
Vacation rentals in Santa Cruz de la Sierra
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Santa Cruz de la Sierra
Guests agree: these stays are highly rated for location, cleanliness, and more.

Luxury, comfort, ideal location
Bienvenidos a la mejor ubicación de Santa Cruz! En el corazón del centro empresarial, pero en una calle tranquila. Supermercados y mucho más a la vuelta de la esquina. A pocos pasos encontrarás decenas de restaurantes increíbles: parrillada, comida japonesa, italiana o americana. Comida rápida o cenas elegantes. Manzana 40 está a 10 minutos a pie. Ventura Mall está a solo 5 min en auto. Ya sea para trabajo o diversión, este es el lugar ideal! El edificio cuenta con personal de seguridad 24/7.

Modern Studio in Los Cusis
Discover your ideal retreat in Los Cusis, a peaceful and elegant space designed for your comfort, featuring a balcony with a beautiful green view. Its Central Location places you close to shops, restaurants, and green areas—perfect for making the most of the city. The apartment includes a fully equipped kitchen, Smart TV, AC and Wi-Fi. The building offers free laundry facilities. It’s ideal for working, relaxing, or socializing. Enjoy a comfortable, modern, and stylish stay. Welcome!

Equipetrol Luxury Studio
Enjoy luxury and comfort in the heart of Equipetrol! Welcome to the exclusive SKY Luxia, where modern design meets functionality in this stylish, fully equipped studio. The SKY Luxia building offers top-notch amenities: a swimming pool, gym, saunas, rooftop BBQs, game room, modern gym, coworking spaces, and 24/7 security. You’ll be just steps away from the best restaurants, cafés, and nightlife. Book now and enjoy an unforgettable experience in the most vibrant center of Santa Cruz!

Cozy & modern · Fully equipped studio
You'll wake up in a fully equipped Studio that combines home comfort and comfort. You will enter a sophisticated lifestyle; every detail has been carefully designed to meet high expectations. You'll have all amenities. Relax? Immerse yourself in the pool. Exercise? There is Gym! Work? You will be able to continue your routine in the multiple social zones that offer the perfect setting.Have fun? You will be able to play billiard and use the common room ¡Book and discover this Studio!

Green Tower 26th Floor, Luxury, Panoramic Views
Enjoy your stay in the highest Airbnb in Santa Cruz, and in the best building in the city. In the facilities you can enjoy a swimming pool, steam sauna, spectacular views from the 26th floor towards the beautiful Manzana 40 building, the nature of the ecological cordon and the urubo. A few steps from supermarket, restaurants, mall, business center, banks, spa. The tallest and most beautiful restaurants in Santa Cruz, Cielo Skay Bar and Jardin de Asia, are in the same building.

GREEN TOWER SC Luxury Apartment 22nd Floor
Luxury Suite in Green Tower – Santa Cruz Piso 22. Live in the tallest and most exclusive building in the city, on the 22nd floor, with panoramic views of Manzana 40, the ecological cordon and the Urubó. Enjoy world-class cuisine in the same building, in Jardines de Asia, Caudilla, Palosanto and the impressive Sky bar, plus free access to the pool, sauna, and steakhouses. It has a Sport Motion gym. A new apartment! furnished with high-end pieces, including large sofa bed.

apartment with an excellent view
Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Smart Studio in Equipetrol
Welcome to this great Smart Apartment in the best residential and business area of Equipetrol. You're half a block from Av. San Martin and a short walk from restaurants, shops, bars, and more. The apartment is fully furnished with everything you need for a comfortable stay, including a fully equipped kitchen, air conditioning, Wi-Fi, and a large flat-screen TV. It has a swimming pool, barbecue, co-work rooms and washing machines on the terrace and common areas

Movie view, spacious, tub, balcony and garage
Upon entering, you can appreciate the elegance and style of the decor, high ceilings that provide a feeling of spaciousness and brightness. The living room is spacious and comfortable, with a luxury integrated kitchen that adds a touch of warmth and elegance. Social areas to impress, with designer and high-quality furniture. Barbecue and a wonderful infinity pool. But what really stands out about this apartment is the stunning view from the terrace or balcony.

Elegant family apartment in Equipetrol
Have fun with the family in this new, central, and stylish accommodation. Beautiful and modern apartment located in the best area of Santa Cruz. Just a few steps away from the city's best restaurants, pharmacies, supermarkets, cafes, nightclubs, and shopping malls. Ideal for families, a group of friends, or two couples. You can have all the comforts of a luxury apartment for a cozy and pleasant stay. The building's common areas are a dream!

13° SmartLife - Luxury Equipetrol
Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Top Luxury Executive Apartment | Equipetrol
Descubrí el equilibrio perfecto entre comodidad, estilo y ubicación. Este moderno departamento está completamente equipado y ubicado en Equipetrol, la zona más exclusiva de Santa Cruz. Ideal para parejas, viajeros de negocios o escapadas de fin de semana. Disfrutá de increíbles áreas sociales como: 🏊 Piscina 💪 Gimnasio completo 🎯 Sala de juegos 📍 Cerca de los mejores restaurantes, cafés y centros comerciales.
Popular amenities for Santa Cruz de la Sierra vacation rentals
Other great vacation rentals in Santa Cruz de la Sierra

Full amenities & skyline view” – Macororo 15, Lux

Maximum comfort 3 blocks from the Hotel LosTajibos

Mar Adentro 1st row SANTA CRUZ

Exclusive Depto c/Vistas + Vestidor | Equipetrol

Smart apartment with pool and views of SCZ Equipetrol

Luxury Apart and Equipetrol 307

Classic Executive Studio

Luxury Apartment with Views, 22nd Floor
Frequently Asked Questions
What are the best places to stay in Santa Cruz de la Sierra?
Santa Cruz de la Sierra has stays in lively neighborhoods like Equipetrol, known for dining and nightlife, and around the city center near plazas and shops. Guests often appreciate areas with leafy streets, local cafes, and easy access to cultural sites.
What are the best things to do in Santa Cruz de la Sierra with kids?
Families can explore city parks, interactive museums, and local zoos featuring native wildlife. Playgrounds and green spaces in residential neighborhoods add opportunities for outdoor fun.
What are some of the best things to do in Santa Cruz de la Sierra?
Discover central plazas, explore Museo de Historia Natural Noel Kempff Mercado, and wander bustling traditional markets. The city also has botanical gardens, art spaces, and vibrant street life.
How is the weather in Santa Cruz de la Sierra?
Santa Cruz de la Sierra generally has warm, humid conditions year-round, with wetter spells in certain months and a tropical atmosphere. Lightweight clothing and sun protection are often suggested, especially for daytime outings.
What are the best places to visit in Santa Cruz de la Sierra?
Explore Plaza 24 de Septiembre, admire local art at Museo de Arte Contemporáneo, and stroll the city’s botanical gardens. Markets and lively pedestrian zones add extra color to the experience.
What are some hiking trails in Santa Cruz de la Sierra?
Santa Cruz de la Sierra has nature reserves and eco-parks where visitors can follow shaded trails amidst tropical plants and birds. Urban green spaces and parks also provide pathways for relaxed walks.
What are some family activities we can do in Santa Cruz de la Sierra?
Families frequently explore city zoos, botanical gardens, interactive museums, and open-air playgrounds. Participating in local craft workshops or tasting fresh fruit at traditional markets brings a sense of discovery.
What are some of the best day trip ideas from Santa Cruz de la Sierra?
Day trips often include exploring nature reserves, visiting Jesuit mission towns, or discovering small communities with locally rooted traditions. Eco-parks around the city provide hiking, birdwatching, and opportunities to connect with regional culture.
Are there any pet friendly accommodations available in Santa Cruz de la Sierra?
Santa Cruz de la Sierra has pet-friendly vacation rentals in neighborhoods like Equipetrol, Urbarí, and around the city center. Many stays include access to green spaces and parks for walks with your pet.
What are some local tips for visiting Santa Cruz de la Sierra?
Locals appreciate lightweight clothes for the heat, insect repellent, and comfortable shoes for exploring urban sights. Trying locally grown fruits at traditional markets is frequently suggested, and learning some Spanish phrases adds ease to your experience.
What is Santa Cruz de la Sierra known for?
Santa Cruz de la Sierra is known for its lively main plaza, tropical botanical gardens, and dynamic blend of Indigenous and European traditions. The city’s vibrant markets, local cuisine, and arts scene are frequently highlighted.
What are the best hidden gems to explore in Santa Cruz de la Sierra?
Around Santa Cruz de la Sierra, visitors often discover small artisan shops, tranquil eco-parks, and street murals tucked in residential neighborhoods. Community-run cafés and weekend craft markets add unique flavor.
What are the best foods to try in Santa Cruz de la Sierra?
Local favorites include salteñas, sonso de yuca, and traditional dishes made from corn, plantain, and tropical fruits. Refreshing drinks such as mocochinchi and locally roasted coffee are often recommended.
What should I bring for a trip to Santa Cruz de la Sierra?
Pack lightweight clothing, sun protection, insect repellent, and comfortable shoes for walking. Bringing a reusable water bottle and rain jacket can add convenience, especially if you plan outdoor excursions.
What is the nightlife in Santa Cruz de la Sierra like?
Santa Cruz de la Sierra has lively nightlife, with bars and clubs frequently suggested around the Equipetrol neighborhood. In the city center, you can explore relaxed venues featuring live music, local cocktails, and outdoor patios.
What are the most popular events or festivals in Santa Cruz de la Sierra?
Santa Cruz de la Sierra has celebrated cultural festivals, Carnaval, and regional fairs throughout the year. Music, dance, and food events are frequently suggested, especially around holidays and community celebrations.
Are there family friendly vacation rentals in Santa Cruz de la Sierra?
Family-friendly vacation rentals can be found in Equipetrol, Urbarí, and the city center, many with spacious layouts and access to parks or play areas. Hosts often provide amenities for children to make visits comfortable.
When is the best time to visit Santa Cruz de la Sierra?
Visitors often prefer the drier months for outdoor activities and exploring city sights, while some enjoy the lush greenery during wet seasons. Popular festivals and pleasant evenings draw many travelers throughout the year.
Quick stats about vacation rentals in Santa Cruz de la Sierra

Total vacation rentals
Explore 4,570 vacation rentals in Santa Cruz de la Sierra

Nightly prices starting at
Santa Cruz de la Sierra vacation rentals start at G$2,092 GYD per night before taxes and fees

Verified guest reviews
Over 55,490 verified reviews to help you choose

Family-friendly vacation rentals
1,260 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 1,180 rentals that welcome pets

Vacation rentals with a pool
3,160 properties feature pools

Rentals with dedicated workspaces
2,590 properties have a dedicated workspace

Wi-Fi availability
4,240 of Santa Cruz de la Sierra vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santa Cruz de la Sierra rentals

4.7 Average rating
Santa Cruz de la Sierra stays receive an average rating of 4.7 out of 5 from guests
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