Sikeston places to stay

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Top-rated places to stay in Sikeston

Guests agree: these places to stay are highly rated for location, cleanliness, and more.

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Guest favorite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 353 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Mar 9 – 16

G$21,943 GYD per night

Guest favorite

Treehouse in Greenville

5.0 out of 5 average rating, 149 reviews

NEW treehouse B&B for 2 "The Roost” with hot tub

2022 custom built rustic but not primitive cabin 2 hrs south of St Louis near Wappapello Lake. Yes it has indoor plumbing & running water. Accommodates two adults, has a fully equipped kitchen and breakfast items are provided for you to cook. Surrounded by thousands of acres of national forest. Observe wildlife sightings from the deck while soaking in the hot tub, sleep comfortably in a queen size pillowtop Serta bed on a Motion Air base, and relax as you enjoy the ambience of the fireplace.

Apr 2 – 9

G$37,579 GYD per night

Guest favorite

Guest suite in Cape Girardeau

4.97 out of 5 average rating, 115 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Aug 29 – Sep 5

G$16,495 GYD per night

Guest favorite

Apartment in Cape Girardeau

4.94 out of 5 average rating, 175 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Mar 19 – 26

G$25,780 GYD per night

Guest favorite

Barn in Cape Girardeau

4.95 out of 5 average rating, 110 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built only 2 years ago. Minutes from downtown Cape. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Relax in the front porch rocking chairs, hang out in the vaulted ceiling family area or game loft! Enjoy the sounds of nature around the fire pit, roasting marshmallows and watching the sunset. Near Trail of Tears and walking distance to classic dive bar/burger joint.

Aug 14 – 21

G$44,225 GYD per night

Guest favorite

Place to stay in Makanda

4.93 out of 5 average rating, 161 reviews

Maple Ridge Cabin at Panther’s Rest

Secluded, yet convenient, we’re within 5 min of two wineries, ziplining, trail heads, and I-57. This is your unforgettable romantic wine country retreat or comfortable rest after hiking or travel. There is no TV or Wi-Fi (good cell signal though) but that is not why you’re here! Explore the vineyards, walk the trails, and drink complementary on-farm roasted coffee! Your pet is welcome when you add them to the reservation. Maple Ridge Cabin is your gateway to the Shawnee Wine Country!

Nov 7 – 14

G$28,146 GYD per night

Guest favorite

Tiny home in Ozark

4.96 out of 5 average rating, 440 reviews

The Potel Tiny Home 14x40

New Tiny home nestled on the edge of the Shawnee National Forest. A cozy one bedroom with full closet and stacked washer and dryer the bed is a full size. Kitchen with stove, fridge and microwave. It does not have a dishwasher. Living room has a smart TV sign in to your Netflix, Sling, YouTubeTV etc. Wi-fi provided. No cable. Full bathroom with shower unit. Some of our guest has said sitting on the porch watching the beautiful sunsets each night was an added bonus for staying with us.

Dec 22 – 29

G$19,406 GYD per night

Guest favorite

Cabin in Williamsville

4.99 out of 5 average rating, 219 reviews

Secluded Cabin on BlackRiver/ Hot tub- NO PETS!

This is our family cabin. Our family farms soybeans, rice, and corn. We are too busy working during spring, summer, and some of fall to enjoy our cabin much. We are wanting to share our beautiful place for others to enjoy. It is located approximately 10 minutes from Poplar Bluff, MO. We live about 30 minutes away, so we can be available if needed. We have satellite TV and wi-fi. Cabin is pretty secluded nestled among the trees with the Black River flowing within 100 feet of the deck.

Sep 25 – Oct 2

G$38,665 GYD per night

Guest favorite

Treehouse in Perryville

5.0 out of 5 average rating, 518 reviews

TreeLoft at BaseCamp

Welcome to the TreeLoft experience! This is a custom built luxury treehouse for two. It is our hope that upon your stay you will be reconnected to nature and to the one you came with. We created the TreeLoft with an inspired state of mind, and we are hopeful that same inspiration will be experienced and reflected during your stay. Go to sleep counting stars and wake up with the trees! We can't wait to provide you with the TreeLoft experience! We rise by lifting others!

Nov 24 – Dec 1

G$66,510 GYD per night

Guest favorite

Treehouse in Makanda

4.97 out of 5 average rating, 187 reviews

Panthers Inn Treehouse

Come nestle amongst the leaves at Panthers Inn Treehouse. This secluded, well equipped, elevated cabin has the perfect combination of natural beauty and artful luxury. Isolated yet conveniently located 2 minutes from Blue Sky and Feather Hill wineries, within 5 minutes of Panthers Den hiking trail and the Shawnee Hills canopy tour and only 10 min from I-57 exit 40. Panthers Inn is the perfect starting and ending point to your Shawnee Hills Wine Country vacation!

Oct 24 – 31

G$32,599 GYD per night

Guest favorite

Place to stay in Cobden

4.95 out of 5 average rating, 272 reviews

Private Retreat Cabin - Southernmost, IL

A private retreat space, Eva’s Roost is located at Center For Lost Arts near Cobden, Illinois. Uniquely crafted rustic, zen-style cottage, designed to be close to the earth & nature. Extensive, curtainless windows facing the forest & pond allow for private views: sunrise, moonrise, forest & wildlife. Yoga mat, guitar & some art supplies. Personal outdoor space with firepit & comfy adirondack chairs. Entrance to wandering trails right outside your back door.

Aug 5 – 12

G$23,367 GYD per night

Guest favorite

Loft in Cape Girardeau

4.9 out of 5 average rating, 188 reviews

Riverwalk Loft 3

Historical building with modern amenities. We are located right in the middle of downtown life. With the excitement there will come noise from bars, live bands, and the occasional train. If you love staying where fun is happening, this ones for you. Please note: we are located above an arcade bar and you are a building up from the River wall. There is also a currently operational TRAIN track with TRAINS, that make TRAIN noises 200ft from our lofts.

Aug 22 – 29

G$28,005 GYD per night