Guesthouse vacation rentals in Anderson County

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Top-rated guesthouse rentals in Anderson County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

An inviting above-ground pool is surrounded by a wooden deck, set in an open field with lush grass. A wooden fence wraps around the area, and a sunset casts warm hues over the serene landscape.

Guesthouse in Abbeville

4.97 out of 5 average rating, 333 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Guest favorite

A porch swing is set on a wooden deck, adorned with plush cushions featuring intricate patterns. Lush greenery and colorful flowers are visible in the background, adding vibrancy to the serene outdoor setting.

Guesthouse in Six Mile

4.96 out of 5 average rating, 152 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Top guest favorite

A white swing hangs from a tree branch, positioned in front of a modern guesthouse with a metal exterior. Colorful chairs are visible on the porch, contrasting with the earthy tones of the surrounding landscape and the vibrant orange door.

Guesthouse in Honea Path

4.91 out of 5 average rating, 43 reviews

The Honey Flat

Welcome to this newly built flat with a loft in the town of Honea Path, SC. Providing the traveler with a cozy, fun place to sleep for up to 5 people. Perfect place for small family or individual travelers. Centrally located you will find a clean and comfortable atmosphere. Just 15 minutes from Erskine College and 25 minutes from Anderson. Come stay in our fully furnished guesthouse with unique decor and fun pops of color! We look forward to hosting you in our small town with a big heart.

Guest favorite

A wooden swing is positioned on the deck of the dock, overlooking the calm waters of Lake Hartwell. The serene landscape stretches into the distance, framed by tree-covered shores and a clear blue sky.

Guesthouse in Anderson

4.94 out of 5 average rating, 188 reviews

Private-Lake getaway-7 mile view from dock

Spacious two story guest house on a private road situated on Lake Hartwell. Use the double deck dock with 7 mile view for all day fishing, swimming or just relaxing. The guest house with central heating and air is fully furnished and has a fully equipped kitchen, wifi, 3 streaming flat screen tvs, two full baths, washer/dryer combo and a large attached deck. Owners live on property but in different residence. Outdoor cameras overlook parking area. Only reserved guests have property access.

Top guest favorite

A tranquil scene is captured with a covered dock situated on calm waters. Lush greenery surrounds the area, complemented by soft sandy shores. The sky displays a blend of clouds and blue, providing a serene backdrop to this peaceful lakeside location.

Guesthouse in Townville

5 out of 5 average rating, 23 reviews

Charming Waterfront Guest House

Cozy, yet spacious one-bedroom guest house nestled in a private, deep water cove with its own dock. Conveniently located just south of Interstate 85 and centrally located on the lake, our guest house provides a quiet escape with space for trailer parking and electric charging. Enjoy the convenience of being in close proximity to a public boat ramp. Whether you're seeking a peaceful retreat, or fishing tournament accommodations, our Airbnb is the perfect choice for your next lakeside adventure.

Superhost

The kitchen features wooden cabinetry and a stainless-steel refrigerator. A window with white blinds allows natural light, while a light fixture illuminates the countertop. Appliances include a stove, microwave, and dishwasher, with ample space for meal preparation.

Guesthouse in Anderson

4.85 out of 5 average rating, 193 reviews

Farmhouse by the lake - Private guest house

1,200 square foot apartment over a quiet barn on a cul-de-sac of a lake community. Near I-85, T. Ed Garrison Livestock Arena, downtown Pendleton, Clemson, and Lake Hartwell. Perfect for Clemson football games, horse/livestock shows or trail riding at Garrison Arena, lay over with horse, graduation, visiting your college student, fishing tournaments, or vacationing near Lake Hartwell. A private guest house overlooking sheep pastures and woods. Accessed by flight of stairs.

Top guest favorite

A wooden gazebo overlooks a serene pond surrounded by lush greenery. A single chair is positioned on the gazebo's deck, inviting relaxation while enjoying the tranquil view of the water and the natural landscape beyond.

Guesthouse in Donalds

4.99 out of 5 average rating, 371 reviews

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

Top guest favorite

A tranquil winter scene captures snow-covered branches and a snowy landscape. Soft clouds partially obscure the sun, creating a muted, serene atmosphere. Pathways meander through the pristine snow, while dried foliage adds texture in the foreground.

Guesthouse in Liberty

4.93 out of 5 average rating, 196 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Guest favorite

A modern guest house with dark wood siding is highlighted, featuring a stairway leading to a spacious deck. An orange chair adds a pop of color, while potted plants adorn the deck area, creating an inviting outdoor space surrounded by trees.

Guesthouse in Piedmont

4.99 out of 5 average rating, 89 reviews

Shou-Sugi-Ban Retreat on the Saluda River

The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Top guest favorite

A charming cottage is set among lush greenery, featuring a spacious deck that extends from the front. Large windows provide natural light, while surrounding trees and plants create a serene atmosphere.

Guesthouse in Greenville

5 out of 5 average rating, 120 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Guest favorite

A travel trailer is parked on a gravel area surrounded by trees. The exterior features light colors with dark accents, while a picnic table is positioned nearby on a partially rocky ground.

Guesthouse in Six Mile

4.9 out of 5 average rating, 125 reviews

Camper at Hickory Lodge and Guesthouse

Simple, relaxed atmosphere on a nicely wooded property less than 10 minutes from public launch and Sunset Marina on Lake Keowee. Boat parking is available. Only 19 minutes from Memorial Stadium, 15 minutes from Seneca, Pickens, Clemson. LESS THAN A MILE FROM DUKE OCONEE PLANT Need another bedroom? Please see our other listings

Top guest favorite

The glowing salt water pool is illuminated in vibrant blue under the night sky. A poolside deck provides access to lounge chairs, and the spacious cabana is visible in the background, its exterior lights enhancing the serene ambiance.

Guesthouse in Clemson

4.99 out of 5 average rating, 239 reviews

Clemson Cabana

Come & enjoy your own personal oasis. You'll have full private access to the salt water pool, mineral spa hot tub, outdoor ping pong table, and the gas grill. The cabana is designed for some major Rest & Relaxation. We are conveniently located less than a mile from local restaurants and grocery stores.