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Vacation rentals in San Antonio

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Apartment in Santiago
5 out of 5 average rating, 3 reviews

Santiago lake Route

Disfruta de una estancia cómoda y tranquila en el corazón de Santiago de Veraguas. Nuestro alojamiento combina ubicación privilegiada, ideal para quienes buscan comodidad y conveniencia. A solo 3 minutos a pie de la Avenida Central, tendrás todo al alcance: supermercados, abarroterías, restaurantes etc. Es el espacio perfecto para relajarte antes o después de una gran aventura. Será un placer recibirte y brindarte un lugar acogedor donde tu estadía sea verdaderamente reconfortante. Te esperamos!

A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.74 out of 5 average rating, 57 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Home in Santiago
4.83 out of 5 average rating, 24 reviews

House minutes from Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Guest favorite
Home in Canto del Llano
4.92 out of 5 average rating, 48 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Home in Santiago
5 out of 5 average rating, 4 reviews

La Casita de Yary

My place is special for its comfort and location. This place is perfect to enjoy on business trips, as a group, or to relax as a family. Strategically located at the entrance to the city of Santiago, it puts you close to everything: supermarkets, restaurants, shopping malls, and more. 🏡 The space Enjoy a comfortable, modern, and welcoming environment that will make your stay an unforgettable experience. Smoking inside the property is prohibited.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 5 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A cozy corner is shown with a light-toned futon, paired with a small wooden table and two modern chairs. Natural light enters through two windows, complementing the warm wooden paneling on one wall.
Condo in Panama City
4.58 out of 5 average rating, 36 reviews

Departamento 2E - BEST place in town.

Accessible apartment in the heart of Santiago, located 300m from the Central Bus Station and within walking distance of supermarkets and businesses. With good distribution of space, fresh and illuminated and with all basic services. The apartments provide a harmonious balance in the middle of the rush characteristic of the city, perfect for stays of families, friends, professionals, couples.

A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Apartment in Santiago
4.81 out of 5 average rating, 16 reviews

d'rosas apartments 3PB

Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from the city center, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Superhost
Cottage in Parita District
4.79 out of 5 average rating, 47 reviews

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Top guest favorite
A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in Paris
5 out of 5 average rating, 8 reviews

Farmhouse

Relax with the whole family in this accommodation where tranquility is breathed. It is a farmhouse 100 meters from a Grade A milking parlor. Surrounded by nature with beautiful sunsets and centuries-old trees. It is fully equipped.

Superhost
A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 114 reviews

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

Guest favorite
Home in Santiago
5 out of 5 average rating, 10 reviews

Meters from Mall, Supermarkets, Hospital, etc.

Cozy, spacious, wifi, meters from Pricemart, pharmacies, restaurants, 40 minutes from Playa Torio, for families and groups of friends

Popular amenities for San Antonio vacation rentals