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Vacation rentals in San Antonio

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Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.7 out of 5 average rating, 43 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Superhost
Home in Santiago
4.95 out of 5 average rating, 20 reviews

House minutes from Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Top guest favorite
Home in Canto del Llano
5 out of 5 average rating, 8 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

The space features a kitchen nook with a wooden table and two patterned stools. Light grey curtains frame a window, while a door leads to an outdoor area. A modern refrigerator and a stovetop are visible in the kitchen area, complemented by a neutral wall color.
Tiny home in El Estero de San José
5 out of 5 average rating, 3 reviews

Furnished apartment in Aguadulce

Mini house ideal for 1 or 2 people. It has a king-size bed, private bathroom, closet, TV, Wi-Fi, and ceiling fan. Integrated kitchen with breakfast bar, refrigerator, microwave, coffee maker, and kitchen utensils. Located in a quiet and safe residential area, just 10 minutes from downtown Aguadulce. Perfect for those who need a comfortable and accessible place to rest during their time in the city.

A cozy corner is shown with a light-toned futon, paired with a small wooden table and two modern chairs. Natural light enters through two windows, complementing the warm wooden paneling on one wall.
Condo in Panama City
4.63 out of 5 average rating, 32 reviews

Departamento 2E - BEST place in town.

Accessible apartment in the heart of Santiago, located 300m from the Central Bus Station and within walking distance of supermarkets and businesses. With good distribution of space, fresh and illuminated and with all basic services. The apartments provide a harmonious balance in the middle of the rush characteristic of the city, perfect for stays of families, friends, professionals, couples.

Superhost
Home in Santiago
4.22 out of 5 average rating, 9 reviews

Peaceful, Clean, and Conveniently Located House

This house is located in a quiet location on the edge of the city of Santiago about 10 minutes walking distance from the main shopping area of Central Ave. The house is fully furnished with air conditioning throughout the entire house. There is also a spacious kitchen with all the necessary appliances. You can enjoy the private backyard as you lay in the hammock.

Guest favorite
The two-story colonial house is showcased with a white facade and wooden accents. Decorative balconies with railings are present at the front, along with several potted plants adding color. The street is lined with other buildings, under a clear blue sky dotted with clouds.
Cottage in Parita District
4.8 out of 5 average rating, 44 reviews

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Superhost
A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Apartment in Santiago
4.88 out of 5 average rating, 8 reviews

d'rosas apartamentos 3PB

Discover the comfort in our cozy home in the heart of Santiago, Veraguas. Just a 5 minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring local culture and resting after a day of adventure. We look forward to seeing you!

Guest favorite
Apartment in Santiago
4.86 out of 5 average rating, 7 reviews

Accommodation in Santiago Centro

Enjoy the easy access to everything from this perfectly located accommodation, in the center of Santiago 2 minutes from the cathedral church, park, and the central Ave. Fresh and comfortable on the ground floor of a property a large terrace with access to the patio surrounded by nature.

A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in Paris
5 out of 5 average rating, 3 reviews

Farmhouse

Relax with the whole family at this place where the tranquility is breathable. It is a farmhouse 100 meters from a Grade A milk-milking shed. Surrounded by nature with beautiful sunsets and ancient trees. It is fully equipped.

Guest favorite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A large round mirror is mounted on a wall featuring elegant marble patterns, reflecting a warm wood accent. A small green plant is positioned nearby, adding a touch of nature to the space. The background reveals hints of a softly lit kitchen area.
Home in Santiago
4.53 out of 5 average rating, 15 reviews

Family Hosting

Basic accommodation, 2 bedrooms, fourth studio, safe and quiet for travelers, 5 minutes from Downtown so you can rest. 70% remodeled house

Popular amenities for San Antonio vacation rentals