Hotel vacation rentals in St. Charles County

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Top-rated hotel rentals in St. Charles County

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Hotel room in St. Louis

4.91 out of 5 average rating, 122 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings, a fully-equipped kitchen with black stainless appliances and quartz countertops, a spacious walk-in closet, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, and bright 7’ industrial steel-frame windows with views of the tree-lined street and shops below. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

A spacious communal lounge area is featured, with multiple seating arrangements including gray sofas and leather chairs. Light wood flooring complements the modern decor, while standard ceiling lights enhance the bright atmosphere. Potted plants add a touch of greenery, creating a welcoming environment.

Hotel room in St. Louis

4.74 out of 5 average rating, 65 reviews

The West End by Cortex, Forest Park, BJC & Zoo

Welcome to The West End, your ideal retreat in the heart of the Central West End! Just steps away from charming attractions like forest park. Great amenities are: - Fast and stable fiber internet connection - Communal kitchen with 2 sets of range, ovens, fridges, microwaves, and dishwashers. - Complimentary coffee - Secured Gated Parking $10/Night - Hot Tub - Great patio space with seating and a gas grill - Complimentary Netflix, Hulu, Disney+, and ESPN+, where available and local TV channel

Top guest favorite

An inviting common area showcases rich mahogany woodwork and vibrant stained-glass windows. A cozy seating arrangement is complemented by a small side table with a lamp, creating a warm space for relaxation. Decorative chairs and a staircase evoke the building's historic charm.

Hotel room in St. Louis

5 out of 5 average rating, 14 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Enjoy timeless elegance in our World's Fair Suite, set within a church-converted-Inn in the heart of St. Louis. This luxurious space features soaring ceilings, original 1900s stained-glass windows, and rich mahogany woodwork. Unwind in the plush four-poster king bed, or pamper yourself in your private en-suite bath with heated floors. Cap off your evening in our rooftop hot tub with stunning city views. One of 4 exclusive suites at our Inn, perfect for romantic getaways or peaceful retreats.

Top guest favorite

The exterior of a historic brick building is illuminated under a dusk sky, featuring a curved sign with the name of the establishment. Three entrances are visible, with two doors framed by outdoor lighting and a small balcony above, contributing to the architectural character.

Hotel room in Saint Charles

5 out of 5 average rating, 18 reviews

#2 Swiftwalker Parade LeVelo Inn

Make some memories at this unique and family-friendly place.Under the copper eyebrow on the front of the building, this door will lead you down a hallway that will take you to an original staircase of this historic building. Lots of natural light as well as an exterior door that exits out to a parade balcony to check out life on N 2nd Street. king-size bed, living area with large sectional couch for a comfortable stay extra guests with an extra thick queen mattress. Private kitchen/dining.

A private bathroom features a white toilet and a wooden cabinet with a sink. Light orange walls complement the color of two folded towels hung above the cabinet. A framed piece of art and a green lamp add character to the space, illuminated by soft lighting.

Hotel room in Alton

4.95 out of 5 average rating, 39 reviews

Three Bedroom River View Guest House-3 Bathrooms

An escape from the ordinary in our River view guest house. On bottom level is an art glass shop offering classes in stained , fused, and mosaic art glass you may partake in at an additional cost. Bicycle built for two available for cycling the national scenic byway. Walk to shops, casino, restaurants, breweries, and concerts. Cruise ship dock is 1/2 mile away. Extend your stay before or after to enjoy taking a stained glass class offered in our shop below as a souvenir of your trip.

Superhost

The indoor pool area features a hot tub with bubbling water and a lane pool in the background. Large windows allow natural light to fill the space. A mural depicting underwater scenery adorns the wall, enhancing the aquatic ambiance.

Hotel room in Brentwood

The Best of Suite Living! Ideal for Work & Leisure

By staying at our property, you can make the most of your trip, whether it's for work or pleasure. We are conveniently located near renowned destinations including Hanley Park, the St. Louis Children's Aquarium, and Oak Tree Park in the Brentwood neighborhood. We are close to Whole Foods Market, Applegate's Deli, and Camille's Sidewalk Cafe, among other well-known restaurants. You can grab a free breakfast in the morning and get a head start on your day. Enjoy the free parking and Wi-Fi.

Guest favorite

A walk-in rain shower features contemporary gray tile walls and a textured tile floor. Clear glass doors provide an open view of the spacious shower area. A shelf for toiletries is mounted on the wall, and natural light enters through a nearby window.

Hotel room in St. Louis

4.85 out of 5 average rating, 764 reviews

The Maple Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

The mansion exterior features classic red brick with white trim and large windows. Architectural details are evident in the gables and decorative elements, while a welcoming front porch extends from the main entrance. Lush green grass surrounds the property, providing a serene atmosphere.

Hotel room in Saint Charles

4.78 out of 5 average rating, 224 reviews

1st Capitol Mansion Boutique Hotel - Suite 201

This unit is a hotel style unit that is located in the heart of downtown historic St. Charles. It's located right across the street from a coffee shop, wine bar and the oldest local pub in St. Charles. It is just a few blocks away from all of the shopping and restaurants on Main St. The mansion was built in 1902 and still holds all of the charm from back then. This is a private suite with it's entrance from the rear of the building right off the parking lot.

A vibrant display of illuminated fountains is presented in a park setting, with colorful lights casting reflections on the water. The Gateway Arch is visible in the background, framed by trees and buildings, all under a night sky.

Hotel room in St. Louis

4.65 out of 5 average rating, 20 reviews

Downtown Suite l Swim. Gym. Free Breakfast.

Welcome to Residence Inn by Marriott St. Louis Downtown, nestled in Missouri! We provide a great location in downtown St. Louis, spacious lodgings, and great facilities such as a pool and fitness center. Enjoy a daily breakfast buffet - on us! Then, head out to one of the nearby attractions, such as The Gateway Arch and St. Louis Zoo. ✔ Pool ✔ Fitness center ✔ Free breakfast ✔ Pet-friendly ✔ Indoor and outdoor fireplaces ✔ Mini-market ✔ Downtown location

Superhost

A modern king bedroom features a spacious bed adorned with crisp white linens. A cozy sitting area is included, with a vibrant orange chair and side table. Natural light filters through sheer curtains, illuminating the workspace with a desk and ergonomic chair.

Hotel room in Berkeley

4.43 out of 5 average rating, 14 reviews

Near STL Airport + Free Shuttle & Pools

Experience luxury at Renaissance St. Louis Airport Hotel, just a mile from St. Louis Lambert International Airport with a free airport shuttle. Relax at our indoor and outdoor pools, or stay fit in our gym. Ideal for leisure, with nearby access to Enterprise Center, Delmar Loop, and top attractions like Missouri Botanical Gardens & Gateway Arch Riverfront. Perfect for travelers seeking comfort and convenience.

Hotel room in Saint Charles

5 out of 5 average rating, 4 reviews

The Hare Suite at Divine Otter

The Hare Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape, sleeping up to 2 guests. Enjoy upscale furnishings, a modern design, and a spacious full bathroom with plenty of natural light. Located in the heart of Historic Main Street Saint Charles, you’ll be steps away from shops, dining, and more. This impressive suite is the perfect blend of comfort and location!

A tranquil garden scene features a decorative bridge spanning a small pond filled with goldfish. Surrounding the pond, various plants and rocks create a natural landscape, while a wooden fence and trees provide a serene backdrop.

Private room in Ferguson

5 out of 5 average rating, 4 reviews

Haunted 1905 Victorian home

We offer a unique opportunity to sleep in a 100 year old haunted house. There are two known spirits that have been heard and seen on the premises. The bedroom is a simple affair on the third floor, but the center of paranormal activity. For an additional fee, guests can participate in casting a spell of their choice or receive a tarot reading in an authentic witch apothecary.