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Hotel vacation rentals in St. Charles County

Find and book unique hotel rentals on Airbnb

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Popular amenities for St. Charles County hotel rentals

Family-friendly hotel rentals

The exterior of a two-story brick building is shown, featuring multiple windows arranged symmetrically. A sloped roof with gables complements the overall design. Surrounding grass-covered land and a paved parking area create an open, unobstructed view.
Private room in Wentzville
4.63 out of 5 average rating, 64 reviews

Midwest Guest Room "E"

ElijahRating, 5 stars14 months ago
The room was perfect for what I needed. Very simple but definitely worth the price. It was nice to come back to a quiet place after working doubles and being able to relax and sleep.
Guest favorite
A spacious room features a King-sized bed adorned with a patterned throw, accompanied by a pullout sleeper sofa. Two pieces of wall art add a touch of color, while a large television and a dark wood cabinet provide functionality. Soft lighting enhances the inviting ambience.
Hotel room in St. Louis
4.9 out of 5 average rating, 896 reviews

King Redwood Bedroom at BnB in CWE!

RachelRating, 5 stars2 weeks ago
We had a fantastic time staying here during our time in St. Louis! Our room was spacious and comfortable. We really appreciated the great kitchen area and the breakfast foods and coffee/tea that were provided - thank you! It was also super nice to be able to leave our bags after checkout and pick them up in the evening before our night time flights.
The exterior of a two-story brick building is presented, featuring a red roof and multiple windows. A grassy area surrounds the structure, contributing to the peaceful environment. The entrance is highlighted by a central porch supported by white pillars.
Private room in Wentzville
4.73 out of 5 average rating, 91 reviews

Midwest Guest Room "B"

JimRating, 5 stars2 months ago
We have stayed at this location several times and always have enjoyed ourselves. It is a great value for the money.
Guest favorite
A bright bedroom is adorned with a light blue wall, creating a serene atmosphere. The spacious bed is covered with a decorative blanket, flanked by crisp white linens. A bedside table and a dresser provide practical storage, while a large window allows natural light to fill the room.
Hotel room in St. Louis
4.87 out of 5 average rating, 720 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

TannerRating, 5 stars2 weeks ago
Great stay, second time in this location, will be interested in coming back
The exterior of a two-story brick building is presented, featuring a pitched roof with gables. Windows are evenly spaced across the facade, providing natural light. The surrounding landscaping includes grassy areas, contributing to a neat and unobtrusive appearance.
Private room in Wentzville
4.76 out of 5 average rating, 63 reviews

Midwest Guest Room "C"

JimRating, 5 stars24 months ago
This place is perfect for us every time we come to Wentzville. The campus setting is peaceful, and the location is handy to the places we love to visit.
A two-story brick building is presented with a sloped, brown roof and symmetrical design. Windows are evenly spaced along the facade, which is complemented by manicured landscaping and a paved driveway. The surrounding area features open green spaces.
Private room in Wentzville
4.73 out of 5 average rating, 22 reviews

Midwest Guest Room "H"

EmilyRating, 5 stars10 months ago
This place was exactly what I needed for a quiet work location. The room was spacious, and the stay was quiet, without interruption, allowing me to get much-needed work done. The bed was comfortable, and the two large desks allowed me plenty of room to spread out. The wifi worked well for my needs. I would definitely stay here again for a quiet work time or a much-needed retreat from hectic daily life.
Guest favorite
A welcoming guest room features a queen-sized bed with a brass frame and patterned bedding. A wooden side table is positioned beside the bed. A small work desk and chair are situated near the window, while soft lighting casts a warm glow in the space.
Hotel room in St. Louis
4.87 out of 5 average rating, 634 reviews

Evergreen Room Queen Bed at BnB in CWE

JocelynRating, 5 stars2 weeks ago
We really enjoyed this Airbnb! They had such clear instructions both in the bathroom and kitchen - I wish more Airbnb’s were that thorough.
Guest favorite
A two-story brick building is presented, featuring white accents and a gable roof. Large windows are visible on the facade, offering a glimpse of the serene surroundings. The landscaped area includes a green lawn, enhancing the quiet appeal of the location.
Private room in Wentzville
4.71 out of 5 average rating, 92 reviews

Midwest Guest Room "D"

LauraRating, 5 stars1 month ago
We stayed 5 nights for a national horse show. Very convenient and a great price!

Hotel rentals with a patio

The living area features two gray futons facing each other, providing flexible seating arrangements. A dark wooden coffee table sits centrally, adorned with a small potted plant. Natural light enters through the window, highlighting the room's neutral gray walls and wooden flooring.
Private room in St. Louis
5 out of 5 average rating, 10 reviews

Lovely spacious 2 room King suite, super quiet

KathyRating, 5 stars21 months ago
I'm a repeat visitor at Tim's. I have occasional work in the area and appreciate that his place is so close to my destination. The place is clean and comfortable. Appliances are all new. Wifi was solid for me to stream a show and maintain fast remote connection to my client's site for after hours work. There's Aldi's grocery a few blocks away so I shop and eat in for time and cost savings. Tim is super responsive, always helpful.
Top guest favorite
The spacious bedroom features a king-size bed covered with a soft white bedspread. A vibrant mural adorns one wall, while exposed brick adds a historical touch. Hardwood flooring contrasts with the patterned black and white area rug. A large window allows natural light to fill the room.
Hotel room in Saint Charles
5 out of 5 average rating, 13 reviews

#3 Betty Bloomer Le Velo Inn

KristaRating, 5 stars2 months ago
We had never been to St. Louis or the surrounding area prior to booking our stay - and honestly would come back again just to book at Le Velo Inn! It is a great launch for day trips into St. Louis, but it could easily be the primary destination itself. There are many neat shops, cafes, and restaurants within close proximity, yet we found it to be very peaceful and relaxing. It is evident that the owners care about the history and character of the building. As individuals who were new to the area, we felt like we were invited into the history of St. Charles and were able to see what makes it so special. The room/suite itself was wonderful and extremely well-equipped with everything you would need for a getaway, and a luxurious one at that! It was nice to have our own private entrance to the street as well and parking was very easy and convenient. We highly recommend and would absolutely stay here again! Le Velo Inn was a gem that made our trip even more memorable!
Guest favorite
A spacious bathroom features rustic brick walls and a striking freestanding tub. A glass shower enclosure is situated nearby, with natural light filtering through a textured window. Decorative lighting is integrated into a cozy nook, adding a warm touch to the inviting space.
Hotel room in Saint Charles
5 out of 5 average rating, 18 reviews

#4 Penny Farthing Le Velo Inn

JustinaRating, 5 stars1 week ago
This is our second stay at Susanne’s wonderful place, and we can confidently say we’ll always choose to return whenever we’re in the area!
A spacious family room features a modern black leather sofa and a wooden coffee table, positioned over polished hardwood floors. A decorative wall clock and a piece of art adorn the walls, with a cozy fireplace as a focal point. Natural light enters through the windows.
Hotel room in Saint Charles
4.57 out of 5 average rating, 14 reviews

1st Capitol Mansion - Suite 302

MarthaRating, 5 stars2 weeks ago
We had a wonderful stay at Jon’s charming vintage home! It has all the nostalgic charm of a classic college apartment—think character, cozy vibes, and personality—but with the added bonus of thoughtful renovations, true cleanliness, and modern comforts. One of our favorite features was the beautiful wooden staircase accented by a lovely stained glass window—it made every trip upstairs special. The price was very reasonable, especially for the quality of the space, and Jon was a friendly, attentive host who made sure everything was just right. Highly recommend if you're looking for something unique, welcoming, and budget-friendly!
Top guest favorite
The exterior of a historic Victorian house is presented, featuring a light-colored facade with decorative motifs around the windows. Lush greenery frames the entrance, with manicured hedges leading to the front steps. The building showcases multiple stories and distinctive architectural details.
Hotel room in St. Louis
4.96 out of 5 average rating, 57 reviews

Napoleon's Retreat - Lafayette Room

AmeliaRating, 5 stars3 weeks ago
Stayed nearly two weeks here. Lovely, private and very quiet, despite being on a busy street. The park a block away is amazing. House was impeccably clean. I’m looking forward to working in St. Louis again so I could stay here on another trip.
Guest favorite
An open living area with high, wooden ceilings features a spacious kitchen adorned with dark granite countertops. Intricate stained glass windows fill the space with natural light, while a grand staircase and wooden dining area are visible, creating a welcoming atmosphere.
Hotel room in St. Louis
4.97 out of 5 average rating, 34 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

HeatherRating, 5 stars1 month ago
The building is gorgeous, wonderful design, welcoming and comfortable rooms. We had everything we needed for our romantic overnight. The view from the hot tub at night can't be beat, and the two person soaker tub in the Riverfront room really was big enough for two!
Top guest favorite
The exterior of a restored Gothic-style church features a red brick facade and intricate architectural details. Two prominent stained glass windows are showcased, while a tower rises elegantly, capped with a rooftop area. Lush greenery and flowering plants enhance the entrance, contributing to the inviting atmosphere.
Hotel room in St. Louis
5 out of 5 average rating, 12 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

AkshayRating, 5 stars3 months ago
This is a hidden gem that is maintained exceptionally well. The check in was smooth and the owners are very friendly. Only time we saw them was when we checked in and they gave us a tour of the place. The entire property is squeaky clean and provides every comfort offered in a five star hotel. I've stayed in many five star hotels across the world (Ritz Carlton, Four Seasons, Waldorf Astoria) and this is arguably better than those places given the unique experience it offers and the character of this place. I would definitely recommend this to anyone looking for a unique experience in St. Louis. It is also located in close proximity to a lot of local attractions.
Top guest favorite
The exterior of the historic Gothic-style church showcases a unique blend of brick and stone architecture, featuring decorative arched windows and a prominent turret. Lush greenery surrounds the property, while an outdoor patio area with stone seating adds to the inviting atmosphere.
Hotel room in St. Louis
5 out of 5 average rating, 26 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

StephanieRating, 5 stars3 weeks ago
Absolutely wonderful stay! Had a kitchen for use! Also was very thoughtful and had random necessities for use if you forgot yours during travel! Very beautiful and would definitely stay again!!!

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