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Guesthouse vacation rentals in Charleston

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Charleston guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
An open living space is seen with a brown leather sectional sofa adorned with colorful throw pillows. A wooden coffee table sits in front of the sofa on a blue area rug. The kitchen features white cabinetry and modern appliances, with natural light filtering through a nearby window.
Guesthouse in Charleston
4.92 out of 5 average rating, 710 reviews

Island Oasis—Near Downtown

ChristinaRating, 5 stars2 weeks ago
Highlights: The bed is very comfortable for 2 sleepers. We have opposite preferences (I like firm, he likes soft) and we were both reasonably happy. My favorite part was that I didn't shoot off the bed like a cartoon character when he stood up - it's pretty well padded foam so the spring action of your grandma's guest bed is nowhere to be found here. Cotton everything was such a relief - I never find this much cotton at an Airbnb! The comforter, sheets, pillowcases, and towels...seriously heaven. The shower got hot quick with great pressure and was tall enough for my 6'2" husband. Guest mode on the Roku TV was an excellent discovery. The kitchen was well appointed and everything was easy to find and not cluttered or missing items. But most of all, the cherry on top was all the recommendations! I have lived in Charleston and worked on James Island and all the extra tips and tricks were new even to me. Can't recommend enough!
Guest favorite
A well-maintained lawn features a manicured, artificial turf area leading to a charming guest house. Surrounding greenery and a path of gravel create a welcoming entry. The guest house displays a simple entrance, framed by lush foliage, contributing to a private, tranquil setting.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 250 reviews

Bungalow Under The Oaks

CheyenneRating, 5 stars1 week ago
If you’re looking for a cute little place to chill for the weekend, this is a great choice! While the bungalow is a little smaller than anticipated (for 2 adults/2dogs), the fully fenced yard makes up for everything else. The yard is pretty much completely shaded by beautiful oak trees, and my dogs loved every second we spent out there. The road is busy during the day, but at night, it quiets down, and all you can hear are the cicadas.
Guest favorite
Two classic cars are parked in front of a detached garage, showcasing a vintage white convertible and a sleek gray vehicle. The garage features two closed doors, framed by light green siding and surrounded by trees, adding to the serene environment.
Guesthouse in Summerville
4.88 out of 5 average rating, 801 reviews

New Loft in Historic Summerville

BayleeRating, 5 stars1 day ago
Had an amazing stay!! Jacquelynn was extremely kind and was the definition of an amazing host!
Guest favorite
A studio apartment is shown, featuring a king bed with decorative pillows and a comfortable couch. A wooden dining table and chairs are visible, alongside a chest of drawers. Natural light enters through two windows, creating a bright and inviting space.
Guesthouse in Mount Pleasant
4.94 out of 5 average rating, 255 reviews

Green Garden Studio @greengardenstudio2017

HelenRating, 5 stars3 weeks ago
This was the cutest above garage studio. It is very well done, clean and comfortable. The property is very well maintained- we would definitely stay here again! The AC was not working properly when we arrived but Holly responded immediately and got it working. Highly recommend!!
Top guest favorite
The living area is arranged with a spacious sectional sofa adorned with colorful pillows. A wooden coffee table sits in the center, complemented by a light rug. Natural light filters through the windows, illuminating the space and highlighting the rustic wooden beam above.
Guesthouse in Charleston
5 out of 5 average rating, 108 reviews

Liz Lane Cottage- entire guesthouse

KellieRating, 5 stars2 weeks ago
Beautiful accommodations, away from the hustle, but still close enough to be convenient. The home was clean and neat. We were in Charleston for a graduation, so this was a nice place to rest up and relax in between activities.
Superhost
A charming yellow cottage is framed by lush greenery, with a cozy seating area featuring bright blue chairs. A colorful hammock hangs nearby, creating an inviting space for relaxation. Sliding glass doors lead into the cottage, promoting a cheerful and welcoming atmosphere.
Guesthouse in Charleston
4.84 out of 5 average rating, 118 reviews

Romantic Beach Style Cottage close to everything!

NatalieRating, 5 stars1 month ago
Clean & conscious hosts! Mindful of needs that may crop up, lovely home & family. Flexible! Perfect oasis away from the bustle of Charleston.
Top guest favorite
A spacious bedroom features a wooden bed frame adorned with a floral-patterned comforter. Two bedside tables with lamps are positioned on either side of the bed. Bright light filters in through a window, complemented by soft neutral walls and warm wood flooring.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 137 reviews

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!

JonathanRating, 5 stars1 week ago
This was our second time at Treehouse and it was just as good as the first! Katey and Jules are great hosts. The location is amazing - 10 minutes to downtown Charleston and 10 minutes to the beach. We love walking down Coleman to Shem Creek and enjoying the sights and sounds of the marsh. We love patriots point park and taking the water taxi to downtown. You won’t find a better a place for a couple getaway!
Top guest favorite
A charming two-story house is set among lush landscaping, with a spacious lawn and shaded by large trees. A gravel driveway curves toward the home, while a detached garage is visible on the left, providing convenient parking options.
Guesthouse in Johns Island
4.98 out of 5 average rating, 268 reviews

Private waterfront apt in the oaks

AustinRating, 5 stars3 weeks ago
This was an incredible stay! My wife and I absolutely loved everything about it. The dock was such a peaceful spot to relax. We spent hours enjoying the views and soaking up the serene atmosphere. The property was immaculately clean, which made it feel so comfortable and inviting. Nancy and Joe were incredibly welcoming, going above and beyond to make us feel at home. The freshly baked muffins were such a thoughtful touch and truly made our stay feel special. We couldn’t have asked for a better experience and can’t wait to come back. Highly recommend!

Guest house rentals with a patio

Guest favorite
A modern two-story guest house is depicted, featuring a combination of white and light brown exteriors. A covered entryway with pergola extends over the front door. A tranquil pool is visible in the foreground, surrounded by landscaped greenery and stone paving.
Guesthouse in Mount Pleasant
4.96 out of 5 average rating, 129 reviews

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

MaryRating, 5 stars1 month ago
The most important thing for me when I am staying away from home is cleanliness. Georgia's place was spotless! It had everything I needed and was within an easy drive to restaurants, grocery stores, and a great coffee shop. I would not hesitate to return.
Top guest favorite
A bright and airy living area features a light blue sofa, accompanied by a small table and chair set. The fully equipped kitchen is visible in the background, showcasing modern appliances. Natural light floods the space through the windows, enhancing the inviting atmosphere.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 84 reviews

Coastal Charm: Village Hideaway

LeanaRating, 5 stars3 weeks ago
Christina's place is the reason why you want to book an Airbnb. Extremely clean, smart layout and impeccable style and furnishings. We felt like we were staying in a luxury residence! Christina was also a great host, provided all the necessary instructions and recommendations and even helped with coordinating my rent the runway. big thanks and would definitely stay here again when we are back in town!
Top guest favorite
A living area features two modern chairs and a round table. The light wood flooring complements the wall adorned with a floral design. A black shelving unit holds decor, and a mounted television provides entertainment, creating a stylish and inviting space.
Guesthouse in Charleston
4.95 out of 5 average rating, 120 reviews

Spacious 1 bedroom cottage in Avondale

HannahRating, 5 stars1 week ago
This beautiful cozy little home was absolutely perfect for our honeymoon!!! We had an amazing trip, and so much of that was due to staying at Derek’s airbnb. The location of this place was awesome! Lots of nice restaurants and places to grab food nearby (Mex 1 Coastal Cantina was walking distance - we went here multiple times!!). It was the perfect location to go to folly beach or downtown charleston, very central to everything! Inside it is so cute, cozy, and clean! We drove from multiple states away and when we got in late, we were happy to find the space with lights on and ac set to a comfortable temp. We were also surprised to find a bottle of wine as a congratulations for our wedding; That was so kind!! Both the bed and the couch in the living room were SO COMFY!!!! We were very pleased with that. We really appreciated all of the kitchen-ware and utensils etc. that were stocked in the kitchen. We were also thankful that they supplied 2 beach chairs and beach towels.
Top guest favorite
A light-filled living area features a comfortable sectional sofa and a ceiling fan. Two windows provide natural light, while a TV is mounted on the wall. A decorative painting adds color above the sofa, and a woven area rug lies underfoot.
Guesthouse in Johns Island
4.96 out of 5 average rating, 123 reviews

Driftwood Cottage

HopeRating, 5 stars1 week ago
This is a very nice cottage in a lovely and quiet setting. The cottage was spotless and all furnishings were new. Check-in was easy.
Guest favorite
A shaded outdoor seating area is furnished with a comfortable couch and chairs, surrounded by tropical plants. A flat-screen TV is mounted on the wall, while a dining table awaits nearby. The entrance door adds a touch of charm to the inviting space.
Guesthouse in North Charleston
4.91 out of 5 average rating, 137 reviews

My Happy Place

GlennRating, 5 stars1 week ago
we came to watch our Granddaughter graduate High school. The pool house was very well kept, yard and pool area is like paradise. Kim was on top of everything, but we had full run of the area. We have stayed at many AirBB this was our top experience. 5 stars on all areas. We will be back for longer stay for sure.
Top guest favorite
A warm living space is highlighted by a comfortable brown sofa and accent pillows. A sleek coffee table sits on a patterned area rug, while two decorative stools provide additional seating. The bedroom area features a queen-sized bed with soft linens and bedside lamps, enhanced by natural light from nearby windows.
Guesthouse in Hanahan
4.99 out of 5 average rating, 194 reviews

The Violet Villa w/no cleaning fee

RileyRating, 5 stars4 days ago
Beautiful place to stay! Neighborhood was rather tight quarters, but I think that’s what comes with living in town. The hosts were very descriptive and thoughtful with what they included in the home.
Guest favorite
A charming cottage is surrounded by tall trees, showcasing vibrant autumn foliage. Large glass doors provide plenty of natural light, while a small porch is visible to the side. Greenery and shrubs add to the serene outdoor setting.
Guesthouse in Johns Island
4.91 out of 5 average rating, 181 reviews

Cozy Cottage! 5 mins from Kiawah!

KarlaRating, 5 stars2 weeks ago
What a gem this cottage was!!! The outdoor tub was the perfect ending to a busy summer day. The house was so quiet and the property, and especially the street, was a stunner!!!
Top guest favorite
A bright bedroom is highlighted by a spacious bed with white linens and decorative pillows. Natural light floods in through two windows adorned with bamboo shades. Green plants add a refreshing touch on bedside tables. A light blue throw blanket is casually draped over the foot of the bed.
Guesthouse in Riverland Terrace
5 out of 5 average rating, 62 reviews

Walk to restaurants! New, beautiful & clean home

NicoleRating, 5 stars4 weeks ago
We stumbled upon this Airbnb when we realized it was graduation weekend in Charleston. This place was perfect. We had a car so it was easy to get in and out of city— only about 5 miles. The location is also a 10 minute drive to the beach. The owners provided so much great information. They made sure checkin and everything was ok but from a distance via texts. The space was so cute and absolutely perfect for my daughter and I but could easily work for a family of four. The decor and setup was beautiful. Great hosts, great space, great location (walkable coffee/breakfast spot)… would highly recommend.

Guest house rentals with a washer and dryer

Top guest favorite
A wooden walkway leads from a sandy area to the beach, bordered by native vegetation. In the distance, two individuals are seated on the sand, overlooking the ocean and a serene sky at dusk.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 155 reviews

Beach, downtown, Alhambra Hall weddings so close!

DonnaRating, 5 stars3 days ago
We loved our little hideaway in beautiful Old Villag e! So peaceful, charming, close to everything we wanted to do! ....we biked OV, Shem Creek, Sullivans...and enjoyed the cute, clean, all we needed "home sweet home" while there! Very comfortable, quiet, well appointed. Robert and his adorable family were accommodating yet respectful of their guests privacy. It was an absolute pleasure to stay there! My sister and husband rented it first and it came highly recommended for the cleanliness, location and ease of everything! So we booked it too and were also very pleased! Easy peasy check out too! Thank you, Robert! Donna and Alex
Top guest favorite
The exterior of the garage apartment is presented with a light grey facade. A gabled roof enhances the structure's height. The garage door features three sections with paned windows at the top, while surrounding greenery and a simple front pathway contribute to a welcoming atmosphere.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 252 reviews

Cozy Apartment in Mount Pleasant

TaylorRating, 5 stars2 weeks ago
Dorothy's stay was perfect! It's such a cozy apartment and had everything we needed and more. The neighborhood is beautiful and it was easy to get to downtown Charleston (~15 min away) and other locations via Uber/Lyft. She was so easy to communicate with and quick to respond. I'd highly recommend!
Guest favorite
An outdoor patio area features a square stone layout with a firepit at the center. Two wooden chairs are positioned around the firepit, and string lights provide soft illumination in the trees above. A grill is visible nearby, surrounded by greenery.
Guesthouse in West Ashley
4.9 out of 5 average rating, 623 reviews

Cozy Cottage w Games, Firepit, Grill, and More!

AshleyRating, 5 stars2 days ago
The house was adorable and very cozy! We had a wonderful stay and appreciated the snacks provided, along with the recommendations of places to go while we enjoyed our stay. Would highly recommend and would stay again if I were ever back in the area! :)
Top guest favorite
A small outdoor balcony is shown with two striped chairs positioned at a round table. A potted plant with bright pink flowers adds a pop of color to the wooden decking. Sunlight filters through greenery in the background.
Guesthouse in Charleston
5 out of 5 average rating, 258 reviews

James Island "La Casita" Nestled btw Beach & City

RebekahRating, 5 stars3 weeks ago
We had a wonderful stay in Charleston and can't say enough great things about this Airbnb! John was an amazing host—responsive, welcoming, and truly went above and beyond. The home was fabulous and had everything we needed for a comfortable and relaxing stay. The location was perfect—close to all the best spots in Charleston, from dining and shopping to the historic sights. A huge bonus was being able to use their charger, which was so convenient. We highly recommend staying here and will absolutely keep this place in mind for our future Charleston visits!
Top guest favorite
A charming gazebo is framed by lush greenery, surrounded by manicured shrubs and colorful seasonal plants. The gazebo features decorative lattice walls, allowing natural light to filter through. A winding pathway leads to this serene outdoor space, inviting relaxation amidst the tranquil setting.
Guesthouse in Summerville
4.97 out of 5 average rating, 262 reviews

Summerville’s Tiny Oak Hideaway

JoanneRating, 5 stars3 weeks ago
our stay at the Tiny Oak was fabulous. We had everything we needed and more. we love being able to walk to everything.
Guest favorite
An open living space showcases a fully-equipped kitchen with stainless steel appliances and a dining area. The lounge features stylish blue and white striped chairs, a cream-colored couch, and wall art above a wooden coffee table, surrounded by natural light from large windows.
Guesthouse in Hampton Park Terrace
4.86 out of 5 average rating, 191 reviews

Serene Location - Next to Hampton Park: Haven Hom

DeborahRating, 5 stars2 days ago
5 star all the way! From the minute we walked in we were relaxed! Beautiful, immaculate and so well appointed! We wish we could have stayed longer!
Top guest favorite
A cozy fire pit area features a circular arrangement of dark wooden chairs surrounding a glowing fire. The path is outlined with stone, and lush greenery surrounds the space, creating a welcoming outdoor setting for relaxation and gatherings.
Guesthouse in Charleston
5 out of 5 average rating, 174 reviews

The Guesthouse at Old Orchard

ShannonRating, 5 stars1 month ago
We had a fabulous stay at this property! Everything was immaculately clean and beautiful. We arrived late in the evening, but had no trouble finding the place and getting inside. Brandy went above and beyond leaving fresh-baked sweet rolls and a handwritten welcome note on the kitchen counter. The furnishings were so cute and it was a nice, welcoming space that looked just like the photos. I appreciated the little extras like plenty of towels in the bathrooms, tea and snacks in the kitchen, beach towels in the laundry closet and more. We enjoyed sitting out on the little patio in the morning enjoying the beauty of the property. Brandy was friendly and responsive. We accidentally locked ourselves out on the patio one morning, but Brandy hustled back to the house to rescue us. lol I would highly recommend this property for your next southern getaway. 15-20 minutes from Folly Beach and downtown Charleston and close to restaurants and stores, it was an ideal location!
Guest favorite
A fully equipped kitchen area displays a coffee maker and a single-serve brewing machine on a black countertop. Various storage containers and kitchen utensils are neatly arranged, with decorative items and plants positioned on open shelves above.
Guesthouse in Mount Pleasant
4.96 out of 5 average rating, 309 reviews

Shem Creek Bungalow: Coastal Comfort Redefined

NathanRating, 5 stars3 days ago
Stayed here on a recommendation and the place was perfect. Would recommend it to anyone interested in private little getaway.

Quick stats about guesthouse rentals in Charleston

  • Total rentals

    220 properties

  • Total number of reviews

    25K reviews

  • Family-friendly rentals

    40 properties are a good fit for families

  • Pet-friendly rentals

    60 properties allow pets

  • Rentals with a pool

    10 properties have a pool

  • Rentals with dedicated workspaces

    100 properties have a dedicated workspace

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