
Guesthouse vacation rentals in Greenville County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Greenville County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Nishleigh's Nook - West End Downtown Greenville
Welcome to your cozy retreat in the West End of Downtown Greenville! This newly constructed, detached garage studio near the up and coming West End Village, Unity Park, and downtown offers easy access to the city's best entertainment, boutique shops, and vibrant food scene. Enjoy a queen-sized memory foam bed, a fully equipped kitchen, and a dedicated dining area. High-speed Wi-Fi and a smart TV are included. Perfect for a peaceful escape with all the comforts you need for a memorable stay.

The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Bungalow on a 3 acre mini farm
This is a tree house like bungalow in beautiful Campobello SC. Enjoy a peaceful, rural retreat that is central to Upstate SC and Western NC. We are about 5 miles to downtown Landrum SC, 25 minutes to Spartanburg SC, 40 minutes to Greenville SC, 45 minutes to Asheville NC, and about 22 minutes to the Tryon Equestrian Center in NC. Inside the unit, downstairs is the kitchen, dining area, and bathroom, Upstairs in the loft are 4 different beds (Queen, Three Singles) &.a common area.

Greenville With A View!
ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Entire Cottage w/Hot Tub - Easy Checkout!
The Cozy Cottage is a stunning 600-square-foot space containing 1br and 1ba, walk-in closet, full kitchen, washer and dryer, dishwasher, and living space. We have several premium features including an adjustable climate control system for the queen bed (BedJet) and access to our hot tub in the nearby outdoor living space! There is a dedicated 2 car parking pad for our guests and excellent lighting from the parking area all the way to the cottage.

Holly Hideaway! 10 Highway miles to Clemson U!
Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Shou-Sugi-Ban Retreat on the Saluda River
The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Sally's Cottage
Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Cozy Pet-Friendly Home | Near Greenville & I-85
You’ll love staying here because it’s the perfect mix of comfort, privacy, and charm. Whether you’re relaxing by the fire pit, enjoying the peaceful outdoor space, or unwinding inside with all the comforts of home, this cozy retreat offers everything you need for a relaxing and memorable stay. Plus, it’s pet-friendly and located in a quiet neighborhood close to everything!

Modern guesthouse in downtown TR
Steps from the Swamp Rabbit Trail, Tandem Coffee, Topsoil and more! Enjoy a stylish, relaxed stay at our centrally-located place. Whether you're an outdoor enthusiast or fun-loving foodie, you'll find something just for you nearby. Only a short drive to downtown Greenville, Furman University or Paris Mountain. Within an hour drive of Asheville and Clemson University!

The Biltmore Suite
This newly built in-law suite is in a wonderful location just half a mile from the Swamp Rabbit trail and downtown Greenville's Falls Park. The apartment includes 2 parking spots, and additional street parking about a block away. Long term stays available; inquire for pricing. Please not we cannot acquire pets, even service animals, due to an owner allergy!

Gilded Frog Guesthouse. Rainfall Shower, King Bed
Welcome to the Gilded Frog Studio. Conveniently located between Greenville and Easley and only minutes from I85, we are positioned right in the heart of the growing Powdersville area. Whether you're visiting Greenville or looking for a local place to stay to catch a Clemson game, we offer the amenities you need to make your stay effortlessly enjoyable.
Popular amenities for Greenville County guesthouse rentals
Family-friendly guest house rentals

Five minute walk to Downtown Greer New Everything!

The Travelers Loft

Cozy faux-cabin loft by GSP, BMW

Chic CityFlat-walk to Main St, parking! &pvt patio

Private 1-bedroom studio apartment

1950's Cottage- Close to Downtown & Furman

The Backyard Bungalow On the Trail

Third Place Coffee Cottage
Guest house rentals with a patio

Guest Cottage with Private Drive

Clean. Comfortable. Convenient.

The Dwelling Place: Just a mile from downtown TR

Chic Studio with Private Deck

Country-Clubhouse Tiny Home. Close to downtown!

Cozy 2BR Holiday Escape on 11 Acres-Pet Friendly

Fairy Forest Cabin with Hot Tub at Table Rock

Sugar Creek Retreat
Guest house rentals with a washer and dryer

The Spring Valley Retreat

Upscale cottage in Downtown Fountain Inn

The oaks cottage

Cozy Above Garage Apartment on Paris Mountain

Just off Main near Taylors Mill - Clean & Comfy

Adorable renovated private house w/ parking.

2BR Guesthouse Retreat Near Furman w/ Pond Views

Gorgeous Downtown Studio & Dog Friendly!
Destinations to explore
- Smoking-friendly rentals Greenville County
- Family-friendly rentals Greenville County
- Cabin rentals Greenville County
- Rentals with a fireplace Greenville County
- Rentals with a washer and dryer Greenville County
- Fitness-friendly rentals Greenville County
- Apartment rentals Greenville County
- Townhouse rentals Greenville County
- Waterfront rentals Greenville County
- Rentals with outdoor seating Greenville County
- Tiny house rentals Greenville County
- Rentals with a fire pit Greenville County
- RV rentals Greenville County
- Loft rentals Greenville County
- Farmstay rentals Greenville County
- Condo rentals Greenville County
- Rentals with pools Greenville County
- Rentals with lake access Greenville County
- Rentals with an EV charger Greenville County
- House rentals Greenville County
- Serviced apartment rentals Greenville County
- Pet-friendly rentals Greenville County
- Rentals with an accessible height toilet Greenville County
- Rentals with a kayak Greenville County
- Private suite rentals Greenville County
- Rentals with breakfast Greenville County
- Rentals with a hot tub Greenville County
- Rentals with a patio Greenville County
- Guesthouse rentals South Carolina
- Guesthouse rentals United States
- Blue Ridge Parkway
- River Arts District
- Gorges State Park
- The North Carolina Arboretum
- Table Rock State Park
- Chimney Rock State Park
- Mountaintop Golf & Lake Club
- Ski Sapphire Valley
- Lake Lure Beach and Water Park
- Tryon International Equestrian Center
- Jump Off Rock
- Wade Hampton Golf Club
- Biltmore Forest County Club
- Old Edwards Club
- Vineyards for Biltmore Winery
- French Broad River Park
- Victoria Valley Vineyards
- Woolworth Walk
- Thomas Wolfe Memorial
- Discovery Island
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- Saint Paul Mountain Vineyards
- City Scape Winery