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Vacation rentals in Santa Cruz de la Sierra

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz de la Sierra

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
An expansive rooftop pool is illuminated by soft lighting, reflecting the city skyline at night. Lounge chairs are neatly arranged along the pool's edge, and the sleek wooden deck complements the modern aesthetic of the space.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 121 reviews

Luxurious and modern apartment. Equipetrol Sky Elite

This luxurious studio is located in the Equipetrol neighborhood, Sky Elite Building, one block from the Los Tajibos Hotel; it represents the perfect combination of exclusivity and first-class amenities in the city of Santa Cruz de la Sierra, surrounded by restaurants, shops, cafes, pharmacies and supermarkets. The building offers more than 3,000 square meters of social areas including a modern gym, extensive swimming pool, barbecue, coworking, private movie theater, sauna and whirlpool.

Top guest favorite
Green Tower, one of the tallest buildings in Bolivia, showcases modern architecture with its glass facade reflecting the surrounding cityscape. The image captures the building's contemporary design, set against a backdrop of Santa Cruz, featuring both urban and natural elements.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 40 reviews

Green Tower 26th Floor, Luxury, Panoramic Views

Enjoy your stay in the highest Airbnb in Santa Cruz, and in the best building in the city. In the facilities you can enjoy a swimming pool, steam sauna, spectacular views from the 26th floor towards the beautiful Manzana 40 building, the nature of the ecological cordon and the urubo. A few steps from supermarket, restaurants, mall, business center, banks, spa. The tallest and most beautiful restaurants in Santa Cruz, Cielo Skay Bar and Jardin de Asia, are in the same building.

Guest favorite
A modern living space features a blue sofa bed opposite a simple coffee table. A wooden partition separates the sleeping area, which includes a bed with a light blue cover. Colorful wall art depicting birds adds visual interest, while large windows with light curtains provide natural light.
Apartment in Santa Cruz de la Sierra
4.88 out of 5 average rating, 152 reviews

Apartment in Equipetrol

Enjoy a quiet, safe, and elegant space in the city's commercial and financial center, Equipetrol Norte. It is located in front of Green Tower, steps from Manzana 40 and the Equipetrol Business Center. A two-minute walk from Hipermaxi and Fidalga supermarkets, pharmacies, and three minutes from the country's largest and most modern shopping mall: Ventura Mall Direct access to cafes, bars, international franchises, and the city's best restaurants without having to drive.

Guest favorite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.95 out of 5 average rating, 55 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Guest favorite
A modern sitting area is presented, featuring a gray sofa adorned with decorative cushions and a yellow accent chair. A round coffee table holds a small floral arrangement. Colorful artwork hangs on the wall above, complementing the patterned area rug beneath.
Condo in Santa Cruz de la Sierra
4.9 out of 5 average rating, 137 reviews

Magnificent Apartment Exclusive Area Equipetrol

Spectacular apartment in the most privileged area of Santa Cruz. In addition to having shops, luxury restaurants, and shopping centers nearby. Bicycles and Electric Scooters with the Mobi App. Fully furnished apartment equipped with the essentials for a pleasant stay. Access to a swimming pool overlooking the city, co-work, conference room, entertainment room, poker table, barbecues, and outdoor areas with a beautiful view of Equipetrol, all on the 8th floor.

Top guest favorite
A spacious bed is positioned against a large window, offering a view of the cityscape. Soft pillows and a neatly arranged blanket enhance the comfort of the sleeping area. A small rug lies on the floor, complementing the modern decor.
Apartment in Santa Cruz de la Sierra
4.88 out of 5 average rating, 136 reviews

Comfortable/modern studio apartment beautiful view 300Mbps

Bienvenidos a la zona más activa de Santa Cruz! El precio ya incluye todas las comisiones no pagarás nada adicional en la app. El apartamento es un monoambiente totalmente equipado, moderno y cómodo. Cuenta con una cama de 2 plazas y un sofá cama además del baño privado, lavadora/secadora, cocina y todos los electrodomésticos necesarios. Internet Wi-Fi, tv cable y NETFLIX. Cerca de supermercados, los mejores restaurantes de la ciudad y malls.

Guest favorite
A tranquil studio space features a spacious bed dressed with light linens and decorative pillows. A cozy seating area includes a dark grey sofa and a round wooden coffee table. Natural light streams through a large window draped with light curtains, highlighting a wall accentuated with soft textures.
Condo in Santa Cruz de la Sierra
4.87 out of 5 average rating, 262 reviews

Quiet Monoenvironment in Equipetrol

Enjoy the simplicity of this quiet studio in the heart of Equipetrol, where you can be close to restaurants, supermarkets, squares, churches, the business center if you come for work in the same way. In your leisure time, the studio has Wify, TV, Netflix, kitchen, microwave, oven, refrigerator and everything you need to be comfortable inside the building, since in the social areas you can enjoy the pool, churrasqueras, game room and coWork

Guest favorite
Apartment in Santa Cruz de la Sierra
4.9 out of 5 average rating, 128 reviews

Beautiful 1-bedroom apartment

One-bedroom apartment, perfect for your next stay in Santa Cruz de la Sierra! Centrally located a few steps from Equipetrol, the city's commercial, business and social center. The unit has a cozy space that offers all the necessary amenities for a comfortable and memorable stay. It includes a service area, washer and dryer, iron, coffee maker, dishes, bed linens, 2 55” smart TVs with cable, Netflix, and a sofa bed. Reserve now!

Guest favorite
A modern lobby is characterized by sleek marble flooring and stylish accent walls. The reception desk, made of dark stone, holds a digital display. Comfortable seating areas feature neutral-colored chairs, and soft lighting enhances the spacious, welcoming environment.
Apartment in Santa Cruz de la Sierra
4.93 out of 5 average rating, 14 reviews

Beautiful Luxurious Apartment With Balcony.

Come to the best place in all of Santa Cruz on Equipetrol ⭐️ exclusive, luxurious, modern, SAFE, elegant, with the best social areas in the country. You have banks, pharmacies, restaurants, supermarket, everything within walking distance. Enjoy your vacation, business or work stay to the fullest at Sky elite in the middle of Equipetrol Avenue 3 ring in front of the Tajibos hotel. Very high-speed 300 Mbps WiFi and cable TV🌎.

Guest favorite
A modern bedroom features a spacious bed with light-colored bedding and decorative pillows. Wooden paneling creates a warm aesthetic, complemented by wall-mounted plants. Natural light enters through floor-to-ceiling windows, and a small bedside lamp offers a soft glow.
Condo in Santa Cruz de la Sierra
4.94 out of 5 average rating, 129 reviews

Modern Studio in downtown Equipetrol

We offer you a comfortable stady with everything you may need, in this modern and new place with our top quality service. This place is fully furnished and has a beautiful view. Is located in the best area from Santa Cruz, and also near of fancy restaurants, malls and business area. You can have access to building's social areas like: co-work zone, pool, steakhouse and laundry. (pics)

Top guest favorite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 12 reviews

Apartment in Equipetrol Top Luxury and Unparalleled View

Enjoy a modern apartment in the heart of Equipetrol, on the 6th floor with an incredible panoramic view of Santa Cruz. The building offers luxurious social areas and an exclusive private paddle tennis court, the trendy sport. The apartment is fully equipped with luxury furniture and all the necessary amenities, with every detail thought out for business or leisure trips.

Guest favorite
A spacious room features a large bed with a soft cream-colored coverlet and light-colored walls. A comfortable sofa sits adjacent to a low coffee table. Natural light enters through a large window, with a small desk and chair positioned nearby.
Condo in Santa Cruz de la Sierra
4.93 out of 5 average rating, 129 reviews

Apt. 1: Spectacular Apartment in Santa Cruz

New apartment in the best area of Santa Cruz. Located in the heart of the Business Center, close to the most important malls, restaurants, supermarkets and training. It's an exceptional place to stay

Popular amenities for Santa Cruz de la Sierra vacation rentals

Frequently Asked Questions

  • What are the best places to stay in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has stays in lively neighborhoods like Equipetrol, known for dining and nightlife, and around the city center near plazas and shops. Guests often appreciate areas with leafy streets, local cafes, and easy access to cultural sites.

  • What are the best things to do in Santa Cruz de la Sierra with kids?

    Families can explore city parks, interactive museums, and local zoos featuring native wildlife. Playgrounds and green spaces in residential neighborhoods add opportunities for outdoor fun.

  • What are some of the best things to do in Santa Cruz de la Sierra?

    Discover central plazas, explore Museo de Historia Natural Noel Kempff Mercado, and wander bustling traditional markets. The city also has botanical gardens, art spaces, and vibrant street life.

  • How is the weather in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra generally has warm, humid conditions year-round, with wetter spells in certain months and a tropical atmosphere. Lightweight clothing and sun protection are often suggested, especially for daytime outings.

  • What are the best places to visit in Santa Cruz de la Sierra?

    Explore Plaza 24 de Septiembre, admire local art at Museo de Arte Contemporáneo, and stroll the city’s botanical gardens. Markets and lively pedestrian zones add extra color to the experience.

  • What are some hiking trails in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has nature reserves and eco-parks where visitors can follow shaded trails amidst tropical plants and birds. Urban green spaces and parks also provide pathways for relaxed walks.

  • What are some family activities we can do in Santa Cruz de la Sierra?

    Families frequently explore city zoos, botanical gardens, interactive museums, and open-air playgrounds. Participating in local craft workshops or tasting fresh fruit at traditional markets brings a sense of discovery.

  • What are some of the best day trip ideas from Santa Cruz de la Sierra?

    Day trips often include exploring nature reserves, visiting Jesuit mission towns, or discovering small communities with locally rooted traditions. Eco-parks around the city provide hiking, birdwatching, and opportunities to connect with regional culture.

  • Are there any pet friendly accommodations available in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has pet-friendly vacation rentals in neighborhoods like Equipetrol, Urbarí, and around the city center. Many stays include access to green spaces and parks for walks with your pet.

  • What are some local tips for visiting Santa Cruz de la Sierra?

    Locals appreciate lightweight clothes for the heat, insect repellent, and comfortable shoes for exploring urban sights. Trying locally grown fruits at traditional markets is frequently suggested, and learning some Spanish phrases adds ease to your experience.

  • What is Santa Cruz de la Sierra known for?

    Santa Cruz de la Sierra is known for its lively main plaza, tropical botanical gardens, and dynamic blend of Indigenous and European traditions. The city’s vibrant markets, local cuisine, and arts scene are frequently highlighted.

  • What are the best hidden gems to explore in Santa Cruz de la Sierra?

    Around Santa Cruz de la Sierra, visitors often discover small artisan shops, tranquil eco-parks, and street murals tucked in residential neighborhoods. Community-run cafés and weekend craft markets add unique flavor.

  • What are the best foods to try in Santa Cruz de la Sierra?

    Local favorites include salteñas, sonso de yuca, and traditional dishes made from corn, plantain, and tropical fruits. Refreshing drinks such as mocochinchi and locally roasted coffee are often recommended.

  • What should I bring for a trip to Santa Cruz de la Sierra?

    Pack lightweight clothing, sun protection, insect repellent, and comfortable shoes for walking. Bringing a reusable water bottle and rain jacket can add convenience, especially if you plan outdoor excursions.

  • What is the nightlife in Santa Cruz de la Sierra like?

    Santa Cruz de la Sierra has lively nightlife, with bars and clubs frequently suggested around the Equipetrol neighborhood. In the city center, you can explore relaxed venues featuring live music, local cocktails, and outdoor patios.

  • What are the most popular events or festivals in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has celebrated cultural festivals, Carnaval, and regional fairs throughout the year. Music, dance, and food events are frequently suggested, especially around holidays and community celebrations.

  • Are there family friendly vacation rentals in Santa Cruz de la Sierra?

    Family-friendly vacation rentals can be found in Equipetrol, Urbarí, and the city center, many with spacious layouts and access to parks or play areas. Hosts often provide amenities for children to make visits comfortable.

  • When is the best time to visit Santa Cruz de la Sierra?

    Visitors often prefer the drier months for outdoor activities and exploring city sights, while some enjoy the lush greenery during wet seasons. Popular festivals and pleasant evenings draw many travelers throughout the year.

Quick stats about vacation rentals in Santa Cruz de la Sierra

  • Total vacation rentals

    Explore 4,570 vacation rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra vacation rentals start at G$2,092 GYD per night before taxes and fees

  • Verified guest reviews

    Over 55,490 verified reviews to help you choose

  • Family-friendly vacation rentals

    1,260 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,180 rentals that welcome pets

  • Vacation rentals with a pool

    3,160 properties feature pools

  • Rentals with dedicated workspaces

    2,590 properties have a dedicated workspace

  • Wi-Fi availability

    4,240 of Santa Cruz de la Sierra vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Cruz de la Sierra rentals

  • 4.7 Average rating

    Santa Cruz de la Sierra stays receive an average rating of 4.7 out of 5 from guests

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