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Vacation rentals in Mesilla

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Top-rated vacation rentals in Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
An aerial view of a Pueblo Style home is presented, showcasing a serene pool surrounded by a spacious outdoor area. The home is set against a backdrop of rolling hills and a cloudy sky. Desert vegetation is seen throughout the landscape, enhancing the natural beauty.
Home in Las Cruces
4.97 out of 5 average rating, 155 reviews

Desert Oasis with Pool

Pueblo Style home on 1+ Acre with Pool! This charming 4BR/2BA Pueblo Style home features stunning details throughout. Gorgeous saltillo tile in the living areas with beautiful wood beam accents, and a kiva-style fireplace for cozy winter nights. The primary suite offers direct access to the covered patio for summer dips in the pool and evening Sunsets. The 4th bedroom is huge and could be used as a second living area. The pool is not heated but will be open and cleaned all year. Sorry no pets.

Top guest favorite
The kitchen features white cabinetry with glass-fronted doors, a granite countertop, and stainless steel appliances. A decorative rug lies on the floor, while plants and artwork add touches of color. Ample natural light illuminates the space, creating a welcoming atmosphere for meal preparation.
Guesthouse in Mesilla
4.95 out of 5 average rating, 107 reviews

Relax in the ❤️ of Old Mesilla. Close to plaza.

Welcome to Casa de Martiana! This gorgeous casita is located just a few short blocks (about 1/4 mile) from the plaza in Old Mesilla where you will find tons of great restaurants (mostly delicious Mexican food), wineries, bars, unique shopping and fun events. There is a market in the square on Fridays and Sundays with neat jewelry, art and other local treasures. The area is rich in history and culture and has many tales of days when Billy the Kid and Pat Garrett used to wonder the village.

Guest favorite
Home in Mesilla Park
4.94 out of 5 average rating, 156 reviews

Conway Cottage 2

Step into your newly renovated one-bed, one-bath haven located at the heart of Mesilla Park. Enjoy a leisurely walk to Picacho Roasters for a delightful coffee experience, or hop on a cruiser bike for a charming ride to historic Mesilla. Immerse yourself in the local ambiance, sipping a drink to the backdrop of live music. As the morning sun rises, take a stroll amidst century-old trees that grace Conway Avenue. Welcome home to a blend of modern comfort and the timeless charm of Mesilla Park.

Top guest favorite
A welcoming porch features two light blue chairs positioned beside a rustic table under a wooden beam ceiling. A ceiling fan hangs above, and a colorful door adds a touch of character. A dried chili pepper wreath decorates the entryway, enhancing the outdoor oasis.
Guesthouse in Mesilla
5 out of 5 average rating, 236 reviews

Ocotillo Casita in Historic Mesilla.

Mesilla STR Permit #0830 We've renovated 90-year-old historic structures to create sustainable, environmental friendly spaces with rainwater harvesting, solar energy, electric solar-powered car charger. This renovated adobe casita is the 2nd structure after our main house. The 3rd is a smaller vacation rental called Yucca Casita. We are within 2 blocks of the historic Mesilla plaza with its farmers market, shops, galleries, restaurants, and walking trails along historic acequias (canals).

Top guest favorite
Guesthouse in Las Cruces
4.96 out of 5 average rating, 144 reviews

1 king bd with big fenced back yard pets welcome

Casita La Pacana is nestled in the middle of town surrounded by old pecan trees. Feels like the country but is in the middle of town. 1 bedroom, completely renovated casita that has 1 kind bed, a large living room, streaming TVs in both living room and bedroom, full kitchen including a dishwasher and washer/dryer, hardwood floors, authentic Talavera tile, large shower with a bench seat, huge back yard, and ample parking! This little casita has everything to be your home away from home.

Top guest favorite
A bright interior features a queen bed adorned with geometric patterned bedding. Adjacent to the bed, two armchairs offer comfortable seating. A small loft area with a twin bed is visible overhead. A mirror and lamps provide additional lighting in the room.
Tiny home in La Mesa
4.97 out of 5 average rating, 206 reviews

Little House with Private Patio and Hot Tub

Our guesthouse is located on historic Highway 28, also known as the Don Juan de Onate Trail, which connects El Paso and Las Cruces. It is one of the area's most scenic routes. You can find breweries, multiple wineries, and the famous Chopes restaurant and bar along the route. The highlight of the 10-mile drive from our little house in San Miguel to historic Mesilla takes you through unique canopies of pecan trees, in the largest pecan-producing county in the nation.

Top guest favorite
A spacious room features a regal four-poster bed adorned with golden bedding. Antique-style lamps on either side illuminate the space, while a cozy seating area in the corner invites relaxation. Exposed wooden beams and a decorative fireplace add to the historic Southwestern charm.
Guest suite in Mesilla
4.99 out of 5 average rating, 126 reviews

Josefina's King Suite in Mesilla Plaza.

Josefina's King Suite is located just off the Plaza in Historic Old Mesilla. Behind the thick adobe walls, you will find this tranquil retreat. Charmed by the ambiance of our historic Southwestern design and the Garden Greenhouse, our luxurious King Suite offers a cozy step back in time, weaving together old world charm and modern comforts like WIFI, mini fridge, AC, plush bathrobes and more. If the King is already booked, please check out our Queen Suite!

Top guest favorite
A spacious outdoor area showcases a desert landscape with gravel and low-lying plants. A large round table is accompanied by a bright red umbrella, offering shade. The casita's entrance features a patio with seating and a welcoming purple trim, enhancing the inviting exterior.
Home in Mesilla
4.97 out of 5 average rating, 194 reviews

Charming Adobe One Block from the Mesilla Plaza

Beautiful, private casita built in the 1930's one block from the plaza. Historic charm with modern conveniences. Perfect for quiet retreat. Fenced flagstone patio in back yard fully equipped with gas grill, outdoor fireplace, outdoor dining area and french doors opening from the house. Large front yard fully enclosed. Full front porch creates shade. This house is peaceful but just steps from the fiestas and activities on the historical Mesilla Plaza.

Top guest favorite
An adobe-style home is displayed, featuring a gravel pathway leading to an entrance framed by wooden gates. Two turquoise chairs sit beside a small table under a budding tree. Planted flowers in bright pots add color to the exterior, enhancing the welcoming appearance.
Home in Mesilla
4.98 out of 5 average rating, 169 reviews

Sombra Del Valle in Historic Mesilla.

Sombra Del Valle is a beautiful home located in a quiet neighborhood and within 5 minute walking distance to the historic Mesilla plaza and 2 minute walking distance to a Brewery and restaurant and approximately 5 minute drive to NMSU. The home is comfortable and spacious; great for family trips, honeymoons, or just a fun getaway. There is free guest private parking. Once you stay here you will want to come back; it’s a home away from home.

Top guest favorite
A cozy interior space features a queen bed with a bright yellow throw pillow. A kitchenette with a microwave, mini-fridge, and sink is present. Natural light filters through the windows, which are adorned with blue curtains. A small table and chairs complement the room's design.
Guesthouse in Las Cruces
4.97 out of 5 average rating, 359 reviews

Cozy Casita w/private patio near Old Mesilla

This adorable casita is located just one mile from Historic Mesilla and 5 min from the interstate. The one bedroom 1 bath casita is perfect for visitors and travelers alike. Furnished with a queen bed, table and chairs and a outfitted kitchenette with microwave/air fry toaster oven/Keurig /double hot plate/ sink and mini-fridge. Also includes Wi-Fi , Smart TV (no cable), mini-split AC/ heater, and a private outdoor patio table and gas grill.

Top guest favorite
A charming casita features a turquoise door and a light exterior, framed by subtle landscaping. The sky is filled with vibrant orange and yellow hues as the sun sets, creating a striking contrast against the white walls and windows.
Guesthouse in Mesilla
4.99 out of 5 average rating, 216 reviews

Cozy Casita De Mesilla (Mesilla Cottage)

Cozy casita just steps from Old Mesilla’s historic plaza and coffee shops. Unwind in your private courtyard with a hot tub, or curl up by the fireplace inside the guesthouse. A kitchenette adds comfort for longer stays. Mesilla Bosque State Park by the Rio Grande is only 4 minutes by car—or a short bike ride—perfect for birdwatching, sunsets, and peaceful walks. The ideal spot for a romantic getaway or quiet retreat.

Top guest favorite
A warm sleeping area features a queen bed with a neutral quilt and accent pillows. Two bedside lamps illuminate the space with soft light. The ceiling showcases rustic wooden beams, while a framed artwork hangs above the bed, complemented by a textured area rug beneath.
Guesthouse in Las Cruces
4.94 out of 5 average rating, 141 reviews

Rustic Downtown Hideaway

This Rustic guest home has all the amenities, 1 Queen bed, couch sleeps small person or child, and walk-in shower. Inspired by the old west, this guest home has reclaimed wood and tin roof from an old barn in New Mexico. Within walking distance to cafes, restaurants, bars, and shops. Easy private access, keyless entry, and off street parking.

Popular amenities for Mesilla vacation rentals

When is the best time to visit Mesilla?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$21,951 GYDG$20,906 GYDG$22,578 GYDG$20,906 GYDG$22,787 GYDG$21,324 GYDG$20,488 GYDG$20,697 GYDG$20,697 GYDG$20,697 GYDG$21,951 GYDG$22,578 GYD
Avg. temp4°C7°C10°C14°C19°C25°C27°C25°C22°C15°C9°C4°C

Frequently Asked Questions

  • Are there family-friendly vacation rentals in Mesilla?

    Mesilla has more than 40 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in guesthouse rentals in Mesilla?

    Experience the best of Mesilla with our guesthouse rentals, starting at about $70 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Mesilla?

    Four-legged friends are welcome in Mesilla. Choose from more than 40 vacation rentals for guests traveling with pets.

  • Are there vacation rentals with a dedicated workspace in Mesilla?

    Yes! Work meets play with ease at over 30 vacation rentals in Mesilla featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there Mesilla condo rentals on Airbnb with pools?

    Yes! Dive into the perfect getaway at one of over 10 condo rentals with pools in Mesilla, available on Airbnb. Make a splash and soak up the sun in style!

  • Where should I stay in Mesilla?

    Make yourself at home in Mesilla by choosing from our most frequently booked neighborhoods. We have over 540 vacation rentals in Avienda de Mesilla, and over 210 vacation rentals in Mesilla.

  • Do house rentals in Mesilla have air conditioning?

    Absolutely! We offer over 30 house rentals with air conditioning in Mesilla. Enjoy a tailored experience with all the comforts you desire.

  • Do condo rentals in Mesilla have a kitchen?

    Absolutely! We offer over 10 condo rentals with a kitchen in Mesilla. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Mesilla have wifi?

    Absolutely! We offer over 30 house rentals with wifi in Mesilla. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Mesilla have free parking?

    Absolutely! We offer over 20 house rentals with free parking in Mesilla. Enjoy a tailored experience with all the comforts you desire.

Quick stats about vacation rentals in Mesilla

  • Total vacation rentals

    Explore 70 vacation rentals in Mesilla

  • Nightly prices starting at

    Mesilla vacation rentals start at G$10,453 GYD per night before taxes and fees

  • Verified guest reviews

    Over 7,650 verified reviews to help you choose

  • Family-friendly vacation rentals

    40 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 40 rentals that welcome pets

  • Vacation rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Mesilla vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mesilla rentals

  • 4.9 Average rating

    Mesilla stays are highly rated by guests—averaging 4.9 out of 5!

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