
Vacation rentals in Isla Grande
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Isla Grande
Guests agree: these stays are highly rated for location, cleanliness, and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

BeachfrontHouse+Kitchen+Balcony+AC+WiFi@IslaGrande
✔️SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Isla Grande, Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐Wifi 📺TV 🍳Cocina 🌊Frente al mar ❄️A/C 🚗Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

CARA AL MAR Cacique (Parque de Portobello)
Une maison ! véritable îlot de verre au cœur de la jungle ! Au beau milieu du Parque National de Portobello (accès uniquement en 4x4 AWD) blotti au sommet de la colline, entre ciel/mer, à l'abri de tout regard, une maison transparente où le verre épouse la nature de tous côtés créant une connexion unique entre l'intérieur et l'extérieur, ideal pour se reposer, se déconnecter, confortable, spacieuse, fraîche (clim centrale), exclusive. Elle est le témoin d'un spectacle grandiose qui vous attend !

AeolusGuestHouse Home in Portobelo National Park
Welcome to AeolusGuestHouse, a hidden retreat in Jose del Mar, inside the Portobelo National Park. Surrounded by protected jungle, mangroves, and calm lagoon. Ideal for disconnecting in nature. Kayaks are available, and boats pick you up at the dock in front of the house for local tours, including Venas Azules just 15 minutes away. The home offers 2 bedrooms, 4 beds, an equipped kitchen, AC, parking, and helpful hosts always ready to assist. Pure nature, zero crowds, unforgettable stays.

Beachfront House in Caribbean sandy beach
Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

Beachfront Home | En-Suites + Chef & Tours Avail
Wake up to the sound of the waves… More than a beachfront home, Zola Sol is a curated wellness and lifestyle experience, thoughtfully designed around you. Whether you’re looking to relax, reconnect, or celebrate, we can personalize your stay with experiences such as private chef, wellness services, juice offerings, boat tours, and more—all seamlessly arranged before or during your visit. Your Airbnb reservation is simply the first step in creating an unforgettable Zola Sol experience.

Entire Villa with pool in front of beach!
Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

KasaKai Penthouse · Caribbean Sea View· Beachfront
This exclusive beachfront penthouse offers one of the closest true beach experiences from Panama City. Wake up to panoramic Caribbean Sea views, enjoy direct private access to the water, and relax in your own green outdoor area, ideal for quiet moments or private barbecues. Perfect for travelers seeking privacy, comfort, and nature, this penthouse combines a unique feet-in-the-water experience with high-end amenities, creating an unforgettable seaside stay.

“Hermosa y Cómoda Villa en Playa Escondida Resort”
Luxury Resorts y Villa, front lagoon view y playa solamente a 2min, Disfruta de una estadía cómoda y tranquila en este alojamiento totalmente equipado, ideal para matrimonios, familias, grupos pequeños o viajeros de negocios. Tiene capacidad para hasta 6 huéspedes, ofreciendo un ambiente acogedor, limpio y funcional,una terraza amplia,sin duda para una estancia agradable,

Casa "El Terrenito" - Ocean Front
Amplia casa frente al mar con 2 habitaciones, una hab. con 3 camas queen y 2da con una king y una twin. Cocina, sala, comedor. Tiene todos los implementos para cocina, sabanas, estufa,nevera, A/C. Especial para relajarse!! Para fanáticos de la pesca podemos proporcionar una panga de pesca! Precio adicional por día y el capitán. Puede llevar mascota.

Casa Palenque Panamá
Disfruta de una espectacular casa frente al mar, ideal para grupos y familias de hasta 14 personas. Relájate con vistas directas a la playa, amplios espacios interiores y exteriores, y todas las comodidades para una estancia inolvidable. Perfecta para descansar, convivir y crear recuerdos únicos con el sonido del mar como fondo. Somos pet friendly.

Sparrow's Point
Un lugar paradisiaco que muestra al caribe panameño en su mejor esplendor!! La playa de arena blanca protegida por una bahía de aguas cristalinas y enmarcada por la selva tropical crean un idílico contraste entre el verde del follaje y el azul de la laguna. Despierte a 10 pasos del mar.
Popular amenities for Isla Grande vacation rentals
Other great vacation rentals in Isla Grande

The Bird's Nest in the Clouds

Villa con Terraza Privada en Playa Escondida

casa-cabaña Cacique

Vista al mar, apartamento de lujo Playa Escondida

Luxury Beachfront Escape | Playa Escondida Resort

Dreamy, Modern Caribbean Home at Playa Escondida

Room at Finca Cacique- Jungle and Sea

Seaside Caribbean Beach House
Frequently Asked Questions
Where is Isla Grande located?
Isla Grande is situated just off Panama's northern Caribbean coast, in Colón Province. It is found near the entrance to the Portobelo National Park area, surrounded by tropical waters and natural scenery.
When is the best time to visit Isla Grande?
Travelers frequently suggest visiting Isla Grande during the dry season for clearer skies and calmer seas. The rainy months bring lush landscapes and a quieter atmosphere, with both offering distinct ways to experience the island.
What are some things to do near Isla Grande?
You can explore sandy beaches, snorkel around coral reefs, and experience local seafood restaurants on Isla Grande. The island also has relaxed walking paths and is known for welcoming Afro-Caribbean cultural influences and music.
How is the weather near Isla Grande?
Isla Grande typically has a warm, humid tropical climate year-round, with temperatures often between 77 and 88°F (25 and 31°C). Rain is common outside of the dry season, and brief showers can occur throughout the year.
Destinations to explore
- Panama City Vacation rentals
- Cahuita Vacation rentals
- Bahía Ballena Vacation rentals
- Coveñas Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Bocas del Toro Province Vacation rentals
- Uvita Vacation rentals
- San Andrés Vacation rentals
- Rio Hato Vacation rentals
- Boquete Vacation rentals
- El Valle Vacation rentals
- Cartago Vacation rentals





