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Family-friendly vacation rentals in Depew

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Depew

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Top guest favorite

A living area is displayed, featuring a dark sofa alongside a patterned armchair. A decorative area rug covers the wooden floor. The background shows a kitchen space with bar seating and modern appliances, contributing to a welcoming atmosphere.

Apartment in Cheektowaga

4.95 out of 5 average rating, 216 reviews

Close to Niagara Falls and Airport, Mall nearby

Niagara Falls is only 30minutes away.Very nice neighborhood. 4minutes from Galleria Mall.Plus many more stores nearby.Many places to eat and have some drinks! Sleeps-5 plus we have a clean pack and play for your little one. Has own keypad entrance. Full sleeper sofa in living room. One bedroom has a queen bed and tv. The 2nd bedroom has a twin bed and offers tv and a workspace. Very clean! Kid friendly and pet friendly. Pets can do their business out front. There are dogs that use the back yard.

A wooden coffee table features a circular design with a textured surface, adorned with decorative beads and a scented candle. In the background, a grey sectional couch with striped black and white pillows offers a comfortable seating area.

Home in Cheektowaga

4.86 out of 5 average rating, 102 reviews

Dreamy beautiful family Escape Buffalo super Host

We're Alex and Jamie, and we'd like to warmly welcome you to our lovely home. We live in a very quiet, safe, and friendly neighborhood. During your stay, you'll have access to our back patio and a spacious, fully fenced backyard. Inside, the first floor features a living room, kitchen, full bathroom, and two bedrooms. The second floor offers a cozy lounge area, a half bathroom, and a large master bedroom. Each room is equipped with a queen-size bed and a USB charger. We hope you enjoy your stay!

A spacious living room features two black leather sofas facing each other. A TV is mounted on the light blue wall, positioned above a low media console. Natural light filters through sheer curtains on a large window, enhancing the inviting atmosphere.

Home in Cheektowaga

4.74 out of 5 average rating, 108 reviews

Niagara Falls | Highmark | Buffalo Vacation House

This is an entire house with 3 bedrooms ( 1 king bed and 2 queen beds) and 2 bathrooms, (2nd bathroom is in the basement) large backyard, driveway, garage and FREE STREET Parking. Neighborhood: this is a highly secured and safe area, no need to worry about security at all Cleanliness: Very nice and clean area, very well maintained neighborhood. My promise: The happiness of my guests is my true promise, I am always grateful to make any changes to make my guests happy and comfortable Welcome

A comfortable living area is displayed, featuring a large sectional sofa with decorative cushions and a wooden coffee table. A 50" Smart 4K TV is positioned on a stand, showcasing a scenic landscape. The space is illuminated by natural light from the adjacent kitchen.

Apartment in Depew

4.91 out of 5 average rating, 116 reviews

Fireman's Park View

Book your stay at our homey and welcoming 3 bedroom space, designed for guests to enjoy. We are a short 10 min drive from the Buffalo Airport. There is plenty to do during your stay: downtown Buffalo and Niagara Falls are both a 20 min drive, and our quiet, safe neighborhood is the perfect place to relax for the evening. We suggest taking a walk at Reinstein Woods nature preserve. With a park in the backyard and access to an abundance of restaurants and shops nearby, you will love this space!

An aerial view of a round above-ground pool, featuring vibrant floating pool toys in bright colors. Adjacent to the pool, a composite deck is visible with stylish outdoor furniture arranged for relaxation, set against a backdrop of green grass.

Apartment in Depew

4.91 out of 5 average rating, 280 reviews

Modern Oasis Pool & Hot Tub near Buf/Falls/Stadium

This spacious 3 bedroom 2nd floor apartment is updated with you in mind. The entire space has everything you could want during your stay. This is the perfect spot in the Buffalo area - close to the airport 10-15min, 15min to downtown, 18min to Bills Stadium, 40min to Niagara Falls & minutes from many shopping options including the famous Galleria Mall & Niagara Outlets. Both short term & long term stays are welcome. The space easily accommodates individuals, couples, families, & groups.

Top guest favorite

A cozy bedroom features a wooden sleigh bed with a plaid comforter. A decorative lamp sits on a nightstand beside the bed. A trunk labeled 'LOVE' is placed at the foot of the bed, and a window with a checkered valance allows natural light to filter in.

Guest suite in Lancaster

4.98 out of 5 average rating, 167 reviews

"The Suite Spot", Adorable apartment with deck

Kick back and relax in this calm, stylish space. This second floor apartment boasts a newly remodeled bathroom, a full kitchen, a comfortable bedroom perfect for two & a cozy sitting area with chairs that convert into twin beds. It also offers off street parking for one vehicle & a private entrance on the deck. It's a perfect place to relax & enjoy the summer & fall. Along with our dog Toby & our cat Taffy who will welcome you (but will not be a bother) we invite you to enjoy our home.

A living area features a wall-mounted television above a rustic wooden table. A small ladder shelf stands to the left, adorned with decorative items. The kitchen area is visible in the background, showcasing wooden cabinets and coffee-making equipment.

Apartment in Depew

4.79 out of 5 average rating, 398 reviews

The Shecave - 2 Bedroom Apt

This is perfect for your staycation or for a cozy pit stop. If you’re looking for a short term, no frills, respite, or workplace area, this is the place for you. This is not intended as a party house. Plenty of take out, pick up, or delivery of food. We PRIDE ourselves on the CLEANLINESS of our spaces. Great for a visit to Niagara Falls. Close to Galleria Mall. Quiet and safe neighborhood. **Please be at least 25 book.** **Photo ID will be required from you after booking.**

Top guest favorite

A comfortably arranged living area features two light gray sofas adorned with decorative pillows, set around a round black coffee table. Natural light enters through the large windows, illuminating a woven area rug on the hardwood floor, while lamps provide soft ambient lighting.

Guest suite in Williamsville

4.95 out of 5 average rating, 294 reviews

**Village Home In Buffalo- BEST LOCATION!**

Welcome “home” and discover why Buffalo is called the ‘City of Good Neighbors’! Whether it’s for a day, week, or even longer, feel comfortable and cozy, in this 1 bedroom apartment. Being less than 2 miles from the Buffalo Niagara Int’l airport, a quick Uber ride will bring you to Williamsville and offer you a true Buffalo experience. Enjoy the small town vibe of the village, and allow Williamsville to be your gateway to adventure! (Downtown Buffalo- 9mi, Niagara Falls- 17mi. )

A small table surrounded by four colorful chairs is positioned near a window, which is adorned with light curtains. Books are displayed on wall-mounted shelves nearby, and an air conditioning unit is visible. A bedside lamp adds soft illumination to the space.

Home in Buffalo

4.93 out of 5 average rating, 106 reviews

Cozy Home for Relaxing Getaways

Nestled in a peaceful neighborhood, our beautiful 1115 square feet ranch house offers a charming design. As you step inside, you are greeted by a spacious living area adorned with tasteful décor and plush furnishings. The kitchen is a chef's dream, our home offers kids toys and books. Book your stay at our beautiful home and experience a truly unforgettable getaway. We look forward to hosting you and making your stay a memorable one. Welcome to your home away from home.

Top guest favorite

A spacious kitchen features warm wooden cabinetry and modern stainless steel appliances. Natural light floods through windows, illuminating the open layout that connects to a cozy living area. A decorative light fixture hangs from the vaulted ceiling, enhancing the inviting design.

Home in Buffalo

4.95 out of 5 average rating, 132 reviews

KING BED! Brand New! Fabulous & Fresh Farmhouse!

Top to bottom BRAND NEW home! Custom interior design & a relaxing, SPARKLING space! KING primary en-suite w/ walk in closet! 1st floor laundry, kitchen w/ every cooking amenity possible- coffee/tea bar, filtered water & ice on fridge, FREE parking & WIFI, private yard; deck w/ gas grill & fire pit, family friendly-high chair & pack n play available! Minutes from TONS of malls & yummy restaurants. Close to airport & train station. Dead End Street!

A comfortable living area showcases two armchairs and a spacious sofa, all adorned with decorative pillows. A circular coffee table anchors the space, while a patterned rug adds warmth. Natural light filters through sheer curtains, softly illuminating the neutral-toned walls and accent artwork.

Apartment in Buffalo

4.9 out of 5 average rating, 116 reviews

Lovely 2-bedroom unit w/game room & free parking

Enjoy a stylish experience at this centrally-located place. Close to everything Buffalo has to offer. Be to the airport, Highmark stadium, down town Buffalo or Galleria mall in minutes. 2 bed 1 bath. One off street parking spot. House is located on a dead end street in a nice quiet neighborhood. Game room in the basement for the kids or adults, along with access to free washer and dryer. Free WiFi. Only a 28 minute drive to Niagara Falls.

Top guest favorite

The studio features an open layout with a cozy seating area including a gray sofa and matching chairs. A dining table accommodates four, and a spacious bed is present in the corner. Natural light filters through the window treatments, highlighting the neutral color scheme.

Guest suite in Lancaster

4.91 out of 5 average rating, 180 reviews

Work or Play this is your Home Away!

Newly remodeled private studio with private entrance. Lots of parking space. 700sq ft.of living space for you to enjoy! Private balcony overlooking stunning backyard views with a pond. Only 13 min away from Buffalo airport! Shopping centers within a mile. Downtown Buffalo- 20 min. drive Flix Movie Theater- 2 min. drive New Era field- 20 min. drive Niagara Falls- 40min. drive Galleria Mall- 12 min. drive

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Popular amenities for Depew family-friendly rentals

Free parking on premises

Air conditioning

Family-friendly home rentals with a hot tub

Top guest favorite

A spacious living area features a comfortable sofa and a wooden coffee table, complemented by a flat-screen TV mounted on the wall. Natural light filters through the skylight and window, illuminating the modern decor that includes a stylish bed and tasteful accents.

Loft in Fort Erie

4.98 out of 5 average rating, 132 reviews

Mins. to Crystal Beach | Loft| Hot Tub| Spa Bath!

A cozy fire pit is surrounded by four colorful adirondack chairs, set in a pebbled area. Soft outdoor lights hang in the background, illuminating the space while creating a warm ambiance during the evening.

Home in Buffalo

4.84 out of 5 average rating, 178 reviews

Near |UB |Duff’s| Niagara Falls| Fire Pit & HotTub

Two lounge chairs are positioned on a grassy area, facing a calm expanse of Lake Erie. A slender tree stands nearby, and a black iron fence marks the boundary, offering an unobstructed view of the water under a partly cloudy sky.

Home in Fort Erie

4.94 out of 5 average rating, 139 reviews

Crystal Beach Executive Waterfront Lakehouse

Top guest favorite

The serene expanse of Lake Ontario is showcased during sunset, with vibrant shades of pink, purple, and orange reflecting on the calm water surface. The sky displays soft, colorful clouds that complement the tranquil scene, enhancing the natural beauty of the lakeside environment.

Cottage in Ransomville

5 out of 5 average rating, 105 reviews

Restful Retreat - Waterfront

A spacious living area features a plush brown couch and a cozy white lounge chair next to a modern black coffee table. A well-lit dining area with seating for eight is visible, along with a bright kitchen and stylish decor elements.

Home in Niagara Falls

4.91 out of 5 average rating, 117 reviews

Luxury Family Oasis W/ GameRoom/King Bed/Hot Tub

A dining area features a large, ornate dining table surrounded by eight intricately designed chairs. A vibrant area rug is placed beneath the table, and a pendant light illuminates the space. Bar stools are positioned at a counter in the background, enhancing the open layout.

Home in Buffalo

4.81 out of 5 average rating, 203 reviews

Downtown Home W HOT TUB Private Deck & HiddenRoom

A cozy living area features a gray sectional sofa adorned with colorful pillows. A round mirror hangs on the wall beside a plant accent. A small coffee table sits on plush carpet, with a dining space visible in the background through a doorway.

Home in Niagara Falls

4.95 out of 5 average rating, 205 reviews

*Close to the Falls*Hot Tub*Easy Checkout*Parking*

Top guest favorite

A cozy interior features a comfortable seating area with a sofa and decorative pillows. A small wooden table sits in front of the sofa, and a wall-mounted television is positioned above a modern fireplace. The bright, open layout connects to a kitchenette visible in the background.

Tiny home in Port Colborne

4.97 out of 5 average rating, 173 reviews

Tiny Farm Retreat

Family- and pet-friendly home rentals

A spacious living room is illuminated by natural light from multiple windows. A large blue sectional sofa is paired with a glass-top coffee table set on a soft, textured rug. A sleek TV stand supports a flat-screen television, with tasteful wall art adding color to the walls.

Home in Elmwood Village

4.91 out of 5 average rating, 109 reviews

Gates Circle 2 Bed Newly Renovated Haven

A green, textured sectional sofa is arranged in a cozy corner with soft cushions in shades of yellow and orange. A floor lamp stands nearby, illuminating the space. Large windows with decorative glass filters natural light, and a framed artwork adds a touch of color to the wall.

Apartment in Buffalo

4.95 out of 5 average rating, 172 reviews

Inviting King & Queen-parking-laundry-pets

An open living room features a modern farmhouse-inspired fireplace wall with a wall-mounted TV above it. Cozy seating arrangements include a gray couch and armchair with yellow and gray accents, while a wooden coffee table occupies the center of the space.

Home in Kenmore

4.96 out of 5 average rating, 107 reviews

Modern Kenmore Getaway | Renovated Home in Buffalo

A cozy living area features a dark gray couch accented with orange and neutral pillows. A rustic coffee table sits on a patterned area rug, while a small desk and chair are positioned near a window, complemented by a potted plant.

Apartment in Buffalo

4.95 out of 5 average rating, 182 reviews

Family/Pet-Friendly | 3BR Near Niagara & Downtown

Top guest favorite

An open living and dining area is displayed, featuring a light wood dining table surrounded by white chairs. A cozy seating arrangement is visible in the background, with a large window allowing natural light to fill the space, highlighting the modern decor.

Apartment in North Buffalo

4.98 out of 5 average rating, 131 reviews

Spacious 3 Bed Delaware Art Park Apartment

A serene landscape features rolling fields and a cluster of trees silhouetted against a sunset. The sun casts a warm glow, illuminating the horizon with soft light. A hay bale lies in the foreground, contributing to the peaceful rural setting.

Farm stay in Orchard Park

4.92 out of 5 average rating, 126 reviews

The Cottage @ Chestnut Hill Guest House & Farm

Top guest favorite

A fenced-in area showcases a private heated pool surrounded by lush greenery and blooming flowers. Lounge chairs are positioned nearby on the patio, providing a space for relaxation. The pool features clear water and is well-maintained, inviting guests for a refreshing swim.

4.91 out of 5 average rating, 117 reviews

Carols Country Inn ☆☆☆☆☆

Top guest favorite

The living area is furnished with a stylish chair and a small table, offering a cozy corner. A mounted flat-screen TV is above a decorative non-working fireplace, accompanied by a flower vase. Built-in shelves display pottery and knick-knacks, complemented by a view into the dining area.

Apartment in North Buffalo

4.97 out of 5 average rating, 240 reviews

Charming Upper in Lively Entertainment District

Family-friendly home rentals with a pool

Top guest favorite

A lift bridge is positioned over a calm waterway, with its reflection clearly visible in the water. The surrounding environment features trees and grass, contributing to a serene landscape under a clear sky.

Guest suite in Thorold

4.97 out of 5 average rating, 222 reviews

Niagara Bike Trails, Golfing, Wineries

An aerial view captures the villa nestled among lush greenery, showcasing a saltwater pool surrounded by lounge chairs. The structured layout of the property is visible alongside the landscaped backyard, offering a serene outdoor space for relaxation.

Villa in Niagara-on-the-Lake

4.86 out of 5 average rating, 145 reviews

Bright & Beautiful Villa with Pool

A private swimming pool is surrounded by well-maintained gardens and mature trees. Lounge chairs are positioned nearby for relaxation. The pool features steps leading into the water, while a covered seating area is partially visible, inviting outdoor enjoyment.

Guest suite in Niagara Falls

4.87 out of 5 average rating, 135 reviews

Comfy suite with private pool(4-6)

An in-ground pool is centered within a concrete patio area, showcasing clear blue water reflecting the surrounding greenery and wooden fencing. Steps lead from the patio to the shallow end of the pool, providing easy access for guests.

Guest suite in North Buffalo

4.87 out of 5 average rating, 280 reviews

Parkside Suite in Desired Urban Neighborhood

A deck area features comfortable seating arrangements with two armchairs and a coffee table. The inviting swimming pool can be seen in the background, surrounded by lush greenery. Decorative plants accentuate the space, providing a serene outdoor atmosphere.

Home in Niagara-on-the-Lake

4.9 out of 5 average rating, 197 reviews

Boutique Wine Country Home with Pool and Hot Tub

Top guest favorite

The kitchen features rich wooden cabinets and a spacious layout with granite countertops. An array of stainless steel appliances is present, including two ovens and a large refrigerator. Ample natural light enters through the window, illuminating the organized cooking space with a breakfast bar.

Home in Buffalo

5 out of 5 average rating, 17 reviews

Spacious, Kid Friendly, Near UB & Niagara Falls

An outdoor hot tub is nestled beneath a wooden pergola, featuring jets and seating. In the background, a swimming pool is visible, surrounded by greenery and blue skies, evoking a relaxing atmosphere.

Cottage in Niagara-on-the-Lake

4.89 out of 5 average rating, 295 reviews

Modern Farmhouse XL Hot Tub NOTL 15Mins- Falls

A colorful play structure is set in a spacious backyard, featuring a slide and swings. A trampoline is visible in the background, surrounded by lush green grass and shaded by mature trees.

Home in Buffalo

4.76 out of 5 average rating, 41 reviews

Luxurious, comfortable pool home in Buffalo

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