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Guesthouse vacation rentals in Mesa

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mesa guesthouse rentals

Family-friendly guest house rentals

Superhost
Guesthouse in Phoenix
4.86 out of 5 average rating, 557 reviews

Architectural Dream Guest House

JohnRating, 5 stars2 weeks ago
Great especially if you have transport great kitchen and patio wonderful design.... all the uber drivers were in awe of the architecture. good fir morning run just great
Guest favorite
Guesthouse in Phoenix
4.93 out of 5 average rating, 1,390 reviews

Centrally Located Renovated Guest House

KaylaRating, 5 stars1 day ago
Shaayna’s place was super clean which is something 100% important! Clean bathroom and tub/shower! Clean appliances! It’s located in a very peaceful area! Check in is pretty easy and WiFi is great! You’ll love it here!
Guest favorite
Guesthouse in Gilbert
4.95 out of 5 average rating, 309 reviews

Two Bedroom, clean guest house in Gilbert

Di AnnRating, 5 stars3 weeks ago
The house was just as pictured and exactly what we needed. It was clean, convenient and quiet! It made our graduation visit so easy. I'm not sure the AZ heat will get any easier on us, but we would definitely be happy to stay here again.
Top guest favorite
Guesthouse in Phoenix
4.97 out of 5 average rating, 451 reviews

The Cozy Container with pool & gym

RyleyRating, 5 stars5 days ago
Easy to follow instructions! Nice spot to lay your head!
Top guest favorite
Guesthouse in Phoenix
5 out of 5 average rating, 107 reviews

Private, Spacious, Desert View on 1.5 acres!

DavidRating, 5 stars2 months ago
We had an incredible stay with Christina and Erik in Phoenix and they were both such great hosts. The guest house is beautifully updated, spotless, and offers a stunning view of the backyard and surrounding mountains. My son especially enjoyed watching the horses and chickens right from our window, and we loved how peaceful and private everything felt—despite being just a 10-minute drive from the city. We’ll absolutely be staying here again when we’re back in the area!
Top guest favorite
Guesthouse in Phoenix
4.98 out of 5 average rating, 1,018 reviews

Boutique Hotel Style Guest House

LaraRating, 5 stars1 week ago
We were driving through Phoenix and this was absolutely the best we could have asked for. Phil and Peggy’s casita was exactly what we needed—clean, well-equipped, comfortable bed, and cute outdoor space for our pup. This was one of the highest-quality airbnbs I’ve ever stayed in. Highly recommended
Top guest favorite
Guesthouse in Paradise Valley
4.97 out of 5 average rating, 179 reviews

1BR Guest House with Private Yard

AudraRating, 5 stars1 week ago
We had a great stay! Quiet and loved the separate yard for our pup. Would highly recommend
Guest favorite
Guesthouse in Tempe
4.91 out of 5 average rating, 352 reviews

Unique urban habitat near ASU/downtown Tempe

TonyRating, 5 stars2 weeks ago
Great stay in Tempe. The bathroom was amazing—super clean and modern—and the natural lighting throughout the place made it feel bright and welcoming. AC was a little on the noisy side, but nothing that kept me from getting good sleep.

Guest house rentals with a patio

Guest favorite
Guesthouse in Encanto
4.91 out of 5 average rating, 244 reviews

McDowell Suite

SteveRating, 5 stars2 weeks ago
As advertised, well equipped, clean and comfortable. I would stay again.
Guest favorite
Guesthouse in Phoenix
4.92 out of 5 average rating, 126 reviews

Sunshine Studio! Phx/Scottsdale border!

MichaelRating, 5 stars1 week ago
Perfectly adequate little studio in Phoenix. If you plan on spending most of your days out and about it’s perfect. But if you like to stay in your rental and just enjoy the location I would drop a little more cash and get somewhere with more yard space and a pool.
Guest favorite
Guesthouse in Phoenix
4.93 out of 5 average rating, 226 reviews

Granada - Adorable, Chic Studio Apt Biltmore Area

DeidraRating, 5 stars2 weeks ago
Luis has such a cute, cozy, comfortable, clean and quiet place. I needed a place to stay for a couple of days while my floors were getting installed. The decor and colors were so warm & lovely and the location was convenient. The studio has everything needed for an enjoyable stay. Great staycation for me. I'll definitely stay there again and recommend to out of town guests.
Top guest favorite
Guesthouse in South Mountain
4.97 out of 5 average rating, 115 reviews

Hidden Oasis at South Mountain!

CadeRating, 5 stars4 days ago
Such a great little place, a nice retreat from the world with beautiful surroundings. Also close enough to everything to be perfect for business in and around the city.
Guest favorite
Guesthouse in Phoenix
4.92 out of 5 average rating, 146 reviews

Downtown Studio - Woodland Historic District

CynthiaRating, 5 stars5 days ago
Rob's place was peaceful, clean, comfortable and in a great location He was very responsive if I needed him. Thanks Rob!
Top guest favorite
Guesthouse in Moon Valley
4.97 out of 5 average rating, 147 reviews

Zen Modern Casita w/ Private Pool + King Bed

GretchenRating, 5 stars2 weeks ago
Another great stay at Ann's casita!! Ann is an amazing host, her casita is wonderful! Highly recommended!
Top guest favorite
Guesthouse in Scottsdale
4.98 out of 5 average rating, 128 reviews

Entire Private Guest House with King Master

VeronicaRating, 5 stars1 month ago
I really enjoyed my stay!! I was in town for my son graduation and Camille's listing exceeded my expectations and will definitely recommend for anyone the area!! I would definitely stay again when I'm in town!!
Top guest favorite
Guesthouse in Phoenix
4.99 out of 5 average rating, 217 reviews

Your favorite PHX guesthouse!

RachelRating, 5 stars1 week ago
Bradley’s place was perfect! I really appreciated the thoughtful touches like the real plants, coffee station, and bathroom toiletries. It was peaceful, comfortable, and felt just like home. The private entrance with an enclosed gate was an added bonus and made the space feel extra safe. I will definitely stay here again when I return to Phoenix. I highly recommend!!!

Guest house rentals with a washer and dryer

Top guest favorite
Guesthouse in Willow
5 out of 5 average rating, 206 reviews

Adorable Willo Cottage in Historic Central Phoenix

AndreaRating, 5 stars1 week ago
So cute, clean, and in a peaceful nice neighborhood. Lynne was so friendly and went above and beyond to make us feel welcome!
Guest favorite
Guesthouse in Gilbert
4.91 out of 5 average rating, 101 reviews

Private Guest Studio in the Country

SandyRating, 5 stars1 month ago
Enjoyed our stay in this quiet little house. The kitchen and bathroom had the touches of being in one’s own home. Medicine cabinet had things you would find in your cabinet at home.
Guest favorite
Guesthouse in Gilbert
4.97 out of 5 average rating, 104 reviews

Gilbert Guesthouse: Centrally Located Cozy Studio

ShayRating, 5 stars1 week ago
This is our third time staying here, and we love it! One of the best stays in Gilbert!
Top guest favorite
Guesthouse in Phoenix
4.98 out of 5 average rating, 989 reviews

Private studio! Central to popular locations.

MollyRating, 5 starstoday
This is a great place. Mike and Paige’s casita is decorated with many nice touches, it is super clean and comfortable with everything one needs.
Guest favorite
Guesthouse in Garfield
4.97 out of 5 average rating, 109 reviews

Downtown Phx | Private Guesthouse & Parking

CarolRating, 5 stars3 weeks ago
What a beautiful place! Off street parking in a gated driveway made us feel quite secure. Everything was very clean. So thoughtful to leave keurig cups, sweeteners and flavored creams for the guest! Ten minutes drive to the airport. Walkable to downtown. Our hosts always responded quickly to any questions and were very considerate. And the apartment looked like a picture from a decorator magazine. We definitely recommend these hosts and this apartment
Top guest favorite
Guesthouse in South Mountain
4.93 out of 5 average rating, 348 reviews

Casita Hideaway at South Mountain

AnitaRating, 5 stars1 week ago
This place was really great and I highly recommend it to anyone. Place was clean and very well stocked with what needed. Instructions for check-in were simple and easy to follow. The best part is the location!! I enjoyed it as it was close to several restaurants, Target & Walmart, South Mountain Preserve and downtown Phoenix. I would definitely stay again!
Superhost
Guesthouse in Arcadia
4.87 out of 5 average rating, 125 reviews

Beautiful Private Guest House in Arcadia

QuiannaRating, 5 stars1 month ago
Enjoyed the stay! Will book when given the chance again. Host is very nice and friendly.
Top guest favorite
Guesthouse in Coronado
4.99 out of 5 average rating, 149 reviews

DARK HOUSE | private, modern Spanish casita

KyllaRating, 5 stars1 month ago
I have stayed at Donna’s listing more than a few times- it’s one of my favorite places to stay! Great location, value, amenities and extremely comfortable and organized. I can’t wait to stay again!

Quick stats about guesthouse rentals in Mesa

  • Total rentals

    140 properties

  • Nightly prices starting at

    G$6,295 GYD before taxes and fees

  • Total number of reviews

    11K reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Pet-friendly rentals

    30 properties allow pets

  • Rentals with a pool

    50 properties have a pool

Destinations to explore

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  4. Maricopa County
  5. Mesa
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