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Guesthouse vacation rentals in Greenville

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Top-rated guesthouse rentals in Greenville

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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A white pergola is observed against a light-colored brick wall, creating a shaded area. The structure features a simple, open design complemented by delicate vines that hang gracefully. Sunlight filters through, casting a pattern on the stone patio below.

Guesthouse in Greenville

4.98 out of 5 average rating, 104 reviews

The Spring Valley Retreat

Newly renovated in 2021, very comfortable guesthouse located in a quiet neighborhood just 10 minutes from downtown Greenville. Created by highly experienced bed and breakfast owners, this space is carefully crafted to be a relaxing, restful place for travelers. Two bedrooms, a kitchen with brand-new appliances, dining area, smart TV, a desktop space, WiFi, and an outdoor porch spot to enjoy nice weather days. Note that if you search the address on Google, it will pull up photos before renovation

A charming log cabin is nestled among lush greenery, featuring wooden walls and a sloping roof. The front door is framed by two windows adorned with flower boxes. Two white chairs sit on a stone pathway, inviting relaxation in the serene outdoor setting.

Guesthouse in Greenville

4.92 out of 5 average rating, 675 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

A rustic porch constructed from natural logs features a wooden swing for relaxation. The floor is made of planks, providing a warm, inviting space. Light streams gently through the open door, leading into the cabin. Surrounding greenery enhances the tranquil ambiance.

Guesthouse in Sunset

4.92 out of 5 average rating, 392 reviews

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Top guest favorite

Guesthouse in Greenville

5 out of 5 average rating, 413 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Top guest favorite

A serene lake scene is captured during sunset, where vibrant oranges and purples reflect off the calm water. The silhouette of distant mountains is visible against the colorful sky, framed by lush greenery along the shoreline.

Guesthouse in Inman

4.99 out of 5 average rating, 128 reviews

Foothills Favorite

Custom designed 1 bedroom suite in the Lake Bowen/Landrum/Inman area. Comfortable yet sleek space tucked above a semi-detached garage; private entry & stairway to suite. Private deck overlooks green spaces, wooded area & Lake Bowen (best views late fall and winter). Enjoy mountain views at nearby Lake Bowen park, local wineries, and scenic highways. Minutes from Landrum & Tryon & Equestrian Center. NOTE: At present, we are continuing to clear some tree debris from hurricane Helene.😊

Top guest favorite

The exterior of a tree house-like bungalow is captured, featuring a two-car garage with beige doors. Colorful flowers in shades of purple and green line the gravel path, complemented by lush greenery and trees in the background.

Guesthouse in Campobello

4.97 out of 5 average rating, 121 reviews

Bungalow on a 3 acre mini farm

This is a tree house like bungalow in beautiful Campobello SC. Enjoy a peaceful, rural retreat that is central to Upstate SC and Western NC. We are about 5 miles to downtown Landrum SC, 25 minutes to Spartanburg SC, 40 minutes to Greenville SC, 45 minutes to Asheville NC, and about 22 minutes to the Tryon Equestrian Center in NC. Inside the unit, downstairs is the kitchen, dining area, and bathroom, Upstairs in the loft are 4 different beds (Queen, Three Singles) &.a common area.

Top guest favorite

A spacious living area features minimalist decor with neutral colors. A comfortable couch faces a wall-mounted TV, while a dining table is positioned nearby. Large glass sliding doors provide natural light and open to an outdoor space. Essential kitchen appliances are arranged on a side console.

Guesthouse in Greenville

4.94 out of 5 average rating, 206 reviews

Gorgeous Downtown Studio & Dog Friendly!

This has moved to 30 days+ starting Jan 2024! Message me if you're trying to book and your dates aren't showing available! This location is unmatched. Steps from Falls Park which includes one of the most majestic waterfalls, green space and Swamp Rabbit Trail for all your running/walking and biking needs. Directly across the street from the Greenville Drive baseball stadium. One block from all the finest restaurants, shopping and best attractions downtown offers.

Top guest favorite

An inviting pool deck features a clear swimming pool with a diving board, overlooking a vast mountainous vista. The scene is framed by leafless trees and potted plants, while the sky displays soft, fluffy clouds and bright blue patches.

Guesthouse in Greenville

4.97 out of 5 average rating, 239 reviews

Greenville With A View!

ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

A well-equipped kitchen featuring open shelving and modern appliances. A microwave, coffee maker, and toaster are positioned on the counters, with a small table beneath a colorful rug. Natural light enters from a window, illuminating the space and plants arranged on the shelves.

Guesthouse in Greenville

4.8 out of 5 average rating, 315 reviews

1950's Cottage- Close to Downtown & Furman

My 50's cottage is charming and cozy, very clean and convenient to downtown, Traveler's Rest & Furman University. Located in a quiet space with parking right beside the cottage. We are a straight shot to downtown Greenville in about 7 minutes. I listen to my awesome guests and have made a few recent updates: new electrical outlets in bathroom, new larger hot water heater for longer showers!

Top guest favorite

A cozy window seat is positioned beneath a large window, offering views of the surrounding greenery. Decorative pillows in various textures are arranged on the seat, while elegant curtains frame the window, enhancing the serene atmosphere of the nook.

Guesthouse in Greenville

5 out of 5 average rating, 128 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

The exterior of a modern guest house is showcased, featuring a sloped roof and large glass sliding doors that open to a patio area. Softly filtered light enters through sheer curtains, while a landscaped yard with gravel pathways and wooden fencing provides an inviting space.

Guesthouse in Travelers Rest

4.97 out of 5 average rating, 124 reviews

Modern guesthouse in downtown TR

Steps from the Swamp Rabbit Trail, Tandem Coffee, Topsoil and more! Enjoy a stylish, relaxed stay at our centrally-located place. Whether you're an outdoor enthusiast or fun-loving foodie, you'll find something just for you nearby. Only a short drive to downtown Greenville, Furman University or Paris Mountain. Within an hour drive of Asheville and Clemson University!

Top guest favorite

A newly constructed in-law suite is shown, featuring a light grey exterior. The structure is set in a well-kept backyard with green grass and trees, offering a welcoming atmosphere. Sunlight casts gentle shadows across the space, highlighting the separate entrance beside the garage.

Guesthouse in Greenville

4.96 out of 5 average rating, 227 reviews

The Biltmore Suite

This newly built in-law suite is in a wonderful location just half a mile from the Swamp Rabbit trail and downtown Greenville's Falls Park. The apartment includes 2 parking spots, and additional street parking about a block away. Long term stays available; inquire for pricing. Please not we cannot acquire pets, even service animals, due to an owner allergy!

Vacation rentals for every style

Get the amount of space that is right for you

Houses

A space thats all yours, with room for everyone

Cabins

Kick off your hiking boots at these rustic lodgings

Cottages

Quaint homes, peaceful surroundings

Popular amenities for Greenville guesthouse rentals

Free parking on premises

Air conditioning

Family-friendly guest house rentals

Top guest favorite

The living area features a comfortable arrangement of seating, including a plush sofa and two armchairs, all positioned around a central coffee table. A colorful area rug adds warmth, while natural light filters through a partially draped window, illuminating the space.

Guesthouse in Travelers Rest

5 out of 5 average rating, 48 reviews

Travelers Rest Country Retreat Two miles to NGU

Top guest favorite

The exterior of the property is shown, featuring yellow siding complemented by dark shutters on the windows. A single door with glass panels is visible, providing a welcoming entrance. A grassy area is located at the base of the wall, enhancing the outdoor setting.

Guesthouse in Liberty

4.93 out of 5 average rating, 197 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

The open living area features a striped armchair facing a wooden coffee table. A kitchen with white cabinetry and a breakfast bar is seen in the background, equipped with modern appliances and natural lighting from multiple windows.

Guesthouse in Simpsonville

4.94 out of 5 average rating, 244 reviews

Private Suite in Downtown Simpsonville

The kitchen features a functional layout with a white refrigerator and a window providing natural light. A wooden countertop is complemented by bar stools and a small dining area with a decorative fruit bowl and tableware set. Shelves display glasses and a vibrant art piece is visible.

Guesthouse in Greenville

4.78 out of 5 average rating, 46 reviews

Quiet Guest Apartment in the Woods

The exterior of a newly renovated cottage is presented, featuring light-colored siding and a welcoming red front door. A small covered porch is accentuated by planters, while a neatly manicured lawn surrounds the home. A clear blue sky and accessible pathway enhance the inviting appearance.

Guesthouse in Inman

4.98 out of 5 average rating, 48 reviews

Cozy 1 BR Cottage - Great Location!

Top guest favorite

A spacious private suite features a king bed with soft linens and decorative pillows. The dark accent wall adds depth, while a small kitchenette is visible in the background. Nightstands flank the bed, accompanied by soothing lighting. A plush area rug and bright decor contribute to a welcoming ambiance.

Private room in Pelzer

4.98 out of 5 average rating, 129 reviews

South Oaks Guesthouse

The room features two spacious beds dressed in white linens with colorful throw pillows. A warm lamp provides soft lighting, while framed artwork adorns the walls. A wooden dresser is positioned nearby, and a closet can be seen in the background.

Private room in Brevard

4.97 out of 5 average rating, 104 reviews

Studio 84, Brevard NC

A rustic cabin features a wooden exterior with a star decoration, surrounded by landscaped rocks and plants. A covered porch provides seating and is complemented by an umbrella. The structure is nestled among tall trees, creating a serene environment.

Guesthouse in Townville

4.86 out of 5 average rating, 257 reviews

Lisa’s Lodge

Guest house rentals with a patio

Top guest favorite

The exterior of the guest house is showcased, featuring a sturdy wooden door adorned with decorative hardware. The structure is framed by light-colored stone walls and has two small windows flanking the entrance, with a sloped roof that complements the rustic design.

Guesthouse in Spartanburg

5 out of 5 average rating, 95 reviews

The Lodge at Pythian Park

A charming guest house is depicted with a white exterior and a small balcony. Stairs lead up to the entrance, under a sunset sky painted with hues of orange and purple. The grassy area surrounding the house adds to the serene atmosphere.

Guesthouse in Lyman

4.94 out of 5 average rating, 32 reviews

Budget Bliss: Cozy Elegance

Top guest favorite

A spacious guest cottage room features a comfortable king-size bed with a light grey upholstered headboard. A small round table is paired with two stylish armchairs. Modern kitchen appliances are visible in the corner, complemented by a contemporary chandelier centered overhead.

Guesthouse in Travelers Rest

4.86 out of 5 average rating, 7 reviews

Guest Cottage with Private Drive

A spacious studio features a cozy sleeping area with a large bed adorned with a light-colored coverlet. A small dining table and black chairs are visible against the background of a well-equipped kitchen. Natural light brightens the room, highlighting a neutral color palette.

Guesthouse in Greenville

4.9 out of 5 average rating, 70 reviews

Chic Studio with Private Deck

Top guest favorite

The studio space showcases a king-size bed with a medium-firm mattress, alongside a cozy couch and a stylish desk. Natural light enters through small windows, while recessed lighting brightens the room. A tasteful decor element includes a round mirror and accent pieces on the walls.

Guesthouse in Hendersonville

4.97 out of 5 average rating, 104 reviews

Modern Studio near downtown

Top guest favorite

A clean and modern kitchen area features white cabinetry and granite countertops, equipped with stainless steel appliances. A quaint dining space with a round table and two chairs is positioned nearby, while a cozy seating area with a blue armchair and gray sofa can be seen in the background.

Guesthouse in Greer

4.96 out of 5 average rating, 51 reviews

Sugar Creek Retreat

Top guest favorite

A spacious bedroom features a king bed dressed in a patterned quilt, complemented by colorful accent pillows. A dresser and mirror are visible, while natural light filters through the adjacent windows. Two chairs and a table are set near the window, enhancing the inviting atmosphere.

Guesthouse in Tryon

4.99 out of 5 average rating, 193 reviews

1 bedroom guest house on horse property in Tryon

Top guest favorite

A serene outdoor space features Adirondack chairs arranged around a stone fire pit. A tranquil pond reflects the surrounding greenery, creating a peaceful atmosphere. Light filters through the trees, enhancing the natural beauty of the setting.

Guesthouse in Greenville

4.95 out of 5 average rating, 40 reviews

Tranquil 2BR Guest House on Pond by Furman

Guest house rentals with a washer and dryer

The spacious living area features a comfortable gray sofa with decorative pillows, a small dining table, and modern kitchen appliances. Natural light fills the room through sliding glass doors that open to a view of the outdoors. A light-colored area rug adds warmth to the space.

Guesthouse in Fountain Inn

4.97 out of 5 average rating, 103 reviews

Upscale cottage in Downtown Fountain Inn

Top guest favorite

A scenic view of a tranquil stream winding through rocky terrain, surrounded by lush greenery. A modern pedestrian bridge spans the water, with visitors enjoying the natural setting. Sunlight filters through the trees, creating a peaceful atmosphere ideal for relaxation and exploration.

Guesthouse in Pelzer

4.98 out of 5 average rating, 45 reviews

Serene country escape on 11 acres-15% off last min

Top guest favorite

A stone fire pit is surrounded by a circular arrangement of pavers. Two gray Adirondack chairs sit on a nearby wooden deck, positioned to face the fire pit. Fallen leaves cover the ground, and trees provide a natural backdrop.

Guesthouse in Seneca

5 out of 5 average rating, 27 reviews

Hartwell Hideway

A modern kitchen is presented with white cabinetry and stainless-steel appliances. A large wooden island provides seating for four, featuring pink bar stools. Natural light fills the space through a window, while subtle grey accents enhance the overall design.

Guesthouse in Duncan

4.98 out of 5 average rating, 63 reviews

Adorable renovated private house w/ parking.

Top guest favorite

A stacked washer and dryer unit in white is positioned against a light-colored wall, featuring clear glass doors that display the interior. The appliances are modern and sleek, providing convenient laundry facilities for guests.

Guesthouse in Greenville

5 out of 5 average rating, 20 reviews

Upscale 1BR pet+ monthly near everything GVL

Top guest favorite

A modern kitchen is highlighted by dark cabinetry and a marble countertop. A wooden table with high-backed chairs is situated in the center, providing a space for gathering. Shelves display various kitchen items, and natural light filters through a nearby window.

Guesthouse in Mauldin

5 out of 5 average rating, 9 reviews

Beautiful guest house

Two round coffee tables are positioned in front of a dark sofa, featuring wooden surfaces with a rich grain. A small potted plant sits atop one of the tables. A soft rug with neutral tones is placed on the floor, complementing the overall decor.

Guesthouse in Greenville

4.96 out of 5 average rating, 97 reviews

Nishleigh's Nook - West End Downtown Greenville

Top guest favorite

A screened-in porch features a spacious blue sectional sofa adorned with striped cushions, arranged around a wooden coffee table. A woven side table stands nearby, and a vibrant area rug adds a pop of color. Lush greenery is visible through the screened walls.

Guesthouse in Columbus

5 out of 5 average rating, 60 reviews

Carriage House in the Woods

Quick stats about guesthouse rentals in Greenville

Total rentals
30 properties
Nightly prices starting at
G$12,553 GYD before taxes and fees
Total number of reviews
3K reviews
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Wifi availability
30 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool

Destinations to explore