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Vacation rentals in Santa Clara

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Clara

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Costa Esmeralda
4.98 out of 5 average rating, 190 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Superhost
An open-concept loft is showcased with a high, sloped ceiling and large windows that invite natural light. Comfortable seating is arranged around a glass table, while a dining area and a cozy sleeping space can be seen in the background. Nature views are visible through the windows.
Home in Santa Rita Arriba
5 out of 5 average rating, 3 reviews

The Bird's Nest in the Clouds

Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain, birds, and our chickens. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. Please read description fully.

Top guest favorite
A charming apartment building is nestled among lush greenery and tall trees. The exterior features a welcoming porch with railings and is surrounded by tropical plants, creating a serene environment. Natural sunlight filters through the leaves, highlighting the vibrant foliage.
Guesthouse in Gamboa
4.94 out of 5 average rating, 78 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
5 out of 5 average rating, 57 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Top guest favorite
Apartment in Panamá
4.98 out of 5 average rating, 217 reviews

Casco viejo cómodo y espectacular-parking

Escápate y descubre casco antiguo en este remodelado , cómodo y céntrico alojamiento en el corazón de Casco Viejo. Nuestra ubicación es lo mejor, te hará regresar. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. La propiedad data del siglo XVII (1756) historia y buen ambiente. Podrás explorar la zona a pie, cocina full equipada, cama king europea, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar -Cocina full equipada

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Las Colinas de Caceres de Arraijan
4.98 out of 5 average rating, 220 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favorite
Apartment in Panamá
4.98 out of 5 average rating, 126 reviews

Apartamento completo en Panama

Este encantador apartamento está ubicado en uno de los mejores barrios de Panamá, San Francisco, un lugar céntrico donde encontrarás amplía gastronomía, lugares de diversión, cerca a estaciones de buses, y al centro comercial más importante de la ciudad, Multiplaza. Este apartamento céntrico y tranquilo es una oportunidad que no querrás dejar pasar. Ofrece la combinación perfecta de comodidad, belleza y ubicación conveniente.

Guest favorite
Chalet in Veracruz
4.89 out of 5 average rating, 113 reviews

A beachfront property very near to Panama city

The village name is Veracruz, this is a small fishing village located at the pacific ocean. It´s 20 minutes driving to Panama city. There are public buses or taxis available 24/7 The studio is located in a very quit área of Veracruz. And it´s an ideal place to retrait in the evening and enjoy the tranquility. On the beach of Veracruz are several nice restaurants and bars with live music located

Top guest favorite
A dining table is set with elegant glassware and plates, positioned by a balcony that overlooks lush green foliage. The scene captures the natural light filtering through nearby plants, providing a nice view of the tranquil outdoor setting.
Condo in Panama
4.99 out of 5 average rating, 260 reviews

Patty’s Cozy Studio with K bed in Casco Viejo

Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!

Top guest favorite
A serene rooftop infinity pool reflects city lights and the night sky. The panoramic view captures the skyline of Ciudad de Panamá, showcasing tall buildings illuminated against the dark water, creating a calm atmosphere for relaxation.
Apartment in Panamá
4.99 out of 5 average rating, 122 reviews

Sky Lounge/ APT 1 BR-vista al Mar/Pool bar & GYM

Moderno apartamento de lujo en la Cinta Costera, ideal para ejecutivos, parejas o familias. Dormitorio amplio con vista al mar, baño privado, cocina y electrodomésticos. Diseño elegante con seguridad 24/7, gimnasio, piscinas, 4 restaurantes, bar y Sky Lounge. Ubicación privilegiada cerca de supermercados y excelente oferta gastronómica en Ciudad de Panamá. PANAMA

Top guest favorite
Home in Panama City
5 out of 5 average rating, 7 reviews

La Casa del Lago 2025

Casa nueva frente al lago en Cerro Azul, decorada por un arquitecto de D&G con muebles traídos de Bali. Cuenta con 3 habitaciones, 3 baños y 4 camas dobles , cocina equipada, BBQ, aires acondicionados y agua caliente. Cocina un delicioso BBQ con tus amigos frente al lago y disfruta los atardeceres desde una vista inigualable con acceso directo y kayak incluido.

Guest favorite
Cabin in Altos del Maria
4.94 out of 5 average rating, 35 reviews

Blue Sky Lodge; la mejor vista en Altos del María

Esta cabaña de lujo recién construida en la montaña ofrece un diseño moderno, acabados de calidad y vistas panorámicas de 180° de montañas y mar. Se encuentra en una comunidad cerrada segura, rodeada de un jardín verde, con amplias ventanas de vidrio que favorecen la conexión con la naturaleza. El clima es agradable, con temperaturas entre 23°C y 28°C. .

Popular amenities for Santa Clara vacation rentals

  1. Airbnb
  2. Panama
  3. Distrito Arraijan
  4. Santa Clara