Vacation rentals in Perryville

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Quick stats about vacation rentals in Perryville

  • Total vacation rentals

    Explore 30 vacation rentals in Perryville

  • Nightly prices starting at

    Perryville vacation rentals start at G$14,617 GYD per night before taxes and fees

  • Verified guest reviews

    Over 1,220 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    20 of Perryville vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Perryville rentals

  • 4.9 Average rating

    Perryville stays are highly rated by guests—averaging 4.9 out of 5!

Top-rated vacation rentals in Perryville

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious living area features exposed brick walls and original wood floors. Large windows provide natural light, while a comfortable sofa and dining table accommodate relaxation and meals. An area rug adds color, and modern lighting enhances the inviting atmosphere.
Loft in Perryville
4.97 out of 5 average rating, 333 reviews

Downtown Loft Amazing Bath Tub & Shower

Downtown Perryville, MO **DISCLAIMER** you will hear restaurant chatter & music if you do not have a tv/or radio playing between the hours of 10:30am & 1:30am. If you go to bed early I recommend headphones, ear plugs or play nature sounds on Alexa. This is a pet friendly loft apartment so I would not recommend if you are allergic to dogs or cats. This apartment is located above one of the most popular destination restaurant's around "Mary Jane Burgers & Brew" on the Downtown Historic Square.

FamilyLocationSleep quality

Top guest favorite
The geodesic dome is illuminated warmly from within, creating a welcoming glow against the night sky. The structure's unique shape and large window reveal a glimpse of the cozy interior, showcasing a serene space ideal for relaxation and connection with nature.
Dome in Perryville
4.94 out of 5 average rating, 174 reviews

The Snow Globe*OffGrid DomeGLAMP*Adventurers Only

EXPERIENCE The Dome in the Woods • IMMERSE in complete silence with the absence of electricity: no hum or vibrations from this completely solar/propane fueled geodesic dome. NoAC • GLAMP in this OFF GRID ADVENTURE. 430 sq ft floor plan. 14 ft ceiling. 20 ft bay window with endless nature view at the foot of your bed. Lofted 7ft. • STARGAZE from the deck or fire pit • NESTLE in the romantic wooded nature of southeast MO. S of St Louis.N of Memphis • UNPLUG, UNWIND, RELAX. Adventure seekers only!

LocationFamilyKitchen

Superhost
A 20-foot yurt is situated among bare trees, surrounded by nature. A spacious wrap-around deck enhances outdoor living. The structure features a circular design with a clear dome top and a single door visible. Nearby, a separate area can be seen, possibly for cooking or relaxation.
Yurt in Fredericktown
4.87 out of 5 average rating, 126 reviews

St Francis River: The Blue Yurt and Hot Tub

Let your adventure begin inside the tranquil experience of this 20 ft yurt. Don't let the space fool you, the uniquely curved walls give ample space for a romantic getaway or a relaxing time with friends. The clear dome top provides a magical viewing experience from the queen size bed. The yurt is nestled in the heart of the Ozark Mountains. The expansive, romantically lighted, wrap-around deck provides a panoramic view of the St. Francis River where you can immerse yourself in the hot tub.

LocationGetting aroundKitchen

Guest favorite
The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.
Treehouse in Cape Girardeau
5.0 out of 5 average rating, 210 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

ValueFamilyGetting around

Guest favorite
A modern tiny home exterior features a stone façade and large glass windows allowing ample natural light. The welcoming front porch is furnished with two white adirondack chairs, providing a cozy spot to enjoy the view of the surrounding landscape.
Tiny home in Bloomsdale
4.91 out of 5 average rating, 188 reviews

Miette Suite at Baetje Farms

Welcome to the Luxury Tiny Homes at Baetje Farms, where comfort meets countryside. These homes will awaken your senses and enlighten your soul with the cozy, yet spacious intimate feel beneath the stars. Nestled between rolling hills of the Forche du Clos Valley and a spring feed babbling creek the tiny homes are the newest addition to Baetje Farms. Just 3 miles off Interstate-55 at the entrance to wine country, in Bloomsdale, MO, Baetje Farms is the World Renowned Goat Cheese Creamery!

LocationFamilyView

Top guest favorite
The treehouse structure is elevated, supported by stilts, with large windows that reflect the surrounding greenery. The exterior features a combination of wood finishes, and warm lighting casts a welcoming glow in the evening. The pathway leads through the natural landscape to the entrance.
Treehouse in Perryville
5.0 out of 5 average rating, 710 reviews

Private Treehouse Retreat | Hot tub

The TreeLoft is the first of two treehouses at BaseCamp—designed for cozy seclusion, romance, and rest. Nestled in a private forest just 1 hour from St. Louis, it blends upscale comfort with immersive nature, while still being 20–35 minutes from hiking, wineries, and dining. ✨Our NEW treehouse, The TreeRise, offers an even more elevated, spacious experience at BaseCamp. Perfect for romantic getaways, anniversaries, personal retreats, and intentional escapes to unplug and reconnect.

ValueFamilyOutdoor spaces

Top guest favorite
Treehouse in Perryville
4.95 out of 5 average rating, 205 reviews

Rustic reTREEt Treehouse Getaway

This treehouse features a gorgeous floor-to-ceiling stone indoor/outdoor fireplace, vaulted ceiling, and many large windows which provide natural light and beautiful views. The interior design fuses natural elements of wood and stone, with a more refined and polished urban country look. A partition wall creates intimate spaces w/in this large (950 sq.ft.) open floor plan. Highlights: king size bed, corner claw tub, rainfall shower, reading area, 65" TV, large deck,BBQ grill and WIFI.

FamilyValueSleep quality

Top guest favorite
The sleeping area features a queen-size bed with decorative pillows and a textured blanket. Soft lighting is provided by wall sconces, and a framed artwork enhances the wall above. A wooden bench rests at the foot of the bed, complementing the warm tones of the decor.
Guest suite in Perryville
4.96 out of 5 average rating, 408 reviews

Tranquil, Spacious Retreat to Rest and Relax!

This Private Guest Suite is nestled on the lower level of the home and offers a peaceful setting with great charm in which to rest and relax during your travels. ✦Features....... ✦Just 4 min from I-55 ✦Queen-Size Bed with Memory Foam topper ✦Sofa-bed for additional sleeping ✦Peaceful, Outdoor Sitting Area with Gas Firepit ✦55" Roku TV w/ surround sound ✦55" Roku TV in Bedroom & Electric Fireplace ✦Located at the end of a private lane - NO through traffic ✦NO Steps! ✦Home Gym

LocationFamilyLayout

Top guest favorite
An inviting modern cabin exterior is illuminated at dusk. The deck features outdoor seating with a table and chairs, complemented by a hot tub nearby. Soft lighting outlines the steps, providing a warm glow against the backdrop of a deep blue sky.
Cabin in Pomona
5.0 out of 5 average rating, 157 reviews

Modern Cabin at Trillium Ridge

Tucked into the rolling hills of the Shawnee National Forest, our modern cabin offers a welcoming retreat where comfort and nature meet. Wander down a private trail to explore or climb at the Holy Boulders, or take an easy drive to local wineries and see the iconic sights of Little Grand Canyon, Inspiration Point, and Pomona Natural Bridge. When you’re ready to slow down, return to soak in the hot tub, unwind in the sauna, and settle into our cabin made for rest and connection.

LocationValueCheck-in

Top guest favorite
A modern tiny home is set amidst a natural landscape, featuring a sleek black exterior with wooden accents. A stone pathway leads to the entrance, while a fire pit area with Adirondack chairs is visible in the foreground, surrounded by gravel and trees.
Tiny home in Ste. Genevieve
4.95 out of 5 average rating, 103 reviews

The Caamp

The Caamp located directly across the road from The Barn at Lone Eagle Landing and Pebble Creek provides a close and convenient place to stay along with a breath taking view of the upper Coffman valley. The Caamp is also very close to Chaumette and Charleville. If outdoor adventure is what you seek The Caamp serves as a great landing zone to explore nearby attractions like Pickle Springs and Hawn State Park. Sit back and enjoy the view from this gorgeous and cozy tiny home.

ValueFamilyWalkability

Top guest favorite
The treehouse is elevated on wooden stilts, surrounded by lush greenery. A wooden deck with a railing extends from the entrance, creating a welcoming outdoor space. Large windows brighten the upper level, while a sun art piece adorns the side of the structure.
Treehouse in Makanda
4.96 out of 5 average rating, 451 reviews

Panthers Inn Treehouse

Come nestle amongst the leaves at Panthers Inn Treehouse. This secluded, well equipped, elevated cabin has the perfect combination of natural beauty and artful luxury. Isolated yet conveniently located 2 minutes from Blue Sky and Feather Hill wineries, within 5 minutes of Panthers Den hiking trail and the Shawnee Hills canopy tour and only 10 min from I-57 exit 40. Panthers Inn is the perfect starting and ending point to your Shawnee Hills Wine Country vacation!

FamilyValuePets

Top guest favorite
The historic log cabin features a traditional wood exterior, accented by a sloped roof and a welcoming front porch. Two rocking chairs and vibrant flower pots are positioned at the entrance, set against a tranquil landscape. Soft lighting enhances the inviting appearance as dusk approaches.
Cabin in Ste. Genevieve
4.97 out of 5 average rating, 230 reviews

Sassafras Creek Cabin

Historic log cabin circa 1840 moved to property June 2020. Take a step back in time with furniture and decor to match the cabin’s time period. Located between two houses in newly formed Ste. Genevieve National Historical Park. It is a 10 minute walk to the main part of downtown and other historic tour sites. Adjoins Early American gift shop called Sassafras Creek Originals which is housed in the circa 1850 Brooks house. Close to wineries, biking and hiking.

FamilyValueParks

Popular amenities for Perryville vacation rentals

When is the best time to visit Perryville?

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Avg. priceG$21,926 GYDG$24,432 GYDG$25,058 GYDG$28,190 GYDG$25,476 GYDG$26,311 GYDG$20,882 GYDG$21,091 GYDG$22,344 GYDG$20,673 GYDG$24,014 GYDG$23,179 GYD
Avg. temp1°C4°C9°C14°C20°C25°C26°C25°C21°C15°C8°C3°C

Frequently Asked Questions

  • What are the best places to stay in Perryville?

    Stay in Perryville’s central neighborhoods for easy access to shops, parks, and local attractions. Options range from cozy homes to larger vacation rentals, catering to solo travelers, families, and groups.

  • What are the best things to do in Perryville with kids?

    Enjoy playgrounds and recreation areas, visit museums with hands-on exhibits, and participate in seasonal festivals. Perryville’s parks and family-friendly events encourage exploration for all ages.

  • What are some of the best things to do in Perryville?

    Explore local museums, stroll the town's historic center, and visit parks for relaxing walks. Perryville also has community events and gatherings that highlight its local culture.

  • How is the weather in Perryville?

    Perryville has cold winters around 26–43°F (-3–6°C) and summers warming to 69–89°F (21–32°C). Spring and fall bring milder temperatures, though spring can be notably rainy. Pack layers and a rain jacket to stay comfortable throughout the year.

  • When is the best time to visit Perryville?

    Spring and fall are often recommended for comfortable temperatures and pleasant outdoor conditions, with daytime highs around 58–71°F (14–22°C). These seasons coincide with popular festivals and blooming landscapes.

  • What are the best places to visit in Perryville?

    Visit historic sites, local museums, and community parks for a window into Perryville’s heritage and outdoor spaces. The town has unique shops and galleries highlighting local artisans.

  • What are some hiking trails in Perryville?

    Perryville has walking paths in its parks and nature areas, with routes shaded by trees and featuring native plants. Trails are suitable for all ages and encourage relaxed exploration.

  • What are some family activities we can do in Perryville?

    Families can explore community parks, visit local museums, and attend festivals that feature games and entertainment. Outdoor recreation and shared learning experiences are frequently suggested.

  • What are some of the best day trip ideas from Perryville?

    Explore nearby nature reserves, visit towns with historic main streets, or head to regional museums for learning experiences. The area around Perryville has scenic spots and cultural attractions.

  • Are there any pet friendly accommodations available in Perryville?

    Pet friendly accommodations are available in Perryville, especially around residential areas and close to green spaces. Look for listings that mention pet policies to ensure a smooth stay with your companion.

  • What are some local tips for visiting Perryville?

    Engage with local shops for regional specialties, attend community gatherings to experience Perryville's culture, and check event calendars for seasonal happenings. Travelers often appreciate the warm welcome and relaxed pace.

  • What is Perryville known for?

    Perryville is known for its rich history, welcoming community, and regional cultural traditions. The city has historic landmarks and annual events that celebrate its agricultural and small-town heritage.

  • What are the best hidden gems to explore in Perryville?

    Discover locally owned shops, art galleries, and small museums that highlight Perryville’s creative community. Neighborhood parks and historic architecture often reward curious visitors looking beyond main streets.

  • What are the best foods to try in Perryville?

    Perryville has hearty Midwestern cuisine, with dishes like barbecue, fried chicken, and homemade pies frequently suggested. Locally sourced produce and traditional comfort foods are popular choices in area restaurants.

  • What should I bring for a trip to Perryville?

    Pack clothing for variable weather, including layers and a light rain jacket, plus comfortable walking shoes for town and nature outings. If visiting during festivals, consider bringing reusable water bottles and sunscreen.

  • What is the nightlife in Perryville like?

    Perryville has a laid-back nightlife scene, featuring casual bars, locally owned restaurants, and occasional live music. Evenings often center around relaxed social spaces and community gatherings.

  • What are the most popular events or festivals in Perryville?

    Perryville hosts agricultural fairs, cultural celebrations, and community festivals, often scheduled around late spring and Labor Day weekend. Seasonal events showcase regional traditions and local artists.

  • Are there family friendly vacation rentals in Perryville?

    Perryville has vacation rentals welcoming families, with options near parks and quiet neighborhoods. Many homes provide comfortable amenities suitable for children and multigenerational groups.