House vacation rentals in La Mesa

Find and book unique houses on Airbnb

Top-rated house rentals in La Mesa

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in Pacific Beach

4.9 out of 5 average rating, 124 reviews

Luxury Stay Steps to Ocean & Bay

This ultimate San Diego getaway is steps to the beach & mission bay! Fully renovated with high-end luxury design details, this home is perfect for families & couples. Experience the So-Cal indoor/outdoor lifestyle with a cantina door that opens to a built in barbecue, outdoor fire pit & covered lounge area. Located in walking distance to Mission Bay, Mission Beach, restaurants, bars, shopping, coffee shops & more. This modern beach house has everything you need for the perfect vacation getaway

Top guest favorite

The open living space features natural wood beams overhead and large windows allowing ample light. A large sectional couch with colorful cushions enhances comfort, while a kitchen island with bar seating is visible, highlighting modern appliances and a warm atmosphere.

Home in North Ocean Beach

4.96 out of 5 average rating, 505 reviews

Swanky Casa Ocean Beach 1 Blk to Beach w A/C

Two bedrooms & prime location! 250 steps to the beach 2 blocks the mainstreet. Split system A/C for independent control of each bedroom. Amenities include surfboards, bikes, & beach toys. Ocean Beach offers numerous bars/restaurants including the famous Hodad's & OB Noodle House, antique stores, & weekly Farmer's Market. Excellent walkability! PLEASE NOTE: Currently has potential for construction noise, a new unit is being built behind the home. Risk for noise is reflected in the rental rate.

Top guest favorite

Home in Point Loma Peninsula

4.99 out of 5 average rating, 136 reviews

Bayview Paradise

Known as the Huguette House, this luxury private single-family two bedrooms two bathrooms home in La Playa the heart of Point Loma, San Diego offers 180-degree panoramic views of the world-famous San Diego Bay and Downtown Skyline. views of the San Diego bay, marina, and Coronado Island during the day and spectacular views of the Downtown San Diego skyline at night, fully equipped kitchen, and laundry room, 2 bedroom suites with queen beds .2 luxury bathrooms, HDTV, computer desk and WFI

Guest favorite

A light-filled living room features a soft blue sofa adorned with textured throw pillows. Two side tables with lamps flank the sofa, and a rustic coffee table holds a decorative bowl filled with natural elements. Artwork depicting a tranquil beach scene is displayed above.

Home in Pacific Beach

4.9 out of 5 average rating, 392 reviews

Sunny Beach Retreat | Walk to Bay & Ocean

Sunny Beach Retreat | Walk to Bay & Ocean | Family-Friendly Experience your dream beach getaway in San Diego! This bright and airy home features a spacious living area, an updated kitchen, and a quiet location just one block from Mission Bay Park with 12+ miles of bike paths. Enjoy off-street parking, a laundry room, and family-friendly amenities. Short drive to Downtown, La Jolla, and Coronado. Air mattress available for extra guests. Book now for the perfect beach escape!

Guest favorite

A living area features a spacious sectional sofa in black leather with a modern coffee table, offering two woven placemats. Natural light floods the room through windows, highlighting the warm wood floors and neutral wall color. A lamp adds soft illumination.

Home in North Park

4.83 out of 5 average rating, 690 reviews

1925 Hillcrest Cottage in with City Views!

Freshly Painted! LOCATION, LOCATION, LOCATION!! Upgraded internet. Escape to beautiful San Diego in this very unique 1925 Built Craftsman one-bedroom, one-bathroom cottage that sleeps up to 2-3. Only five minutes from downtown, Balboa Park, the San Diego Zoo and surrounded by a wide variety of fun and popular attractions. It is perfect for those that want complete privacy but close to everything! This cottage has a full kitchen and beautiful city views.

Guest favorite

A spacious living area is visible, featuring a light grey wall that enhances natural light. A large sectional sofa is arranged around a coffee table, while a decorative chandelier hangs above a dining table with a turquoise surface. Vibrant artwork adorns the wall, adding color to the room.

Home in Mission Beach

4.94 out of 5 average rating, 139 reviews

Dream Home Beach House! 3BR/3BA Ocean Views

This San Diego Beach House is an amazing, renovated home with 3 bedrooms and 3 bathrooms located on the first, second, and third floor of a duplex with ocean views of the South Mission Beach Jetty and Ocean Beach across the Mission Bay Channel. We can accommodate up to 8 adults and 2 children for 10 total guests. This house is intended for family vacations—it is not a party house. The owners live two doors down if you ever need assistance with anything.

Guest favorite

An open living space features vaulted wooden ceilings and large windows allowing natural light. A round dining table with four chairs is positioned in the center, while a cozy seating area with blue chairs and decorative cushions is visible. Art decor and bicycle accents enhance the ambience.

Home in Pacific Beach

4.96 out of 5 average rating, 157 reviews

New! Bayside Bungalow - Upscale Beach Retreat!

Wake up every morning and enjoy a stroll along the water when staying at our new Bayside Retreat in Crown Point. Our recently remodeled (2022) guest house is just 1 block to the Bay and within walking distance to restaurants, bars, shopping and, nightlife. The guest house is bright and open with vaulted ceilings and brand new everything! Enjoy 600 thread count luxury cotton linens, a silky-soft down alternative duvet, and air conditioning.

Guest favorite

A modern living area features a comfortable grey sofa adorned with yellow accent pillows alongside a matching armchair. A round mirror reflects natural light from the window, enhancing the bright, airy atmosphere of the space. Decorative plants add a touch of greenery.

Home in San Diego

4.93 out of 5 average rating, 112 reviews

Cozy Cottage | Walk to SDSU | Free Laundry

Perfect Space for a Couples Staycation! ☀ Spacious, modern, and beautifully designed property ☀ Prime location near public transportation, top restaurants, shops, and attractions ☀ Fully furnished with all the essentials for ultimate comfort ☀ Enjoy year-round comfort with air conditioning and heating ☀ Stay connected with high-speed internet, perfect for work or streaming ☀ Only 25 minutes from San Diego International Airport!

Guest favorite

A spacious living area is enhanced by a beamed cathedral ceiling and large windows offering natural light. A comfortable grey sofa is arranged around a glass coffee table, accompanied by a stylish dining area featuring chic chairs and a vibrant piece of wall art.

Home in Adams North

4.95 out of 5 average rating, 303 reviews

Jacuzzi, Firepit, Sauna & Ice Bath, Rest & Relax

Located in the heart of Normal Heights, close to the City Center/Zoo/Balboa Park with access to all major Freeways. Designed with the eye toward comfort and entertainment. *Spacious living space with a beamed cathedral ceiling *Mini Split Units for individual room temperature *Stylish & unique *Private Backyard *Far Infrared Sauna *Kingsize Bed *Walk to coffee, yoga, gyms, dining, entertainment, shopping!

Guest favorite

Home in Mission Hills

4.97 out of 5 average rating, 109 reviews

Ultimate Getaway: Spa, Game Rooms, Firepit, Views

Casa Blanca by Rental With A View in San Diego is no ordinary vacation rental. Stunning panoramic views? Yep. Hot tub? Yep. Outdoor spaces? Got Four of em’ if you’re counting. Game room? Not one, but two. And that’s just the tip of the iceberg. This house has a clear mission statement: REJUVINATING RELAXATION and MAXIMUM FUN!

Guest favorite

A charming single-story house is depicted with a white exterior and a red door. Flanking the entrance are two red chairs on the porch. A white picket fence borders a well-kept lawn, adorned with blooming roses, and palm trees are visible in the background.

Home in Mission Valley

4.82 out of 5 average rating, 407 reviews

Cottage near Sea World, Old Town, & Beaches

Guests who have stayed here before have consistently said that the location is second to none. Proximity to the trolley line, downtown, the bay, beaches, and other popular San Diego destinations make this vacation rental an attractive option for those looking to pack it all in while enjoying this beautiful city.

Guest favorite

A rooftop deck is shown, featuring a spacious glass table surrounded by modern chairs. An umbrella provides shade, enhancing comfort while enjoying views of the surrounding neighborhood and palm trees. Bright sunlight fills the area, creating an inviting outdoor space.

Home in Mission Beach

4.94 out of 5 average rating, 202 reviews

Bayside Retreat Steps to Sand- Great for Families!

Your Perfect San Diego Getaway Starts Here! Nestled in North Mission Beach on Pismo Ct., this modern luxury beach house offers stunning bay views, designer interiors, central A/C, and a rooftop deck—all just steps from the sand, and walking distance to amazing restaurants, shops & more.