Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Guest favorite

Tiny home in Pacific

4.95 out of 5 average rating, 167 reviews

Route 66 railroad shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Oct 9 – 16

G$22,507 GYD per night

Guest favorite

Home in Augusta

4.99 out of 5 average rating, 221 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Nov 21 – 28

G$36,488 GYD per night

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 496 reviews

301 Guesthouse SuperHost/Shop Discounts/Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Sep 18 – 25

G$28,574 GYD per night

Guest favorite

Guest suite in Saint Charles

4.95 out of 5 average rating, 300 reviews

Creekside Suite - Peaceful, Spacious, and Comfy

Enjoy your stay in a spacious walkout basement-level suite that includes bedroom, bathroom, living/dining room & patio. Bedroom has queen bed, dresser, desk & TV. Living room has futon, books, games & TV. TVs have Netflix. Suite has minifridge, microwave, toaster & coffee-maker. Eat at the dining table or sit up to the window counter to look out on the creek & woodlands behind the house. Situated in a quiet, safe neighborhood with parks & ponds. Just 8 miles from historic downtown St Charles.

Jul 9 – 16

G$22,363 GYD per night

Guest favorite

Cabin in Defiance

4.95 out of 5 average rating, 110 reviews

Hillside Cabin on 43 Acres w/ Private Lake & View!

Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!

Nov 15 – 22

G$49,608 GYD per night

Superhost

Tiny home in Pacific

4.89 out of 5 average rating, 494 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- fun, colorful plastic dinnerware, toys, books, puzzles, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Apr 1 – 8

G$22,664 GYD per night

Guest favorite

Farm stay in Lake Saint Louis

4.92 out of 5 average rating, 194 reviews

Updated Farmhouse 2 bd 2 acres

Updated Farm House on 2 acres,3 beds, 1 bth, this house has 2 bedroom with 3 beds, a fully equipped kitchen, living room, a full bathroom,double sinks,and laundry facilities, this house is a duplex, with 2 separate units, the upstairs is for Airbnb guest, the lower unit has a tenant, each unit has its own space and entrance. 25 minutes from the St. Louis Airport, close to the Missouri Wineries, Bush wild life area, and only 10 minutes to the Katie Trail along the Missouri River.

Dec 16 – 23

G$26,053 GYD per night

Guest favorite

Guesthouse in Marthasville

4.96 out of 5 average rating, 224 reviews

Hazel's House by the Katy Trail

In the heart of Missouri Wine Country. Within walking distance of the Katy Trail and Lake Creek Winery. Many wineries within a 25-30 minute drive. Enjoy a weekend getaway in a 2 bed 1 bath home. Hazel's House is clean, comfortable and private overnight accommodations. We are not a bed and breakfast, no food included, but there is coffee. Please make sure the location is suitable. We are located out in the country and the internet can be spotty.

Mar 6 – 13

G$23,552 GYD per night

Guest favorite

Home in Dittmer

4.95 out of 5 average rating, 359 reviews

Honeymoon Suite Camp Skullbone In The Woods

Romantic quiet cozy chalet for two! Vintage décor with all the modern amenities of home. Relax inside to unwind, kick back and watch a movie, surf the web via free wi-fi, curl up with a good book, open up a board game for a friendly challenge or share a drink with that special someone. Want some fresh country air? Lace-up those hiking boots and take like Camp Skullbones. . Enjoy the stars on the intimate deck with the glow from the gas fire pit.

Oct 4 – 11

G$31,335 GYD per night

Guest favorite

Loft in Washington

4.99 out of 5 average rating, 298 reviews

2nd Street Loft - Riverview

Complete Rehab, this historic 1883 storefront building hosts a well known artist and his gallery on the 1st floor. Above is your "loft space" close to wineries, Amtrak, featuring great views of the Missouri River. You’ll love this Downtown Washington location because of the walkable shops, bars, and restaurants many in historic buildings. The loft is great for couples, solo adventurers, and business travelers who can walk a flight of stairs.

Sep 13 – 20

G$20,887 GYD per night

Guest favorite

Guest suite in Dardenne Prairie

4.89 out of 5 average rating, 197 reviews

Treehouse Spa Suite

Treehouse Day Spa is nestled on 3 wooded acres in St.Charles County. Get away from it all while being close to it all at the same time. Augusta wineries, Main Street St. Charles and the Streets of Cottleville are all within minutes of the location! There are two rental units in the treehouse: The spa suite and the penthouse. They each have a separate entrance and are private spaces. Recharge your battery! Regroup Relax Refresh

Aug 1 – 8

G$16,142 GYD per night

Guest favorite

Home in Defiance

5.0 out of 5 average rating, 19 reviews

The Wilderness Home

Welcome to The Wilderness home. Nestled away on a 3.5 acre lot, this home offers plenty of privacy and nature. Located in the heart of wine country, all your destinations are just minutes away! Recently renovated, the Wilderness home offers a clean and updated feel while still maintaining the charm of an older home. Perfect for everyone from weekend get-awayers to wedding guests, this house has something for everyone!

Jan 7 – 14

G$46,680 GYD per night

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Defiance vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Stay near Defiance's top sights

Chandler Hill Vineyards15 locals recommend

August A. Busch. Memorial Conservation Area4 locals recommend

Weldon Spring Conservation Area3 locals recommend

Historic Daniel Boone Home15 locals recommend

Defiance Roadhouse3 locals recommend

Wine Country Gardens11 locals recommend

Other great vacation rentals in Defiance

Guest favorite

Home in Defiance

5.0 out of 5 average rating, 13 reviews

Venue at Defiance Farmhouse

Jul 16 – 23

G$42,352 GYD per night

Guest favorite

Cottage in Augusta

4.91 out of 5 average rating, 45 reviews

Romantic Augusta Cottage-Relax & get away!

Dec 24 – 31

G$33,618 GYD per night

Superhost

Guesthouse in Washington

4.83 out of 5 average rating, 52 reviews

Beautiful Guesthouse Sanctuary

Oct 18 – 25

G$32,982 GYD per night

Guest favorite

Home in Wentzville

5.0 out of 5 average rating, 28 reviews

Spacious (basement) apartment in Wentzville

Jan 15 – 22

G$29,263 GYD per night

Guest favorite

Place to stay in Warrenton

4.96 out of 5 average rating, 47 reviews

1888 Schoolhouse in Wine Country

Mar 21 – 28

G$23,226 GYD per night

Guest favorite

Tiny home in Gray Summit

5.0 out of 5 average rating, 26 reviews

Sherry’s Shouse! 1 mile-Purina, Pet’s stay Free!

Aug 28 – Sep 4

G$29,864 GYD per night

Guest favorite

Farm stay in Labadie

5.0 out of 5 average rating, 60 reviews

Romantic escape -100 acre horse farm near Purina.

Oct 15 – 22

G$42,343 GYD per night

Guest favorite

Home in Augusta

4.92 out of 5 average rating, 73 reviews

Honey Ridge Hideaway- Historic Home with Vineyard

Apr 18 – 25

G$106,038 GYD per night

Show all

Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Local attractions
Chandler Hill Vineyards, August A. Busch. Memorial Conservation Area, and Weldon Spring Conservation Area
Popular amenities
Kitchen, Wifi, and Pool
Wifi availability
10 properties include access to wifi
Total number of reviews
560 reviews
Nightly prices starting at
G$14,593 GYD before taxes and fees

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Tiny home in Pacific

Home in Augusta

Home in Saint Charles

Guest suite in Saint Charles

Cabin in Defiance

Tiny home in Pacific

Farm stay in Lake Saint Louis

Guesthouse in Marthasville

Home in Dittmer

Loft in Washington

Guest suite in Dardenne Prairie

Home in Defiance

Vacation rentals for every style

Hotels

Unique stays

Homes

Popular amenities for Defiance vacation rentals

Stay near Defiance's top sights

Other great vacation rentals in Defiance

Home in Defiance

Cottage in Augusta

Guesthouse in Washington

Home in Wentzville

Place to stay in Warrenton

Tiny home in Gray Summit

Farm stay in Labadie

Home in Augusta

Quick stats about vacation rentals in Defiance

Total rentals

Local attractions

Popular amenities

Wifi availability

Total number of reviews

Nightly prices starting at

Destinations to explore