Guesthouse vacation rentals in Anderson County

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Top-rated guesthouse rentals in Anderson County

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Top guest favorite

A gravel path meanders through a grassy area, flanked by low shrubs and tall trees, creating a serene and natural environment. Soft sunlight casts a gentle glow over the scene, highlighting the rich green foliage and the open field stretching out in the distance.

Guesthouse in Abbeville

4.97 out of 5 average rating, 342 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Top guest favorite

A porch swing is set on a wooden deck, adorned with plush cushions featuring intricate patterns. Lush greenery and colorful flowers are visible in the background, adding vibrancy to the serene outdoor setting.

Guesthouse in Six Mile

4.96 out of 5 average rating, 160 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Guest favorite

A wooden swing is positioned on the deck of the dock, overlooking the calm waters of Lake Hartwell. The serene landscape stretches into the distance, framed by tree-covered shores and a clear blue sky.

Guesthouse in Anderson

4.94 out of 5 average rating, 197 reviews

Private-Lake getaway-7 mile view from dock

Spacious two story guest house on a private road situated on Lake Hartwell. Use the double deck dock with 7 mile view for all day fishing, swimming or just relaxing. The guest house with central heating and air is fully furnished and has a fully equipped kitchen, wifi, 3 streaming flat screen tvs, two full baths, washer/dryer combo and a large attached deck. Owners live on property but in different residence. Outdoor cameras overlook parking area. Only reserved guests have property access.

Superhost

A spacious yellow barn-style structure with a green roof is visible, featuring three symmetrical gabled dormers. The ground level includes three garage doors, framed by lush greenery and a wooden fence, with a serene backdrop of trees.

Guesthouse in Anderson

4.86 out of 5 average rating, 198 reviews

Farmhouse by the lake - Private guest house

1,200 square foot apartment over a quiet barn on a cul-de-sac of a lake community. Near I-85, T. Ed Garrison Livestock Arena, downtown Pendleton, Clemson, and Lake Hartwell. Perfect for Clemson football games, horse/livestock shows or trail riding at Garrison Arena, lay over with horse, graduation, visiting your college student, fishing tournaments, or vacationing near Lake Hartwell. A private guest house overlooking sheep pastures and woods. Accessed by flight of stairs.

Guest favorite

A spacious living area is presented with high ceilings. A neutral-toned sofa and an armchair are complemented by a coffee table at the center. Colorful artwork, including a world map, adorns the walls, contributing to a vibrant yet relaxing atmosphere.

Guesthouse in Pendleton

4.89 out of 5 average rating, 264 reviews

La Bella Farm

Do you want to be close to Clemson(11 miles), Anderson(9 miles) OR Greenville(20miles)! Do you want to just get away from all of the noise and busy life. Then you have found your spot! This is a great detached garage apartment. Settled in the quiet country side of Pendleton SC. 1 bedroom&1 bathroom with an additional sofa bed&blow up mattress. Great view of nothing but beautiful land from the kitchen window yet minutes away from Death Valley,restaurants,shopping and 85.

Top guest favorite

The bedroom features a king-size memory foam bed dressed in striped linens, complemented by a ceiling fan overhead. A small dining table with yellow chairs sits nearby, and framed black-and-white photos adorn the wall. Two closed doors offer additional storage.

Guesthouse in Anderson

4.94 out of 5 average rating, 17 reviews

Forested Retreat-Scenic Above Garage Suite

Welcome to our quiet mother-in-law suite located in the charming town of Anderson, South Carolina! Our cozy 1 bed 1 bath newly renovated above-garage apartment is the perfect spot for a peaceful and relaxing stay. Located in a quiet setting in the woods, you'll feel at one with nature while still enjoying all the modern amenities you need for a comfortable stay within 30 minutes to Greenville and Clemson and 10 minutes to Anderson University.

Top guest favorite

A comfortable living area is presented with a mix of seating options, including a couch and two armchairs. Natural light enters through the windows, which are dressed in soft curtains. A coffee table sits in the center, complemented by tasteful decor on the walls.

Guesthouse in Donalds

4.99 out of 5 average rating, 382 reviews

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

Guest favorite

The exterior view of the Shou-Sugi-Ban Guest House features a dark wooden facade with a sloped roof. A spacious deck is present, furnished with two orange chairs and a potted plant. Lush greenery surrounds the area, providing a natural feel.

Guesthouse in Piedmont

4.99 out of 5 average rating, 103 reviews

Shou-Sugi-Ban Retreat on the Saluda River

The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Top guest favorite

A charming cottage is set among lush greenery, featuring a spacious deck that extends from the front. Large windows provide natural light, while surrounding trees and plants create a serene atmosphere.

Guesthouse in Greenville

5 out of 5 average rating, 136 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Top guest favorite

The exterior of the apartment building is visible, featuring a rustic design with wooden elements and a metal roof. A spacious driveway leads to the double garage doors, surrounded by landscaped greenery and blooming flowers. Trees in the background provide a peaceful environment.

Guesthouse in Hartwell

4.98 out of 5 average rating, 115 reviews

1 bedroom lake front apartment with gorgeous views

Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipped with a kitchen and a private laundry facility.

Top guest favorite

Large glass doors open to a serene outdoor space with natural stone pathways and grassy areas. Trees are visible in the background, and a seating area with wooden furniture is arranged on a patio. Soft natural light fills the room.

Guesthouse in Pendleton

5 out of 5 average rating, 30 reviews

Nested Studio Woodscape

Escape to our modern rustic and refined small studio apartment, nestled in the country. Tucked away in the trees, it sleeps four, with one bathroom. Experience the perfect blend of serene seclusion and contemporary comfort in this charming retreat. Ideal for nature lovers and close to nearby attractions. Book now for an unforgettable getaway!

Guest favorite

A travel trailer is parked on a gravel area surrounded by trees. The exterior features light colors with dark accents, while a picnic table is positioned nearby on a partially rocky ground.

Guesthouse in Six Mile

4.89 out of 5 average rating, 131 reviews

Camper at Hickory Lodge and Guesthouse

Simple, relaxed atmosphere on a nicely wooded property less than 10 minutes from public launch and Sunset Marina on Lake Keowee. Boat parking is available. Only 19 minutes from Memorial Stadium, 15 minutes from Seneca, Pickens, Clemson. LESS THAN A MILE FROM DUKE OCONEE PLANT Need another bedroom? Please see our other listings