Bed and breakfast vacation rentals in Missouri

Find and book unique bed and breakfast rentals on Airbnb

Top-rated bed and breakfast rentals in Missouri

Guests agree: these bed and breakfast rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A dining area features a checkered blue and white tablecloth covering a round table set with plates and glassware. A vase of white tulips adds a touch of color. Large glass doors allow natural light to enter, providing views of the wooded surroundings.

Farm stay in Philadelphia

5 out of 5 average rating, 11 reviews

Scenic Farm Retreat: Deck, Campfire & Fresh Food

Unwind at our rustic, countryside vacation rental near historic Hannibal, Missouri! Our family-friendly farm accommodation boasts a large wooded private deck, a cozy fire pit for starry evenings, and scenic woodland trails for family walks. Wake up at our rural retreat with fresh produce served up for a delicious cooked breakfast. Experience the charm of homestead living while staying close to Hannibal's historic sites. Relax, recharge, and create lasting memories at our stunning rustic getaway!

Top guest favorite

A wooden staircase leads up to a cozy outdoor seating area, shaded by a large umbrella. Soft light from lanterns creates a warm ambiance. Nearby, a circular stone fire pit holds a glowing fire, surrounded by trees offering a serene outdoor setting.

Tiny home in Park Hills

4.96 out of 5 average rating, 658 reviews

🔝❤️ PEACEFUL TREETOP COTTAGE

Small place for big occasions. PERSONALIZE your stay at our cozy wooded retreat with optional private European style HOT TUB, SAUNA, MASSAGES, intimate world-class FINE DINING, fire pit with FREE firewood + s'mores, and much more. We provide a HOMEY stay, EXCLUSIVE services, ROMANTIC privacy and affordable LUXURY for relaxing, reconnecting & rejuvenating. We're best for guests valuing quality over quantity, and those CELEBRATING life. We GUARANTEE an enjoyable and stress-free stay. PET FRIENDLY.

Guest favorite

A bright living area features light-colored walls and a cozy ambiance. A spacious dark sofa is complemented by a patterned area rug and a wooden coffee table. A large TV is placed on a storage unit, and a stylish light fixture hangs from the ceiling. Potted plants add a touch of greenery.

Home in St. Louis

4.87 out of 5 average rating, 574 reviews

Sunny 2 Bedroom Apartment in Historic Home

Recently renovated sunny 2 bed, 1 bath apartment on the top (3rd) floor of an historic home in the Central West End. Private entrance off driveway, with street parking available. A great place to stay while exploring the best St. Louis has to offer! Walk to shops, restaurants, universities, and medical centers. Close to public transportation, and an 8 minute drive from downtown. We welcome guests of all backgrounds. Whether you're traveling for work, fun, or family, we are happy to host you.

Top guest favorite

A serene landscape features several horses grazing in a lush green pasture. The expansive grassy area is bordered by a wooden fence and trees in the background, creating a peaceful rural setting.

Guesthouse in Wright City

5 out of 5 average rating, 263 reviews

Red Mule Ranch - Breakfast included

Cozy, rustic, “bunkhouse." Charming cedar log double bed. Private bath. Located on 85 acre horse farm. Lrg pond, beautiful pastures. Near Innsbrook, Cedar Lakes Cellars Winery, Big Joel's Safari, Long Row Lavender Farm, and many local wineries & antique shops. Homemade breakfast (5 choices), at NO extra charge, & chocolate chip cookies are in your room upon arrival. Perfect anniversary getaway. Your favorite pie/ cake can be made for a small charge. NO cleaning fees #1 Airbnb Host in Missouri

The cabin exterior features rustic wooden siding and a welcoming front porch adorned with seating and potted plants. The surrounding area is green and well-maintained, and large windows allow natural light to illuminate the inviting space.

Cabin in Hollister

4.78 out of 5 average rating, 74 reviews

Cozy Hollister Cabin: Perfect for Families!

This welcoming 3-bedroom, 3-bath Hollister vacation rental is the ideal retreat for a group looking for an Ozark adventure. The cabin boasts an inviting interior that instantly makes you feel right at home, with a fully equipped kitchen and laundry room to ensure a stress-free stay. Sip morning coffee on the front porch before heading out for Branson sightseeing or fishing. The property is also just a short drive from Silver Dollar City where the crew can enjoy fun amusement rides and shopping!

Guest favorite

A charming bedroom features a spacious bed layered with colorful pillows and a textured throw. Brightly painted walls are adorned with an array of artwork and photographs. Natural light filters in through large windows, while a ceiling fan adds a touch of elegance to the vibrant decor.

Home in St. Louis

4.99 out of 5 average rating, 112 reviews

Kalisto House: 420 Retreat w/Concierge & Hottub

Take it easy at this tranquil retreat in historic Tower Grove Heights, St. Louis. Nestled in a preserved 120-year-old flat, Kalisto House offers an immersive experience for the canna-curious to the Cannaseur. With cannabis-inspired art, a serene meditation room, and concierge service, this sanctuary invites you to explore, unwind, and connect. From personalized pairings to guided rituals, every detail is curated for an unforgettable, elevated escape. Ask about premium & bespoke experiences.

Top guest favorite

Private room in Columbia

4.99 out of 5 average rating, 429 reviews

The Fairway Suite

Fairway Suite is close to the city center, parks, and art and culture. It is a place that is good for couples, solo adventurers, and business travelers. The neighborhood is built around The Columbia Country Club, Columbia's "original club", and boasts at least one historic home. With Stephens Lake Park and Stephens College Stables in close proximity, not to mention downtown Columbia, there is great convenience to many options for leisure and relaxation, shopping, or medical community.

Guest favorite

Private room in Liberty

4.88 out of 5 average rating, 225 reviews

Jewell Street B&B

A real Jewell on Jewell Street! PRIVATE entrance, room, bath, and breakfast nook. You will love it because of the people and the quaint and comfortable historic home built in 1920 with all the modern amenaties. We offer luxurious bedding, big screen TV, high speed internet in a relaxing and enjoyable setting. It is a peaceful, atmosphere close to William Jewell College, Historic Liberty Square, 20 Minutes from KCI, with shuttle service available for a nominal fee.

Guest favorite

Home in Gray Summit

4.87 out of 5 average rating, 183 reviews

Sunset Mountain Forest Privacy

Nowhere else will you find a jacuzzi tub, private pool with an amazing view, gas fireplace, 3 bedrooms and 2 full bathrooms on the main floor with private entrance, spacious living room, kitchen, and covered deck, plus free laundry for this price! Host stays in separated lower level and the only places shared are the laundry room and outdoors. Great for dog owners attending Purina Farms, 3 individuals, 3 couples, or a couple and 2-5 kids. Great for weekend getaways!

A parlor space showcases a round table at the center, surrounded by classic seating options including a striped sofa and armchair. Elegant lamps provide soft illumination, while framed artwork adorns the walls. A floral area rug adds a touch of charm, enhancing the inviting atmosphere.

Home in Marquand

4.88 out of 5 average rating, 16 reviews

Belmont Inn Bed & Breakfast- Whole House (4 BDRMS)

At Belmont B&B you will find a residence where Victorian splendor reigns while modern convenience prevails. The Belmont’s porches are ready for relaxation and laughter, or can provide a quiet meditative space to indulge in a good read or. The Belmont offers 4 splendid sleeping rooms, a beautiful front parlor, a modern kitchen, shared restroom accommodations, and a lovely dining room to enjoy your complimentary continental breakfast.

The suite features a king-sized bed, a cozy loveseat in front of a stone fireplace, and a spacious two-person jacuzzi tub. A kitchenette is visible, along with a 4K TV mounted on the wall. Indoor plants add a refreshing touch to the warm decor.

Guesthouse in Reeds Spring

4.85 out of 5 average rating, 355 reviews

Branson White River Suite

The Branson White River Suite has its own deck and private entrance. Themed with forest accents & a peaceful outdoor look. Has a loveseat in front of the fireplace, a Jacuzzi tub, a private entrance, soft robes, 14 foot ceilings, a king size bed, and a beautiful view that overlooks the Ozark mountain range. Comes equipped with 4K TV & DVD player, complimentary continental style breakfast items inside each suite.

Top guest favorite

A wooden staircase with ornate banisters leads to the upper level of the home. Natural light filters through a window at the landing, highlighting the rich hardwood floors. A decorative wall piece is mounted nearby, and a small metal rack is positioned at the bottom of the stairs.

Home in St. Louis

4.92 out of 5 average rating, 1,013 reviews

Benton Manor, 5 mins from everything in the city

This attractive two bedroom home with finished basement that has additional beds is conveniently located in the historic Benton Park area just slightly west of the Soulard neighborhood. Historic charm with all the modern amenities. Beautiful hardwood floors, high ceilings with grand windows and staircase await. Why stay in a hotel when you can have so much more for less?