House vacation rentals in Downtown San Diego

Find and book unique houses on Airbnb

Quick stats about house rentals in Downtown San Diego

  • Total vacation rentals

    Explore 170 vacation rentals in Downtown San Diego

  • Nightly prices starting at

    Downtown San Diego vacation rentals start at G$12,558 GYD per night before taxes and fees

  • Verified guest reviews

    Over 14,860 verified reviews to help you choose

  • Family-friendly vacation rentals

    110 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 60 rentals that welcome pets

  • Rentals with dedicated workspaces

    80 properties have a dedicated workspace

  • Wi-Fi availability

    160 of Downtown San Diego vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Downtown San Diego rentals

  • 4.8 Average rating

    Downtown San Diego stays are highly rated by guests—averaging 4.8 out of 5!

Top-rated house rentals in Downtown San Diego

Guests agree: these houses are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1
Top guest favorite
A modern kitchen features sleek wooden cabinets and white countertops, with a central island that provides additional seating. Stainless steel appliances are present, and a wall of glass allows natural light to fill the space. Cookware hangs elegantly above the island.
Home in Hillcrest
4.95 out of 5 average rating, 363 reviews

Walk to Balboa Park and Hillcrest from an Immaculate Home

Take a stroll through the park, then unwind with a leisurely dinner under the festoon lights. Classic crown molding, hardwood floors, and pared-back tones of gray and taupe create an air of calm at this elegant haven spread out over 1500 square feet. You will find the space charming & spacious with over 1500 sq. feet. This single level property is the lower level of a historic duplex. Hardwood floors, crown molding, gas fireplace and laundry room. Street parking is usually readily available. This A+ location of Banker's Hill is NOT impacted by air plane noise. Enjoy the entire lower level duplex and use of the back yard with patio set for dining. Please note the upper tenant may also want to use this space so this area could be shared. We would love to greet you but are also fine with allowing you to access with a code on the front door. We live nearby and are happy to make suggestions for dining or things to do. Located near numerous restaurants, and Balboa Park, Hillcrest, the zoo, Downtown, Little Italy, and the Convention Center are all within 10 minutes. Be at the beach in less than 15 minutes. The bus line runs up First Ave for easy access to Downtown and Uptown. Near trolley and train station. We are within 10 minutes to the San Diego International Airport and a quick Uber ride to Downtown, Little Italy. Walk to the heart of Hillcrest, Balboa Park and the Zoo. Be at the beach in less then 15 minutes. Central location near the I-5, I-163 & I-8. Because of the hardwood floors, you will hear the footsteps above. The kitchen is well stocked if your a cook and we have an area where you can set up your laptop. wireless available and 3 smart TV's for your enjoyment. Small market less than 1 block away.

Top guest favorite
A charming Spanish bungalow is framed by vibrant greenery and colorful flowers. A small staircase leads to the main entrance, which features a decorative security screen door. The exterior showcases white stucco walls, accentuated by terracotta details and surrounded by lush tropical plants.
Home in Bankers Hill - Park West
4.96 out of 5 average rating, 506 reviews

Admire Harbor Views from the Porch at a City Gem

Unwind in a cozy colorful casita in this light-filled 1920s Spanish bungalow decorated with Mexican folklorico. Take a walk into Little Italy for dinner. Or to a show at the Old Globe.What’s best, is how close you are to so much, all without needing a car. A very small single car garage is provided, think compact car. Street parking is free but challenging at times. The house is located directly below the incoming flight path. You are encouraged to read the reviews regarding this.Ideal for four.

Top guest favorite
The living room features a comfortable sectional couch alongside a grey armchair and two soft ottomans. A round wooden coffee table is centered on a textured rug, showcasing a vase, candles, and books. A flat-screen TV and ceiling fan enhance the cozy atmosphere.
Home in Greater North Park
4.97 out of 5 average rating, 112 reviews

Designer unit w/FirePit- Petco Park, Zoo, Downtown

Welcome to our 1920's craftsman in San Diego's Best neighborhood! *Unbeatable Location! Minutes Petco Park, Downtown, Zoo, Conv Center *Washer & Dryer *Thoughtfully Renovated *Boutique hotel-like experience Fire pit, grills, and outdoor dining area! This chic apartment is located on the edge of the iconic Balboa Park, and is walkable to trendy restaurants and bars. Less than a mile from the San Diego Zoo, mins to Gaslamp Quarter, Convention center, airport, and a 10 minute drive to beaches.

Superhost
A spacious living area features large windows allowing ample natural light. A 85-inch 4K TV is mounted on the wall above a sleek entertainment unit. Comfortable seating includes a plush gray sofa and decorative pillows, with a coffee table at the center of the room.
Home in Downtown San Diego
4.91 out of 5 average rating, 205 reviews

NEW Luxury 3BR HOUSE❤️of DT Walk Petco w/Garage AC

Located in the heart of Downtown San Diego, this unique house has been completely remodeled and re-imagined to make your stay unforgettable. Designed with the eye toward comfort and entertainment. 7 min walk Petco Park/14 min walk to Convention Center/6 min to Zoo/9 min Airport/12 min to SeaWorld/9 min to Coronado *Stunning bathrooms w/ dual showers, tub, smart glass *Full Kitchen, AC Central *SONOS Sound System, 4K TVs every room *Walk to coffee, yoga & gyms, dining, entertainment, shopping!

Guest favorite
Home in Downtown San Diego
4.97 out of 5 average rating, 155 reviews

Modern Surf Themed Home - Heart of Gaslamp

Step into a modern surf-themed retreat in the vibrant heart of San Diego's Gaslamp Quarter. Perfectly blending laid-back coastal vibes with sleek, urban style, this one-of-a-kind home is designed to be your getaway oasis in the middle of all the action. 7 actual beds no air mattresses or sofa-beds. This is the only 4-bedroom 4-bath for rent in all downtown San Diego. It is close to Convention Center, Petco Park, and Nightlife. This is not a party house. Person booking home must be over 25.

Top guest favorite
A spacious living area is characterized by high ceilings with exposed beams and large windows allowing natural light. A comfortable gray sofa, adorned with colorful cushions, is paired with a bright yellow accent chair. A modern coffee table and entertainment unit complete the inviting space.
Home in Little Italy
4.9 out of 5 average rating, 756 reviews

#1 LOCATION - Rare Luxury Home in Downtown

***THE BEST RATED RENTAL IN DOWNTOWN SAN DIEGO*** Location doesn't get better than this! Right in the heart of the lively Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. Just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & Zoo! All the frills: + Prime location! 98/100 Walker Score rating + Private parking + Private Sundeck & Backyard Stay at this modern luxury home for your next trip!

Top guest favorite
Home in San Diego
4.97 out of 5 average rating, 196 reviews

Condé Nast Villa | Speakeasy · Hot Tub · Sleeps 10

🏡 1,131 sq ft of curated interior space 🍳 Fully stocked kitchen 🛏️ 3 Queen Beds, 2 Twin Beds & 2 Twin Rollaway Beds 📺 Outdoor Lounge Area w/TV 🛁 Insta-worthy cast iron clawfoot hot tub — outdoors 🧺 Complimentary Washer & Dryer 🔒 Fully gated backyard 🚗 Private Parking (2 spots) 🏙️ 7 min to downtown 🦁 8 min to Zoo & Balboa Park ✈️ 12 min to airport & beach —>Want to enjoy the speakeasy? Just a heads-up—it’s not included in the base rate, but can be added for an additional fee!

Guest favorite
A bright living area features large floor-to-ceiling windows allowing ample natural light. A light wood coffee table is situated in front of a comfortable sofa adorned with decorative pillows. A large television stands on a modern console, with a potted plant adding a touch of greenery.
Home in Little Italy
4.83 out of 5 average rating, 224 reviews

Little Italy 2BR Loft Near Waterfront & Convention

Discover the heart of San Diego from our spacious loft in Little Italy, the culinary gem of downtown. Perfectly situated for both business and leisure travelers, you're steps away from the waterfront, convention center, and vibrant city life. Embrace the urban experience with convenience at your doorstep, including eclectic bars and restaurants. We provide a white noise machine and earplugs, though the lower floor offers a quieter retreat. Experience the best of city living!

Top guest favorite
A spacious living area is presented with a soft sofa adorned with decorative pillows. The room features large windows that offer views of the city skyline and Interstate 5. Warm lighting from a ceiling fixture complements the wooden beams overhead, enhancing the inviting atmosphere.
Home in Little Italy
4.98 out of 5 average rating, 317 reviews

Downtown View - 2 Story House Next to Little Italy

Two story house with 2 living rooms; 3 blocks to Little Italy restaurants, bars, & shops. Near Balboa Park, San Diego Zoo, Gaslamp, Waterfront Park & the Harbor. Museums, restaurants, theaters & nature are all nearby. Located in historic Bankers Hill, next to Interstate 5, near the airport and city center. With 2 living rooms, my house is perfect for travelers needing separate space. One parking spot is available. Extra large vehicles will have to park on the street.

Guest favorite
The entrance features a charming arched porch with a tiled roof and elegant railings. Two outdoor sconces flank the front door, which is framed by well-maintained landscaping with palm plants. Sunlight casts gentle shadows across the steps leading up to the door.
Home in South Park
4.88 out of 5 average rating, 159 reviews

South Park Spanish Stunner Renovated & Central

Charming Spanish, newly renovated home and close to everything! Come stay in this brand new place with space for the whole gang! Arched windows and vaulted ceilings make it a beautiful light and bright space. Chef's kitchen ready for you to make big family meals. Great outdoor space to sit back and relax and enjoy the perfect SoCal weather. Central location to get anywhere within minutes while still being in a fun walkable neighborhood!

Guest favorite
A private hot tub is positioned on the outdoor terrace, with a panoramic view of the city at dusk. Soft lighting from the surrounding area creates a relaxing atmosphere, while patio furniture and an umbrella are visible nearby. Large sliding doors provide access to the indoor living space.
Home in Mission Hills
4.96 out of 5 average rating, 142 reviews

The California

Welcome to your dream vacation home in the heart of San Diego, perched high atop the hills of Mission Hills on California St! This beautifully remodeled home has breathtaking panoramic views of downtown San Diego, the sparkling bay, the airport, Point Loma, and even South Coronado Island off the coast of Baja on clear days. Come experience the best of San Diego from the comfort of your own private abode! 🌅

Top guest favorite
The living room features a 22-foot ceiling highlighted by a hand-blown glass chandelier. A spacious white sectional couch is complemented by two white chairs, arranged around a unique square coffee table. Large windows frame the room, with modern artwork displayed on the walls.
Home in Downtown San Diego
4.98 out of 5 average rating, 374 reviews

Designer Downtown Home | Sleeps 10

Experience luxury in downtown San Diego! This rare 4-BR home comfortably fits 10 guests with 7 real beds. Featuring stunning 24-ft ceilings, a chef's kitchen, and unique artwork, it's a perfect urban retreat. Walk to the Gaslamp Quarter, Petco Park, and the Convention Center. Enjoy premium amenities, a dedicated workspace, and garage parking. Your ideal home base for exploring the city!

Popular amenities for Downtown San Diego house rentals

When is the best time to visit Downtown San Diego?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$42,069 GYDG$44,999 GYDG$48,976 GYDG$50,441 GYDG$49,395 GYDG$54,836 GYDG$58,394 GYDG$50,650 GYDG$45,836 GYDG$44,999 GYDG$44,790 GYDG$49,604 GYD
Avg. temp15°C15°C16°C17°C18°C20°C21°C22°C22°C20°C17°C14°C

Destinations to explore