roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can sleep 6. But we can provid

The interior of the studio showcases a spacious layout, featuring a king size bed adorned with yellow and white pillows. A dark gray sofa complements the decor, facing a coffee table with a plant. Large glass doors provide a view of the garden and outdoor seating.

Home in La Mesa

4.9 out of 5 average rating, 249 reviews

Hidden King Suite with Garden, Parking - 4 Guest

Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

A spacious outdoor area features a clear blue pool surrounded by palm trees. Lounge chairs are positioned nearby, and a shaded table with chairs offers a spot for relaxation. The backyard showcases a privacy fence and ample sunlight.

Home in La Mesa

4.85 out of 5 average rating, 201 reviews

Sunny SD l Pool l BBQ l Pool Loungers l Sleeps 10

Escape to a fresh 4-bedroom retreat for family and friends (10 ppl max). Updated in January of 2024 with new furniture, and fixtures. Bask in the sun on the deck, take a dip in the pool. Enjoy the private and fenced backyard, BBQ, or the recently renovated and modern Kitchen. This home is perfect for vacations or remote work. Explore San Diego beaches and all the area has to offer, the most popular tourist destinations are all within a 20-30 minute drive. 20 minutes to the beach! Book with us!

Top guest favorite

An outdoor patio area features a round table with four chairs, all adorned with colorful cushions. A large red umbrella provides shade, and a decorative rug adds vibrancy to the stone surface. Surrounding greenery and blooming plants create a serene environment.

Home in La Mesa

4.98 out of 5 average rating, 311 reviews

Travel Writer's Pad

Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Top guest favorite

The spacious living area features a comfortable sofa, a dining table with chairs, and a full kitchen with modern appliances. A front-loading washer and dryer are visible, along with a wall-mounted air conditioning unit. Neutral tones are complemented by natural lighting.

Home in La Mesa

4.96 out of 5 average rating, 534 reviews

Clean 1BR/1BA Guest House Peaceful Private Casita

Discover the perfect home away from home in San Diego! Our cozy and tranquil guest house is located just a short drive from the city's top attractions, including the San Diego Zoo and beautiful beaches. Relax and unwind in the comfortable living room and enjoy all the amenities you need for a peaceful stay. With a comfortable queen-sized bed, full kitchen, and fresh towels, you'll have everything you need to feel at home. Book your stay with us today and experience the best of San Diego!

The kitchen area features modern black cabinetry and stainless steel appliances, including a microwave and compact refrigerator. A smart TV is mounted on the wall, complementing the wooden counter workspace equipped with essential cooking utensils. A dining table with two chairs is positioned nearby.

Home in La Mesa

4.84 out of 5 average rating, 223 reviews

Newer "Manor Studio"

Centrally located in San Diego County this newer studio style unit has a private entrance, private patio area and street parking. Furnished with a queen size bed, love seat, full bathroom and kitchen area. One large drawer to accommodate personal items, and a wall rack to hang clothing. There is a smart TV with WiFi streaming capabilities and lots of USB plugs to charge your devices. On street parking in front of unit (no parking in driveway). No Pets allowed. No Hair Dying allowed.

A view into a modern living space reveals a sleek kitchen with bar seating and a spacious dining area. Natural light floods the room through large glass doors, showcasing lush greenery outside. A cozy area is completed with a colorful rug beneath and a inviting seating arrangement.

Home in La Mesa

4.94 out of 5 average rating, 218 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Top guest favorite

A colorful studio space features turquoise walls and a ceiling fan. A comfortable sofa with decorative pillows is paired with a coffee table. A bed with a floral-patterned comforter sits against a window, while a TV and white refrigerator complete the modern setup.

Home in La Mesa

4.99 out of 5 average rating, 249 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

A charming historic tudor home is showcased from the street view, featuring a distinct angular roof and decorative wooden accents. Lush greenery surrounds the property, complemented by a stone wall and pathway leading to the entrance. The inviting front lawn provides ample space for outdoor activities.

Home in La Mesa

4.92 out of 5 average rating, 131 reviews

(Relist!) Relax at a Stunning 1931 Historic Tudor!

Come & enjoy our 1931 historic tudor home! Beautifully rebuilt within the last 2 years. This house has a huge front lawn and space to roam. Enjoy the serenity this large property has to offer. Three peaceful patios to enjoy your morning coffee. The kitchen has an 48-inch 1950’s oven for the chef in the family. Bay windows, arched entryways and original light fixtures make this such a charming place to stay. Centrally located to enjoy everything San Diego & La Mesa has to offer.

A light-filled living space features a white sofa adorned with colorful cushions and a patterned throw. A framed image of a cow's head hangs on a yellow and white accent wall. A small table sits nearby with a potted plant, complementing the minimalist design.

Home in Lemon Grove

4.93 out of 5 average rating, 199 reviews

NEW- King Bed: Very clean, Quiet, A/C, parking

Enjoy a stylish experience at this centrally-located place. Kick back and relax in this calm, stylish suburban feel home near major local attractions. 15 minutes from downtown 15 minutes from the party scene 17 minutes from San Diego zoo 18 minutes from beaches 20 minutes from sea world 20 mins from Coronado CA 23 mins from the Mexico port of entry 40 MIN TO SAFARI ZOO 40 minutes from Legoland 1 hr to the desert 1.5 hrs to LA Near everything yet far away from city chaos

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Popular amenities for La Mesa house rentals

Free parking on premises

Air conditioning

House rentals with a hot tub

Top guest favorite

The outdoor space features a solar-heated pool with soft lighting, alongside a hot tub glowing in green. A dining area with a table and chairs is shaded by a red umbrella. Warm string lights enhance a cozy atmosphere in the evening.

Home in Greater North Park

5 out of 5 average rating, 118 reviews

3 BR Urban Oasis with Pool and Spa in Great Area

A modern living area features a dark sectional sofa adorned with patterned pillows. A large area rug with geometric design complements the space. A flat-screen TV is mounted on the wall, opposite a wooden sideboard. Soft lighting is provided by a pendant lamp and a floor lamp.

Home in San Diego

4.87 out of 5 average rating, 124 reviews

Sunny Casita Spa, Zoo, Views, Downtown

A serene outdoor space features a salt-water pool surrounded by a concrete patio and manicured grass. An umbrella provides shade over the poolside area, with lush greenery and mountains visible in the background under a partly cloudy sky.

Home in San Carlos

4.87 out of 5 average rating, 192 reviews

Bright and spacious home with views, pool & spa.

Top guest favorite

An inviting rooftop lounge area features a sectional sofa and a coffee table on a neutral rug, surrounded by natural wood elements. The space is sheltered by a wooden pergola, with panoramic views of palm trees and the distant skyline under a bright blue sky.

Home in Normal Heights

4.99 out of 5 average rating, 144 reviews

Private Luxurious Rooftop Deck & Private Jacuzzi.

A spacious backyard is highlighted by outdoor seating arrangements around a modern fire pit. Ambient lighting frames the area, while a dining table and BBQ grill are visible, providing inviting options for outdoor gatherings.

Home in San Diego

4.92 out of 5 average rating, 129 reviews

Modern 3BR•Huge Private Yard•Hot Tub•8 Mins to DT

A gas fire pit is surrounded by four outdoor chairs, offering a cozy gathering spot. The expansive backyard provides views of the surrounding hills and valley, with twinkling lights from nearby homes under the twilight sky.

Home in San Carlos

4.93 out of 5 average rating, 441 reviews

Spacious home with incredible backyard views

A spacious living area is enhanced by a beamed cathedral ceiling and large windows offering natural light. A comfortable grey sofa is arranged around a glass coffee table, accompanied by a stylish dining area featuring chic chairs and a vibrant piece of wall art.

Home in Adams North

4.95 out of 5 average rating, 310 reviews

Jacuzzi, Firepit, Sauna & Ice Bath, Rest & Relax

A private hot tub is positioned on the outdoor terrace, with a panoramic view of the city at dusk. Soft lighting from the surrounding area creates a relaxing atmosphere, while patio furniture and an umbrella are visible nearby. Large sliding doors provide access to the indoor living space.

Home in Point Loma Peninsula

4.98 out of 5 average rating, 124 reviews

The California - Indulge in San Diego luxury

House rentals with a pool

An outdoor area features a spacious pool surrounded by lounge chairs and colorful umbrellas. The two-story house is visible in the background, illuminated by warm lights. Soft purple lighting accentuates the pool's edge, creating a relaxing ambiance as the sun sets.

Home in University Heights

4.89 out of 5 average rating, 142 reviews

Your Modern Lux Pool Resort in the Heart of SD

A backyard pool area is surrounded by tropical palm trees, showcasing a clear, inviting pool with a rock formation. The house, featuring large windows and a spacious deck, serves as a backdrop against a bright blue sky.

Home in Allied Gardens

4.89 out of 5 average rating, 234 reviews

San Diego Retreat / Cal King x 2 / Pool, Parking!

A spacious outdoor area features a large swimming pool surrounded by lounge chairs and tables with umbrellas. Lush greenery and palm trees are visible along the perimeter, creating a relaxed atmosphere. The patio is designed for comfort, making it ideal for gatherings in the sun.

Home in San Diego

4.93 out of 5 average rating, 193 reviews

Stunning San Diego Home w/Pool,Spa,Outdoor Oasis

A tranquil pool area is surrounded by lush landscaping, featuring palm trees and various plants. Two lounge chairs with an umbrella are positioned beside the pool, reflecting a serene evening sky with hues of pink and purple.

Home in University Heights

4.98 out of 5 average rating, 126 reviews

University Heights Oasis Getaway

A light-filled living room features a suspended hanging chair, a modern grey sofa adorned with patterned pillows, and a circular coffee table. A large television is mounted on the wall, while a ceiling fan and floor lamp provide comfort. A warm area rug anchors the space.

Home in City Heights

4.93 out of 5 average rating, 105 reviews

Designer Luxury Rental With Pool

A private heated pool is framed by a spacious deck featuring lounge chairs. A vibrant red umbrella provides shade nearby. Palm trees and greenery offer a touch of nature, with the house and outdoor seating areas in view.

Home in Chula Vista

4.87 out of 5 average rating, 100 reviews

Dream Vacation! Sunny 3 Bedroom Home!

A private pool is surrounded by natural stone and lush greenery. Palm trees provide shade, while a bamboo privacy fence enhances the secluded atmosphere. The clear blue water invites relaxation, showcasing gentle ripples under the sunlight.

Home in Chula Vista

4.9 out of 5 average rating, 186 reviews

Oasis with ocean views/Pool/Hot tub! Sleeps 10!

Home in Spring Valley

4.96 out of 5 average rating, 150 reviews

Upscale Resort House /Views, Saltwater Pool/Spa !

House rentals with free parking

Top guest favorite

An outdoor patio area features a glass table shaded by an orange umbrella. Two chairs are positioned nearby, surrounded by green grass and trees. The peaceful setting includes wooden fencing in the background, adding to the privacy of the space.

Home in La Mesa

4.99 out of 5 average rating, 82 reviews

Escape to tranquility: the perfect retreat

Top guest favorite

A modern living area features a large couch with decorative cushions and a wooden coffee table. A ceiling fan and ample natural light are present from the windows. A dining area is visible in the background, with white furniture complementing the clean, neutral color palette.

Home in La Mesa

4.98 out of 5 average rating, 61 reviews

Remodeled 1B/1B. Heat, Pets

A spacious outdoor deck is illuminated by string lights, featuring comfortable lounge chairs arranged for relaxation. A dining table accommodates multiple guests, while a fire pit offers warmth and ambiance. Potted plants enhance the tranquil environment, creating an inviting atmosphere for outdoor gatherings.

Home in La Mesa

4.74 out of 5 average rating, 34 reviews

Exquisite, Modern, Walk to Bliss

A sunlit bedroom features a spacious queen bed adorned with decorative bedding and a light throw. A minimalist bench sits at the foot of the bed, while a desk and lamp occupy a corner. Windows provide natural light, illuminating the soft-toned walls.

Home in El Cajon

5 out of 5 average rating, 6 reviews

Cozy quiet getaway, great mattress (1-br)

A modern kitchen features sleek black cabinetry and stainless steel appliances. A spacious countertop provides ample prep area, while stylish open shelving displays decorative items. Soft natural light filters in through a window, highlighting a patterned rug on the floor.

Home in La Mesa

5 out of 5 average rating, 4 reviews

Modern, Private, & Stylish Home

The exterior of the mid-century home is presented, featuring a welcoming red door and a trimmed path leading to it. Surrounding greenery enhances the front yard, while palm trees stand tall alongside the property. A driveway is visible, offering access to the side of the home.

Home in La Mesa

4.96 out of 5 average rating, 57 reviews

Cozy Mid-Century Charmer | Huge Backyard | Firepit

A private pool area is surrounded by lush greenery, highlighting bright flowers and palm trees. Comfortable seating is positioned nearby, with a pergola visible in the background. The sunset casts warm colors over the scene, enhancing the tranquil outdoor setting.

Home in La Mesa

4.9 out of 5 average rating, 39 reviews

SunnySD Private Pool-SoCal Oasis

Top guest favorite

A bright corner space features a window with a view of outdoor greenery. A wooden table is set for two, surrounded by black metal chairs. A cozy blue armchair and a side table complement the warm tones of the hardwood flooring and a colorful area rug.

Home in El Cajon

5 out of 5 average rating, 32 reviews

Charming Cozy Studio Centrally Located

Quick stats about house rentals in La Mesa

Total rentals
290 properties
Total number of reviews
12K reviews
Family-friendly rentals
180 properties are a good fit for families
Pet-friendly rentals
90 properties allow pets
Rentals with a pool
70 properties have a pool
Rentals with dedicated workspaces
170 properties have a dedicated workspace

Destinations to explore