Family-friendly vacation rentals in Mesa County

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Mesa County

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Paonia

4.91 out of 5 average rating, 640 reviews

Kale's Private & Romantic Rental with New King Bed

Kale's Cottage features a kind size bed and is the epitome of unique and comfortable stays in Western Colorado. Our award-winning, pet-friendly Solargon boasts an elegant design, and is located just a half-mile walk away from the charming downtown of Paonia. The 374 sq ft space offers a fully stocked kitchen, seasonal wood stove, work/dining table & spacious private bathroom with shower. Whether for a special getaway, work, hiking, business or adventure, this is your perfect home away from home.

Apr 20 – 27

G$17,674 GYD per night

Guest favorite

Home in Grand Junction

4.9 out of 5 average rating, 228 reviews

Hill View in the Ridges

What you will find during your stay here? Awe-inspiring natural beauty of the Red Rocks of the Colorado National Monument. Exhilarating outdoor adventures including hiking, skiing. Hundreds of miles of world-class mountain biking trails such as Kokopelli Trail. Incredible whitewater rafting on the Colorado River. Stunning golf courses whose green fairways are juxtaposed against the craggy Redland desert. All with in miles of the Redlands Golf course, Lunch Loop bike trail and Two Rivers Winery.

Aug 29 – Sep 5

G$27,221 GYD per night

Guest favorite

Guest suite in Crawford

4.97 out of 5 average rating, 538 reviews

Crawford’s Mountain View Getaway

Enjoy a stunning Rocky Mountain View of Needle Rock and the Pitkin Range. The space has many amenities for 1 to 12 people. Families, hunters, couples, all are welcome to enjoy the indoor/outdoor private areas with their rustic southwest decor in the lower level walkout. 1.5 miles from the "last genuine cowtown" Crawford, CO, (you might see a cattle drive going through town), 1 mile from the Crawford Lake, 11 miles to Black Canyon of the Gunnison National Park. Cleaning info in things to note.

Mar 27 – Apr 3

G$27,252 GYD per night

Guest favorite

Home in Grand Junction

4.99 out of 5 average rating, 141 reviews

Blue Door Farm Vacation Rental

Beautiful, sunny, and brand-new vacation rental in the heart of southwestern Colorado's peach and wine country. Blue Door Farm Vacation Rental LLC offers full accommodations for 1 to 6 guests, with sweeping views of the Grand Valley from the high desert to the Grand Mesa. It is a 15 minute drive to downtown Palisade and Grand Junction, and only 5 minutes to one hour's drive to amazing year-round outdoor recreation, including hiking, biking, skiing, agritourism, music festivals and wineries.

Dec 26 – Jan 2

G$35,685 GYD per night

Guest favorite

Home in Grand Junction

4.92 out of 5 average rating, 153 reviews

5200SqFt, Hillside Rock In House, Stunning Views

One of a kind 4BR 3BA 5,200 sqft home. Stunning views of the CO Ntl Mnt and entire Grand Valley. Our grandpa, a home builder, designed this rustic house as a masterpiece for his family. He wanted it to be part of nature, so he fit it between trees and inside left exposed the massive sandstone slab on which it’s built. This large house has entertained our family and friends for generations, and we’re thrilled that now you can share it with yours, too. Be in nature but minutes from downtown!

Apr 8 – 15

G$70,148 GYD per night

Guest favorite

Guest suite in Fruita

4.97 out of 5 average rating, 205 reviews

Bookcliff Ranch Casita

The Bookcliff Ranch Casita is on a secluded, "end of the road" 110 acre ranch a short 5 mile drive from the quaint, friendly, always active town of Fruita - a mountain biker's paradise with 100s of miles of biking & hiking trails. The Casita is close to the North Fruita Desert Trail Head's biking, hiking, horse, & OHV trails. The casita includes access to our pool. We are pet friendly with a small $30 one time fee per dog. Trailer parking and options for horse boarding are also available.

Jul 9 – 16

G$24,971 GYD per night

Guest favorite

Guest suite in Grand Junction

4.83 out of 5 average rating, 120 reviews

Private Suite in Unique GJ Home !!

Recently remodeled suite in the lower level of my home! Great for long term traveling Medical Professionals! Private Bedroom/Living Room/Bathroom Suite in a convenient GJ location. Unique house, (Frank L Wright 'Usonian House'), wall of windows, suite opens to sub-level yard & patio. Close to CO Mesa Univ & St Mary's Hospital. Wi-fi, queen bed, desk, off street parking, and private entrance. Restaurants, shops & activities nearby. Using safe Covid practices! Accept guests over 25 yrs only.

Jun 9 – 14

G$20,476 GYD per night

Guest favorite

Guest suite in Paonia

4.99 out of 5 average rating, 273 reviews

Very spacious private floor with beautiful views.

Self check-in to the space makes it especially convenient for travelers no matter when you arrive. Views of the surrounding mountains are breathtaking.Our place is good for couples, solo adventurers, and business travelers. The space is on your own floor, completely separated from our upstairs space and with a private entrance. Enjoy a self-serve continental breakfast with freshly ground coffee and an assortment of teas. The location is quiet and private, yet so close to town.

Jun 22 – 29

G$17,239 GYD per night

Guest favorite

Barn in Palisade

4.9 out of 5 average rating, 511 reviews

Beautiful Vineyard Barn House

Our spacious and newly renovated large barn has a beautiful view of the Grand Valley. Relax among the vines under Mt. Garfield. Drink wine at one of the many wineries. Enjoy peace and quiet while picking a peach in the orchard or grapes in the vineyard. We are conveniently located 2 miles from downtown Palisade and 13 miles from downtown Grand Junction. From skiing, to mountain biking, to rafting, to hiking, and road biking there are outdoor activities nearby for all levels.

Aug 24 – 31

G$46,397 GYD per night

Superhost

Home in Paonia

4.73 out of 5 average rating, 262 reviews

Downtown n' Private

Location, Location, Location. Your B&B is one block from the bustling Paonia downtown! The house is spacious with a zest for the past and features one of the best covered patios in town! Summer gardens and privacy are what make this an excellent choice. For all you Verizon patrons your phone will squeak by here too. Take advantage of the furnished kitchen or enjoy the towns local fair. Your accommodations are flanked by Dons Market, and Sweetgrass cafe.

Oct 1 – 8

G$18,808 GYD per night

Guest favorite

Home in Hotchkiss

4.95 out of 5 average rating, 149 reviews

The Moon House. Come mingle with the stars.

The Moon House is the perfect getaway for travelers that are looking for a little more space, elegance, and amenities. Relax, unwind, and enjoy the views of the West Elks and the night sky on the covered porch with fire pit. The house telescope lets you explore the galaxy and the soaking tub is a perfect nightcap to your hikes and wine tours. Bring your friends or family for an unforgettable western slope adventure. Book now to guarantee your reservation!

Dec 19 – 26

G$38,492 GYD per night

Guest favorite

Apartment in Grand Junction

4.94 out of 5 average rating, 249 reviews

In town, bike friendly, modern apt.

Enjoy Grand Junction in our newly renovated modern apartment. Centrally located with only a short walk to Main Street's many great restaurants! Our favorites are Bin 707, Il Bistro Italiano, Cafe Sol, Dream Cafe, and Pablo's Pizza. GJ's Lunch Loop trails are only a 10 minute ride away. Check out this site for top spots to visit! https://www.tripadvisor.com/Attractions-g33450-Activities-Grand_Junction_Colorado.html

Sep 18 – 25

G$21,470 GYD per night