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Guesthouse vacation rentals in Suwannee River

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Suwannee River

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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The exterior of a charming guest house is illuminated by soft outdoor lights, highlighting its blue siding and white trim. A covered porch extends from the entrance, while potted plants line the pathway, set against a backdrop of trees and an open lawn.

Guesthouse in Gainesville

4.88 out of 5 average rating, 222 reviews

Sunflower Acres Cottage

Cute, cozy, freshly remodeled, private guest house on a beautiful 5 acre farm. Enjoy your own backyard herb garden with privacy fence, picnic table and fire pit. New kitchen with gas stove, microwave, toaster oven, coffee-maker, and dining area perfect for enjoying meals. The bedroom is equipped with a smart TV, queen bed, & extra blankets. This country getaway is near the University of Florida (12 miles), Blue Springs (21 miles) Ginnie Springs (24 miles), and historic High Springs (15 miles).

Top guest favorite

The inviting exterior features a two-story home framed by lush green grass and mature trees. Arched windows and a symmetrical design enhance the charm, while a driveway leads to the front entrance, providing easy access to the peaceful surroundings.

Guesthouse in Leesburg

4.98 out of 5 average rating, 398 reviews

Silver Lake Guest Pool House Very Private !

The Silver Lake Pool Guest house Is your home away from home 1400 sq feet plenty of room! The pool house is a peaceful place to relax or take a swim in a large salt water pool . Mt Dora Tavares, Eustis 10 to 15 minutes away from Pool house Forty five minutes Daytona, Tampa Smyrna beach and parks Minutes from grocery stores restaurants malls Full kitchen also grilling. We are happy to help you with your needs ! Home is great for couples families, solo adventurers, and business travelers

Top guest favorite

A bright kitchen features open shelving and stylish cabinetry with a farmhouse sink. A dining table is set for two, showcasing elegant dishware. Soft light is provided by a gold pendant light overhead, highlighting the clean lines and modern design.

Guesthouse in Jacksonville

4.98 out of 5 average rating, 250 reviews

Luxury Avondale Guest House, Walk to Shops

Featured in the Jacksonville Home Magazine! The Luxury Avondale Guest House is in the exquisite historic neighborhood of Avondale. Ten minutes from downtown sports & entertainment complexes, and several major health care facilities, St. Vincent's Hospital, Baptist Medical Center and the world renowned MD Anderson Cancer Center. Three short blocks to “The Shoppes of Avondale,” with an outstanding array of restaurants and venues to enjoy a streetside café-style meal, cocktail and desserts.

Top guest favorite

A well-appointed sleeping area features a spacious bed dressed in light gray bedding, flanked by two bedside tables with stylish lamps. Colorful wall art complements the space, while natural light streams through several textured windows, enhancing the tranquil ambiance.

Guesthouse in Gainesville

4.97 out of 5 average rating, 576 reviews

Renovated Private Studio - Walking Distance to UF

NEWLY RENOVATED - Enjoy your Gainesville stay in this mid-century modern studio 0.5 miles from UF and 2 miles from UF and HCA hospitals. No detail was overlooked in this beautifully designed detached guest house with an abundance of natural light, upscale finishes, and endless amenities - kitchenette, mini fridge/freezer, smart TV, and more! This conveniently located private and quiet space in the heart of Gainesville is perfect for anyone visiting for just one night or a few weeks.

A rustic cabin is nestled among trees, featuring a spacious front porch with a wooden railing. Two kayaks, one red and one orange, rest on the ground nearby. The structure has multiple windows allowing natural light inside, complemented by a sloped metal roof.

Guesthouse in Fort White

4.98 out of 5 average rating, 129 reviews

Adorable cozy cabin near North Florida Springs

Keep it simple at this peaceful cabin….Centrally-located to Itchetucknee Springs, Ginny Springs, Poe Springs, Blue Springs, Santa Fe River, Suwannee River. This area is popular for diving , snorkeling, boating, fishing, kayaking, tubing and hiking or just relaxing with nature. Full kitchen, living room and separate bedroom with a comfortable queen bed and walk-in closet. A large bathroom with walk-in shower. Wi-fi throughout. 42” smart tv in living room, 32” smart tv in bedroom.

Top guest favorite

A bright living area features a dark blue sofa with colorful cushions and a round dining table surrounded by four wooden chairs. Light-colored curtains frame the windows, and a flat-screen TV is mounted on the wall. A welcoming entry door is visible to the right.

Guesthouse in Ocala

5 out of 5 average rating, 188 reviews

Blue barn newly remodeled 12 blocks to downtown

Newly remodeled Queen bed & full sleeper sofa - sleeps 4 just 12 blocks to downtown Ocala 8 miles to the WEC ( World Equestrian Center). Detached from the main house w/washer dryer, fenced in patio, 1 parking space, full kitchen. Sorry no pets. Not baby proofed. Gigablast high speed internet. Air-Bnb is separated from the main house but on the same property. Please do not go in the back yard of the main house. Security Cameras records the outside gravel parking space.

The spacious living area features a comfortable sectional sofa in shades of gray, with decorative pillows for added comfort. Large windows allow natural light to stream in, with views of the surrounding greenery. A coffee table sits in front of the sofa, complemented by a dining table visible in the background.

Guesthouse in Archer

4.96 out of 5 average rating, 179 reviews

Your own private space of peace and quiet.

Keep it simple at this peaceful and centrally-located place. While being only 15 miles from the nightlife of downtown Gainesville, this is country living at it best. With no street lights the stars are bright and easily counted. The mornings are bright and full of the music of bird songs. The cute 2 bedroom apartment (one double bed, two single beds) is on the SECOND FLOOR. It is easy to get lost in the whisper of the trees. This is a place to rest your soul and unwind.

Top guest favorite

A modern guest house is showcased, featuring a light green exterior and a wooden deck with Adirondack chairs. Lush greenery surrounds the space, with trees providing shade and a small garden area visible in front. Natural light is welcomed through large windows.

Guesthouse in Gainesville

5 out of 5 average rating, 108 reviews

Azalea Guesthouse - Close to UF and downtown

Lots of character in this brand-new guest house located in the heart of town on a quiet canopied neighborhood and walking distance to UF, stores and coffee shops. Wake up in the morning to birds singing in the lush backyard, enjoy your coffee on the deck, or an evening stroll around the quiet neighborhood. Just a few blocks from UF and downtown, this retreat is perfect for your next Gator game weekend or to enjoy the nature, art and culture Gainesville has to offer!

A well-lit studio bedroom features a spacious bed covered with a light blue blanket. Two windows provide natural light, while a mounted television and air conditioning unit are positioned on the wall opposite the bed. Neutral colors create a calming environment.

Guesthouse in Gainesville

4.9 out of 5 average rating, 229 reviews

Downtown Studio - 1/2 Mile from UF Campus

This Downtown Studio has just been remodeled and is located on a very private and tranquil property situated in the heart of Gainesville. Half a mile from UF Campus and 1.5 miles to Shands Hospital / VA. Within a few blocks are many of Gainesville's favorite restaurants, coffee shops, museums and nightlife. Facilities available are: Amazon Fire TV with access to Netflix and Prime TV; high speed internet; induction cook-top, coffee press, microwave and a fridge.

A two-story black wooden structure is depicted, featuring a spacious balcony adorned with seasonal decorations. Stairs lead to the upper level, and a covered area with parking is visible below. Surrounding greenery includes tall trees, enhancing the natural setting.

Guesthouse in Lake City

4.88 out of 5 average rating, 1,088 reviews

Studio loft/ kitchenette/porch/bath

3 Miles from I75 exit 414 .studio apartment w/ porch over barn. Fire pit with wood available. Grill. Hammock swings under oaks. Stalls available. Close to riding/hiking trails in O'leno State Park. Close to springs for tubing/kayak/canoe. Ichetucknee Spring State Park, Ginny Springs, ++. Also 15 minutes from Santa Fe River and paddling/kayak/canoe rentals . Diving excursions available in High Springs. Quiet setting w/ pastures and grand daddy oaks.

A well-appointed studio apartment features an open layout with a combined kitchen and living area. Warm wood tones mingle with soft white walls, while leather seating surrounds a coffee table. A spacious bed with crisp linens is positioned near large windows, allowing natural light to fill the space.

Guesthouse in Jacksonville

4.96 out of 5 average rating, 258 reviews

Avondale Studio

Located in Avondale, Jacksonvilles historic district, this Garage Studio offers everything one needs for a getaway or a business trip. Walking distance to the Shoppes of Avondale. There are multiple restaurants/bars/outdoor cafe dining all within walking distance in either direction. The 2nd story garage apartment offers a balcony with views into Boone Park. Fully renovated in 2021 offering a full kitchen and bathroom. You have a private parking space as well.

A charming exterior features a light-colored wooden panel house surrounded by greenery. Pink azalea flowers bloom near the entrance. A wooden deck with a lattice design provides outdoor seating and accessibility, situated alongside a paved area leading up to the building.

Guesthouse in O'Brien

4.84 out of 5 average rating, 532 reviews

River Retreat

In the heart of Florida's cave diving region. Located right on the Suwannee River. Near by attractions; Royal Spring with Boat Ramp; 4 miles; Little River Spring; 8 miles;Troy Spring; 17 miles; Blue Hole Spring; 20 miles; Ichetucknee Spring; 22 miles; . As of now, the dock and stairs going down to the river are under re-construction. But can still get down to the river. I have 3 large dogs, let me know when you might arrive. So I can have them inside.

Vacation rentals for every style

Get the amount of space that is right for you

Apartments

Convenient locations with everyday essentials

Cabins

Kick off your hiking boots at these rustic lodgings

Cottages

Quaint homes, peaceful surroundings

Popular amenities for Suwannee River guesthouse rentals

Free parking on premises

Air conditioning

Family-friendly guest house rentals

Top guest favorite

A cozy sleeping loft is featured with a spacious bed, draped in an earthy orange and green bedding. Soft light emanates from a bedside lamp, complementing the warm hues of the room. Blackout curtains frame a window, enhancing privacy and comfort.

Guesthouse in Jacksonville

4.99 out of 5 average rating, 146 reviews

MidCentury Guesthouse-NO Cleaning Fee+Restaurants

A cozy swing chair is situated under a shade structure, surrounded by lush greenery. The view showcases a sparkling pool, sun loungers, and a large blue umbrella providing shade from the sun, creating a tranquil space for relaxation.

Guesthouse in Jacksonville

4.89 out of 5 average rating, 333 reviews

Private Bungalow with Pool/55” tv

Top guest favorite

An outdoor patio area features a screened enclosure with a private swimming pool. Comfortable seating is arranged around the pool, and lush greenery surrounds the space, providing a serene environment. Potted plants add a touch of color, enhancing the tranquil setting.

Guesthouse in Deer Island

4.95 out of 5 average rating, 125 reviews

Sapphire Cottage - sleeps 6, on 5 acres with canal

Top guest favorite

A cozy studio space features a comfortable bed dressed with white pillows and a beige throw. A small dining area with a table and chairs is visible in the background, along with a kitchenette equipped with a microwave and coffee-maker. A television is mounted on the wall.

Guesthouse in Gainesville

4.95 out of 5 average rating, 146 reviews

Getaway Guesthouse

Top guest favorite

An RV is parked on a concrete pad in a green area, featuring a retractable awning for shade. Nearby, simple steps lead to the entrance. The camper's exterior is a combination of silver and black, with a door and a small propane tank visible.

Guesthouse in Gainesville

4.92 out of 5 average rating, 128 reviews

Cozy Camper Stay

The exterior view showcases a two-story blue carriage house surrounded by lush greenery. A saltwater pool lies in the foreground, accompanied by paved seating areas featuring comfortable chairs. The fenced yard offers privacy, with mature trees providing ample shade.

Guesthouse in Jacksonville

4.97 out of 5 average rating, 122 reviews

Spacious 2/1 in historic walkable neighborhood

The exterior of the two-story farmhouse features a welcoming porch with wooden beams and decorative shutters. A paved walkway leads to the entrance, framed by lush greenery and small seating areas. The large glass doors provide a glimpse of the inviting interior.

Guesthouse in Fernandina Beach

4.8 out of 5 average rating, 169 reviews

Beautiful farmhouse in Fernandina Beach

A cozy studio features a spacious bed with a decorative blue and white coverlet. Natural light streams through the floral-patterned curtains, illuminating the wood-grain flooring. A ceiling fan, air conditioning unit, and various furniture pieces provide comfort and functionality within the inviting space.

Guesthouse in DeLand

4.9 out of 5 average rating, 485 reviews

The Cottage at True Trail Farm

Guest house rentals with a patio

A comfortable living area features a large sectional sofa adorned with yellow and grey cushions. A flat-screen television hangs above a decorative fireplace. A coffee table with a small plant is centered on a textured area rug, and natural light filters through the nearby windows.

Guesthouse in St. Augustine

4.9 out of 5 average rating, 264 reviews

SaraCasa - First Floor House 2Br/1.5Bath

The exterior of the guesthouse is set amidst a lush garden, featuring vibrant greenery and well-maintained foliage. A wooden staircase leads to the entrance, while a stone pathway winds through the landscape, providing a peaceful access point to the front door.

Guesthouse in Jacksonville

4.92 out of 5 average rating, 113 reviews

The Treehouse - Murray Hill

Top guest favorite

The exterior of the loft showcases a charming A-frame structure, accentuated by wooden beams and a warm glow from the illuminated windows. Soft string lights create an inviting atmosphere around the pathway, which is framed by lush greenery and leads to a shared firepit.

Guesthouse in Gainesville

4.95 out of 5 average rating, 249 reviews

Walk to UF! Historic King Bed Loft w/ Private Deck

Top guest favorite

A charming single-story house with a yellow exterior is surrounded by mature trees. A decorative wall feature is visible near the entrance, complemented by neatly arranged plants. A gravel pathway leads to a small patio area, with seating options evident within the enclosed yard.

Guesthouse in Mount Dora

4.95 out of 5 average rating, 133 reviews

Adorable Private 1-Bedroom guesthouse with deck

Top guest favorite

A serene sunset is captured over a sprawling green landscape, featuring distant trees and a winding driveway that leads into the horizon. Fencing outlines the fields, with soft clouds painted in hues of orange and pink across the evening sky.

Guesthouse in Reddick

5 out of 5 average rating, 129 reviews

Ocala - Reddick Equestrian Studio Apartment.

Top guest favorite

A charming kitchen features a bright red retro refrigerator and a compact microwave, with wooden countertops providing ample workspace. White cabinetry offers storage, while black and white patterned tiles complete the floor. A coffee maker is prominently displayed, adding to the functional design.

Guesthouse in Mount Dora

4.99 out of 5 average rating, 142 reviews

The Idle Hour Cottage - Walk to Downtown!

A serene landscape features a hammock strung between two palm trees, overlooking a grassy expanse. The sky is adorned with vibrant hues of pink and orange, signaling a beautiful sunrise. Silhouettes of trees frame the scene, creating a tranquil atmosphere.

Guesthouse in Ponte Vedra Beach

4.92 out of 5 average rating, 144 reviews

Guesthouse/TPC/Guana Views/Walk Beach/Hot Tub

Top guest favorite

A two-story guest house is surrounded by vibrant greenery, featuring a staircase leading to a welcoming entrance. Natural light highlights the exterior, which includes large windows and a simple design, offering a sense of tranquility and connection to nature.

Guesthouse in Gainesville

5 out of 5 average rating, 101 reviews

"Nest" in the Guest House up in the Trees near UF

Guest house rentals with a washer and dryer

Top guest favorite

A spacious living area features two armchairs with wooden accents, a flat-screen television, and a decorative cabinet. Air conditioning is conveniently located, while a sunlit area leads to a bedroom space in the background. Neutral-colored walls and carpet create a calming atmosphere.

Guesthouse in Ocala

4.94 out of 5 average rating, 333 reviews

A Garden Cottage

A modern kitchen features ample counter space with quartz countertops and a marble backsplash. Stainless steel appliances include a refrigerator, oven, and dishwasher. A large sink is positioned beside light wooden cabinetry, with decorative pendant lights illuminating the area.

Guesthouse in Jacksonville

4.88 out of 5 average rating, 299 reviews

Downtown Jacksonville Historic District

A modern kitchen is showcased with sleek gray cabinets and stainless steel appliances. A spacious island with a granite countertop provides seating for four, while pendant lights illuminate the area. White cabinetry and warm wood flooring enhance the inviting space.

Guesthouse in Sanford

4.95 out of 5 average rating, 164 reviews

Little Hidden Cottage- Near Sanford Airport

Top guest favorite

A spacious living area features a light-colored sofa, complemented by a wooden coffee table with books. A cozy bed is visible in the background, alongside a modern fan and decorative wall art. Soft gray tones create a relaxing ambiance throughout the room.

Guesthouse in St. Augustine

4.99 out of 5 average rating, 377 reviews

Pelican Guesthouse-Spacious/Quiet/Comfortable

The exterior of the guest house is showcased, featuring a welcoming porch with red doors flanked by white railings. Lush greenery surrounds the pathway, while a lighted pergola is visible to the side, creating inviting outdoor spaces in a tree-lined setting.

Guesthouse in Orange Park

4.91 out of 5 average rating, 170 reviews

Graceful Southern Guesthouse + Outdoor Living Area

Top guest favorite

A well-appointed kitchen features a retro teal refrigerator and modern appliances set against dark blue cabinetry. White countertops provide ample prep space. A dining area with wooden bar stools invites casual meals, while a vibrant artwork on the wall adds a touch of character to the room.

Guesthouse in Jacksonville

4.96 out of 5 average rating, 165 reviews

Stylish Bungalow Near Dining,Parks & Entertainment

Top guest favorite

A comfortable living area features a blue sectional sofa facing a flat-screen TV and a built-in bookshelf with decorative items. A round dining table is visible, alongside a wooden chair and a cozy rug on hardwood flooring. Large windows allow for natural light.

Guesthouse in St. Augustine

4.96 out of 5 average rating, 821 reviews

1 Block to Dtown!☆Kitchen☆Free Parking☆Super Clean

A covered porch is showcased, adorned with climbing plants and vibrant foliage. Two sets of double doors lead into the cottage. A mix of potted plants and outdoor seating arrangements provides a welcoming atmosphere, inviting guests to enjoy the surrounding natural beauty.

Guesthouse in Mount Dora

4.88 out of 5 average rating, 335 reviews

A Lakeshore Cottage vintage 1926

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