Family-friendly vacation rentals in Depew

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Depew

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

The exterior of a single-story home is displayed, featuring a well-maintained lawn with vibrant green grass. A wooden deck is positioned at the entrance, providing a welcoming access point. Trees and a clear blue sky add a natural backdrop to the property.

Home in Orchard Park

4.96 out of 5 average rating, 101 reviews

Cozy Stay at Home in Orchard Park

Game Day Getaway in Orchard Park Welcome to your perfect retreat in Orchard Park, NY! This newly renovated home is just 5 minutes from Highmark Stadium, ideal for Bills fans. Located on a quiet street, it’s also 5 minutes from the charming Village of Orchard Park and 10 minutes from downtown Buffalo. Enjoy a fully equipped modern kitchen, cozy bedrooms, and a spacious deck for relaxing. Whether for game day, exploring, or a peaceful escape, this home has everything you need for a memorable stay.

Superhost

A cozy sleeping area features a spacious bed with a light-colored coverlet. Decorative pillows are arranged at the head of the bed, complemented by bedside tables and lamps. Natural light filters through sheer white curtains, enhancing the calming ambiance of the room.

Guesthouse in Cheektowaga

4.79 out of 5 average rating, 234 reviews

Warm & Cozy private Guesthouse/ Entire place.

Hi there! This is Aklima and Farhad, and we’re thrilled to have you stay at our guest house. It’s connected to our house, but both have their own private entrances. Just a friendly reminder, you might spot our kids playing in the backyard, so please be mindful of that. We love living here and meeting new people, which is why we started Airbnb. We’re committed to providing the best hospitality at an affordable price. This place is surrounded by nature and in a peaceful area! Enjoy your stay!

Top guest favorite

A modern kitchen showcases white cabinetry and a marble countertop. A central island features a wooden countertop with orange stools positioned around it. Stainless steel appliances, including a refrigerator and oven, are visible alongside a mosaic tile backsplash. Natural light fills the space.

Home in Orchard Park

5 out of 5 average rating, 277 reviews

Luxury Village Farmhouse

Welcome to our charming, old (but newly renovated!) Orchard Park Village Farmhouse! Large, but cozy, living and dining spaces and a huge kitchen with all the amenities. We have 2 large bedrooms, each is a "master suite" with bathroom and walk-in closets. In one bedroom, the king bed can be converted to 2 twins, if required. Queen sleeper sofa in living room. We're a short 1/4 mile walk to all the village shops, restaurants and coffee shops. 2 off-street parking spaces, wifi, AC, and laundry.

Guest favorite

A vibrant planter filled with pink flowers hangs next to a spacious heated pool. Lush greenery surrounds the pool area, complementing the calm blue water. A patio area with a rustic chair is visible, inviting relaxation by the poolside.

Home in Alden

4.91 out of 5 average rating, 120 reviews

Carols Giant Heated Pool Buffalo, NY

Do you enjoy luxury? You and your family have our entire home to enjoy sleeps 5 Features : piano, fireplace, fenced in pool :vaulted gazebo Our home includes 3 bedrooms (queen beds) , 2 baths, master suite has bath Deep soaker tub & shower, washer/dryer a beautiful gazebo at the poolside , charcoal grill available, inground private heated pool. pool open may 28 2024 Our home is short drive to falls approx 40 mins Uber to Buffalo Niagara airport in 18 m Darien Lake (15 min

Top guest favorite

A single-story bungalow is showcased with a well-maintained lawn. The brick exterior is complemented by large windows that allow natural light. Neatly trimmed bushes and shrubs frame the entrance, while a pathway leads to the front door. A lamp post stands to the right, adding subtle illumination.

Home in Cheektowaga

4.94 out of 5 average rating, 105 reviews

Bungalow near BuffaloNiagara International Airport

Relax and unwind at this peaceful bungalow in suburban Buffalo. Comfortable 3-bedroom house located 2 miles from airport, 13.4 miles from Bills Stadium, 24 miles from Niagara Falls and only 15-minute drive from downtown Buffalo, NY. Two of the bedrooms are equipped with a queen-sized bed and the 3rd bedroom has a full sized bed. With plenty of storage space in the dressers and closets. Full kitchen/dining area. Laundry is available on site with a washer and dryer located in the basement.

Top guest favorite

The exterior of the home showcases a classic two-story structure with white siding and blue shutters. A welcoming front porch is framed by lush greenery and large trees, offering shade and a peaceful ambiance. An American flag is displayed prominently, enhancing the home’s charm.

Home in Lancaster

4.99 out of 5 average rating, 102 reviews

The Farmhaus - rustic 1800s homestead sleeps 12

Built in 1819 and located steps away from one of the oldest dwellings in Erie County, the Farmhaus invites guests to step back in time and enjoy its rustic charm and spacious layout. Beautifully decorated to match its beginnings, this home features original woodwork, a large yard, and updated kitchen and baths. Close to restaurants & breweries, Buffalo Airport (5 mi), Highmark Stadium (18mi), Lancaster Speedway (.5 mi), downtown Buffalo (15 mi), Niagara Falls (30 mi), Letchworth (48m)

Top guest favorite

A living area is displayed, featuring a dark sofa alongside a patterned armchair. A decorative area rug covers the wooden floor. The background shows a kitchen space with bar seating and modern appliances, contributing to a welcoming atmosphere.

Apartment in Cheektowaga

4.94 out of 5 average rating, 252 reviews

Close to Niagara Falls and Airport, Mall nearby

Niagara Falls is only 30minutes away.Very nice neighborhood.4minutes from Galleria Mall. Plus many more stores nearby.Many places to eat and have some drinks! Sleeps-5 we have a clean pack and play for your little one. Has own key entry Couch in living room , roll away bed. One bedroom has a queen bed and tv.The 2nd bedroom has a twin bed and offers tv and a workspace. Very clean! Kid friendly and pet friendly.Pets can do their business out front. There are dogs that use the back yard.

Guest favorite

A living area features a wall-mounted television above a rustic wooden table. A small ladder shelf stands to the left, adorned with decorative items. The kitchen area is visible in the background, showcasing wooden cabinets and coffee-making equipment.

Apartment in Depew

4.8 out of 5 average rating, 428 reviews

The Shecave - 2 Bedroom Apt

This is perfect for your staycation or for a cozy pit stop. If you’re looking for a short term, no frills, respite, or workplace area, this is the place for you. This is not intended as a party house. Plenty of take out, pick up, or delivery of food. We PRIDE ourselves on the CLEANLINESS of our spaces. Great for a visit to Niagara Falls. Close to Galleria Mall. Quiet and safe neighborhood. **Please be at least 25 book.** **Photo ID will be required from you after booking.**

Superhost

A welcoming brick exterior of an upstairs apartment is shown, featuring a neatly manicured lawn. A small tree with white bark stands prominently in the front yard, surrounded by decorative stones. The entrance includes steps leading to a door with windows, reflecting natural light.

Apartment in Cheektowaga

4.83 out of 5 average rating, 113 reviews

Upstairs apartment near the airport

Cozy & stylish upstairs apartment in a quiet suburb. Less than three miles from the airport for stress-free travel! Less than one mile from the Walden Galleria Mall, one of the largest in NY state! Less than 10 miles from downtown Buffalo rich in culture, history, art, GREAT food, and night life. 24 miles to Niagara Falls for beautiful hikes and sight seeing. A fun 2 hour road trip to Toronto! Clean & comfortable with everything you need for a short or long-term stay!

Top guest favorite

The exterior of the timber-frame home is shown, featuring large two-story windows and wood accents. A covered veranda extends from the structure, offering seating. Surrounding greenery and manicured grass enhance the natural setting, inviting a peaceful retreat in the countryside.

Home in East Aurora

4.97 out of 5 average rating, 129 reviews

Timber-frame home on 12 wooded acres

Featured in Buffalo Spree and Artvoice, this timber-frame home features stunning hickory and black walnut interiors illuminated by two-story windows that face the morning sun. Radiant floor heating and earthen-plaster climate design. Wake up in queen and king beds, lounge under covered verandas, and shop right next door at Thorpe’s organic farm store. • 7 minutes from the Village of East Aurora • 24 minutes from Bills stadium • 1 hour from Niagara Falls

Top guest favorite

A spacious balcony extends from the second floor, featuring two outdoor chairs and a small table. The view showcases a lush green lawn leading to the lake, framed by residential houses and trees under a clear blue sky.

Cottage in Fort Erie

4.96 out of 5 average rating, 151 reviews

Steps to the Beach + Lakeviews + HotTub + Elevator

Unwind at this The Red Lakehouse just steps from the beach, featuring a private hot tub, fire pit, and covered balcony with Lake Erie views. Perfect for families, groups, and getaways, this professionally designed home offers 3 bedrooms with private ensuites for ultimate comfort and privacy. Minutes to Niagara Falls, Crystal Beach, and the USA border — yet tucked in a quiet, relaxing neighbourhood. A spotless, thoughtfully curated stay.

Guest favorite

A comfortable living area showcases two armchairs and a spacious sofa, all adorned with decorative pillows. A circular coffee table anchors the space, while a patterned rug adds warmth. Natural light filters through sheer curtains, softly illuminating the neutral-toned walls and accent artwork.

Apartment in Buffalo

4.88 out of 5 average rating, 138 reviews

Lovely 2-bedroom unit w/game room & free parking

Enjoy a stylish experience at this centrally-located place. Close to everything Buffalo has to offer. Be to the airport, Highmark stadium, down town Buffalo or Galleria mall in minutes. 2 bed 1 bath. One off street parking spot. House is located on a dead end street in a nice quiet neighborhood. Game room in the basement for the kids or adults, along with access to free washer and dryer. Free WiFi. Only a 28 minute drive to Niagara Falls.