Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

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Guest favorite

Condo in San Carlos District

4.95 out of 5 average rating, 137 reviews

Punta Caelo beachfront apartment San Carlos

Escape to a place where the sky meets the sea, a place so beautiful that it takes your breath away and brings peace to your soul. Relax in one of many of the comfortable social areas surrounded by lush gardens. Play, sunbathe or exercise in any of the swimming pools, take in the picturesque scenery of the Pacific Ocean. Stop at our restaurant and have a great meal. Come, visit us and return home refreshed and full of wonderful memories. We are centrally located just off the Pan-American highway.

Aug 8 – 15

G$33,421 GYD per night

Guest favorite

Condo in Playa Coronado

5.0 out of 5 average rating, 14 reviews

Stunning Beachfront Condo at PH Coronado Bay

Coronado Bay is the most highly sought-after building in Coronado! Enjoy your view of paradise from your private balcony in this beautifully updated efficiency condo with direct beach access, 1 rooftop and 2 beach-level pools! Picasso's, the famous expat hangout; Luna Rossa, a great Italian restaurant; and two well-stocked mini-markets are a short walk away. We live here year-round, so we will be here to greet you, provide a tour of Coronado Bay, and help with anything you need during your stay.

Oct 3 – 10

G$16,312 GYD per night

Guest favorite

Condo in Chame

4.96 out of 5 average rating, 136 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

Oct 25 – Nov 1

G$31,926 GYD per night

Guest favorite

Home in Costa Esmeralda

4.96 out of 5 average rating, 104 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sand! Come relax with the whole family at this piece of paradise. Majestic Sand is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool with multiple hammocks with views of amazing palm trees.

Oct 31 – Nov 7

G$41,506 GYD per night

Guest favorite

Villa in Chame

4.83 out of 5 average rating, 122 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide.

Aug 10 – 17

G$23,721 GYD per night

Guest favorite

Apartment in Nueva Gorgona

4.96 out of 5 average rating, 70 reviews

Amazing view! Beachfront @Nueva Gorgona Bahia

Luxury Apartment, Ph Bahia Resort, near of Coronado with 2 bedrooms and one with a fascinating ocean view, living room with sofa bed, dining room, kitchen, terrace and 2 full bathrooms. Totally new and with luxury finishes. Building "Resort Hotel" type, with direct access to the beach and 4 private pools, with Restaurant, Snack Bar in the pool area, and a Beach Bar with music at night in front of the sea, with Tennis, Volleyball, Basketball court , playground, billiards, private parking.

Oct 6 – 13

G$21,953 GYD per night

Superhost

Cabin in Panamá Oeste

4.8 out of 5 average rating, 220 reviews

Cabaña Mirador by Casa Amaya

Casa Amaya es un complejo de cabañas ubicado a una hora de la ciudad capital, en Chicá de Chame, con temperaturas agradables entre 18 y 24 grados, donde podrás contactarte con la naturaleza y relajarte con tu pareja, amigos o familia. Otras cabañas: https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya Contamos con generador eléctrico en caso de apagón.

Jan 9 – 16

G$13,595 GYD per night

Guest favorite

Apartment in Nueva Gorgona

4.86 out of 5 average rating, 144 reviews

Condo Nueva Gorgona Beach Front for 4 peoples

Condo Gorgona Beach Front is located on the 6th floor of Royal Palm, facing the beach with ocean views from the balcony and the room. It has 3 swimming pools, direct access to the beach, restaurant, address and more. This cozy apartment for a family or friends of 4 is an excellent economic option to enjoy luxurious amenities within the building. We treat each property like a hotel, so we invite you to enjoy this cozy apartment as you deserve. Book now!

Nov 22 – 29

G$15,582 GYD per night

Guest favorite

Home in El Valle de Antón

4.93 out of 5 average rating, 117 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Jun 16 – 23

G$23,672 GYD per night

Guest favorite

Guesthouse in El Valle de Antón

5.0 out of 5 average rating, 31 reviews

Spacious Casita with Bamboo View

Walk to the artisan mercado, restaurants and Cerro Cara Iguana trailhead. High ceilings, new fridge, washer and dryer. Private hammock patio for an afternoon nap. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. Living room has a small smart TV for your USB or media accounts. Internet and a small workspace available. * Non smoking property, inside and out

May 25 – Jun 1

G$18,524 GYD per night

Guest favorite

Cabin in Panamá Oeste

4.88 out of 5 average rating, 118 reviews

Altos del Maria Cabaña La Loma de Styria

Relax with the whole family in this quiet place to stay. It is a fantastic, fresh and pleasant place where you can do many ecotourism activities, the best option if you want to have one of the best views you can imagine. Great for couples too. We have 2 bedrooms 2nd floor 2 bathrooms. Multiple places to take beautiful photos

Sep 14 – 21

G$25,342 GYD per night

Guest favorite

Condo in Nueva Gorgona

4.94 out of 5 average rating, 125 reviews

Fabulous Beach Friendly-Ph Royal Palm-Gorgona

FIRST LINE TO THE SEA WITH DIRECT DESCENT TO THE BEACH FROM THE PH POOLS. Fabulous BEACH APT, Beach Front Unit, comfortable, unique and to relax in Family, has 4 incredible pools, Jacuzzi, sauna, sports fields, board games and beach access and Restaurant service, coming is never wanting to leave

Jun 6 – 13

G$32,308 GYD per night