Guesthouse vacation rentals in Greenville County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Greenville County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Fountain Inn

4.92 out of 5 average rating, 264 reviews

Main Street Guest Cottage

The Main Street Cottage is close to downtown Fountain Inn, five excellent restaurants, the county library, Younts performance center, museum, Farmers Market, Swamp Rabbit Trail (hiking, cycling), and I-385 (Greenville in 20 min). You’ll love this separate apartment because of the location, the outdoors space and the small town ambiance. Very good for couples, business travelers, and families (with kids). We are within two blocks of downtown, but the apartment enjoys a quiet residential setting.

Aug 14 – 21

G$17,246 GYD per night

Guest favorite

Guesthouse in Greer

4.96 out of 5 average rating, 259 reviews

CLEAN 1 BD Suite - 1.7 Miles From Downtown Greer

Welcome to our NEW modern detached guesthouse. It features a private entrance with plenty of parking. The kitchen is equipped with a refrigerator, oven, microwave, Beverage station, and Basic kitchen tools. The living room includes a couch that seats 3, a tv, and access to your own private outdoor area. The bedroom features a comfortable queen-size bed and TV. The bathroom has a huge walk-in tiled shower. We're Located 1.7 miles from downtown Greer, so there is always something to do nearby.

Jul 3 – 10

G$21,306 GYD per night

Guest favorite

Guesthouse in Travelers Rest

4.99 out of 5 average rating, 101 reviews

The Travelers Loft

Light and airy contemporary guest house with new upscale furnishings, nestled on 40 acres of woodland and meadows. Perfect for 2-4 guests. 2.5 miles from downtown Travelers Rest and the 'Swamp Rabbit Trail'. Great for biking or walking. 25 minutes to the city of Greenville and 45 to the mountains of Asheville, NC. Located less than 30 minutes from the Greenville Airport. This second story guest house has private parking, and a beautiful deck for grilling out or just relaxing after a busy day.

Aug 15 – 22

G$20,255 GYD per night

Guest favorite

Guesthouse in Greenville

4.92 out of 5 average rating, 580 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Mar 2 – 9

G$15,329 GYD per night

Guest favorite

Guesthouse in Lyman

4.99 out of 5 average rating, 123 reviews

Blue Heron Hideaway Lakeside Retreat

Welcome to this bright, lakefront space with views from every window. Enjoy kayaking, swimming, fishing, and evenings by the fire-pit. In winter, cozy up by the indoor fireplace and just relax. Take a drive into downtown Greenville, the gem of the upstate, where a walk through Falls Park and across the suspension bridge is a must! We are 15 minutes from GSP airport and BMW, in the foothills of the beautiful Blue Ridge mountains. You won’t be at a loss for things to do here in the upstate.

Sep 19 – 26

G$29,244 GYD per night

Guest favorite

Guesthouse in Greenville

4.99 out of 5 average rating, 356 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Sep 3 – 10

G$24,347 GYD per night

Superhost

Guesthouse in Pendleton

4.9 out of 5 average rating, 240 reviews

La Bella Farm

Do you want to be close to Clemson(11 miles), Anderson(9 miles) OR Greenville(20miles)! Do you want to just get away from all of the noise and busy life. Then you have found your spot! This is a great detached garage apartment. Settled in the quiet country side of Pendleton SC. 1 bedroom&1 bathroom with an additional sofa bed&blow up mattress. Great view of nothing but beautiful land from the kitchen window yet minutes away from Death Valley,restaurants,shopping and 85.

Jun 22 – 29

G$17,616 GYD per night

Guest favorite

Guesthouse in Greenville

4.97 out of 5 average rating, 189 reviews

Greenville With A View!

ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Sep 18 – 25

G$28,771 GYD per night

Superhost

Guesthouse in Greenville

4.82 out of 5 average rating, 270 reviews

1950's Cottage- Close to Downtown & Furman

My 50's cottage is charming and cozy, very clean and convenient to downtown, Traveler's Rest & Furman University. Located in a quiet space with parking right beside the cottage. We are a straight shot to downtown Greenville in about 7 minutes. I listen to my awesome guests and have made a few recent updates: new electrical outlets in bathroom, new larger hot water heater for longer showers!

Dec 11 – 18

G$15,254 GYD per night

Superhost

Guesthouse in Greenville

4.89 out of 5 average rating, 191 reviews

The Carriage House (pet friendly)

Our cozy apartment is a 1 BR/1 BA apartment in a converted two car detached garage, on in a neighborhood that is walkable & bikable. Pet fee schedule in the description. No Cats! It is convenient to restaurants, shopping. 6 minutes to Haywood Mall, 8 minutes to downtown Greenville & 3 minutes to Woodruff road. 1.5 miles from Greenville Convention Center & Greenville downtown airport.

Jun 9 – 16

G$21,332 GYD per night

Guest favorite

Guesthouse in Greenville

4.93 out of 5 average rating, 193 reviews

“The Dogwood Cottage” near Greenville

This cozy little cottage is a great quick stay for a couple or even a convenient and relaxing stay for just one person. Close to downtown and great local restaurants. This Airbnb listing is shared with another listing on the same property and may see other guest coming or going. For longer stays, there is a washer and dryer available on the property for shared use.

May 23 – 30

G$21,139 GYD per night

Guest favorite

Guesthouse in Greenville

4.97 out of 5 average rating, 178 reviews

The Biltmore Suite

This newly built in-law suite is in a wonderful location just half a mile from the Swamp Rabbit trail and downtown Greenville's Falls Park. The apartment includes 2 parking spots, and additional street parking about a block away. Long term stays available; inquire for pricing. Please not we cannot acquire pets, even service animals, due to an owner allergy!

Jul 4 – 11

G$26,021 GYD per night