We’re sorry, some parts of the Airbnb website don’t work properly without JavaScript enabled.

Airbnb your place

Airbnb your place

Santa Fe River vacation rentals

Book unique cabins, vacation rentals, and more on Airbnb

Top-rated vacation rentals in Santa Fe River

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

1 of 3 pages

Cottage in Hawthorne

4.85 out of 5 average rating, 109 reviews

Live Oak Oasis on Morris Lake

Unspoiled nature greets your every turn at this charming 650 SF lakefront retreat. A short distance from 10 of Florida's finest 1st magnitude springs, ranging from 30 - 90 minute drive, makes the location a perfect basecamp for adventure travel. Rest beneath the shade of Live oaks that pull the breeze ashore. Enjoy Sand hill cranes and hummingbirds from the cabana. Incredible sunsets from new dock. Paddle boat & paddle boards available for adventures. WiFi, Netflix, Laundry, HOT outdoor shower!

Oct 14 – 21

G$20,714 GYD per night

Guest suite in Gainesville

4.97 out of 5 average rating, 416 reviews

Private guest suite in a quiet modern farmhouse

This is an elegant and newly renovated private guest suite with its own separate entrance and private bathroom located in a 1950s single family residential home. Most of the furnishings are custom made! This is an ideal place to stay for visiting parents, traveling professional students, business travelers, general visitors to Gainesville, or anyone looking for a quiet place to stay. It is NOT a location to host parties, gatherings, or to hang out in groups. Please, NO SMOKING in our suite.

Jul 26 – Aug 2

G$14,169 GYD per night

Cabin in Branford

5.0 out of 5 average rating, 123 reviews

Sweetbay River Camp-Ichetucknee River Access

Come enjoy a peaceful getaway on four private acres *near* the Ichetucknee and the Santa Fe rivers! Float the crystal clear river, take your boat out, or just hang in the hammock and enjoy a bonfire! The cabin is in a wildlife sanctuary, so you will see many deer and other animals in the yard and around the neighborhood. The house comes with private access to an Ichetucknee tube/kayak launch as well as the exit point and a private boat ramp. Only four miles to Ichetucknee Springs State Park!

Dec 17 – 24

G$27,939 GYD per night

Cabin in La Crosse

4.91 out of 5 average rating, 129 reviews

Tiny Farmhouse on The Grove

Take it easy at this unique and peaceful getaway just minutes outside the city of Alachua and 20 minutes from Gainesville. A tiny house on the farm surrounded by nature, wildlife, and farm animals. We have 2 goats, 2 zebus, and 4 donkeys that make up our little farmhouse retreat. The cabin is stylish and cozy offering a full size bed, futon, WiFi and TV. . Has everything you need for a relaxing getaway. 7 min to Alachua 17 min to High Springs 15 min to Gainesville 28 min to Ginnie Springs

Feb 3 – 10

G$23,535 GYD per night

Cabin in Alachua

5.0 out of 5 average rating, 102 reviews

Rose Cottage at Alpaca Acres

Relax at this cozy, tranquil cottage on our small farm in the country outside Gainesville yet close to Santa Fe College, High Springs and Alachua. Compact cottage has a full kitchen and bath, queen bed, twin air mattress, indoor seating and outdoor picnic area. We have a few friendly alpacas, chickens, dogs, and assorted birds. Well cared for pets welcome, property is fully fenced. Great place to stay to explore the springs, go antiquing, or check out Gainesville's food, music and fun.

Jan 19 – 26

G$17,424 GYD per night

Campsite in Alachua

4.93 out of 5 average rating, 217 reviews

Pileated Place

Welcome to our A-frame cabin, nestled into the start of a small pine forest. It’s complete with two cots, a hinged wall/awning, firepit, hammock, and elevated spaces to eat. Just bring your sleeping bag and other camp gear that helps you feel cozy and at home in the woodslands. From this soft pine needled space, enjoy the view across the pond, meet our farm dogs, and enjoy the reconnection of nature and Old Florida. Please note this is a primitive site. Weather and the like are influx. <3

Oct 16 – 23

G$14,259 GYD per night

Cabin in Hawthorne

4.95 out of 5 average rating, 129 reviews

Charming Lakefront Log Home

Welcome to your perfect lake retreat! Located on a no public access lake. This charming log home has a private dock and boat ramp suitable for launching your boat for fishing or skiing. There are kayaks on premises for use. This is an ideal location to enjoy North Florida’s lake life with family, friends, or work retreat. Includes a fully stocked kitchen, covered porch, fire pit, gas grill, and WiFi if you feel the need to plug in. NOT suitable for parties or events. NO loud noise, please.

Sep 23 – 30

G$35,732 GYD per night

Tiny home in Alachua

4.95 out of 5 average rating, 263 reviews

Ela's Tiny House: Springs, Trails & Disc Golf!

Ela's Tiny House is a 40ft Thomas School Bus converted into a unique and elegant experience! Nestled on 28 Acres of beautiful Florida nature, you can soak up the sun and unwind. Enjoy laying in a hammock and star gaze, catch a stunning sunrise or play a round of disc golf. Paddle board the Santa Fe River, swim with manatees @ Ichetucknee Springs, or soak in the cool waters @ Blue Springs. The Historic town of Alachua, High Springs and Gainesville all within a 20 min drive.

Sep 3 – 10

G$14,972 GYD per night

Cabin in Fort White

4.93 out of 5 average rating, 271 reviews

Log Cabin in Spring Country WiFi - TV

New Hideaway Western Theme Cabin Amish made real log cabin nestled among trees and wildlife (lots of deer) Minutes away from Ginnie, Ichetucknee, Poe, and Blue Springs Kayakers and Canoes love our convenience to rivers and springs Fire pit and FREE FIREWOOD onsite(enough for one fire) FREE WIFI INSIDE CABIN Large private property with lots of trees Relax on the porch or around the fire and make some awesome memories in your private log cabin This is a no pet cabin

Mar 8 – 15

G$20,278 GYD per night

Cabin in High Springs

4.94 out of 5 average rating, 359 reviews

Getaway Gilchrist Springs - Orlando

An easy drive from the city, Getaway is a new way to experience the great outdoors. Nestled across dozens of acres of private woodlands, our modern, tiny cabins have everything you need (comfy bed, bathroom, fresh linens) and nothing you don’t. Featuring a private outdoor area (hello, fire pit), each cabin is designed to help you relax, unwind and disconnect from the everyday. Plus, as part of your stay, you'll receive firewood, a s'mores kit, coffee and bottled water*.

Apr 30 – May 7

G$28,625 GYD per night

Tiny home in Alachua

4.84 out of 5 average rating, 240 reviews

Shiva Tiny Home ~ Outdoor waterfall shower

SHIVA TINY HOME by Simplify Further ~ find us on IG for more pics/tours @simplifyfurther Enjoy your own tiny home experience. +Built in April 2022. +10x16ft tiny house on wheels. +Nearby to shops, restaurants, and cafes. +Centrally located between Gainesville & High Springs. +20 minutes to stunning, freshwater blue springs. Is Shiva booked for your dates? Check out our other listings! Booking with a group? Parvati Tiny Home is located on the same property.

Jan 3 – 10

G$16,964 GYD per night

Apartment in Waldo

4.99 out of 5 average rating, 148 reviews

Fernbank on beautiful Lake Alto. Laketime Getaway

Visit this beautiful, tranquil lakeside spot for an amazing getaway. It's a six acre property, an inspiring place to study, write, or get work done with fun things to do while on a break. Swim, kayak, canoe, paddle board or enjoy sitting on the dock. Visit the barn for basketball, ping pong, and corn hole. It's a studio apartment with a private bathroom and beds for four, plus two couches and air beds available. Note: This is an upstairs apartment.

Jun 18 – 25

G$22,326 GYD per night

Vacation rentals for every style

Get the amount of space that is right for you

Cabins

Kick off your hiking boots at these rustic lodgings

Hotels

Stylish accommodations and amenities

Unique stays

Spaces that are more than just a place to sleep

Popular amenities for Santa Fe River vacation rentals

Laptop-friendly workspace

Air conditioning

Other great vacation rentals in Santa Fe River

Cabin in Keystone Heights

4.83 out of 5 average rating, 132 reviews

Keystone Lake Front Cabin

Jun 14 – 21

G$20,782 GYD per night

Cabin in Fort White

4.9 out of 5 average rating, 238 reviews

Cabin 3 Bowman's on Santa Fe River near Springs

Oct 4 – 11

G$23,554 GYD per night

Cabin in Live Oak

4.78 out of 5 average rating, 236 reviews

Suwannee River Paradise

Jun 10 – 17

G$21,268 GYD per night

Cabin in Fort McCoy

4.85 out of 5 average rating, 175 reviews

Camp Fox Den. A waterfront A-frame with a view.

Mar 3 – 10

G$16,993 GYD per night

Cabin in Live Oak

4.92 out of 5 average rating, 106 reviews

Florida Country Cabin Getaway

May 13 – 20

G$38,843 GYD per night

Cabin in Micanopy

4.99 out of 5 average rating, 154 reviews

The Cabin at Shimmering Oaks

Sep 10 – 17

G$35,400 GYD per night

Cabin in Fort McCoy

4.93 out of 5 average rating, 126 reviews

Reality Check / Salt Springs with a view

Nov 26 – Dec 3

G$30,261 GYD per night

Cabin in Fort McCoy

4.81 out of 5 average rating, 110 reviews

The Griffin Ranch Historic Cottage

Feb 23 – Mar 2

G$16,973 GYD per night

Other great vacation rentals in Santa Fe River

Home in Micanopy

4.97 out of 5 average rating, 221 reviews

Beautiful House, Historic District, Micanopy

Apr 18 – 25

G$21,608 GYD per night

Farm stay in Lake Butler

4.8 out of 5 average rating, 312 reviews

The Tofu House at Moonrise Farm

Oct 3 – 10

G$16,294 GYD per night

Home in Earleton

4.97 out of 5 average rating, 177 reviews

Lake House Escape & Play

Jul 8 – 15

G$24,427 GYD per night

Farm stay in Williston

4.97 out of 5 average rating, 143 reviews

Delightful Barn Apartment Horse Farm

Dec 4 – 11

G$22,431 GYD per night

Apartment in Melrose

4.88 out of 5 average rating, 168 reviews

The Orchid of Lake Santa Fe

Oct 3 – 10

G$19,792 GYD per night

Tiny home in Gainesville

4.81 out of 5 average rating, 393 reviews

Wooded Oasis: Tiny House-4 Miles From UF

Jun 27 – Jul 4

G$14,093 GYD per night

Farm stay in Middleburg

4.93 out of 5 average rating, 177 reviews

A Private Loft at Grand Landings Equestrian Center

Sep 20 – 27

G$22,483 GYD per night

Guesthouse in Gainesville

4.98 out of 5 average rating, 636 reviews

Unique Container "Caja Verde" 1 Mile UF & Downtown

Jun 26 – Jul 3

G$18,390 GYD per night

Destinations to explore