Vacation rentals in Santa Cruz Department

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz Department

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Loft in Santa Cruz de la Sierra

4.9 out of 5 average rating, 164 reviews

Executive loft with amazing view

This loft is perfectly designed for guests doing travel or business. Located on a quiet street near to the city zoo in a centrally-located area offers easy access to many attractions, including the corporate zone, airport, restaurants and malls. The Loft & Kitchen: • 50” LED TV • Netflix • Wifi Services • Washer Dryer • Balcony • Microwave • Pots, pans, platters • Minibar Common Spaces: • Gym • Game room • Sauna • 3 Cinema rooms • 24/7 security • Pool • Barbecue grill

May 12 – 19

G$5,399 GYD per night

Guest favorite

Home in Samaipata

4.89 out of 5 average rating, 54 reviews

BEAUTIFUL HOUSE IN SAMAIPATA

Beautiful cozy house in Samaipata with a wonderful view! Located in a very safe area with ample parking of its own. On a land of almost 4 hectares surrounded by nature typical of the place and beautiful gardens that can be appreciated even from the inside for its large windows! The house has all the necessary amenities; churrasquera, clay oven and structure to cook the traditional pig to the stick. Ideal for recharging positive energy and breathing fresh air.

Oct 20 – 27

G$40,967 GYD per night

Guest favorite

Condo in Santa Cruz de la Sierra

4.82 out of 5 average rating, 108 reviews

Apartment in Condominium Buganvillas

We are in one of the most privileged condominiums, safe due to its high control and trained personnel. The entire condominium is surrounded by abundant nature with refined gardens, with walkways and well achieved lighting, giving it the touch of tranquility and guaranteed well-being. Common areas: Pools, hot tubs, courts, jogging circuit and playgrounds. Steps away are the "Feria Expos", supermarkets, pharmacies, laundry, living room and spa and food court.

Mar 15 – 22

G$11,411 GYD per night

Guest favorite

Condo in Santa Cruz de la Sierra

4.9 out of 5 average rating, 69 reviews

AptComplete 1 Bedroom in Exclusive Condominium

1 Bedroom apartment located in an exclusive area of the city; strategic accesses of the city to the business center, shopping centers, restaurants, historic center and airport. Great for business or vacation guests. Spacious Condominium with more than 2,000m2 of common and recreation areas, 24/7 security and surveillance personnel, safe parking option on the street with little traffic.

Apr 27 – May 4

G$8,428 GYD per night

Superhost

Apartment in Centro

4.79 out of 5 average rating, 19 reviews

Apartment. Central Spacious in front of Parque Urbano 2 Dorm.

Beautiful 2 bedroom apartment (one en suite), 2 bathroom, with all amenities, central and quiet. Located between 1 and 2 ring in front of the Urban Park, which is an open space of beautiful vegetation ideal for walking. It is close to the Blacut Plazuela, Estadio y Cine Center. The condominium has a pool, parking for one vehicle and 24/7 security.

May 27 – Jun 3

G$7,312 GYD per night

Guest favorite

Apartment in Santa Cruz de la Sierra

4.94 out of 5 average rating, 81 reviews

Exclusive apartment on the best area of SC

Hermoso y cómodo departamento ubicado en la zona más exclusiva y segura de Santa Cruz, a pocos minutos de los principales centros comerciales, supermercados, restaurantes y de fácil acceso a cualquier parte de la ciudad. El departamento cuenta con las comodidades necesarias para que tengas una grata estadía ya sea por viajes de negocio y/o turismo.

May 3 – 10

G$7,426 GYD per night

Superhost

Casa particular in Santa Cruz de la Sierra

4.85 out of 5 average rating, 13 reviews

Very comfortable house 3 rooms

Very comfortable house with three spacious bedrooms and 2 full baths, kitchenette, dining room, shared pools, shared pools, shared churrasqueras, green trails, large gardens, Polo courts, tennis, soccer and basketball and a beautiful natural lagoon. has free parking, WiFi, TV. Located 20 minutes from downtown very close to Viru Viru Airport

May 9 – 16

G$9,657 GYD per night

Superhost

Apartment in Santa Cruz de la Sierra

4.79 out of 5 average rating, 164 reviews

Equipetrol Exclusive Zone, Cozy Monoambiente

Beautiful studio apartment located in Equipetrol, one of the most exclusive areas of the city. It has WiFi, smart TV with Netfflix and other amenities. It's ventilated and bright. The building has a pool and 24/7 doorman service.... be welcome!! Learn more about its features when clicking on "Show more"

Oct 27 – Nov 3

G$4,747 GYD per night

Superhost

Apartment in Santa Cruz de la Sierra

4.93 out of 5 average rating, 30 reviews

LumiArt: Apartamento artistico de lujo

''LumiArt'' is unique and has its own style. The apartment is brand new, fully equipped and spacious. It is located near consulates, pharmacies, restaurants and has the business center with block 40 blocks away. Open for families, executives and anyone who wants to have an amazing stay!

Dec 17 – 24

G$13,213 GYD per night

Guest favorite

Loft in Santa Cruz de la Sierra

4.92 out of 5 average rating, 39 reviews

Great location with a pool and gym

A new apartment in excellent location. A few meters from Equipetrol and short distance to downtown. If you are looking to rest, pool, gym and top-notch facilities in the social areas. The apartment is a studio, a single space with everything you need on your stay and comfort.

Mar 9 – 16

G$5,688 GYD per night

Superhost

Apartment in Santa Cruz de la Sierra

4.86 out of 5 average rating, 21 reviews

Downtown StunningTerrace Apartment

This special place is close to everything, making it easy to plan your visit. Close to many cultural and downtown attractions such as museums, coffe shops, cathedrals and many more. The apartment is very tranquil, easy to access, comfortable and with an amazing terrace.

Oct 16 – 23

G$13,741 GYD per night

Superhost

Villa in Santa Cruz de la Sierra

4.89 out of 5 average rating, 9 reviews

Unique family retreat

My family (five children) and I, lived here for many years, enjoying the many fruit trees, the hundreds of birds, squirrels the pool and our beautiful dogs. Now that the children have left the nest, other families can create new and beautiful memories.

Jul 20 – 27

G$30,722 GYD per night