Vacation rentals in Semmes

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Top-rated vacation rentals in Semmes

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Guest favorite
A modern bedroom features a spacious bed with neutral bedding and decorative pillows, complemented by a geometric area rug on light wooden floors. Two large windows with sheer curtains allow natural light to fill the space, while a stylish television stands on an angular wooden stand.
Townhouse in Washington Square
4.96 out of 5 average rating, 207 reviews

Downtown , Modern Spacious & Near I-10

Enjoy a little piece of Mobile, Alabama by staying at this centrally located townhouse near all the best restaurants and the hustle and bustle of downtown. This unique space is a minute from I-10 giving you easy access to the interstate and quick driving time to just about anywhere. Minutes from the convention center, cruise terminal, Washington Square, and the famous Callaghan's Irish Social Club. Spacious, clean, modern, and convenient are all descriptions for this cute, newly remodeled space.

Top guest favorite
The charming exterior of a single-story cottage is framed by a large tree. A welcoming front porch features wooden railings and a green door, while light blue shutters complement the neutral siding. Lush greenery lines the path to the home, enhancing its inviting presence.
Home in Mobile
4.93 out of 5 average rating, 134 reviews

Cozy Home Minutes to Downtown

RELAX & UNWIND at this PEACEFUL, SPACIOUS & COZY Cottage located in the popular Midtown area of Mobile! Upon arrival you will feel right at home. You will find this cottage is very spacious equipped with a King size bed, Queen size bed, Full size bed, Master bathroom & Guest bathroom & a fully equipped kitchen! Enjoy a glass of wine, a good book or some family time outback in the peaceful backyard! A short commute to all the restaurants, bars & attractions! This cottage is the perfect getaway!

Top guest favorite
The exterior of a modern brick home is showcased, featuring a sloped roof and large front windows. Well-maintained landscaping includes shrubbery and a neat lawn, with a paved walkway leading to the entrance. The inviting facade is highlighted under a clear blue sky.
Home in Semmes
4.98 out of 5 average rating, 41 reviews

The Bare Minimum Bachelor Pad 3 bed/2 baths

If you're looking for simplicity and comfort without the frills, you've found the perfect spot! Located in Semmes, Al near mobile. This 3-bedroom, 2-bath retreat is all about the basics, offering just what you need for a laid-back stay. No fuss, no clutter, just space to relax, recharge, and enjoy the essentials. With no distracting art on the walls or extra knick-knacks, this place is perfect for anyone who appreciates clean lines and an "everything-you-need-and-nothing-you-don't" vibe. 😊

Top guest favorite
Home in Mobile
4.94 out of 5 average rating, 658 reviews

Charming Midtown • Walkable • Easy DT Access

Centrally located in charming, walkable Midtown Mobile’s Old Dauphin Way Historic District, my home is just minutes from: 🎭 Mardi Gras parade route (2 mi), USS Alabama (5.3 mi), GulfQuest Museum (2.8 mi), Saenger Theatre (2.6 mi), LODA District (2.6 mi), Ladd-Peebles Stadium (0.8 mi), and Convention & Civic Centers (2.9 mi). 🏥 Near USA Health (2.5 mi) & Mobile Infirmary (3.2 mi). 🏖️ Dauphin Island (45 mins). ✈️ 15 mins to Mobile Regional Airport with quick access to I‑10/I‑65.

Top guest favorite
A serene bedroom is equipped with a queen-size bed featuring dark wood furniture. The walls are painted in soft light tones, and natural light filters through the blinds of two windows. A ceiling fan provides ventilation, while a chair with decorative cushions adds a cozy touch.
Home in Mobile
4.94 out of 5 average rating, 109 reviews

Three Notch Cutie

Your family will be close to everything at this centrally located home located in the Tillman's corner area of Mobile, AL. The house is approximately 1/4 mile from a new Dollar General and 3 miles from interstate I-10. In 2024 we did an interior renovation of the house, so that it now features LED lighting, freshly painted walls, new floors, new appliances, a tile shower, granite countertops, and brand new furniture. We ask that you take care of our investment. Thank you!

Top guest favorite
A charming bungalow is set amid a lush, green landscape, featuring a brick porch with two red Adirondack chairs and an American flag. Mature live oak trees provide shade, and manicured hedges line the front yard, enhancing the welcoming appearance of the home.
Apartment in Washington Square
4.91 out of 5 average rating, 32 reviews

Oakleigh Efficiency Studio private entry Weekly

Our private entrance cottage is a one bedroom,bath, self contained unit with a kitchenette with a microwave, coffee pot, toaster, undercounter fridge, dishes, glasses and cooking utensils.There is a full size bed, SmartTV, love seat and computer desk space. Wonderful back deck for sunny afternoons or evening cocktails. Private entrance with keyless entry. On street parking with security lighting in wonderful walking neighborhood. Owners unit attached at front of property

Top guest favorite
Tiny home in Semmes
4.92 out of 5 average rating, 50 reviews

Peaceful Backyard Suite

Enjoy the sounds of nature when you stay in this unique place. Shade trees can be seen through the fixed windows near the cathedral ceiling. Feels as though you are in a treehouse! Bedroom has one queen bed & can be closed off from kitchen & living room. House is new and within a fenced yard. It’s to the rear of owner’s home and backs up to a flower nursery. Very quiet. Great place to study, work online, or just relax. Swing on Front Porch. Pets for short term. No cats.

Guest favorite
A welcoming living area features two beige armchairs facing a round coffee table, with a dark sofa in the foreground. A wall-mounted TV is positioned above a shelf displaying various decorative items. Natural light enters through two windows, illuminating the warm wooden floors.
Home in Mobile
4.93 out of 5 average rating, 114 reviews

Updated historic home w/ fast Wi-Fi near downtown

Beautifully renotaved historic home in Oakley Garden Historic District. Located within walking distance or a short ride to downtown, the Mardi Gras Parade, and all the popular restaurants and attractions. Within 5-minute walking distance to the popular Callaghan's Irish Social Club (best burger in Mobile and recently voted the best bar/social club in the South!), The Hummingbird Way Oyster Bar or the popular Washington Square Park. Experience the magic of Mobile!

Guest favorite
A single-story home is set on a large lot surrounded by trees. The front features a welcoming porch with steps leading to the entrance, framed by symmetrical windows with dark shutters. The yard is covered in grass, providing ample outdoor space.
Home in Mobile
4.92 out of 5 average rating, 63 reviews

Cozy South Alabama Home

Your family will be close to everything when you stay at this centrally-located place. Minutes from South Alabama (USA), Springhill College, Mobile Tennis Center, parks, golf, Mobile Art Museum, Fair Grounds, and much more. The home sits on a large lot easy to find. Large fenced back yard for you and your four legged family members to enjoy. Also has a large covered back deck to enjoy along with a gas grill. Walking distance to the park and Japanese’s garden.

Top guest favorite
A welcoming living room features a green sofa adorned with colorful cushions, paired with a wooden coffee table. Natural light fills the space through two windows with bamboo shades, while decorative wall art adds character. A small side chair and a lamp complement the inviting atmosphere.
Cottage in Mobile
4.96 out of 5 average rating, 206 reviews

{BOHO}Stylish Stay + King Bed

Please take a few minutes to read our reviews and hear why guests love our place so much... we work hard to provide a five star experience for every single guest we host. We know you will love it too! Our duplex is situated in a very friendly walkable neighborhood. Starbucks is just a short walk down the street. Walking distance to Aldi, Guncles gluten free bakery, and Soul Caffeine coffee shop.

Top guest favorite
The exterior of a two-story home is shown, featuring a well-manicured lawn and a welcoming porch with seating. Red, white, and blue decorations hang along the porch, and an American flag is displayed prominently. Lush greenery surrounds the property, enhancing the inviting atmosphere.
Guest suite in Mobile
4.96 out of 5 average rating, 164 reviews

Haven on Hamilton

Cozy, private guest suite convenient to the interstate, airport and great local restaurants. Located just half an hour from Dauphin Island and historical downtown Mobile. Local attractions include the USS Alabama, Mobile cruise terminal, and more. You can have the quiet, country feel with all the convenience of city living.

Top guest favorite
A cozy bedroom features a queen bed with a decorative light pink coverlet. Two bedside tables with lamps provide illumination. Dark robes hang beside the bed, and a colorful area rug adds warmth to the hardwood floor. Natural light enters through a window, enhancing the space.
Condo in Mobile
4.95 out of 5 average rating, 198 reviews

The Oak Haven - Ideal for Remote Work & Pets!

This unit is available for 1 month MINIMUM stays Welcome to The Oak Haven at Summerville Court, a cute & cozy historic condo! Be sure to checkout some highlights of the house, including the detailed guidebook and wall art that features local shops and restaurants! We are 5.0 Star Superhosts and look forward to hosting you!

Popular amenities for Semmes vacation rentals

  1. Airbnb
  2. United States
  3. Alabama
  4. Mobile County
  5. Semmes