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Vacation rentals in Santa Panagia

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Top-rated vacation rentals in Santa Panagia

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Villa in Syracuse
5 out of 5 average rating, 73 reviews

Timeless: Detached villa with infinity pool

In the heart of the Plemmirio Marine Protected Area, this 90-square-meter (969-square-foot) detached villa features an 80-square-meter (861-square-foot) heated infinity pool and offers breathtaking panoramic views of the Sicilian coast from Plemmirio to Capo Passero. The villa is surrounded by a private 8,000-square-meter park featuring an abundance of typical Sicilian vegetation (olive, carob, almond, and fig trees; Mediterranean pines; mulberry trees; and a rock garden with Mediterranean scrub).

Guest favorite
A spacious terrace features a built-in L-shaped seating area adorned with numerous cushions. Two modern chairs and a coffee table are placed at the center. The backdrop reveals a stunning sunset view of Noto's rooftops and the distant sea.
Home in Noto
4.96 out of 5 average rating, 52 reviews

Penthouse Lady Packard

Lady Packard’s Penthouse is a stunningly elegant, spacious and comfortable house with four levels, all above ground because of the sloping, pedestrian street on which it is built. Free parking is just steps away. The location is ideal, peaceful with amazing views, and just a few minutes’ walk from the Cathedral at the city's center. The house sleeps 6 adults in 3 separate bedrooms. Perfect for a family holiday or a friends getaway, the common spaces comfortably accommodate everyone at once.

Guest favorite
An outdoor balcony features a small wooden table paired with two white chairs. Potted plants add greenery, while the view showcases nearby buildings against a clear blue sky. Natural light brightens the space, creating a refreshing atmosphere for relaxation.
Apartment in Syracuse
4.96 out of 5 average rating, 268 reviews

One step to Ortigia! Bicycles & Balcony

Bright and stylish renovated flat just steps from the city center and Ortigia—you can walk to all the must-see spots with ease. Cozy and welcoming, it’s the perfect home base for your holiday in Sicily! ☀️ Sunny balcony for relaxing moments en plein air 🚲 FREE bicycles available throughout your entire stay 🚗 Hassle-free street parking – and it’s free 24/7! We also have two more apartments in the same building—check out my profile to discover them and read our glowing 5-star reviews!

Top guest favorite
A charming balcony is presented, featuring a small round table with a floral centerpiece and two cushioned chairs. The railing offers a view of the serene blue sea and the historic buildings lining the waterfront, creating a relaxing setting for morning coffee or evening drinks.
Condo in Syracuse
4.99 out of 5 average rating, 351 reviews

Sea-View Loft. Stylish, Spacious and Comfortable

Experience the magic of Ortigia in this elegant, thoughtfully designed 80m² apartment that blends charm, comfort, and relaxation. Ideal for couples or small groups, it is located just steps from the island’s most iconic sights. Enjoy a stunning sea view balcony, a bright living area complete with a sofa bed, a fully equipped kitchen, a cozy bedroom, and two modern bathrooms. Amenities include fast WiFi, A/C, and heating. For your convenience, the building is served by an elevator.

Top guest favorite
A serene pool area is surrounded by lush greenery, featuring a crystal-clear swimming pool. Comfortable loungers and a white umbrella are positioned nearby. A decorative stone bench displays two patterned pillows, adding a subtle touch to the inviting outdoor space.
Vacation home in Syracuse
4.93 out of 5 average rating, 41 reviews

Casa Sirokos

Casa Sirokos is a detached villa facing the pool, surrounded by the greenery of the most scenic residential neighborhood in Syracuse. It features local architecture that blends with large outdoor spaces and gardens typical of the Sicilian countryside. The cottage is one of two independent accommodations that are part of this property, which also offers an apartment located on the second floor of an ancient manor house. The sophisticated and relaxing atmosphere sets us apart!

Superhost
A spacious sleeping area features a large bed with soft green accents and warm wooden flooring. A comfortable chair is positioned beside the bed, and a round rug with leaf patterns adds a touch of nature. Natural light filters in through large windows covered with shades.
Condo in Syracuse
4.8 out of 5 average rating, 5 reviews

Light and Relaxation: Large Open Space on the Garden

Located in a private wing of the villa with a separate entrance, this 95-square-meter open space combines refinement and modernity. The large windows flood the rooms with natural light, while the decor naturally defines the different areas. A perfect balance between design, comfort and nature: the spaces blend harmoniously with the garden, creating relaxation and privacy. For safety and comfort reasons, the property only accommodates children aged 10 and over.

Top guest favorite
The spacious sleeping area features a large white bed positioned against an arched stone wall. Soft lighting highlights the texture of the stones, while decorative elements add a touch of charm. A woven rug lies at the foot of the bed, contributing to the room's cozy appeal.
Home in Syracuse
4.94 out of 5 average rating, 184 reviews

Agàpe Ortigia

Agàpe Ortigia is an accommodation created with Love in the magical island of Ortigia, in the historic center, a stone's throw from the Duomo and the major sites of interest. The independent room is large and spacious, has a double bed, TV, free Wi-Fi, tea and coffee corner, but the peculiarity of this accommodation apart from the furnishings is the bathroom which, in addition to having the main amenities, offers a large sunken tub where you can relax.

Superhost
A modern living area is presented, featuring a flat-screen television mounted on a light-colored wall unit. A dining table with four black chairs is positioned nearby, and a dark area rug is laid on the tiled floor. Soft lighting is provided by exposed bulbs.
Apartment in Syracuse
4.74 out of 5 average rating, 35 reviews

Casa Salgiò

Cozy and modern apartment on the outskirts of Syracuse, just a 10-minute drive from the historic center and in a well-served area. The apartment, completely renovated, consists of a living area with a double sofa bed, an equipped kitchenette, a bedroom, a small room with a bed, a bathroom with a shower, a storage room and a laundry area. The living room and bedroom overlook a veranda from which you can see glimpses of the sea and Mount Etna.

Top guest favorite
A scenic terrace features a large umbrella providing shade, overlooking the sparkling sea. Decorative potted plants add greenery to the space, while distant historic buildings can be seen along the coastline, enhancing the view.
Apartment in Syracuse
5 out of 5 average rating, 33 reviews

Palazzo GiuFa

Apartment, with terrace overlooking the sea, of about 150 m2 equipped with 2 kitchens, 2 bedrooms, 1 sitting room, 3 bathrooms, 1 panoramic lounge of about 60 m2. The apartment of absolute value, inside a building of the same owner, is located in the historic center of Ortigia very close to the free beach of Cala Rossa and a few dozen meters from all the attractions of Ortigia. The furniture is modern but with many Sicilian references.

Guest favorite
Apartment in Syracuse
5 out of 5 average rating, 6 reviews

Sky Rooftop Ortigia

In the vibrant heart of Ortigia, just a few steps from the touristic port, this charming home welcomes you in a truly unbeatable location. Here, you can immerse yourself in the authentic atmosphere of the historic center, surrounded by picturesque alleys, local shops, and traditional restaurants, with the sea always within sight. The apartment is located on the third floor and is accessible by stairs only.

Guest favorite
A softly lit hallway features a framed floral painting above a white console table. A green glass lamp and a small potted plant are placed on the table, while another plant sits nearby on the floor, contributing to a calming atmosphere.
Condo in Syracuse
4.97 out of 5 average rating, 62 reviews

Comfortable apartment with reserved parking space

Apartment in an area well served by shops, supermarkets, bars, pizzerias, tobacconists, newsagents, bakery, bank and a characteristic street market with fish, fruit and typical products. Well equipped kitchen. Easily accessible by car and equipped with a reserved parking space inside a fenced condominium courtyard. The apartment is equipped with books and various touristic documentation on Sicily.

Top guest favorite
Vacation home in Syracuse
4.96 out of 5 average rating, 28 reviews

Alfeo Studio with Kitchen and Balcony with Sea View

Alfeo, Double room with equipped kitchenette and dining area, equipped with kettle, coffee machine, satellite TV, air conditioning, WiFi, private bathroom and balcony overlooking the sea. Panorama Alfeo is a property consisting of two mini apartments and a room, located in the historic center of Ortigia. The privileged location is great for visiting the island without having to use the car.

Popular amenities for Santa Panagia vacation rentals

  1. Airbnb
  2. Italy
  3. Sicily
  4. Santa Panagia