
Hotel vacation rentals in St. Charles County
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Top-rated hotel rentals in St. Charles County
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for St. Charles County hotel rentals
Family-friendly hotel rentals

Midwest Guest Room "E"
The room was perfect for what I needed. Very simple but definitely worth the price. It was nice to come back to a quiet place after working doubles and being able to relax and sleep.

King Redwood Bedroom at BnB in CWE!
We had a fantastic time staying here during our time in St. Louis! Our room was spacious and comfortable. We really appreciated the great kitchen area and the breakfast foods and coffee/tea that were provided - thank you! It was also super nice to be able to leave our bags after checkout and pick them up in the evening before our night time flights.

Midwest Guest Room "B"
We have stayed at this location several times and always have enjoyed ourselves. It is a great value for the money.

Blue Spruce Room Queen Bed at BnB in CWE!
Great stay, second time in this location, will be interested in coming back

Midwest Guest Room "C"
This place is perfect for us every time we come to Wentzville. The campus setting is peaceful, and the location is handy to the places we love to visit.

Midwest Guest Room "H"
This place was exactly what I needed for a quiet work location. The room was spacious, and the stay was quiet, without interruption, allowing me to get much-needed work done. The bed was comfortable, and the two large desks allowed me plenty of room to spread out. The wifi worked well for my needs. I would definitely stay here again for a quiet work time or a much-needed retreat from hectic daily life.

Evergreen Room Queen Bed at BnB in CWE
We really enjoyed this Airbnb! They had such clear instructions both in the bathroom and kitchen - I wish more Airbnb’s were that thorough.

Midwest Guest Room "D"
We stayed 5 nights for a national horse show. Very convenient and a great price!
Hotel rentals with a pool

Home Away From Home | Free Airport Shuttle
Thank you so much, the room was cozy and clean, and everything went smoothly with check-in and check-out!!

St. Louis Suite l Swimming. Gym. Free Breakfast.
Enjoyed my stay, will certainly be back!

Downtown Studio l Swimming. Gym. Free Breakfast.
Prefect area, next view from the room, front desk staff was nice and helpful, breakfast there was good and they had a lot of food out. Will be staying here again.

Perfect Getaway Near The Airport | Free Breakfast
Nice place and good service room, good restaurant and food but the waitress wasn't friendly but I had a great experience besides that

Luxury Queen Room Near Airport | Free Shuttle
Hotel rentals with a patio

Lovely spacious 2 room King suite, super quiet
I'm a repeat visitor at Tim's. I have occasional work in the area and appreciate that his place is so close to my destination. The place is clean and comfortable. Appliances are all new. Wifi was solid for me to stream a show and maintain fast remote connection to my client's site for after hours work. There's Aldi's grocery a few blocks away so I shop and eat in for time and cost savings. Tim is super responsive, always helpful.

#3 Betty Bloomer Le Velo Inn
We had never been to St. Louis or the surrounding area prior to booking our stay - and honestly would come back again just to book at Le Velo Inn! It is a great launch for day trips into St. Louis, but it could easily be the primary destination itself. There are many neat shops, cafes, and restaurants within close proximity, yet we found it to be very peaceful and relaxing. It is evident that the owners care about the history and character of the building. As individuals who were new to the area, we felt like we were invited into the history of St. Charles and were able to see what makes it so special. The room/suite itself was wonderful and extremely well-equipped with everything you would need for a getaway, and a luxurious one at that! It was nice to have our own private entrance to the street as well and parking was very easy and convenient. We highly recommend and would absolutely stay here again! Le Velo Inn was a gem that made our trip even more memorable!

#4 Penny Farthing Le Velo Inn
This is our second stay at Susanne’s wonderful place, and we can confidently say we’ll always choose to return whenever we’re in the area!

1st Capitol Mansion - Suite 302
We had a wonderful stay at Jon’s charming vintage home! It has all the nostalgic charm of a classic college apartment—think character, cozy vibes, and personality—but with the added bonus of thoughtful renovations, true cleanliness, and modern comforts. One of our favorite features was the beautiful wooden staircase accented by a lovely stained glass window—it made every trip upstairs special. The price was very reasonable, especially for the quality of the space, and Jon was a friendly, attentive host who made sure everything was just right. Highly recommend if you're looking for something unique, welcoming, and budget-friendly!

Napoleon's Retreat - Lafayette Room
Stayed nearly two weeks here. Lovely, private and very quiet, despite being on a busy street. The park a block away is amazing. House was impeccably clean. I’m looking forward to working in St. Louis again so I could stay here on another trip.

Luxury Retreat, Hot Tub,En-Suite Bath, Location+
The building is gorgeous, wonderful design, welcoming and comfortable rooms. We had everything we needed for our romantic overnight. The view from the hot tub at night can't be beat, and the two person soaker tub in the Riverfront room really was big enough for two!

Luxury Retreat, Hot Tub,En-Suite Bath, Location+
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.

Luxury Retreat, Hot Tub,En-Suite Bath, Location+
Absolutely wonderful stay! Had a kitchen for use! Also was very thoughtful and had random necessities for use if you forgot yours during travel! Very beautiful and would definitely stay again!!!
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- Busch Stadium
- Six Flags St. Louis
- Saint Louis Zoo
- Central West End
- Enterprise Center
- Gateway Arch National Park
- Missouri Botanical Garden
- City Museum
- St. Louis Aquarium at Union Station
- Cuivre River State Park
- Pere Marquette State Park
- Meramec State Park
- Saint Louis Science Center
- The Winery at Aerie's Resort
- Cathedral Basilica of Saint Louis
- Castlewood State Park
- St. Louis Country Club
- Missouri History Museum
- Grafton Winery the Vineyards
- Hidden Valley Ski Resort
- Adventure Valley Zipline Tours and Paintball Park
- Raging Rivers WaterPark
- Norwood Hills Country Club
- Boone Valley Golf Club