
Hotels in South San Francisco
Find and book unique hotels on Airbnb
Top-rated hotels in South San Francisco
Guests agree: these hotels are highly rated for location, cleanliness, and more.

Sophisticated Stay | Cable Cars Tours. Gym
Located on Market Street, Hyatt Regency San Francisco Downtown SOMA is a sophisticated destination hotel close to the city’s most innovatively stimulating sights. Attractions are just nearby: ✔Picturesque picnics at Golden Gate Park ✔Contemporary and modern paintings, photographs, sculptures and designs from the 20th century, all housed at SF MOMA ✔Postcard-worthy shots, at Golden Gate Bridge ✔Beaux-Arts wonder, the Palace of Fine Arts ✔Best views of San Francisco at Twin Peaks

Studio Suite in the cultural Epicenter of San Fran
Just one block from Union Square, this resort is ideally located to explore all the San Francisco sights. Just a short walk or iconic cable car ride away from popular attractions in the Bay Area & Michelin star eateries. Covid-19: Enhanced cleaning protocols in place. • Guest checking in must be 18+ with valid ID & card for $250 refundable security deposit (credit card only) • Name on reservation must match photo ID at check-in • Valet parking on-site for $57 + tax per night

Book-filled Writer’s Alcove in the lobby
Channeling the spirit of the Beat Generation, every room at Hotel Emblem is a creative retreat featuring a writing desk with an inspiration board. Enjoy plush pillowtop beds with Italian linens, a 55" HD TV, and unique touches like a meditation bowl, typewriter, and coloring books. Thoughtful amenities include in-room coffee and tea, ROIL bath products, and high-speed internet. With pet-friendly options and hotel bikes, your San Francisco stay is both inspiring and comfortable.

Bay Area Escape | Hotel Room. Free Breakfast
If you plan to explore the Bay Area, The Millwood Inn & Suites is a great jumping-off point. This quaint hotel is located in Millbrae, California, only minutes from Bay Area attractions such as the Golden Gate Bridge. It is also only a six-minute drive from San Francisco International Airport, perfect for those flying in! Be welcomed into a world of comfort and convenience after a long day of exploring California's best. ✔ Free breakfast ✔ Free parking ✔ Fitness center

Fun Escape | Happy Hour. Game Room. Location.
Axiom Hotel, a 4-star establishment in San Francisco's city center, is an ideal accommodation for those looking for a fun hotel to stay in during their trip to SF. It features a fitness center and a game room. Guests can also venture out to see prime attractions nearby, like Moscone Center and the Ferry Building. ✔ Fitness center ✔ Robot-delivered room service ✔ Pet-friendly ✔ Arcade games ✔ Cafe on-site ✔ Breakfast, lunch, dinner, boba and a full bar

Near Coyote Hills Park | Free Breakfast + Kitchen
Residence Inn Fremont Silicon Valley offers a relaxing home base in one of the Bay Area’s most convenient locations. Located just minutes from shopping, dining, Lake Elizabeth, and top attractions like Great America Theme Park, this extended-stay hotel blends apartment-style suites with thoughtful hotel amenities. Whether you're traveling for business or leisure, enjoy a full kitchen, complimentary hot breakfast, outdoor pool, and 24/7 fitness access.

Book today for Private Studio-Free Wifi-Union Sqre
Private HOTEL room w/private bathroom, THE DONATELLO in UNION SQUARE (sleeps 4)in heart of San Francisco $250 ref. sec dep. and valid Gov't photo ID at front desk at check-in If you are not happy with the room assigned or have a special request (room with terrace as shown street view/upper floor etc), Please see front desk Your room is assigned at time of check-in. Therefore, you may not get the room, as shown in the pictures, but very similar.

Monroe Studio 325
The Monroe Residence Club is a residential hotel located centrally in the heart of San Francisco with public transportation at our doorstep and local shops and businesses nearby. It is conveniently located just a block from Whole Foods, blocks from a the iconic Lafayette Park, within walking distance of several hospitals and more! The Monroe offers 24-hour front desk security, breakfast and dinner on-site, as well as common areas for congregating.

King Bed at Shashi Hotel in Mountain View
Experience our King room type at Shashi Hotel Mountain View, an Urban Resort. Conveniently, located in the heart of the Silicon Valley - walking distance to Shoreline Amphitheatre. Taste incredible cocktails and delicious bites at our Emerald Hour Bar designed by our Michelin-rated Chef. Enjoy complimentary amenities including our outdoor pool, fitness center, sauna and steam rooms. New for 2025 - daily wine tasting, yoga, zumba, and live music.

Nob Hill Inn 1 Bedroom Apartment
This 1-bedroom apartment with a living room in the heart of Nob Hill offers the perfect blend of comfort and convenience. What makes this space special is the combination of privacy and space, featuring a separate living area for relaxation and a well-appointed bedroom for restful nights. Located in the prestigious Nob Hill neighborhood, you’ll be steps away from top San Francisco attractions, iconic landmarks, and local dining gems.

Silicon Valley Inn, 1 Full Bed
Fuss-free motel-style setup right off Route 82, a 5-minute stroll from Belmont train station and 3 miles from Hiller Aviation Museum. San Mateo, San Carlos and Redwood City are easily accessible via CalTrain. Your room charge will be paid prior to your arrival. The remaining balance of taxes (12% City Transient Tax) will be charged upon arrival. A refundable security deposit of $XX will also be collected.

The Clift Royal Sonesta San Francisco, Deluxe king
Experience the perfect blend of historic charm and modern style in our newly renovated deluxe king room. Relax in a plush king bed, enjoy a spa-inspired rainfall shower, and stay productive at the sleek work desk. With premium amenities like a mini-bar, Keurig coffee maker, streaming TV, and complimentary WiFi, your stay is both luxurious and convenient.
Popular amenities for South San Francisco hotels
Family-friendly hotels

Bed in 6-Bed Mixed Dorm with AC

1 Bed Female Dorm w/Private Bath

King Bed | Travelodge SF Bay | Near Chase Center

Staypineapple, An Elegant Hotel, Union Square, ...

Near Great America Theme Park + Breakfast & Pool

New Sanctuary In The City | Rooftop Bar

Near Oracle HQ | Free Breakfast + Full Kitchen

Minutes to Airport | Pool + Free Breakfast
Hotels with a pool

Hotel Fiona, Deluxe king courtyard

Berkeley Marina Views + On-site Dining. Pool. Gym.

Handlery Union Square Hotel, Selected by hotel

Deluxe King Bed, Hotel Nikko SF w/ Valet Parking

Near Santana Row & San Jose Convention Center

Hotel Nikko, Deluxe king

Riu Plaza Fisherman's Wharf, Deluxe superior ki...

Boutique stay tucked along Matadero Creek
Hotels with a patio

(Full Bed) Room

Club Wyndham Suites at Fisherman’s Wharf

Unique Hotel Inn at the Opera

Upscale Urban 2bd San Francisco

Apart-hotel City View @ by Union Sq SF

1 King bed in boutique hotel

2 BR at Fisherman's Wharf

Lovely 1 BR at Fisherman's Wharf
Quick stats about hotels in South San Francisco

Total vacation rentals
Explore 50 vacation rentals in South San Francisco

Nightly prices starting at
South San Francisco vacation rentals start at G$29,274 GYD per night before taxes and fees

Verified guest reviews
Over 310 verified reviews to help you choose

Family-friendly vacation rentals
20 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 40 rentals that welcome pets

Vacation rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wi-Fi availability
50 of South San Francisco vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across South San Francisco rentals
Destinations to explore
- Northern California Vacation rentals
- San Francisco Bay Area Vacation rentals
- San Francisco Vacation rentals
- Gold Country Vacation rentals
- Central California Vacation rentals
- San Francisco Peninsula Vacation rentals
- San Jose Vacation rentals
- Silicon Valley Vacation rentals
- North Coast Vacation rentals
- Santa Barbara Vacation rentals
- Wine Country Vacation rentals
- South Lake Tahoe Vacation rentals
- Private suite rentals South San Francisco
- Rentals with an EV charger South San Francisco
- Rentals with a patio South San Francisco
- Condo rentals South San Francisco
- Rentals with breakfast South San Francisco
- Rentals with a hot tub South San Francisco
- Family-friendly rentals South San Francisco
- Rentals with a fireplace South San Francisco
- Pet-friendly rentals South San Francisco
- Fitness-friendly rentals South San Francisco
- Rentals with pools South San Francisco
- Rentals with a fire pit South San Francisco
- Rentals with outdoor seating South San Francisco
- Apartment rentals South San Francisco
- Rentals with a washer and dryer South San Francisco
- House rentals South San Francisco
- Hotel rooms San Mateo County
- Hotel rooms California
- Hotel rooms United States
- Moscone Center
- Stanford University
- Golden Gate Park
- Muir Woods National Monument
- Oracle Park
- Golden Gate Bridge
- Levi's Stadium
- SAP Center
- Twin Peaks
- Mission Dolores Park
- Pier 39
- Henry Cowell Redwoods State Park
- University of California-Berkeley
- Six Flags Discovery Kingdom
- Palace of Fine Arts
- Montara Beach
- Bolinas Beach
- Winchester Mystery House
- California’S Great America
- Davenport Beach
- Baker Beach
- San Francisco Zoo
- Painted Ladies
- Rodeo Beach




