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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
An indoor shower area features a wall of glass block, allowing natural light to filter in. The walls are finished in a smooth concrete texture. Simple wooden shelves hold toiletries, and a showerhead is mounted above a sleek, open shower space.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 127 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favorite
An aerial view showcases a serene saltwater pool framed by lush greenery. Red umbrellas provide shade for outdoor seating areas. The open kitchen and dining space are visible, along with comfortable hammocks situated nearby, offering a relaxed atmosphere for guests.
Home in Costa Esmeralda
4.98 out of 5 average rating, 212 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favorite
The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.
Home in San Carlos
4.94 out of 5 average rating, 149 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Guest favorite
A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.
Cabin in Provincia de Panamá Oeste
4.89 out of 5 average rating, 299 reviews

Buenavista Cabin by Casa Amaya

Casa Amaya is a cabin complex located one hour from the capital city, in Chicá de Chame, with pleasant temperatures between 18 and 24 degrees, where you can get in touch with nature and relax with your partner, friends or family. Other cabins: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya We have an electric generator in case of outages.

Guest favorite
A tranquil outdoor area is depicted, featuring a small private pool surrounded by lush greenery. The charming cottage stands nearby, characterized by large windows and a covered porch that offers ample natural light.
Guesthouse in Panamá Oeste
4.8 out of 5 average rating, 187 reviews

Mountain cabin with private pool in Panama

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Discount for two nights or more. Close to: Laguna de San Carlos, Valle de Antón, beaches of the Panamanian Pacific.

Superhost
Cabin in Altos del Maria
4.83 out of 5 average rating, 145 reviews

Cabin in Altos del María

Cozy cabin in Altos del María, ideal for couples looking to relax in a mountain setting. Enjoy a cold climate, surrounded by nature. It is pet-friendly and is equipped with the essential amenities: a room with a queen-size bed, sofa bed, and inflatable mattress, perfect for up to 4 people. It has a washing machine, grill, hammocks and guard post for added security. The atmosphere is conditioned to blend in with nature. Parking for 3 cars.

Top guest favorite
A bright dining area features a round wooden table surrounded by six turquoise chairs. Large windows allow natural light to fill the space, showcasing a cozy atmosphere. A wooden dresser and potted plants add touches of comfort. Arched openings lead to other rooms.
Home in El Valle de Antón
4.96 out of 5 average rating, 190 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Superhost
Home in Playa Coronado
4.77 out of 5 average rating, 143 reviews

Coronado. Bright pool and jacuzzi, entire house

Have fun with your whole family in this family and fun space within Coronado with security gate. The house has a beautiful bright swimming pool with a beach, a jacuzzi without a heater accompanied by its kiosk and barbecue. The house has 4 bedrooms and 4 remodeled bathrooms 2 bedrooms have pool access Modern kitchen and spacious dining room Close to the beach, restaurants, and supermarkets

Guest favorite
Tiny home in Altos del Maria
4.84 out of 5 average rating, 190 reviews

Arcón House

This earth-sheltered studio home offers a unique and romantic escape in the mountain of Altos del Maria. Cozy space surrounded by a lush green environment, ideal for those seeking a peaceful getaway, or an affordable stay to explore the gated community's amenities. This bunker home provides an inviting haven to unwind and disconnect from the hustle of city life.

Top guest favorite
The modern two-story cabin features large glass windows that offer expansive views of the surrounding greenery. A spacious deck with seating is visible, surrounded by lush vegetation and natural stone pathways leading up to the entrance.
Cabin in Panamá Oeste
4.91 out of 5 average rating, 203 reviews

Altos del María Cabin La Loma de Styria

Relax with the whole family at this peaceful place to stay. It is a fantastic, cool and pleasant place where you can do many ecotourism activities, the best option if you want to have one of the best views you can imagine. Great for couples too. We have 2 bedrooms on the 2nd floor and 2 bathrooms. Multiple places to take beautiful photographs

Top guest favorite
A spacious living area features large windows that provide a view of the ocean. Comfortable seating options include a sectional sofa and armchairs. A round coffee table sits on a textured rug, while ceiling fans circulate air in the bright, airy space.
Condo in Nueva Gorgona
4.95 out of 5 average rating, 224 reviews

Fabulous Beach Apartment-Ph Royal Palm-Gorgona

FIRST LINE TO THE SEA WITH DIRECT ACCESS TO THE BEACH FROM THE PH POOLS. Fabulous BEACH APARTMENT, Beach Front Unit, comfortable, unique and to relax with the family, it has 4 incredible swimming pools, jacuzzi, sauna, sports courts, board games and access to the beach and restaurant service, coming is not wanting to leave ever

Guest favorite
Home in San José
5 out of 5 average rating, 16 reviews

Family Paradise | Pool, Jacuzzi & Garden

Escápate a esta exclusiva villa en Punta Barco, dentro de una urbanización privada. Disfruta piscina y jacuzzi privados, amplias terrazas, un enorme jardin y 4 elegantes recámaras. Perfecta para familias o grupos que buscan lujo, privacidad y cercanía a la playa. El terreno de esta villa es totalmente cercado.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz