Pet-friendly vacation rentals in Mark Twain Lake

Find and book unique pet-friendly homes on Airbnb

Top-rated pet-friendly home rentals in Mark Twain Lake

Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

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Superhost

An inviting interior showcases a spacious living area with comfortable seating and open access to a well-equipped kitchen. The dining area is arranged for family gatherings, featuring a large table surrounded by chairs, with light filtering in through large windows.

Home in Jefferson Township

4.8 out of 5 average rating, 10 reviews

Home & Shop Getaway - Guys Girls or Family Weekend

- Spacious 3-bedroom getaway near Mark Twain Lake - Large shop with outdoor games, poker, and more - 2 cribs/pack n plays available for families - Quick 5-minute walk to Otter Creek, Mark Twain Lake - 10-minute drive to the boat dock - 10-minute drive to town for essentials, Paris - Quiet subdivision for peaceful stay - Fire pit outside for cozy evenings - Almost 3-acre wooded lot for hiking and exploring - TV entertainment with various subscriptions - No cleaning duties required at departure

Guest favorite

A single-story house is set within a spacious yard, surrounded by trees. A red star adorns the front exterior, and a small seating area is visible on the porch. The property is enclosed by a black fence, enhancing the tranquil outdoor space.

Home in Hannibal

4.95 out of 5 average rating, 118 reviews

Little House in the Hollow

Enjoy a private peaceful setting that is Conveniently located. Large fenced in yard for the kids and/or pets. Also has a 4 person hotub which is available year-round. The house is fully stocked for convenience. The house also has covered parking, outdoor fire pit, BBQ grill a play place for the kids and more. You will be within walking distance of 2 National Landmarks (Mark Twain Cave, Cameron Cave) as well as our Winery and Giftshop. Located just two miles from Hannibal's Historic District.

Guest favorite

A classic Queen Anne Victorian home is displayed with its distinctive yellow exterior. The porch features a welcoming seating area, while a neatly manicured garden with colorful shrubs runs along the pathway. Autumn leaves cover the ground, adding a seasonal touch to the setting.

Home in Hannibal

5 out of 5 average rating, 6 reviews

The John Sydney House - Family Friendly Queen Anne

This classic Queen Anne Victorian (c. 1892) has retained many original features that are just breathtaking! A grand oak staircase, original hardwood floors and trim, stained glass, French and Pocket Doors just to name a few. Staying here offers the traveler in search of history a uniquely clear connection to Hannibal's past, its place in time and to the local culture – with modern amenities! This historic home is also spacious, comfortable and family & pet friendly. Walk to downtown!

Guest favorite

A spacious porch is featured, with wooden flooring and railing. Two chairs and a small table are positioned to the side, allowing for views of the open pasture bathed in warm sunlight. The sun's rays create a serene atmosphere as it sets in the background.

Farm stay in Quincy

4.88 out of 5 average rating, 111 reviews

Cozy and Convenient Guesthouse on Family Farm!

Right on the edge of town, and only a quick trip to everything in town, the guesthouse on our family farm is the perfect stay. It's quaint and cozy, yet convenient to the highway, shopping, restaurants, and groceries. You will feel right at home, whether you're cozying up to watch a movie, sitting on the front porch watching the sun set, or cooking breakfast in our full kitchen. Welcome to your farm away from home! Close to the airport! Right off the interstate 2 minutes from Walmart

Guest favorite

A spacious living area features a round coffee table at the center, adorned with a decorative tray and books. Bright natural light filters in through large arched windows, highlighting a cozy sofa and a dining set in the background. A plant adds a touch of greenery.

Home in Quincy

4.93 out of 5 average rating, 56 reviews

Traveler's Hideaway

Remodeled, charming older home with modern amenities, ample natural light and spacious rooms. The layout is perfect for guests' privacy with bedrooms located at opposite ends of the house. The kitchen, living and dining spaces are centrally located with everything you need to settle in and relax after a long day of travel or work. Restaurants, shopping and entertainment are all a short walk or drive away. Come stay with us to experience the best combination of convenience and comfort!

Guest favorite

A contemporary red barn-style building is featured, with a metal roof and several large windows allowing natural light. Two air conditioning units are positioned outside, along the gravel pathway leading to a white door. Green fields are visible in the background.

Barn in Shelbina

5 out of 5 average rating, 13 reviews

Berti’s Nest

You won’t forget the peaceful surroundings of this rustic destination. Located between Shelbina and Shelbyville, Missouri, within one-fourth mile of Shelbina Lakeside Golf Course, Shelbina Lake with fishing, disc golf, walking trail, playgrounds, basketball and tennis courts. Our property offers catch and release fishing also. Shelbina also offers weekend movies at Hawkins Theatre and live productions on occasion. There is a public zero entry pool, in season, at the Aquatic Park.

Guest favorite

A historic two-story Victorian home is surrounded by lush greenery. The porch is covered, providing a welcoming space with steps leading up to the entrance. Large windows allow natural light to fill the interior, and a well-kept lawn adds to the home's charm.

Home in Palmyra

4.93 out of 5 average rating, 41 reviews

Spacious Historic Two Story Home

Located on historic Palmyra Main Street, this home is only 12 minutes to the legendary home of Mark Twain -Hannibal, MO. Bring the whole family to this great place with lots of room for fun. This updated two story historic Victorian home is close to everything, making it easy to plan your visit. Enjoy a large covered front porch to relax. This home has the original refinished hardwood floors throughout. I love the unique hand crafted wood furniture in the dining and living room.

Top guest favorite

The living area features light-colored sofas arranged around a round wooden coffee table. A large flat-screen TV is mounted on the wall opposite. Soft lighting from recessed fixtures enhances the neutral-toned walls, creating a clean and inviting space. Decorative elements add subtle texture.

Home in Shelbina

5 out of 5 average rating, 76 reviews

Shelbina Town & Country Retreat

This fully renovated duplex is located in the center of town on a quiet street a couple blocks from downtown. Our tastefully adorned home suits various accommodation needs. The master bedroom is large with a workspace, and both bedrooms have queen beds as well as a hideaway bed in the living room. This open concept gives your group plenty of space for your stay, and allows the option for home-cooked meals. Outside, the side yard offers a place to grill. Your home away from home.

Superhost

A spacious living area features a cozy seating arrangement with a dark leather sofa and two gray accent chairs. A fireplace adds warmth, while a television is mounted on the wall. Natural light enters through a front window, highlighting the wooden flooring.

Home in Quincy

4.86 out of 5 average rating, 43 reviews

Gramke Guest House w Country Setting

Tucked away on a rural county road, this peaceful setting is away from it all. With the view of a stocked pond out the front window, deer meandering the land and the bright stars at night. 3 Bed 2 Baths and the rest of the house is wide open. 2 car attached garage. Great for long term or short term stays. Owners and other family members are nearby. Welcome to our little slice of heaven. Fiber Internet IL Broker Owned

Top guest favorite

A well-equipped kitchen features modern appliances, including a stainless steel refrigerator and gas stove. A large island with a marble countertop provides seating for four. Light floods the space through overhead fixtures, enhancing the clean, organized layout that encourages home cooking.

Home in Quincy

4.99 out of 5 average rating, 164 reviews

❤️Quincy Quarters 2❤️

Quincy Quarters is a beautifully restored 1880’s Duplex with modern amenities and all the historic charm. This duplex has been home to families for 140 years. Bring your family and your pet and enjoy 140 years of history. Quincy Quarters is close to Oakley Lindsay Center, Blessing Hospital and Quincy University, it is blocks away from South Park and just a couple minutes from downtown Quincy.

Superhost

The kitchen features a modern design with gray cabinetry and sleek countertops. An island with seating is positioned adjacent to a round dining table. Large appliances are visible, and a window allows natural light to illuminate the space, enhancing the kitchen's functionality.

Home in Palmyra

4.92 out of 5 average rating, 26 reviews

Charming Stay Close to Beau & Co

Welcome to Your Small Town Retreat: 2-BR House Near Beau & Company Escape to this cozy and conveniently located 2-bedroom, 1-bathroom house just moments away from the heart of town. Whether you're here for business or pleasure, this charming Airbnb offers comfort, style, and accessibility. The house features two inviting bedrooms, each thoughtfully decorated for a peaceful night's sleep.

Guest favorite

A modern living area features comfortable black recliner sofas arranged around a small wooden table. A television is mounted on the wall across from the sofas, and a well-equipped kitchen is visible in the background, showcasing sleek cabinetry and appliances.

Guesthouse in Hannibal

4.93 out of 5 average rating, 45 reviews

Quiet/ Relaxing Little Studio

Looking for a peaceful place to stay on your weekend away, or on your vacation to Hannibal? Look no further, centrally located to everything Hannibal has to offer, minutes from Historic downtown, as well as, all of the restaurants and amenities. Don't want to go out every night? Enjoy a home cooked meal on the back porch.