Vacation rentals in Chillicothe

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Top-rated vacation rentals in Chillicothe

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Kirksville

4.96 out of 5 average rating, 288 reviews

Private Farmhouse with a Timber View

Cozy, Quiet, Private, Clean w/ FIBER INTERNET We are a farmhouse in the woods 4 miles from Thousand Hills State Park and 5 miles from Truman State University. While staying, you will feel like you are secluded amongst a forrest, yet you'll only be a 5-10 minute drive away from everything in town! The house was built in 2017 with modern finishes. The hottub is always hot and the oversized couches are always comfy. The neighborhood is family/wildlife oriented. Come unwind and relax in the sticks!

Jun 23 – 30

G$28,859 GYD per night

Guest favorite

Farm stay in Excelsior Springs

4.95 out of 5 average rating, 248 reviews

San Vincente Lake Cabin and SundanceKC

Our beautiful light filled cabin with wood-burning fireplace is perched above our spring-fed 15 acre private lake next to the common outdoor lounge area and sand beach. We have 200 acres of gorgeous property with limestone boulders and hiking trails throughout. The lake is great for swimming, kayaking, stand-up paddle boarding and offers excellent fishing. We are five minutes from downtown Excelsior Springs, Excelsior Springs golf course and 3EX municipal airport. Relax, rejuvenate and play.

Dec 14 – 21

G$44,424 GYD per night

Guest favorite

Home in Mooresville

4.99 out of 5 average rating, 181 reviews

RURAL MISSOURI GEM! (NO CLEANING FEE)

CORONAVIRUS CONCERNS We clean and disinfect high-touch surfaces in household areas (e.g. tables, hard-backed chairs, doorknobs, light switches, remotes, handles, desks, toilets, sinks, etc.) after each departing guests. All bedding is properly disinfected. Escape to the quiet countryside just a short drive to Missouri Star Quilt, Kansas City and St. Joseph. As super hosts, our priority is to make your visit the most comfortable, enjoyable and relaxing time at the Mooresville Guest House.

Nov 28 – Dec 5

G$24,633 GYD per night

Guest favorite

Farm stay in Chillicothe

4.8 out of 5 average rating, 15 reviews

Farmer’s Wife Get Away

Chillicothe’s best kept secret. Farmer’s wife get-away, tucked away in a wanna be farm, just outside city limits. Sleeps up to 10 (1 K, 3 Qu, & 1 dbl beds) complete with soaker tub, grill, and free range chickens for that country ambience. Minutes to main street shopping. Close to Jamesport - quant Amish town where you can enjoy all the homemade items your little city slicker heart desires. Hamilton -quilting capitol. With Historical Farr west, Adam Ondi Ahman and Hauns mill close by.

Jun 22 – 29

G$23,495 GYD per night

Guest favorite

Home in Liberty

4.95 out of 5 average rating, 272 reviews

Location! Upscale Historic home w/Chef’s Kitchen

Just off Downtown Historic Liberty square, this 1890s home has been updated to offer guests an upscale luxury experience. Be pampered in the comfortable master suite & enjoy a spa-like experience w/ large clawfoot tub, Carrera Marble shower w/ amazing shower system. Chef’s kitchen includes many amenities. Cook or enjoy meals at large quartz island. Free bottle of wine! Sleeper chaise couch in the living room. This home is like a duplex. Private entrance, and also private back deck.

Jan 4 – 11

G$21,630 GYD per night

Guest favorite

Guesthouse in Trenton

4.91 out of 5 average rating, 45 reviews

Adorable 1 room lake cottage with free parking.

Peaceful lake cottage on 5 acres of lakefront property. Parking on premises. Walking distance to the Black Silo Winery. Beautiful surroundings. Perfect place to get away and relax. Includes Fiber Internet. Private owned lake for your viewing pleasure only. There is no water access included for guests. Yard and gazebo with table and chairs available to use. Sanitized and cleaned with covid precautions in mind. We do have a twin bed we can add to the lake cottage if requested.

Jan 1 – 8

G$20,944 GYD per night

Guest favorite

Guesthouse in Hamilton

4.98 out of 5 average rating, 133 reviews

Spacious 1 BR Carriage House - 2 min walk to MSQC

The Carriage House apartment is located behind the historic home we've restored in Hamilton. The property is nestled one block between popular Main Street shopping (featuring the Missouri Star Quilt Co. shops) and the Missouri Quilt Museum. Everything is within easy walking distance from this beautiful, newly built apartment. Plus, you'll enjoy plenty of space, a full kitchen, free wi-fi and free laundry on site. We can't wait to welcome you to your home away from home!

Apr 16 – 23

G$24,215 GYD per night

Guest favorite

Loft in Jamesport

4.96 out of 5 average rating, 80 reviews

Beautiful 2 -bedroom loft above Bricktown Coffee

Enjoy this beautiful upstairs loft in the heart of Jamesport. Relax in Luxury in our gorgeous master bedroom and enjoy the old fashioned claw foot bathtub. Very spacious living and dining room with beautiful wooden floors. Fully furnished kitchen and a deck to enjoy the early morning. Also a second bedroom with a full size bed. So plenty of room for the family. Grocery store, shops, restaurant and coffee shop all within two blocks.

Jul 25 – Aug 1

G$20,825 GYD per night

Guest favorite

Apartment in Hamilton

5.0 out of 5 average rating, 20 reviews

Rose - Apartment suite in Quilt Town!

Cozy and homey ground level apartment suite "Rose" features a queen bed, fully equipped kitchen, and coffee station. Free WIFI. Sound machine in bedroom for restful sleeping! Great place to stay near Hamilton, MO - home of Missouri Star Quilt Co. Shop at Penneys Quilt Shop, have breakfast at Eggos, golf at Lakeview Golf Course, and community pool just a couple blocks away...lodging in Hamilton, Missouri made fun with the Rose suite!

Jun 29 – Jul 6

G$19,962 GYD per night

Guest favorite

Barn in Breckenridge

5.0 out of 5 average rating, 124 reviews

Relax in Rustic Luxury Overlooking Vineyard

A young vineyard planted in 2018, Catawba Vineyards boasts twenty acres of sprawling farmland property and a newly renovated gambrel-style barn to accommodate overnight guests and indoor/outdoor events. The property is currently developing and constructing its own wine-making processes to become the newest member of the growing north Missouri winery family.

Mar 30 – Apr 6

G$39,270 GYD per night

Guest favorite

Tiny home in Trenton

4.97 out of 5 average rating, 29 reviews

Tiny Cabin

A one of a kind custom built tiny home located closely to Wright Memorial Hospital right outside of town. Complete with two lofts and a full size washer and dryer. Perfect for people traveling for family get togethers and traveling nurses. We are NOT a pet friendly Airbnb, any pets brought into the house will have their booking terminated.

Jun 22 – 29

G$25,490 GYD per night

Guest favorite

Cottage in Chillicothe

4.96 out of 5 average rating, 107 reviews

Meneely guest house

Come enjoy our quaint little cottage just a few short blocks from downtown Chillicothe where you can enjoy food, drink and Chillicothe's gorgeous murals! Our house is located near one of our city parks and just across the street from a track for our running & walking guests.

Mar 21 – 28

G$19,710 GYD per night