Hotel vacation rentals in South San Francisco

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Top-rated hotel rentals in South San Francisco

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in Sunnyvale

4.85 out of 5 average rating, 26 reviews

Bright Studio Suite King Bed with Kitchen

Centrally located in the Silicon Valley, enjoy our spacious suite with fully equipped kitchen. Enjoy FREE breakfast, FREE wireless internet and more. Across the street from Safeway Grocery, Starbucks, Jamba Juice, many specialty shops and an array restaurants. Nearby to Levi Stadium, Shoreline Amphitheater, California's Great America, Winchester Mystery House, Twin Creeks Sports Complex, Santa Clara University, Santa Clara Swim Club, Santa Clara Kaiser and the Santa Clara Convention Center.

Resort in Union Square

4.92 out of 5 average rating, 25 reviews

Chic King Suite at Wyndham Donatello in SF

Escape to a tranquil retreat in the heart of San Francisco's Union Square neighborhood. Discover serenity and sophistication at our elegant resort, where you can unwind and rejuvenate amidst the bustling city. Immerse yourself in the vibrant energy of San Francisco, from its iconic landmarks to its charming neighborhoods. Indulge in the comfort and style of our luxury accommodations. Relax and recharge in our thoughtfully designed space, complete with modern amenities and a soothing ambiance.

Guest favorite

Hotel room in South of Market

4.79 out of 5 average rating, 48 reviews

SoMa 9 Residences Room 7 Shared Bath

SOMA (short for South of Market St) is top of the list for where to stay in San Francisco for the first time. SOMA 9 Residences is located in the Heart of SF SOMA District, were you'll find everything from shopping to fine dining, plus landmarks such as Yerba Buena, Moscone convention center, SF MOMA, and steps away to Giants Ballpark. The proximity to Market St. makes SOMA one of the most accessible areas of the city. There's buses and rail lines (called BART) on just about every block.

Guest favorite

Hotel room in Millbrae

4.91 out of 5 average rating, 91 reviews

Bay Area Escape | Hotel Room. Free Breakfast

If you plan to explore the Bay Area, The Millwood Inn & Suites is a great jumping-off point. This quaint hotel is located in Millbrae, California, only minutes from Bay Area attractions such as the Golden Gate Bridge. It is also only a six-minute drive from San Francisco International Airport, perfect for those flying in! Be welcomed into a world of comfort and convenience after a long day of exploring California's best. ✔ Free breakfast ✔ Free parking ✔ Fitness center

Guest favorite

Hotel room in Union Square

4.9 out of 5 average rating, 58 reviews

San Francisco Suites on Nob Hill

Discover our delightful main-floor parlor, offering the convenience of a private kitchen and a living area with a convertible couch for extra sleeping space. Enjoy the sunny windows facing Pine Street and indulge in the whirlpool Jacuzzi bathtub/shower. Because of its great street-facing location, you might notice a bit of ambient city noise. For those who cherish complete tranquility, we're happy to share that we also have quieter room options available.

Superhost

Hotel room in Pacific Heights

4.81 out of 5 average rating, 57 reviews

Monroe Studio 303

The Monroe Residence Club is a residential hotel located centrally in the heart of San Francisco with public transportation at our doorstep and local shops and businesses nearby. It is conveniently located just a block from Whole Foods, blocks from a the iconic Lafayette Park, within walking distance of several hospitals and more! The Monroe offers 24-hour front desk security, breakfast and dinner on-site, as well as common areas for congregating.

Guest favorite

Hotel room in Mountain View

4.91 out of 5 average rating, 779 reviews

King Bed at Shashi Hotel in Mountain View

Experience our King room type at Shashi Hotel Mountain View, an Urban Resort. Conveniently, located in the heart of the Silicon Valley - walking distance to Shoreline Amphitheatre. Taste incredible cocktails and delicious bites at our Emerald Hour Bar designed by our Michelin-rated Chef. Enjoy complimentary amenities including our outdoor pool, fitness center, sauna and steam rooms. New for 2025 - daily wine tasting, yoga, zumba, and live music.

Guest favorite

Casa particular in San Francisco

4.95 out of 5 average rating, 123 reviews

Boutique large studio in NoPa San Francisco

Self-contained large studio in San Francisco with kitchenette. Located in San Francisco's NoPa area which provides some of the best restaurants and bars in the city as well as close access to the outside spaces of the Panhandle and Golden Gate Park. The studio is located on a quiet street which is a 5 minute walk from the NoPa restaurants and Bi-Rite on Divisadero, 7 mins walk from Alamo Square and 15 mins walk from Golden Gate Park

Hotel room in Marina

4.64 out of 5 average rating, 228 reviews

Queen Street Suite, Dog+, Reserved Parking

This is a street facing room with one queen bed, a sofa; and a full kitchen. We are a small family run Motel in the Marina district, close to Cow Hollow and Pacific Heights. You’ll love this motel because of the walk-able neighborhood, the roomy kitchen, cozy European feel and the free off-street parking. This is a dog friendly room. (with an extra charge of $25 per dog, per night) Sorry, no cats are permitted.

Superhost

Hotel room in Tenderloin

4.88 out of 5 average rating, 69 reviews

Union Square Stay | On Site Restaurant & Bar

The Marker brings sophistication and style to San Francisco like no other. Set in one of the most vibrant and captivating cities in the world, the Beaux-arts style hotel invites you to feel inspired and right at home. Just steps from Union Square, welcome to The Marker, where modern elegance effortlessly blends to classic Bay Area charm. Winner of the Conde Nast Traveler Readers Choice Awards 2019-2022.

Superhost

Hotel room in Stinson Beach

5 out of 5 average rating, 4 reviews

Fish Board Studio includes King Bed w/ Kitchenette

Our Fish Board Studio is a charming private space in our courtyard with our signature dutch door, small kitchen, and accommodations for two (2) adults on a King Bed and one (1) adult or two (2) children on a twin sized futon. It’s perfect for both short and longer stays, and gives you a tranquil space to unwind and relax. The vaulted ceilings and open floor plan make this space feel bright and airy.

Guest favorite

Hotel room in Berkeley

4.96 out of 5 average rating, 133 reviews

Rock Roulade Cocoon

This unique place has a style all its own. Formally a secret famous recording studio for pop-rock bands, it was formally known as “The Hearst”. The first room, (now bedroom) was the control room with recording equipment and the second room (now tub room) was where the musicians played. Welcome pets for a fee if $25/ per pet per night. Payment made through Airbnb.