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Vacation rentals in Santa Clara

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Top-rated vacation rentals in Santa Clara

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
The exterior of the apartment is surrounded by lush tropical greenery, featuring various plants and trees. A balcony is visible on the upper level, providing a vantage point to enjoy the natural setting. Soft sunlight filters through the leaves, creating a serene atmosphere.
Guesthouse in Gamboa
4.96 out of 5 average rating, 80 reviews

Gamboa - Ñeque Studio, casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Top guest favorite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 181 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Top guest favorite
An outdoor space features a heated pool surrounded by light-colored tiles. A covered patio includes modern seating arrangements and a table, suitable for dining. Lush greenery is visible beyond the walls, with a glimpse of the sky above, providing a bright and open feel to the area.
Home in Vacamonte
5 out of 5 average rating, 26 reviews

The Hidden Gem

Here you will find your home away from home in this hidden gem. Furnished with all of the creature comforts, you will have plenty to do from relaxing on the patio while listening to music, to taking a dip in the heated pool, to relaxing on the comfy couch and watching Netflix. The house is situated on a beautiful gated beach property where you can find various activities from kayaking to the local water park. You can find the relaxation you were searching for here in this hidden gem.

Guest favorite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del Maria
4.81 out of 5 average rating, 299 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favorite
The exterior of a modern house is shown, featuring a covered entrance and a driveway with a parked car. Lush green grass and tropical plants add a touch of greenery, complemented by a palm tree. Large windows offer light to the interior spaces.
Home in Panamá
4.81 out of 5 average rating, 16 reviews

Excellent and affordable house in La Chorrera.

The house is completely private, has parking at the entrance, the master bedroom has a double bed, air conditioning and 65” smart TV and a fully private bathroom, a secondary bedroom with a double bed, air conditioning and 43” smart TV, a secondary bedroom with a twin bed, fan and 32” smart TV, and a shared bathroom. The living-dining room has a sofa, coffee table, TV table with a 32” smart TV, a 4-seat dining room, and a fully-equipped kitchen with a 16-foot refrigerator.

Top guest favorite
A view from inside the apartment captures a private balcony with two green chairs and a small round table overlooking a serene landscape. The scene includes a waterway and lush greenery, framed by an open sliding door that invites the natural light indoors.
Condo in Vacamonte
5 out of 5 average rating, 46 reviews

Waterpark, Ocean View & Restfulness

☆ What our guests are saying: "The best Airbnb we've ever been to." "Wonderful view of the sea." "Extremely clean." "The condominium is very safe and perfect for resting." "What a wonderful family vacation we had!" Amenities: ☆ A restaurant, a cafeteria, and a convenience store 2-minute drive away. ☆ Waterpark, pools, and saltwater lagoon. ☆ Free kayaks and boats at the lagoon. ☆ Beach loungers. ☆ Elevator and wifi on condo. ☆ 1 parking space. ☆ 24/7 security.

Guest favorite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 149 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Las Colinas de Caceres de Arraijan
4.98 out of 5 average rating, 217 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favorite
Chalet in Veracruz
4.89 out of 5 average rating, 113 reviews

A beachfront property very near to Panama city

The village name is Veracruz, this is a small fishing village located at the pacific ocean. It´s 20 minutes driving to Panama city. There are public buses or taxis available 24/7 The studio is located in a very quit área of Veracruz. And it´s an ideal place to retrait in the evening and enjoy the tranquility. On the beach of Veracruz are several nice restaurants and bars with live music located

Guest favorite
A modern apartment building is presented, featuring a well-maintained pool area in the foreground. Multiple lounge chairs and tables are arranged neatly around the pool, which reflects the blue sky above. The building showcases large windows, enhancing natural light throughout its levels.
Apartment in La Chorrera
4.89 out of 5 average rating, 38 reviews

The best getaway place in Panama

Enjoy the charmed Panama from our beautiful apartment in Costa Verde, La Chorrera. 30 minutes away from Panama City and 30 minutes away from tipical Panama provinces. Walk distance to the mall, banks, restaurants, pharmacies, stores and much more. Perfect place for you to enjoy all places of Panama. Relax with the whole family at this peaceful place to stay.

Guest favorite
Home in Brisas del Golf de Arraijan
4.95 out of 5 average rating, 20 reviews

" Casa Esmeralda: Spacious and ideal for families"

Spacious and comfortable family home with 3 bedrooms and 2 bathrooms, ideal for families or groups. Located just 20 minutes from Panama City, it's also very close to banks, pharmacies, supermarkets, restaurants, and more. Just an hour from the beach.

Top guest favorite
A spacious living area features a comfortable gray sofa and a stylish wooden coffee table. A swing chair hangs beside a large window, providing natural light. The dining area, with a wooden table and black chairs, is seen in the background, enhancing the open layout.
Home in Gamboa
4.9 out of 5 average rating, 30 reviews

Family home in Gamboa next to the Canal

Gamboa was founded in the 1930s by Americans from the old Panama Canal area. Forget your worries in this spacious and serene space. Enjoy walks on the Panama Canal and Gatun Lake. Birdwatching and hiking trails surrounded by fauna and vegetation.

Popular amenities for Santa Clara vacation rentals