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Vacation rentals in Isla Grande

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Top-rated vacation rentals in Isla Grande

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 114 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Superhost
Home in Isla Grande
5 out of 5 average rating, 4 reviews

Beachfront House + Kitchen + Balcony + A/C + Wi-Fi @ Isla Grande

✔️SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Isla Grande, Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐Wifi 📺TV 🍳Cocina 🌊Frente al mar ❄️A/C 🚗Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

Superhost
An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.
Cottage in Palenque
4.87 out of 5 average rating, 95 reviews

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

Superhost
Home in Mechi
4.67 out of 5 average rating, 9 reviews

Beachfront Home | En-Suites + Chef & Tours Available

Wake up to the sound of the waves… More than a beachfront home, Zola Sol is a curated wellness and lifestyle experience, thoughtfully designed around you. Whether you’re looking to relax, reconnect, or celebrate, we can personalize your stay with experiences such as private chef, wellness services, juice offerings, boat tours, and more—all seamlessly arranged before or during your visit. Your Airbnb reservation is simply the first step in creating an unforgettable Zola Sol experience.

Top guest favorite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique
4.98 out of 5 average rating, 57 reviews

FACING THE SEA Cacique (Portobello Park)

A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Guest favorite
A serene swimming pool is depicted surrounded by lush palm trees, with the tranquil sea visible in the background. The water's clear blue tiles reflect the sky and nearby greenery, while the gentle curvature of the pool edge invites relaxation.
Villa in Portobelo
4.97 out of 5 average rating, 88 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Top guest favorite
An aerial view of a resort along a coastline shows a series of buildings surrounded by lush greenery and sandy beaches. Clear turquoise waters gently lap against the shore, and pathways meander throughout the area, connecting various facilities and natural landscapes.
Condo in Maria Chiquita
4.98 out of 5 average rating, 122 reviews

Apartment in Playa Escondida.

Recap Playa Escondida is a small 'paradise' an hour from the city. It is located in the Republic of Panama, in the coastal area of Costa Arriba in the Caribbean Sea. You can spend the day preparing your barbecue in a waterfront Bohío or if you prefer, savor the delights of the restaurants. And if you decide on physical activities, you will find soccer fields, volleyball, fishing or paddling, and it has water games for children that they will undoubtedly enjoy.

Guest favorite
A dining table made of wood is set for four, featuring yellow plates and cups. Green plants are positioned on either side, with a backdrop of the sparkling sea and distant islands visible through an open balcony. The scene conveys a relaxed outdoor dining experience.
Apartment in Juan Gallego
4.88 out of 5 average rating, 108 reviews

KasaKai Penthouse · Caribbean Sea View· Beachfront

This exclusive beachfront penthouse offers one of the closest true beach experiences from Panama City. Wake up to panoramic Caribbean Sea views, enjoy direct private access to the water, and relax in your own green outdoor area, ideal for quiet moments or private barbecues. Perfect for travelers seeking privacy, comfort, and nature, this penthouse combines a unique feet-in-the-water experience with high-end amenities, creating an unforgettable seaside stay.

Top guest favorite
Apartment in Maria Chiquita
5 out of 5 average rating, 11 reviews

Luxury Beachfront Escape | Playa Escondida Resort

Luxury beachfront apartment literally on the sand in Playa Escondida. Designer furniture, premium mattresses, private bathroom in every bedroom, guest half bath, split A/Cs + central A/C with aromatherapy. Professional kitchen, filtered hot/cold water, dishwasher, full laundry, luxury BBQ & oceanview balcony. 5 min walk to beach club, restaurants, gym, spa & convenience store. Family friendly. No dogs allowed. 1.5 hrs from Panama City.

Superhost
An outdoor seating area is presented with four woven chairs positioned around a rectangular table. The view reveals a serene sea in the background, with a well-kept grassy area and scattered rocks leading to the water's edge. Bright sunlight enhances the peaceful atmosphere.
Home in La Guaira
4.69 out of 5 average rating, 183 reviews

Casa "El Terrenito" - Ocean Front

Amplia casa frente al mar con 2 habitaciones, una hab. con 3 camas queen y 2da con una king y una twin. Cocina, sala, comedor. Tiene todos los implementos para cocina, sabanas, estufa,nevera, A/C. Especial para relajarse!! Para fanáticos de la pesca podemos proporcionar una panga de pesca! Precio adicional por día y el capitán. Puede llevar mascota.

Superhost
Home in Palenque
4.67 out of 5 average rating, 9 reviews

Casa Palenque Panama

Enjoy a spectacular oceanfront house, ideal for groups and families of up to 14 people. Relax with direct beach views, spacious indoor and outdoor spaces, and all the comforts for an unforgettable stay. Perfect for resting, living and creating unique memories with the sound of the sea in the background. We are pet friendly.

Superhost
An aerial view captures a serene bay bordered by lush tropical greenery. A small boat is anchored in the clear waters, and a spacious house is situated near the beach, surrounded by trees and open land, creating a harmonious natural setting.
Home in Playa Blanca
4.76 out of 5 average rating, 79 reviews

Sparrow's Point

Un lugar paradisiaco que muestra al caribe panameño en su mejor esplendor!! La playa de arena blanca protegida por una bahía de aguas cristalinas y enmarcada por la selva tropical crean un idílico contraste entre el verde del follaje y el azul de la laguna. Despierte a 10 pasos del mar.

Popular amenities for Isla Grande vacation rentals

Frequently Asked Questions

  • Where is Isla Grande located?

    Isla Grande is situated just off Panama's northern Caribbean coast, in Colón Province. It is found near the entrance to the Portobelo National Park area, surrounded by tropical waters and natural scenery.

  • When is the best time to visit Isla Grande?

    Travelers frequently suggest visiting Isla Grande during the dry season for clearer skies and calmer seas. The rainy months bring lush landscapes and a quieter atmosphere, with both offering distinct ways to experience the island.

  • What are some things to do near Isla Grande?

    You can explore sandy beaches, snorkel around coral reefs, and experience local seafood restaurants on Isla Grande. The island also has relaxed walking paths and is known for welcoming Afro-Caribbean cultural influences and music.

  • How is the weather near Isla Grande?

    Isla Grande typically has a warm, humid tropical climate year-round, with temperatures often between 77 and 88°F (25 and 31°C). Rain is common outside of the dry season, and brief showers can occur throughout the year.

  1. Airbnb
  2. Panama
  3. Colón Province
  4. Isla Grande