Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

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Top guest favorite

Lush greenery surrounds the charming casitas, with vibrant tropical plants in various colors dotting the landscaped garden. Mountains rise in the background under a partly cloudy sky, creating a serene backdrop for this tranquil retreat.

Guesthouse in El Valle de Antón

5 out of 5 average rating, 41 reviews

The Retreat in El Valle - Mountain House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Superhost

A bright bedroom features a spacious bed layered with soft linens and a cozy throw blanket. Decorative wall art complements the modern design. A bedside lamp adds a warm touch, while large windows offer scenic views of the ocean and natural light filling the room.

Apartment in Nueva Gorgona

4.89 out of 5 average rating, 101 reviews

Cozy Beachfront Apartment

This small and cozy apartment is the perfect place to call home. Located just steps away from the beach with its charming and homey atmosphere. The large windows allow natural light to flood the space. It has everything you need in a compact and convenient space. The living room is warm and inviting. The kitchen is fully equipped with modern appliances, making it easy to prepare meals at home. The bedroom is spacious and bright, with a comfortable bed and plenty of storage for your belongings.

Guest favorite

An expansive view of a tranquil beach is seen, with soft sandy shores meeting clear turquoise waters. The horizon features a blend of blue sky and distant buildings, while palm trees and shaded cabanas dot the beach area.

Condo in Chame

4.96 out of 5 average rating, 165 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

Top guest favorite

An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.

Home in Costa Esmeralda

4.98 out of 5 average rating, 178 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Top guest favorite

A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.

Home in Chame

5 out of 5 average rating, 21 reviews

Summer House

Take the whole family to this fantastic place with many areas to have fun. Close to all the amenities of Coronado, a few minutes from beaches, San Carlos lagoon and just an hour and a half from the city. The PH has a PH pool and a private one, in a quiet and spacious area. You will find 4 supermarkets, pharmacies, and a private hospital (emergency room). Close to country activities, beaches, mountains, lake. It has a gazebo with all the amenities. The place is safe and complete.

Top guest favorite

The exterior of the house features a charming design with a red-roofed upper level and a welcoming terrace. A small pool is visible in the foreground, surrounded by lush greenery and natural rock formations. Cloudy skies create a serene atmosphere, enhancing the tranquil setting.

Home in El Nancito

4.94 out of 5 average rating, 18 reviews

Mountain Retreat: Peaceful & Private Escape

Escape to tranquility in our beautiful rural retreat near Laguna de San Carlos, Panama. Nestled on a private hectare of lush land, this cozy two-bedroom, two-bath house boasts an open terrace with breathtaking views of the San Carlos mountains. Whether basking in summer sun or enveloped in clouds during the rainy season, you’ll find peace and beauty here. Just a 30-minute drive to Coronado and the stunning beaches of Panama Oeste, it’s the perfect sanctuary for your getaway.

Guest favorite

A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.

Cabin in Provincia de Panamá Oeste

4.87 out of 5 average rating, 246 reviews

Buenavista Cabin by Casa Amaya

Casa Amaya is a cabin complex located one hour from the capital city, in Chicá de Chame, with pleasant temperatures between 18 and 24 degrees, where you can get in touch with nature and relax with your partner, friends or family. Other cabins: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya We have an electric generator in case of outages.

Top guest favorite

Loft in Chame

5 out of 5 average rating, 14 reviews

Chica Sector 2 Large Lofts, Sea View and Autodromo

🩷 TWO large independent lofts. (2 people per loft) The 2 lofts are completely independent Each unit: WiFi - Air conditioning - Fridge 1 bedroom 🛏️ (orthopedic bed) 1 living room 🛋️ 1 bath 🚿 Parking 24-hour on-site caretaker 👮‍♀️ Private VIP terrace just for YOU Kitchenette & wood-fired pizza oven 🍙 Enjoy amazing views of the valley, sea, Punta Chame Islands and the new AUTODROMO 🏁 25 km from Coronado 28 km from Costa Verde 50 km from Panama

Superhost

A living area features a spacious couch and a round coffee table with a potted plant. Large glass doors open to a balcony, offering unobstructed ocean views. A wall-mounted television is visible, alongside textured curtains and a decorative area rug on the tiled floor.

Apartment in Nueva Gorgona- Panamá Oeste

4.78 out of 5 average rating, 352 reviews

Lovely Beach Apart. seafront*Royal Palm*P.Gorgona

Private beach apartment, on high floor, with ocean view, two bedrooms, one bathroom, high quality appliances, remote lighting control on any mobile devices, A/C in bedrooms and living room. Netflix and Amazon Prime services on televisions. Tennis courts, basketball, soccer, gym, barbecue area and playground, two floors of social area, swimming pool for exercise and recreation for adults & children's pool) direct access to the beach.

Guest favorite

An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.

Cottage in Altos del Maria

4.94 out of 5 average rating, 163 reviews

Mountain Cottage with Heated Pool and Amazing View

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated infinity pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Top guest favorite

Home in Nueva Gorgona

5 out of 5 average rating, 16 reviews

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Guest favorite

A scenic view of a beach with gentle waves lapping at the shore, flanked by lush greenery. Palm trees sway in the breeze, offering shade to thatched-roof cabanas and a pool area. The backdrop features various buildings along the coastline, creating a picturesque setting.

Condo in Nueva Gorgona

4.91 out of 5 average rating, 126 reviews

Fantastic Beach condo with Beach & mountain views.

Relax with the whole family at this peaceful place to stay. It has a kids area to play, weight room area, sauna, soccer and tennis courts. 2 adult pools and 2 kiddie pools and a Jacuzzi. There is a grill area to rent out and a restaurant on site. This condo has great views of the mountains and the beach.