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Hotel vacation rentals in Santa Cruz

Find and book unique hotel rentals on Airbnb

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Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Santa Cruz hotel rentals

Kitchen
Wifi
Pool
Free parking on premises
Air conditioning

Family-friendly hotel rentals

A well-lit room features a spacious bed with a patterned comforter alongside a twin bed covered in a solid teal throw. Two nightstands are positioned beside the beds, and a wooden desk is placed against the wall, providing additional surface space.
Private room in Santa Cruz de la Sierra

casa particular turista

Lush greenery surrounds a charming pathway leading to a single-story house with a red-tiled roof. Various tropical plants and trees create a serene atmosphere, while clear blue skies overhead enhance the inviting outdoor environment.
Private room in Santa Cruz de la Sierra

Private house with plenty of vegetation 🌴🌻

A bright room features a spacious bed with crisp linens, complemented by a television mounted on a dark wood unit. A small circular table and chair are positioned near the window, which is adorned with flowing red curtains, allowing natural light to fill the space.
Hotel room in Santa Cruz de la Sierra

residencial mia Comfort Room

Guest favorite
A bright room features three spacious beds with white linens, arranged on a warm terracotta floor. Natural light enters through a circular window and a large window overlooking lush greenery, enhancing the tranquil ambiance. Wooden accents are present in the beams and furniture.
Hotel room in Samaipata
5 out of 5 average rating, 7 reviews

Yvy Casa Hotel / Room Gratitude

A spacious room features three beds, including a wooden-framed double bed, a single bed, and a queen-size bed with a colorful quilt. A small wooden table with two chairs is positioned nearby. Large windows provide natural light, complemented by overhead lighting.
Shared hotel room in Valle Sánchez
New place to stay

We are close to the airport

A modern hotel room features a spacious bed dressed in white linens, complemented by soft pillows. Dual bedside lamps provide gentle illumination. A small table and an accent chair are positioned near a large window, allowing natural light to filter in through sheer curtains.
Hotel room in Colinas del Urubó

Hotel in Colinas del Urubo

A well-lit bedroom features a spacious bed with a light-colored covering and decorative pillows. A large mirror reflects the room's openness, while a window adorned with sheer curtains allows natural light to enter. Air conditioning is visible on the wall, adding to the comfort.
Hotel room in Santa Cruz de la Sierra

Hotel Suites Ortiz

Guest favorite
A spacious room features a large bed with neatly arranged white linens and towels. An intricate wall tapestry adds a cultural touch. Sunlight enters through a round window and arched glass doors, while a small table and two chairs are positioned nearby.
Hotel room in Samaipata
5 out of 5 average rating, 10 reviews

Yvy Casa Hotel / Room Alegria

Hotel rentals with a pool

The exterior of the Hotel Radisson is shown, featuring a modern design with sleek lines. The building is illuminated by neon signage, while large glass windows reflect the evening sky. Palm trees are positioned in the foreground, adding a touch of greenery.
Shared hotel room in Santa Cruz de la Sierra
New place to stay

Suite en Hotel

A comfortable sleeping area features a spacious bed with a light-colored blanket. Two decorative pillows are placed on the bed. A bedside table holds a lamp, while a mini refrigerator is located nearby. A standing fan is positioned in the corner of the room.
Private room in Santa Cruz de la Sierra
New place to stay

2 shared rooms in a private condominium

A serene swimming pool is surrounded by lush greenery and flowers, reflecting a clear blue sky. The pool features intricate tiles and gently rippling water, inviting relaxation in a tranquil environment.
Hotel room in El Carmen Rivero Tórrez

Florinda's Garden

A modern structure is set on a gently sloping lawn, featuring large glass windows that invite natural light. The use of wood and stone enhances the exterior design, accompanied by tropical greenery and palm trees in the surrounding area.
Private room in Santa Cruz de la Sierra

Kalomai Resort Cabins

A spacious bedroom features a king sized bed dressed in neutral linens, complemented by decorative pillows. A large window offers ample natural light, while a wall-mounted television and a dark wood dresser add functionality. A small seating area is set beside the window.
Hotel room in Warnes

Sun Hotel, Santa Cruz

A serene outdoor area features a crystal-clear pool surrounded by lush greenery and vibrant flowers. The textured stone patio encircles the pool, while tropical plants add a natural touch to the inviting landscape.
Hotel room in Concepcion
5 out of 5 average rating, 3 reviews

Hermoso Hotel Patuju

Hotel room in Samaipata

El Pueblito Boutique Hotel

Guest favorite
An aerial view of a modern high-rise building surrounded by a lush green landscape. The multi-story structure features a sleek glass façade, reflecting the sunlight, and is positioned near a tree-lined area, providing a natural contrast to its contemporary design.
Hotel room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviews

Costanera Suites

Hotel rentals with a patio

An open area features a welcoming bar with modern furnishings. A combination of high and low seating options is arranged around a light marble counter. Natural light brightens the space, where decorative plants and bookshelves enhance the design.
Hotel room in Santa Cruz de la Sierra
New place to stay

One click away

A spacious hotel room features a large bed adorned with crisp white linens. A desk and chair are positioned beside a large window, allowing natural light to brighten the space. Warm tones are present in the decor, complemented by soft lighting fixtures.
Hotel room in Colinas del Urubó

Luxurious Hotel Suite

Hotel room in Colinas del Urubó
New place to stay

Suite Hotel Radisson Urubo

A modern bathroom is equipped with a spacious glass shower enclosure and a stone vanity. The sink features a sleek faucet, and a large mirror is mounted above the counter, enhancing the room's bright ambiance. Soft towels are neatly arranged nearby.
Hotel room in Santa Cruz de la Sierra

Hotel in the city center

The entrance of Hotel Maywa features a modern façade with a large canopy. Potted plants frame the entryway, and the glass doors provide a clear view into the lobby. The exterior is complemented by a well-maintained walkway and decorative landscaping.
Hotel room in SANTA CRUZ DELA SIERRA

Hotel Maywa

Top guest favorite
A private room is presented with a lively green bedspread atop a spacious bed. An art piece adorns the wall near a window draped in purple curtains. A flat-screen TV sits on a stand, with a decorative table nearby. Warm lighting is provided by a unique ceiling fixture.
Private room in Santa Cruz de la Sierra
5 out of 5 average rating, 6 reviews

Private room

A bright guest room features a spacious bed covered with a colorful floral blanket. Two pillows are arranged at the head of the bed. Sheer curtains frame the window, allowing natural light to fill the room.
Private room in Santa Cruz de la Sierra
4.8 out of 5 average rating, 5 reviews

Guest Room in P.H.

An expansive view of a welcoming single-story structure highlighted by a terracotta roof. Surrounding green grass and landscaped gardens showcase various plants, including cacti and flowering bushes. A clear blue sky complements the natural setting, enhancing the serene atmosphere.
Private room in Samaipata
New place to stay

Nukuri's Rest by Looking Samaipata

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