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House vacation rentals in Isla Grande

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Top-rated house rentals in Isla Grande

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Top guest favorite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 106 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Superhost
An open-concept loft is showcased with a high, sloped ceiling and large windows that invite natural light. Comfortable seating is arranged around a glass table, while a dining area and a cozy sleeping space can be seen in the background. Nature views are visible through the windows.
Home in Santa Rita Arriba
5 out of 5 average rating, 3 reviews

The Bird's Nest in the Clouds

Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain, birds, and our chickens. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. Please read description fully.

Guest favorite
A two-story house is illuminated at night, accentuating its spacious design. Light fixtures highlight the outdoor area, featuring a lawn with soft green grass. The large balcony is adorned with seating, while tall palm trees add to the natural surroundings.
Home in Garrote
5 out of 5 average rating, 10 reviews

Ocean Front Villa

This is a unique oportunity to live in a house on a sea shore yet having wild nature in the backyard. There is soft, green grass area, hamaks, garden chairs and cosy light arrangements so the river shore and the mangroove system looks magical in the night. They attracts variety of wildlife so sometimes, making your morning coffee, you can spot monkeys, sloths, sea birds and lizards, right though the window of the kitchen, or maybe later, resting in the shade of the trees in the hammock

Guest favorite
An outdoor terrace features a table with seating for four, framed by colorful chairs in red and blue. A hammock is suspended nearby, with the serene view of the water and distant hills providing a tranquil backdrop. Natural light illuminates the space, highlighting the coastal setting.
Home in Juan Gallego
4.94 out of 5 average rating, 53 reviews

Kasa Leilani - the perfect getaway!

Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.

Guest favorite
A modern living area features a dark sectional sofa with a decorative pillow. Natural light filters through stylish striped blinds, highlighting the sleek marble flooring. A wooden cabinet and coffee station are positioned in the background, creating a functional and inviting space.
Home in Colón
4.92 out of 5 average rating, 25 reviews

Family Style Living, in Colon #3

Relax with the whole family at this peaceful place. This house is located on reverted Areas transferred back to Panamá, called Arco Iris, there’s plenty of space outside, the inside consist of a modern combination living room+kitchen, bathroom and a large bedroom with acomodación for 4 guest, the place is Airconditioned with Celling fans in the living room and bedroom. This is a third house constructed next to our first rental called, Family Style Living and close to the Panamá Canal

Guest favorite
Home in La Guaira
4.82 out of 5 average rating, 33 reviews

Bella Casa, Caribbean Sea, Juan Gallego (waterfront)

Hermosa Casa de Playa, frente al mar caribe, para descansar y relajarse al 100%. La Casa cuenta con una ubicación privilegiada, mantiene 4 habitaciones (una de ellas cuenta con una mampara para dividir de la sala y ampliar esa área en caso que se desee), sala, comedor, terraza privada, frente a Isla Grande. 3 habitaciones tienen TV con cable y una TV extra en la sala. Todas con con Aire Acondicionado. Cuenta con 2 baños completos. Cocina equipada y lista para disfrutar y Wifi

Superhost
An open living area is showcased with a kitchenette on one side, featuring dishware and utensils arranged neatly. A spacious bed is positioned against the wall, complemented by a colorful headboard. A small wooden table is surrounded by three stools, creating a casual dining space.
Home in Portobelo
4.81 out of 5 average rating, 47 reviews

Casa Dinis, Studio, Downtown Portobelo

Relax! You're in the Caribbean! The Studio is in the historic center of Portobelo, a World Heritage village, you have the opportunity to live a real experience and share with a village full of history, cultural identity and cute people! The Studio is on the low floor of Casa Dinis and has a separate entrance, it has a queen bed and a sofa bed (preferably for children). The space is very comfortable, equipped kitchen, bathroom, air conditioning, Internet and TV welcome!

Superhost
A two-story wooden house is situated by the shore, surrounded by palm trees. The structure features a combination of red and white exteriors, with air conditioning units visible on the main level. A clear blue sky and lush greenery provide a vibrant backdrop.
Home in La Guaira
4.56 out of 5 average rating, 9 reviews

Beautiful oceanfront country house

Casa de Campo facing the sea in the form of a boat.. where you can see, hear and hear the sounds of the sea of birds and nature. It has 4 alcoves with AA of which the main one has a delicious balcony overlooking the sea It is a nice place where you can enjoy hiking, fishing, boating, horseback riding, bathing in waterfalls, rivers and much more! The house is wooden and we design it as if it were an experience inside a boat, it is an ideal place to rest

Superhost
A charming house is set amidst lush greenery, featuring a sloped tiled roof and wooden pillars. Tropical plants and vibrant flowers surround the exterior, creating a serene atmosphere that integrates with the natural landscape.
Home in Cacique
5 out of 5 average rating, 4 reviews

House in Cacique- Jungle and Sea

Finca Cacique offers a peaceful jungle escape just 5 minutes by foot from Cacique beach. This 4-bedroom house (3 with A/C, 1 with fan) is surrounded by nature and visited by monkeys, sloths, and birds. We have 2 kayaks for rent to explore nearby islands such as Isla Mamey and the Tunnel of Love. Enjoy the jungle’s beauty with the sea nearby. (Note: not beachfront property.) Perfect for nature lovers seeking tranquility and adventure.

Guest favorite
A spacious wooden chalet is positioned on a lush green slope, surrounded by tropical vegetation. The structure features an open terrace with railings, allowing for expansive views of the sky. A few palm trees and various plants complement the natural landscape.
Home in Cacique
4.96 out of 5 average rating, 25 reviews

El Paraiso

We are pleased to present a large beautiful house for rent between the village of Cacique and the village of José Pobre in Portobelo National Park. Overlooking the Caribbean Sea, nestled in the jungle, this house has a unique character in the area. Its direct access to a small wild beach, with an exciting reef for snorkeling fans, makes it a privileged place. Ideal for groups and families wishing to reconnect with nature.

Superhost
An aerial view captures a serene bay bordered by lush tropical greenery. A small boat is anchored in the clear waters, and a spacious house is situated near the beach, surrounded by trees and open land, creating a harmonious natural setting.
Home in Playa Blanca
4.75 out of 5 average rating, 73 reviews

Sparrow's Point

Un lugar paradisiaco que muestra al caribe panameño en su mejor esplendor!! La playa de arena blanca protegida por una bahía de aguas cristalinas y enmarcada por la selva tropical crean un idílico contraste entre el verde del follaje y el azul de la laguna. Despierte a 10 pasos del mar.

Superhost
Home in Colón
4.67 out of 5 average rating, 6 reviews

Entire house in 4 altos Colón

From this accommodation centrally you group will have everything at your fingertips. It is a spacious house, with everything you need for a pleasant stay. Most importantly, if you have plans to visit the free area just minutes away.

Popular amenities for Isla Grande house rentals

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  2. Panama
  3. Colón Province
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  5. House rentals