Medicine Lake vacation rentals

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Top-rated vacation rentals in Medicine Lake

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Guest favorite

The front exterior of a home is presented, featuring a bright green door and planters with vibrant flowers. A landscaped circular garden with various plants surrounds a stone border. The property is set in a neat yard, with an American flag displayed and a vehicle parked nearby.

Home in Minneapolis

4.93 out of 5 average rating, 90 reviews

Cozy Luxe Hideaway Near West End, Parks & Downtown

Kick back and relax in this calm, stylish space. Here is a transformed newly remodeled luxury basement level home filled with everything you need. The home is nestled in a quiet neighborhood with quick access to the West End shops, trails, parks, fine dining, entertainment, sporting events and all major routes to Minneapolis Downtown and the MSP airport. Hosts live upstairs on the main level but very private, quiet and require no direct interaction with guests, as everything is self-service!

Guest favorite

Home in Minneapolis

4.91 out of 5 average rating, 23 reviews

Remodeled Home, King Beds, FastWIFI, Lake Access

This charming house just outside of Minneapolis offers a soothing retreat for guests. With 3 bedrooms including 2 king beds & 1 queen bed, there's plenty of space for everyone to unwind. This recently remodeled property includes amenities like heating, AC, fast WiFi (1000 MPBS), & a washer/drier for added convenience. Indulge in the luxury of 2 bathrooms featuring shower, bathtub, and hair dryers. Right down the road from wedding venue Hutton House, lots of space & natural lighting to get ready!

Guest favorite

A coffee maker sits on a granite countertop beside a rotating display of coffee pods. The kitchen area is visible in the background, featuring a mounted TV and shelf with decor. The minimalist design reflects a functional and inviting space.

Apartment in Northeast Minneapolis

4.93 out of 5 average rating, 196 reviews

Modern Minimalist Northeast Apartment

Make yourself at home in our modern minimalist one bedroom apartment. The cozy ~500 sqft apartment provides all the comfort & has been optimized for functionality! Located in Northeast Minneapolis, this apartment is within walking distance to main metro lines, minutes from downtown, and a short ride from the UMN. There are tons of restaurants and upscale or dive bars that are full of character. Explore the local experience of living in the NorthEast Art District. Book your stay today!

Top guest favorite

An open kitchen and dining area is visible, featuring modern appliances and ample cabinetry. A dining table with black chairs is positioned in the foreground, while a small seating arrangement is seen nearby. Natural light enters through a large window, illuminating the inviting space.

Home in Plymouth

4.97 out of 5 average rating, 59 reviews

Mother-in-law suite in Plymouth

We'd love to host you in our mother-in-law suite with large beautiful kitchen & washer and dryer. We are right around the corner from beautiful Medicine Lake, bike trails & parks, and a convenient 15 min drive into downtown Minneapolis. This space is private with a separate entrance & driveway. It is downstairs and we live upstairs. We do our best to minimize pitter-patter, however we do have a 3 year old so you can expect some sound from 8AM-8PM. We look forward to hosting you!

Top guest favorite

A compact bathroom is shown, featuring a stand-up shower enclosed in glass, showcasing clean white walls and a sleek showerhead. A toilet is positioned next to the shower, and a dark-colored towel hangs on a rack. The floor is covered with a patterned rug.

Guest suite in Brooklyn Park

4.94 out of 5 average rating, 63 reviews

Private suite at the red door

Cute mother-in-law suite in a newer townhouse neighborhood. Great area with biking trails, walking trails, shopping, and dining nearby. We live in a very culturally diverse neighborhood with plenty dining/grocery store options. 20 minutes from downtown Minneapolis, easy access to 610 freeway. Less than 5 miles from Arbor Lakes retail shops, with many more restaurants/specialty shops/grocery stores for anything you may need. Perfect for travel nurses also. This is a very safe area.

Guest favorite

A well-appointed bedroom features a spacious bed with a light-colored coverlet. Soft lighting is provided by a bedside lamp on a metallic side table. A decorative wall hanging adds visual interest, while a small chair and a window allow natural light to fill the room.

Home in Minneapolis

4.98 out of 5 average rating, 109 reviews

Light & Bright MN Retreat 15 mins from everything

This charming home features 4 bedrooms and 4 beds, and 2 baths. The open floor plan seamlessly connects the living room to the dining area and kitchen, with beautiful flooring, stainless steel appliances, and an impressive stone fireplace. This home provides a warm and welcoming atmosphere with all new furniture. A fenced-in yard with a huge deck perfect for entertaining. The combination of modern amenities and timeless features creates an atmosphere that feels just right!

Guest favorite

The bathroom features a clean and modern design, with a shower and bathtub combination. A large mirror is positioned above a gray vanity with storage. Decorative signs reading 'WASH', 'BRUSH', and 'FLOSS' are displayed on the wall, accompanied by potted flowers for a touch of color.

Home in Plymouth

4.92 out of 5 average rating, 366 reviews

Blue Cabin

LOCATION: Entire house located off Hwy 169 on the frontage road. Please note the house is right off the highway. My unit is a 650 sq ft house. One bedroom 1 bathroom. Has a full kitchen and laundry free to use. • PROFESSIONALLY CLEANED • EASY ACCESS TO DOWNTOWN (15 MINS) • EASY ACCESS TO AIRPORT & MALL OF AMERICA (30 MINS) • MEDICINE LAKE WALKING PATHS (2 MIN) • FREE COFFEE • FREE PARKING • FREE FAST WIFI • SELF CHECKIN WITH KEYPAD NO SMOKING AND NO PETS PLEASE

Guest favorite

A well-stocked kitchen area features a modern design with a large window allowing natural light. A wooden countertop is complemented by two stools with a distinct patterned base. Plants and decorative elements add vibrancy, while stainless steel appliances are neatly integrated into the space.

Guesthouse in Minneapolis

4.96 out of 5 average rating, 160 reviews

Tropical Scandinavian Treehouse Uptown Newly Built

Designer-owned Uptown hideaway just 1 block from LynLake! Walk to top spots like Sooki & Mimi, The Lynhall, or Lake Harriet. Enjoy a private Queen bedroom, full-size daybed, washer/dryer, separate heat/A/C, and a fully stocked kitchen. Stylish decor and beautiful natural light throughout. On-site street parking. Only 15 mins to MSP Airport. One dog under 20 lbs allowed—larger dogs with approval. Perfect for a cozy, walkable stay in the heart of Minneapolis!

Guest favorite

A circular fire pit, surrounded by log seats, is lit with flames reaching upward. Tall trees border the area, providing a natural backdrop, while a view of the serene lake is visible beyond the fire pit. The earth is slightly uneven, enhancing the rustic setting.

Home in Minneapolis

4.9 out of 5 average rating, 182 reviews

Private Queen 1 BR Apartment in 4 BR Lakeside Home

Secluded, 1 acre, 4 BR 2 BA house on Lake Hannon only 10 min from downtown. Lower level Queen 1-BR apartment (1000 ft2) with private large living room, kitchen and bath. Private lakeside entrance with secure self check-in Huge patio overlooking Hannon Lake w/hammock. Near walking and biking trails Make a campfire & enjoy the view. The lake is a magnet for wildlife but shallow and not a good fishing lake but there are some good fishing lakes nearby.

Guest favorite

A spacious studio setup features a Queen bed adorned with soft linens, complemented by a cozy couch and a small dining table. Natural light filters through the windows, and a decorative mirror enhances the sense of space. A private entrance is visible in the background.

Home in Minneapolis

4.92 out of 5 average rating, 24 reviews

Duplex studio suite

A main level access studio is situated in a convenient location just 10 minutes from downtown and 1 mile from the beautiful Theodore Wirth Park. This quaint retreat offers the perfect blend of urban convenience and natural beauty. The Space: The space is a lower unit studio of a duplex. The entrance is your own and will have your own bathroom and closet. TV, couch, Queen bed, small dinner table and kitchenet with microwave, toaster, small fridge.

Superhost

A well-maintained garden path winds through a vibrant array of flowers and greenery. Colorful blooms in shades of yellow and purple line the sides, while taller plants and decorative structures add depth to the landscape. A serene atmosphere is enhanced by natural textures and plant arrangements.

Condo in Minneapolis

4.84 out of 5 average rating, 316 reviews

Entire apartment ready for your stay. Very Private

For your enjoyment is a clean one bedroom apartment in my home. It has its own private entrance, reserved parking, a luxurious bathroom with a deep soaker tub and a fully equipped kitchen. In the bedroom is a king sized bed and a smart TV connected to the internet for your use. The home is located on a cul de sac in a quiet neighborhood that is close to everything. Within blocks of the house, there are restaurants, shops and several grocery stores.

Top guest favorite

A laundry room contains a white washing machine and a dryer, positioned alongside a utility sink. A bottle of laundry detergent rests on the dryer, and visible plumbing can be seen in the background.

Home in Plymouth

5 out of 5 average rating, 22 reviews

Garden level fully separated suite

Mother in Law Suite in a single family home with a fully separate space and entrance. The Suite has its own living room, bathroom, kitchen and laundry room. This area is very convenient to 394 and 494. 8 minutes to Downtown Wayzata. 20 minutes to Downtown Minneapolis. Convenient off street parking. Code based keypad to allow for easy check-in. Off Street parking space. Backyard with grill.