Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Top guest favorite

A spacious sleeping area features a large bed adorned with plush white pillows. Shelves display vintage cameras and decorative items, while ambient lighting is created by lamps on side tables. The walls are painted a soft blue, adding to the room's calm ambiance.

Tiny home in Pacific

4.96 out of 5 average rating, 275 reviews

Route 66 Railroad Shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Top guest favorite

The charming farmhouse, with a gray exterior, features a welcoming front porch with circular doors. Surrounded by lush greenery and a well-maintained lawn, late afternoon sunlight gently filters through the leaves, adding warmth to the inviting scene.

Home in Augusta

4.98 out of 5 average rating, 257 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Top guest favorite

A cozy studio layout features a spacious queen bed adorned with floral bedding. A round dining table with four chairs is positioned nearby, surrounded by warm hardwood flooring. Natural light enters through a window, enhancing the inviting atmosphere.

Home in Villa Ridge

4.93 out of 5 average rating, 129 reviews

Serenity Valley (No Cleaning Fee)

Discover Serenity in this 675 sq ft Studio cottage on a private wooded lot. Cozy space with 1 queen bed & optional inflatable queen bed for up to 4 guests. Relax on the patio in Adirondak chairs, enjoy a bubble bath in the vintage clawfoot tub, or take in the panoramic woods view on the couch. Amenities include WIFI, washer/dryer, fully stocked kitchen, DishNetwork, pack&play. Just 60 mins from downtown STL, 15 mins from Washington, 20 minutes from Six Flags. Your tranquil escape awaits!

Guest favorite

A private hot tub is illuminated with soft blue lights, surrounded by a wooden fence. String lights hang overhead, enhancing the evening ambiance. The area offers seating options, creating a cozy space for relaxation.

Cottage in Augusta

4.86 out of 5 average rating, 87 reviews

Romantic Augusta Cottage-Relax & get away!

This cottage is designed to strengthen and refresh couples looking for a getaway from busy life. Relax in the comfortable Living room or prepare a meal in the recently updated fully furnished kitchen. Enjoy your nights in the spacious bedroom furnished with a California King sized bed and TV in the room. Enjoy the private hot tub just steps from the door or use the BBQ pit to create a meal to enjoy together. Area restaurants, wineries & golf are just minutes away! You are sure to enjoy!

Top guest favorite

A cozy living area is furnished with a thick-cushioned leather futon, complemented by decorative pillows. A small table sits in front of the futon. A wall clock and a bicycle decoration provide character. Doorways lead to a spacious bedroom and other areas.

Guest suite in Wright City

4.81 out of 5 average rating, 119 reviews

Private Suite w/ Washer & Dryer

Beautifully decorated warm cabin feel. Spacious bedroom with nice desk for your laptop work space. Bathroom has washer and dryer. Living room has thick-cushioned leather futon for second bed, counter space with microwave/air fryer, paper products, and kuerig coffee maker, new 5’ fridge, 50” flat screen TV. Access to outdoor hot tub. Internet was weak so affected some reviews but is super fast now. Near Cedar Lake Winery, Big Joel’s Safari, Long Row Lavender Farm, and Pumpkins Galore

Guest favorite

A bright living room features two light-colored sofas arranged around a dark coffee table, with a geometric patterned rug below. A wooden accent wall hosts a mounted TV and decorative plants. Warm lighting is provided by a side lamp, creating a cozy environment.

Home in Augusta

4.91 out of 5 average rating, 46 reviews

Modern Barnhouse Retreat

♥ Relax and enjoy the incredible views on this home ♥ Close to Katy Trail, Good News Brewery, Mount Pleasant Winery & Augusta Winery. Shuttle services also available! This spacious home is in the heart of wine country. Take some time with your friends, family or partner to unwind and put your worries behind you. This home offers enough room for 4 people to comfortably stay while also creating an intimate ambiance if you wish to enjoy a romantic weekend in wine country.

Guest favorite

A queen-sized bed is featured with a patterned grey bedspread, positioned near a window with wooden blinds. A cozy chair sits in the corner, accompanied by decorative elements, including a globe and a travel-themed sign, enhancing the room's inviting atmosphere.

Guest suite in Weldon Spring

4.94 out of 5 average rating, 53 reviews

Wanderlust

The whole group will enjoy easy access to everything from this centrally located living space. It is located only 10 minutes from the wineries, 8 minutes from the outlet mall, and 15 minutes from downtown St. Charles. With 920 square feet of living space, this dwelling also offers a kitchenette, living room, and game area. There is a full-sized pool table, ping pong table, and foosball table. There is also access to a hot tub and fire pit upon request.

Guest favorite

A single-story home is depicted with a metal roof and a front door featuring a decorative window. Brightly colored flower pots filled with blooms are arranged along the path, complemented by landscaped greenery surrounding the property.

Tiny home in Pacific

4.9 out of 5 average rating, 644 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- toys, books, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Top guest favorite

A spacious loft area is arranged with a cozy sitting area featuring a tan leather couch, blue armchair, and a circular dining table. A large bed is positioned against the wall, with elegant window treatments framing the natural light. A piece of art depicting a forest scene adds character.

Loft in Washington

4.99 out of 5 average rating, 390 reviews

2nd Street Loft - Riverview

Complete Rehab, this historic 1883 storefront building hosts a well known artist and his gallery on the 1st floor. Above is your "loft space" close to wineries, Amtrak, featuring great views of the Missouri River. You’ll love this Downtown Washington location because of the walkable shops, bars, and restaurants many in historic buildings. The loft is great for couples, solo adventurers, and business travelers who can walk a flight of stairs.

Guest favorite

A treehouse-style rental is nestled among vibrant autumn foliage, with wooden steps leading up to the entrance. The structure features a private front porch, framed by surrounding trees and a gravel path, conveying a natural and serene atmosphere.

Guest suite in Dardenne Prairie

4.89 out of 5 average rating, 279 reviews

Treehouse Spa Suite

Treehouse Day Spa is nestled on 3 wooded acres in St.Charles County. Get away from it all while being close to it all at the same time. Augusta wineries, Main Street St. Charles and the Streets of Cottleville are all within minutes of the location! There are two rental units in the treehouse: The spa suite and the penthouse. They each have a separate entrance and are private spaces. Recharge your battery! Regroup Relax Refresh

Top guest favorite

A cozy seating area features an arrangement of two armchairs, one upholstered in blue and the other in green, complemented by a light brown recliner. A wooden coffee table sits at the center, adorned with a decorative tray. Soft lighting is provided by two lamps on either side.

Apartment in Washington

4.96 out of 5 average rating, 423 reviews

Elbert haus

The entire 2nd floor reserved to just one set of guest. Just three blocks from the Missouri Riverfront, historic downtown Washington, and near many fine restaurants. This early 1900s fully restored brick home offers a perfect place to lay your head after an exciting day. The house is located within walking distance of the Amtrak train station, close to the hospital and the trans Missouri Katy bicycle Trail.

Guest favorite

A modern kitchen features exposed brick walls and wooden beams overhead. A central island with seating is complemented by stainless steel appliances and white cabinetry. Natural light illuminates the space, highlighting decorative plants and a wall clock, creating an inviting atmosphere for culinary activities.

Home in Augusta

5 out of 5 average rating, 125 reviews

Augusta Haus

This early 1850's Augusta home has been lovingly revitalized to help those who stay here capture the essence of Augusta. While we have highlighted the craftsmanship of the original builder, we have also incorporated our vision of a comfortable historic home in the very heart of Missouri wine country. Great for couples as well as those traveling with friends or children. Relax and enjoy our Augusta Haus!

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Popular amenities for Defiance vacation rentals

Kitchen

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Pool

Free parking on premises

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Other great vacation rentals in Defiance

Top guest favorite

A well-lit bedroom features a spacious bed adorned with a patterned comforter and decorative pillows. A soft throw rests on the bed, while a standing lamp and wooden bookshelf provide additional touches. A window with light curtains allows natural light to brighten the room.

Private room in Saint Charles

4.95 out of 5 average rating, 113 reviews

Beautiful Private Bedroom & Private Full Bath

A spacious living area features a modern stone fireplace, framed by large windows allowing natural light to fill the room. Two cushioned armchairs complement a plush sectional sofa, centered around a wooden coffee table. A hint of greenery is provided by a potted plant in the corner.

Home in Boles Township

4.86 out of 5 average rating, 35 reviews

Serene 4BD/4BA Countryside +Hot Tub by Lake & Golf

Guest favorite

A two-person wooden soaker tub is set against a backdrop of warm, natural wood paneling. The tub features a smooth, curved design and is equipped with chrome fixtures. A folded white towel rests on the edge, with a wooden rack holding toiletries nearby.

Hotel room in Washington

4.91 out of 5 average rating, 182 reviews

American Bounty: Upper Patio Access

Guest favorite

A private room features two wooden bunk beds with navy blue mattresses. A chair is positioned nearby, and a window allows natural light to brighten the space. Neutral-colored walls and carpeting contribute to a simple, functional layout.

Private room in Marthasville

4.92 out of 5 average rating, 25 reviews

Private room and bath near Katy Trail: Rm #H

Guest favorite

The exterior of a charming two-story house is shown, featuring a wrap-around porch with wooden railings. The front steps lead to a well-maintained lawn, while a colorful sunset sky creates a serene backdrop. Nearby trees frame the scene, adding to the peaceful ambiance.

Home in Labadie

4.96 out of 5 average rating, 48 reviews

Fenced yard-5 min from Purina & near Hidden Valley

A functional kitchen features sleek black cabinetry and a light granite counter. A double sink is positioned under a window, allowing natural light in. Kitchen tools are neatly organized in metallic containers, while an electric stove is complemented by a checkered dish towel hanging nearby.

Apartment in Washington

4.76 out of 5 average rating, 97 reviews

Urban comfort located in downtown Washington

Guest favorite

A spacious living area is depicted, featuring a wall-mounted TV and multiple shelves displaying various items. Light-colored walls surround comfortable seating options, complemented by framed artwork in a variety of styles. Soft, ambient lighting from recessed fixtures enhances the overall warmth of the space.

Private room in O'Fallon

5 out of 5 average rating, 20 reviews

Entire Basement with attached bath & all amenities

A serene pond is framed by lush greenery and gentle trees under a clear blue sky. A grassy area leads to the water's edge, with swans gracefully gliding on the surface. A mound of branches is situated on the bank, completing the tranquil landscape.

Home in St. Peters

5 out of 5 average rating, 3 reviews

Private Entrance Basement Guesthouse -Sports Moms

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Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Nightly prices starting at
G$14,650 GYD before taxes and fees
Total number of reviews
360 reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
August A. Busch. Memorial Conservation Area, Weldon Spring Conservation Area, and Chandler Hill Vineyards

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Vacation rentals for every style

Popular amenities for Defiance vacation rentals

Other great vacation rentals in Defiance

Quick stats about vacation rentals in Defiance

Total rentals

Nightly prices starting at

Total number of reviews

Wifi availability

Popular amenities

Local attractions

Destinations to explore