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Vacation rentals in San Antonio

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.8 out of 5 average rating, 40 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Top guest favorite
A simple exterior view of the property is presented, showcasing a small front yard with grass and a stone pathway leading to the entrance. The charming façade features a covered porch supported by white pillars, while a wrought-iron gate and decorative stone wall outline the front garden.
Home in Pocrí
5 out of 5 average rating, 9 reviews

Cozy simple and peaceful space

Discover a cozy, simple, and peaceful space, designed to offer you the rest you deserve. Located in a central area of ​​Aguadulce, you'll be close to everything you need without sacrificing tranquility. It's the perfect place to relax, unwind from daily stress, and enjoy a comfortable and hassle-free stay. Plus, this accommodation is pet-friendly, so you won't have to leave your pets at home: they're welcome here and can also enjoy the warm and relaxed atmosphere.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 4 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

Guest favorite
A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Apartment in Santiago
4.8 out of 5 average rating, 10 reviews

d'rosas apartamentos 5PA

Disfruta de la sencillez de este alojamiento tranquilo y céntrico.Descubre la comodidad en nuestro acogedor alojamiento en el corazón de Santiago, Veraguas. A solo 5 minutos a pie del centro de la ciudad, disfrutarás de un espacio bien equipado que incluye todas las comodidades necesarias para una estancia relajante. Ideal para explorar la cultura local y descansar después de un día de aventuras. ¡Te esperamos!

A cozy corner is shown with a light-toned futon, paired with a small wooden table and two modern chairs. Natural light enters through two windows, complementing the warm wooden paneling on one wall.
Condo in Panama City
4.66 out of 5 average rating, 29 reviews

Departamento 2E - BEST place in town.

Accessible apartment in the heart of Santiago, located 300m from the Central Bus Station and within walking distance of supermarkets and businesses. With good distribution of space, fresh and illuminated and with all basic services. The apartments provide a harmonious balance in the middle of the rush characteristic of the city, perfect for stays of families, friends, professionals, couples.

Superhost
Home in Santiago
4.22 out of 5 average rating, 9 reviews

Peaceful, Clean, and Conveniently Located House

This house is located in a quiet location on the edge of the city of Santiago about 10 minutes walking distance from the main shopping area of Central Ave. The house is fully furnished with air conditioning throughout the entire house. There is also a spacious kitchen with all the necessary appliances. You can enjoy the private backyard as you lay in the hammock.

Superhost
The two-story colonial house is showcased with a white facade and wooden accents. Decorative balconies with railings are present at the front, along with several potted plants adding color. The street is lined with other buildings, under a clear blue sky dotted with clouds.
Cottage in Parita District
4.78 out of 5 average rating, 41 reviews

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Apartment in Santiago
4.83 out of 5 average rating, 6 reviews

Alojamiento en Santiago Centro

Disfruta del fácil acceso a todo desde este alojamiento perfectamente ubicado, en el centro de Santiago a 2 minutos de la iglesia catedral, parque, y la Ave central. Fresco y cómodo en planta baja de una propiedad una terraza amplia con acceso al patio rodeado de naturaleza.

A charming house is surrounded by lush greenery, featuring tall trees that frame the structure. The red exterior complements the vibrant garden, which includes a variety of colorful plants. A shaded porch invites relaxation, while the expansive lawn offers open space for family activities.
Home in Paris
5 out of 5 average rating, 3 reviews

Casa de Finca

Relájate con toda la familia en este alojamiento donde la tranquilidad se respira. Es una casa de finca a 100 mts de una galera de ordeño de leche Grado A. Rodeada de naturaleza con atardeceres hermosos y arboles centenarios. Esta totalmente equipada.

A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A softly lit bedroom features a spacious bed covered with a textured grey bedspread. Two pieces of wall art adorn the walls above the bed, with a bedside table holding a small plant. A full-length mirror supports the decor, complemented by light-grey curtains.
Apartment in Santiago
4.67 out of 5 average rating, 9 reviews

Apartamento Señorial Urraca

Disfruta de la sencillez de este alojamiento tranquilo y céntrico, ideal para ti, con todo lo necesario para una estadía placentera.

Guest favorite
A single-story house features an arched entry with decorative windows. The front porch is equipped with seating, surrounded by greenery. A paved driveway leads to the home, providing access for vehicles, while the roof offers ample shade.
Home in Santiago
4.9 out of 5 average rating, 10 reviews

Casa Nuevo San Juan

Acceso facil desde la Panamericana. Es un área céntrico tiene disponibilidad de supermercado, farmacia, restaurante, hospital.

Popular amenities for San Antonio vacation rentals

  1. Airbnb
  2. Panama
  3. Distrito Atalaya
  4. San Antonio